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Aliases for OR5A2 Gene

Aliases for OR5A2 Gene

  • Olfactory Receptor Family 5 Subfamily A Member 2 2 3 5
  • Olfactory Receptor, Family 5, Subfamily A, Member 2 2
  • Olfactory Receptor OR11-248 4

External Ids for OR5A2 Gene

Previous GeneCards Identifiers for OR5A2 Gene

  • GC11U990465
  • GC11M058946
  • GC11M059189

Summaries for OR5A2 Gene

Entrez Gene Summary for OR5A2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5A2 Gene

OR5A2 (Olfactory Receptor Family 5 Subfamily A Member 2) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5A1.

UniProtKB/Swiss-Prot for OR5A2 Gene

  • Odorant receptor.

Gene Wiki entry for OR5A2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5A2 Gene

Genomics for OR5A2 Gene

Regulatory Elements for OR5A2 Gene

Enhancers for OR5A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G059544 2 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -126.1 -126133 8.8 CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 ENSG00000269570 ENSG00000245571 ENSG00000255008 LOC101927226 OR4D6 OR4D9 MS4A2 OR4D11 OSBP OR5A2
GH11G059197 1.5 FANTOM5 ENCODE dbSUPER 10.8 +223.8 223846 3.0 TBP PKNOX1 BMI1 YBX1 ZBTB40 RELB ETV6 IKZF2 ZBTB11 JUNB DTX4 OR5A2 OR5AN1 MPEG1 PATL1 OR4D6 FAM111A GC11M058947
GH11G059283 1.3 Ensembl ENCODE dbSUPER 12.3 +138.5 138549 1.9 WRNIP1 BMI1 RAD21 YY1 ZNF143 ZNF207 RELB ETV6 IKZF2 ZNF654 OR5A2 OR5AN1 ENSG00000214797 SLC25A47P1
GH11G059536 1.5 Ensembl ENCODE dbSUPER 10.4 -114.6 -114629 1.8 HDGF PKNOX1 ATF1 CREB3L1 ARNT SIN3A YY1 TCF12 ZNF121 GATA2 OR4D9 OR4D10 OR5A2 OR4D6 OR5AN1 STX3 LOC102723575 GC11P059550
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR5A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR5A2 Gene

59,421,943 bp from pter
59,422,976 bp from pter
1,034 bases
Minus strand

Genomic View for OR5A2 Gene

Genes around OR5A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5A2 Gene

Proteins for OR5A2 Gene

  • Protein details for OR5A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 5A2
    Protein Accession:
    Secondary Accessions:
    • B9EH21
    • Q6IFF4
    • Q96RB0

    Protein attributes for OR5A2 Gene

    324 amino acids
    Molecular mass:
    36016 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5A2 Gene

Post-translational modifications for OR5A2 Gene

  • Glycosylation at Asn6
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5A2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5A2 Gene

Domains & Families for OR5A2 Gene

Gene Families for OR5A2 Gene

Protein Domains for OR5A2 Gene

Suggested Antigen Peptide Sequences for OR5A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5A2: view

Function for OR5A2 Gene

Molecular function for OR5A2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5A2: view
genes like me logo Genes that share phenotypes with OR5A2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5A2 Gene

Localization for OR5A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5A2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5A2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5A2: view

Pathways & Interactions for OR5A2 Gene

genes like me logo Genes that share pathways with OR5A2: view

Pathways by source for OR5A2 Gene

Interacting Proteins for OR5A2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)
Selected Interacting proteins: Q8NGI9-OR5A2_HUMAN ENSP00000303834 for OR5A2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for OR5A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5A2: view

No data available for SIGNOR curated interactions for OR5A2 Gene

Drugs & Compounds for OR5A2 Gene

No Compound Related Data Available

Transcripts for OR5A2 Gene

mRNA/cDNA for OR5A2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5A2 Gene

No ASD Table

Relevant External Links for OR5A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR5A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5A2 Gene:


SOURCE GeneReport for Unigene cluster for OR5A2 Gene:

genes like me logo Genes that share expression patterns with OR5A2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5A2 Gene

Orthologs for OR5A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466611 34
  • 98.97 (n)
OR5A2 35
  • 98 (a)
(Canis familiaris)
Mammalia LOC483455 34
  • 88.3 (n)
-- 35
  • 88 (a)
-- 35
  • 85 (a)
(Rattus norvegicus)
Mammalia Olr332 34
  • 83.02 (n)
(Monodelphis domestica)
Mammalia OR5A2 35
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 65 (a)
-- 35
  • 64 (a)
(Mus musculus)
Mammalia Olfr1441 35
  • 62 (a)
Or5a21 55 Olfr1438
  • chr19:12,332,898-12,333,854
(Bos Taurus)
Mammalia -- 35
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491961 34
  • 54.06 (n)
Species where no ortholog for OR5A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5A2 Gene

Gene Tree for OR5A2 (if available)
Gene Tree for OR5A2 (if available)

Paralogs for OR5A2 Gene

Paralogs for OR5A2 Gene

(450) SIMAP similar genes for OR5A2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR5A2: view

Variants for OR5A2 Gene

Sequence variations from dbSNP and Humsavar for OR5A2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000087784 -- 59,422,847(+) GGAGG(G/T)AGAGC reference, missense
rs1000816131 -- 59,424,433(+) AATAC(-/A)AAACT upstream-variant-2KB
rs1001186228 -- 59,424,783(+) AAAAA(C/T)TGCTC upstream-variant-2KB
rs1001384879 -- 59,421,680(+) TAACA(G/T)TTTTT downstream-variant-500B
rs1001964831 -- 59,424,008(+) GCAAG(A/G)GACAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR5A2 Gene

Variant ID Type Subtype PubMed ID
nsv1050013 CNV gain 25217958

Variation tolerance for OR5A2 Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.66; 82.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR5A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5A2 Gene

Disorders for OR5A2 Gene

Relevant External Links for OR5A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR5A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5A2 Gene

Publications for OR5A2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR5A2 Gene

Sources for OR5A2 Gene

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