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Aliases for OR5A1 Gene

Aliases for OR5A1 Gene

  • Olfactory Receptor Family 5 Subfamily A Member 1 2 3 5
  • Olfactory Receptor OR11-249 3 4
  • OR5A1P 3 4
  • OST181 3 4
  • Olfactory Receptor, Family 5, Subfamily A, Member 1 Pseudogene 3
  • Olfactory Receptor, Family 5, Subfamily A, Member 1 2
  • Olfactory Receptor 5A1 3
  • OR11-249 3

External Ids for OR5A1 Gene

Previous HGNC Symbols for OR5A1 Gene

  • OR5A1P

Previous GeneCards Identifiers for OR5A1 Gene

  • GC11U990236
  • GC11P058987
  • GC11P058967
  • GC11P059210

Summaries for OR5A1 Gene

Entrez Gene Summary for OR5A1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5A1 Gene

OR5A1 (Olfactory Receptor Family 5 Subfamily A Member 1) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5A2.

UniProtKB/Swiss-Prot for OR5A1 Gene

  • Odorant receptor.

Gene Wiki entry for OR5A1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5A1 Gene

Genomics for OR5A1 Gene

Regulatory Elements for OR5A1 Gene

Enhancers for OR5A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G059544 2 FANTOM5 Ensembl ENCODE dbSUPER 9.6 +111.1 111052 8.8 CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 ENSG00000269570 ENSG00000245571 ENSG00000255008 LOC101927226 OR4D6 OR4D9 MS4A2 OR4D11 OSBP OR5A2
GH11G059220 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -215.0 -215027 5.1 CTCF JUN CEBPB JUNB CEBPG DPF2 EP300 NR2F2 RFX5 JUND PATL1 MPEG1 DTX4 OR4D6 OR5A2 OR5A1 OR5AN1 FAM111A OSBP RN7SL42P
GH11G059182 1.3 Ensembl ENCODE dbSUPER 10.1 -250.5 -250466 10.6 ELF3 CTCF ATF1 TAF1 ETV1 MAX ZNF644 RAD21 YY1 TEAD3 DTX4 OR5A2 MPEG1 OR4D6 OR5A1 GC11M058947
GH11G059510 1.2 FANTOM5 Ensembl ENCODE 10.4 +73.0 73044 1.0 ETV1 CEBPB MAFG CEBPG ZNF157 STAT2 NFE2L1 NFE2 FOS EMSY OR4D6 OR4D10 OR5A1 OR5A2 PATL1 MPEG1 STX3 OR4D9 OR4D11
GH11G059158 1.1 Ensembl ENCODE 10.3 -279.5 -279508 0.7 PKNOX1 FOXA2 RB1 MLX WRNIP1 FEZF1 ZNF2 RAD21 RFX5 RARA OR5A2 OR5A1 GC11P059166 ENSG00000245571
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR5A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR5A1 Gene

Chromosome:
11
Start:
59,438,057 bp from pter
End:
59,444,194 bp from pter
Size:
6,138 bases
Orientation:
Plus strand

Genomic View for OR5A1 Gene

Genes around OR5A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5A1 Gene

Proteins for OR5A1 Gene

  • Protein details for OR5A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGJ0-OR5A1_HUMAN
    Recommended name:
    Olfactory receptor 5A1
    Protein Accession:
    Q8NGJ0
    Secondary Accessions:
    • B9EH58
    • Q6IFF2
    • Q96RB1

    Protein attributes for OR5A1 Gene

    Size:
    315 amino acids
    Molecular mass:
    35152 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5A1 Gene

Post-translational modifications for OR5A1 Gene

  • Glycosylation at posLast=88
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5A1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5A1 Gene

Domains & Families for OR5A1 Gene

Gene Families for OR5A1 Gene

Protein Domains for OR5A1 Gene

Suggested Antigen Peptide Sequences for OR5A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGJ0

UniProtKB/Swiss-Prot:

OR5A1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5A1: view

Function for OR5A1 Gene

Molecular function for OR5A1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5A1: view

Phenotypes for OR5A1 Gene

GenomeRNAi human phenotypes for OR5A1:
genes like me logo Genes that share phenotypes with OR5A1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5A1 Gene

Localization for OR5A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5A1: view

Pathways & Interactions for OR5A1 Gene

genes like me logo Genes that share pathways with OR5A1: view

Pathways by source for OR5A1 Gene

Interacting Proteins for OR5A1 Gene

Gene Ontology (GO) - Biological Process for OR5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5A1: view

No data available for SIGNOR curated interactions for OR5A1 Gene

Transcripts for OR5A1 Gene

mRNA/cDNA for OR5A1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5A1 Gene

No ASD Table

Relevant External Links for OR5A1 Gene

GeneLoc Exon Structure for
OR5A1
ECgene alternative splicing isoforms for
OR5A1

Expression for OR5A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5A1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR5A1 Gene



NURSA nuclear receptor signaling pathways regulating expression of OR5A1 Gene:

OR5A1

SOURCE GeneReport for Unigene cluster for OR5A1 Gene:

Hs.553649
genes like me logo Genes that share expression patterns with OR5A1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5A1 Gene

Orthologs for OR5A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OR5A1 35
  • 99 (a)
OneToOne
LOC466612 34
  • 98.84 (n)
dog
(Canis familiaris)
Mammalia LOC100856789 34
  • 86.84 (n)
OR5A1 35
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR5A1 34 35
  • 84.34 (n)
mouse
(Mus musculus)
Mammalia Or5a1 55 Olfr76 34 16 35
  • 83.23 (n)
Or5a3 55 Olfr1441
  • chr19:12,422,311-12,423,264
Or5af1 55 Olfr312
  • chr11:58,831,156-58,832,079
Or5af2 55 Olfr313
  • chr11:58,817,010-58,817,933
rat
(Rattus norvegicus)
Mammalia Olr326 34
  • 82.22 (n)
oppossum
(Monodelphis domestica)
Mammalia OPOR80 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 61 (a)
ManyToMany
Species where no ortholog for OR5A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5A1 Gene

ENSEMBL:
Gene Tree for OR5A1 (if available)
TreeFam:
Gene Tree for OR5A1 (if available)

Paralogs for OR5A1 Gene

Paralogs for OR5A1 Gene

(453) SIMAP similar genes for OR5A1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR5A1 Gene

genes like me logo Genes that share paralogs with OR5A1: view

Variants for OR5A1 Gene

Sequence variations from dbSNP and Humsavar for OR5A1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000881278 -- 59,441,987(+) AGATA(G/T)ATGAT upstream-variant-2KB
rs1001752259 -- 59,441,775(+) TTGAG(G/T)ATACT upstream-variant-2KB
rs1001834605 -- 59,441,717(+) AAAAT(C/G)AAGTC upstream-variant-2KB
rs1005121032 -- 59,444,509(+) GCAAG(A/G)AAAAT downstream-variant-500B
rs1005979095 -- 59,441,658(+) TGAGA(C/G)TCAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR5A1 Gene

Variant ID Type Subtype PubMed ID
nsv1050013 CNV gain 25217958

Variation tolerance for OR5A1 Gene

Residual Variation Intolerance Score: 90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR5A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5A1 Gene

Disorders for OR5A1 Gene

Relevant External Links for OR5A1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR5A1

No disorders were found for OR5A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5A1 Gene

Publications for OR5A1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR5A1 Gene

Sources for OR5A1 Gene

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