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OR5A1 Gene

protein-coding   GIFtS: 46
GCID: GC11P059210

Olfactory Receptor, Family 5, Subfamily A, Member 1


(Previous symbol: OR5A1P)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 5, Subfamily A, Member 11 2     OR11-2492
OR5A1P1 2 3     Olfactory Receptor 5A12
Olfactory Receptor OR11-2492 3     Olfactory Receptor, Family 5, Subfamily A, Member 1 Pseudogene2
OST1812 3     

External Ids:    HGNC: 83191   Entrez Gene: 2199822   Ensembl: ENSG000001723207   UniProtKB: Q8NGJ03   

Export aliases for OR5A1 gene to outside databases

Previous GC identifers: GC11U990236 GC11P058987 GC11P058967


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR5A1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR5A1 Gene:
OR5A1 (olfactory receptor, family 5, subfamily A, member 1) is a protein-coding gene. Diseases associated with OR5A1 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5A2.

UniProtKB/Swiss-Prot: OR5A1_HUMAN, Q8NGJ0
Function: Odorant receptor (Potential)

Gene Wiki entry for OR5A1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR5A1 gene promoter:
         Nkx3-1   Max1   Nkx3-1 v4   AML1a   FOXD3   Nkx3-1 v1   YY1   Nkx3-1 v2   Nkx3-1 v3   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR5A1 promoter sequence
   Search Chromatin IP Primers for OR5A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR5A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

OR5A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR5A1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P059210:  view genomic region     (about GC identifiers)

Start:
59,210,642 bp from pter      End:
59,211,586 bp from pter
Size:
945 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: OR5A1_HUMAN, Q8NGJ0 (See protein sequence)
Recommended Name: Olfactory receptor 5A1  
Size: 315 amino acids; 35152 Da
Secondary accessions: B9EH58 Q6IFF2 Q96RB1

Explore the universe of human proteins at neXtProt for OR5A1: NX_Q8NGJ0

Explore proteomics data for OR5A1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn8
  • Modification sites at PhosphoSitePlus
  • HORDE protein sequence for OR5A1

    See OR5A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004728.1  
    ENSEMBL proteins: 
     ENSP00000303096  
    Reactome Protein details: Q8NGJ0

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR5: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGJ0

    ProtoNet protein and cluster: Q8NGJ0

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR5A1_HUMAN, Q8NGJ0
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR5A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR5A1_HUMAN, Q8NGJ0
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR5A1 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR5A1_HUMAN, Q8NGJ0: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR5A1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR5A1 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR5A1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR5A1):
        Olfactory transduction


    OR5A1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR5A1
    Interactions:

        Search GeneGlobe Interaction Network for OR5A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR5A1 (ENSP000003030964) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR52M1ENSP000003533434STRING: ENSP00000353343
    OR6C74ENSP000003428364STRING: ENSP00000342836
    OR6K6ENSP000003571264STRING: ENSP00000357126
    OR6P1ENSP000003347214STRING: ENSP00000334721
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR5A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR5A1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR5A1 gene: 
    NM_001004728.1  

    Unigene Cluster for OR5A1:

    Olfactory receptor, family 5, subfamily A, member 1
    Hs.553649
    Unigene Representative Sequence: BC137060
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000302030(uc001nnx.1)
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    Additional mRNA sequence: 

    BC137060.1 BC137061.1 

    1 AceView cDNA sequence:

    NM_001004728 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR5A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAACCCTC
    OR5A1 Expression
    About this image

    OR5A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR5A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553649
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR5A1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr761 , 5 olfactory receptor 761, 5 83.23(n)1
    84.08(a)1
      19 (8.61 cM)5
    2586771  NM_146682.11  NP_666893.11 
     121197215 


    ENSEMBL Gene Tree for OR5A1 (if available)
    TreeFam Gene Tree for OR5A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR5A1 gene
    OR5A22  OR5AN12  
    Selected SIMAP similar genes for OR5A1 using alignment to 1 protein entry:     OR5A1_HUMAN(see all similar genes):
    OR5A2    OR5AR1    OR5AN1    OR5B12    OR5B21    OR5F1
    OR8H2    OR8U1    OR8U9    OR5AP2    OR5AS1    OR5AU1
    OR5M11    OR5R1    OR5V1    OR5W2    OR8B8    OR8D1

    OR5A1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for OR5A1
    PGOHUM00000257832 PGOHUM00000261129


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR5A1 (see all 150)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1484488841,2
    --59208744(+) AACATA/GTACTT 1 -- us2k10--------
    rs97878461,2
    C,F,A,H--59208753(+) TTGTAC/AATAAA 1 -- us2k16Minor allele frequency- A:0.21NA EA 250
    rs1417386051,2
    --59208769(+) TACACC/TAAAAT 1 -- us2k10--------
    rs1118898721,2
    C--59208778(+) ATATT-/AAGAGT 1 -- us2k11Minor allele frequency- A:0.00CSA 2
    rs121617771,2
    H--59208870(+) ACATTT/CGTATA 1 -- us2k14Minor allele frequency- C:0.00NS EA 412
    rs1821427281,2
    --59208985(+) AAGATA/GTATTC 1 -- us2k10--------
    rs127947001,2
    C,F,A,H--59209058(+) TTTCTA/GTAGGA 1 -- us2k110Minor allele frequency- G:0.15NS EA NA 634
    rs1505726341,2
    --59209067(+) GATTAA/GGGAAA 1 -- us2k10--------
    rs1426352311,2
    --59209144(+) GCTGT-/GGTGAG 1 -- us2k10--------
    rs1408100211,2
    --59209316(+) ACTATA/GGGCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR5A1 ( 59210642 - 59211586 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for OR5A1: --
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    SeqTarget long-range PCR primers for resequencing OR5A1
    DNA2.0 Custom Variant and Variant Library Synthesis for OR5A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for OR5A1:    
    About MalaCards
    neuronitis


    OR5A1 for disorders           About GeneDecksing


    Export disorders for OR5A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR5A1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR5A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 219982 HGNC: 8319 AceView: OR5A1 Ensembl:ENSG00000172320 euGenes: HUgn219982
    ECgene: OR5A1 Kegg: 219982 H-InvDB: OR5A1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR5A1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR5A1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR5A1 gene:
    Search GeneIP for patents involving OR5A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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