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OR56B4 Gene

protein-coding   GIFtS: 44
GCID: GC11P006085

Olfactory Receptor, Family 56, Subfamily B, Member 4

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 56, Subfamily B, Member 41 2
Olfactory Receptor OR11-672 3
OR11-672
Olfactory Receptor 56B42

External Ids:    HGNC: 152481   Entrez Gene: 1963352   Ensembl: ENSG000001809197   UniProtKB: Q8NH763   

Export aliases for OR56B4 gene to outside databases

Previous GC identifers: GC11U990466 GC11P006094


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR56B4 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR56B4 Gene:
OR56B4 (olfactory receptor, family 56, subfamily B, member 4) is a protein-coding gene. Diseases associated with OR56B4 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR56A3.

UniProtKB/Swiss-Prot: O56B4_HUMAN, Q8NH76
Function: Odorant receptor (Potential)

Gene Wiki entry for OR56B4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR56B4 gene promoter:
         NF-1   FOXF2   RelA   Tal-1beta   CP2   FOXO4   ITF-2   Pax-4a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR56B4 promoter sequence
   Search Chromatin IP Primers for OR56B4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR56B4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

OR56B4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR56B4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P006085:  view genomic region     (about GC identifiers)

Start:
6,129,009 bp from pter      End:
6,129,965 bp from pter
Size:
957 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: O56B4_HUMAN, Q8NH76 (See protein sequence)
Recommended Name: Olfactory receptor 56B4  
Size: 319 amino acids; 35454 Da
Secondary accessions: Q6IFD7

Explore the universe of human proteins at neXtProt for OR56B4: NX_Q8NH76

Explore proteomics data for OR56B4 at MOPED

HORDE protein sequence for OR56B4

See OR56B4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001005181.1  
ENSEMBL proteins: 
 ENSP00000321196  
Reactome Protein details: Q8NH76

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
OR56: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR019424 7TM_GPCR_olfarory/Srsx

Graphical View of Domain Structure for InterPro Entry Q8NH76

ProtoNet protein and cluster: Q8NH76

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: O56B4_HUMAN, Q8NH76
Similarity: Belongs to the G-protein coupled receptor 1 family


OR56B4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: O56B4_HUMAN, Q8NH76
Function: Odorant receptor (Potential)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--
     
OR56B4 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
O56B4_HUMAN, Q8NH76: Cell membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral component of membrane IEA--

OR56B4 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for OR56B4 About    
See pathways by source

SuperPathContained pathways About
1Olfactory Signaling Pathway
Olfactory Signaling Pathway0.82
Olfactory transduction0.82
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for OR56B4
    Olfactory Signaling Pathway


1 Kegg Pathway  (Kegg details for OR56B4):
    Olfactory transduction


OR56B4 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR56B4
Interactions:

    Search GeneGlobe Interaction Network for OR56B4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for OR56B4 (ENSP000003211964) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
InteractantInteraction Details
GeneCardExternal ID(s)
OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
OR2AE1ENSP000003139364STRING: ENSP00000313936
GNALENSP000003340514STRING: ENSP00000334051
GNGT1ENSP000002485724STRING: ENSP00000248572
OR10A3ENSP000003539884STRING: ENSP00000353988
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

OR56B4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for OR56B4 (O56B4)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for OR56B4 gene: 
NM_001005181.1  

Unigene Cluster for OR56B4:

Olfactory receptor, family 56, subfamily B, member 4
Hs.632154
Unigene Representative Sequence: BC136879
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000316529(uc010qzx.2)
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Additional mRNA sequence: 

BC136879.1 BC136880.1 

1 AceView cDNA sequence:

NM_001005181 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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OR56B4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGTCTTGGTT
OR56B4 Expression
About this image

OR56B4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

OR56B4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.632154
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for OR56B4 gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Olfr6631 olfactory receptor 663 69.46(n)
63.42(a)
  257914  NM_001011757.1  NP_001011757.1 


ENSEMBL Gene Tree for OR56B4 (if available)
TreeFam Gene Tree for OR56B4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for OR56B4 gene
OR56A32  OR56A12  OR56A42  OR56B3P2  OR56B12  
Selected SIMAP similar genes for OR56B4 using alignment to 1 protein entry:     O56B4_HUMAN(see all similar genes):
OR56B2P    OR56B1    OR56B3P    OR56A1    OR56A4    OR56A5
OR56A3    OR51L1    OR52N1    OR52N2    OR51G1    OR52J3
OR52L1    OR52N5    OR52R1    OR52Z1    OR51E2    OR51F2

OR56B4 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for OR56B4
PGOHUM00000242580


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for OR56B4 (see all 87)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs65787401,2
C,F,A,H--6127197(+) accccG/Atctct 1 -- us2k15Minor allele frequency- A:0.45NA WA CSA 11
rs1910744401,2
--6127203(+) TCTCTA/TCTAAA 1 -- us2k10--------
rs1821102401,2
--6127238(+) TGGCAC/TACACC 1 -- us2k10--------
rs1867940161,2
C--6127378(+) AGGCCA/GGAAAG 1 -- us2k10--------
rs1926345931,2
--6127569(+) GAGGTA/GATGGA 1 -- us2k10--------
rs71104101,2
C,F,A,H--6127655(+) tacaaC/Atatga 1 -- us2k110Minor allele frequency- A:0.38NA WA CSA EA 371
rs354475911,2
C--6127680(+) AAAAA-/ATCATT 1 -- us2k10--------
rs1384545561,2
--6127694(+) ATCATC/TAAACT 1 -- us2k10--------
rs1418120181,2
C--6127845(+) AAAAT-/TATATA
        
TATAT
1 -- us2k10--------
rs122736411,2
C,F--6128111(+) TTTGCA/CTCACT 1 -- us2k11Minor allele frequency- C:0.04WA 118

HapMap Linkage Disequilibrium report for OR56B4 ( 6129009 - 6129965 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for OR56B4: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing OR56B4
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for OR56B4:    
About MalaCards
neuronitis


OR56B4 for disorders           About GeneDecksing


Export disorders for OR56B4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for OR56B4 gene integrated from 10 sources:
(articles sorted by number of sources associating them with OR56B4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  4. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 196335 HGNC: 15248 AceView: OR56B4 Ensembl:ENSG00000180919 euGenes: HUgn196335
ECgene: OR56B4 Kegg: 196335 H-InvDB: OR56B4

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for OR56B4 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR56B4 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for OR56B4 gene:
Search GeneIP for patents involving OR56B4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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