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Aliases for OR5A2 Gene

Aliases for OR5A2 Gene

  • Olfactory Receptor, Family 5, Subfamily A, Member 2 2 3
  • Olfactory Receptor OR11-248 4

External Ids for OR5A2 Gene

Previous GeneCards Identifiers for OR5A2 Gene

  • GC11U990465
  • GC11M058946
  • GC11M059189

Summaries for OR5A2 Gene

Entrez Gene Summary for OR5A2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5A2 Gene

OR5A2 (Olfactory Receptor, Family 5, Subfamily A, Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5AN1.

UniProtKB/Swiss-Prot for OR5A2 Gene

  • Odorant receptor.

Gene Wiki entry for OR5A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5A2 Gene

Genomics for OR5A2 Gene

Regulatory Elements for OR5A2 Gene

Genomic Location for OR5A2 Gene

59,421,943 bp from pter
59,422,976 bp from pter
1,034 bases
Minus strand

Genomic View for OR5A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR5A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5A2 Gene

Proteins for OR5A2 Gene

  • Protein details for OR5A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 5A2
    Protein Accession:
    Secondary Accessions:
    • B9EH21
    • Q6IFF4
    • Q96RB0

    Protein attributes for OR5A2 Gene

    324 amino acids
    Molecular mass:
    36016 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5A2 Gene

Proteomics data for OR5A2 Gene at MOPED

Post-translational modifications for OR5A2 Gene

  • Glycosylation at Asn 6
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5A2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5A2 Gene

Domains & Families for OR5A2 Gene

Gene Families for OR5A2 Gene

Protein Domains for OR5A2 Gene

Suggested Antigen Peptide Sequences for OR5A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5A2: view

Function for OR5A2 Gene

Molecular function for OR5A2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5A2: view

Phenotypes for OR5A2 Gene

GenomeRNAi human phenotypes for OR5A2:
genes like me logo Genes that share phenotypes with OR5A2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR5A2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5A2 Gene

Localization for OR5A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5A2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR5A2 Gene COMPARTMENTS Subcellular localization image for OR5A2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with OR5A2: view

Pathways & Interactions for OR5A2 Gene

genes like me logo Genes that share pathways with OR5A2: view

Pathways by source for OR5A2 Gene

Interacting Proteins for OR5A2 Gene

Gene Ontology (GO) - Biological Process for OR5A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5A2: view

No data available for SIGNOR curated interactions for OR5A2 Gene

Drugs & Compounds for OR5A2 Gene

No Compound Related Data Available

Transcripts for OR5A2 Gene

mRNA/cDNA for OR5A2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR5A2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5A2 Gene

No ASD Table

Relevant External Links for OR5A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR5A2 Gene

mRNA expression in normal human tissues for OR5A2 Gene

SOURCE GeneReport for Unigene cluster for OR5A2 Gene Hs.553648

genes like me logo Genes that share expression patterns with OR5A2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR5A2 Gene

Orthologs for OR5A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC483455 35
  • 88.3 (n)
  • 88.09 (a)
-- 36
  • 88 (a)
-- 36
  • 85 (a)
(Pan troglodytes)
Mammalia LOC466611 35
  • 98.97 (n)
  • 97.84 (a)
OR5A2 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Olr332 35
  • 83.02 (n)
  • 80.5 (a)
(Bos Taurus)
Mammalia -- 36
  • 59 (a)
(Monodelphis domestica)
Mammalia OR5A2 36
  • 75 (a)
(Mus musculus)
Mammalia Olfr1441 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
-- 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491961 35
  • 54.06 (n)
  • 48.36 (a)
Species with no ortholog for OR5A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5A2 Gene

Gene Tree for OR5A2 (if available)
Gene Tree for OR5A2 (if available)

Paralogs for OR5A2 Gene

Paralogs for OR5A2 Gene

(450) SIMAP similar genes for OR5A2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR5A2: view

Variants for OR5A2 Gene

Sequence variations from dbSNP and Humsavar for OR5A2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1453547 - 59,422,439(+) TATAG(A/G)GCCCA reference, missense
rs1453548 -- 59,424,616(+) TTTTT(A/T)AAAAA upstream-variant-2KB
rs2097161 -- 59,424,868(-) AGATC(A/C)ATCTA upstream-variant-2KB
rs2177243 -- 59,424,259(+) AATTA(G/T)CTGGG upstream-variant-2KB
rs2198452 -- 59,423,767(+) CTTAA(G/T)AAAAG upstream-variant-2KB

Variation tolerance for OR5A2 Gene

Residual Variation Intolerance Score: 68.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.66; 82.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR5A2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR5A2 Gene

Disorders for OR5A2 Gene

Relevant External Links for OR5A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with OR5A2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5A2 Gene

Publications for OR5A2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 67
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 67
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for OR5A2 Gene

Sources for OR5A2 Gene

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