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Aliases for OR56A4 Gene

Aliases for OR56A4 Gene

  • Olfactory Receptor Family 56 Subfamily A Member 4 2 3 5
  • Olfactory Receptor, Family 56, Subfamily A, Member 4 2 3
  • Olfactory Receptor OR11-49 3 4
  • OR11-49 3

External Ids for OR56A4 Gene

Previous GeneCards Identifiers for OR56A4 Gene

  • GC11U990297
  • GC11M005991
  • GC11M005981
  • GC11M005982

Summaries for OR56A4 Gene

Entrez Gene Summary for OR56A4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR56A4 Gene

OR56A4 (Olfactory Receptor Family 56 Subfamily A Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR56A5.

UniProtKB/Swiss-Prot for OR56A4 Gene

  • Odorant receptor.

Gene Wiki entry for OR56A4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR56A4 Gene

Genomics for OR56A4 Gene

Regulatory Elements for OR56A4 Gene

Enhancers for OR56A4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR56A4 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR56A4 Gene

6,001,986 bp from pter
6,003,194 bp from pter
1,209 bases
Minus strand

Genomic View for OR56A4 Gene

Genes around OR56A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR56A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR56A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR56A4 Gene

Proteins for OR56A4 Gene

  • Protein details for OR56A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 56A4
    Protein Accession:
    Secondary Accessions:
    • B9EH17

    Protein attributes for OR56A4 Gene

    313 amino acids
    Molecular mass:
    35116 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI36987.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR56A4 Gene

Proteomics data for OR56A4 Gene at MOPED

Post-translational modifications for OR56A4 Gene

  • Glycosylation at Asn 6 and Asn 184

Other Protein References for OR56A4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR56A4 Gene

Domains & Families for OR56A4 Gene

Gene Families for OR56A4 Gene

Protein Domains for OR56A4 Gene

Suggested Antigen Peptide Sequences for OR56A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR56A4: view

Function for OR56A4 Gene

Molecular function for OR56A4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes for OR56A4 Gene

genes like me logo Genes that share phenotypes with OR56A4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR56A4 Gene

Localization for OR56A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR56A4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR56A4 Gene COMPARTMENTS Subcellular localization image for OR56A4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR56A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR56A4: view

Pathways & Interactions for OR56A4 Gene

genes like me logo Genes that share pathways with OR56A4: view

Pathways by source for OR56A4 Gene

Interacting Proteins for OR56A4 Gene

Gene Ontology (GO) - Biological Process for OR56A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling IBA --
genes like me logo Genes that share ontologies with OR56A4: view

No data available for SIGNOR curated interactions for OR56A4 Gene

Drugs & Compounds for OR56A4 Gene

No Compound Related Data Available

Transcripts for OR56A4 Gene

mRNA/cDNA for OR56A4 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR56A4 Gene

No ASD Table

Relevant External Links for OR56A4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR56A4 Gene

mRNA expression in normal human tissues for OR56A4 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR56A4 Gene

SOURCE GeneReport for Unigene cluster for OR56A4 Gene Hs.553571

genes like me logo Genes that share expression patterns with OR56A4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR56A4 Gene

Orthologs for OR56A4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR56A4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC100298165 35
  • 88.07 (n)
  • 87.86 (a)
-- 36
  • 88 (a)
-- 36
  • 88 (a)
(Canis familiaris)
Mammalia LOC610901 35
  • 79.98 (n)
  • 81.47 (a)
-- 36
  • 91 (a)
-- 36
  • 88 (a)
-- 36
  • 88 (a)
(Mus musculus)
Mammalia Olfr684 35
  • 83.82 (n)
  • 87.06 (a)
Olfr684 16
Olfr683 36
  • 82 (a)
Olfr684 36
  • 87 (a)
(Pan troglodytes)
Mammalia LOC466405 35
  • 99.18 (n)
  • 98.08 (a)
OR56A4 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Olr193 35
  • 84.4 (n)
  • 87.5 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 82 (a)
-- 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
-- 36
  • 67 (a)
(Danio rerio)
Actinopterygii -- 35
Species with no ortholog for OR56A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OR56A4 Gene

Gene Tree for OR56A4 (if available)
Gene Tree for OR56A4 (if available)

Paralogs for OR56A4 Gene

Paralogs for OR56A4 Gene

(443) SIMAP similar genes for OR56A4 Gene using alignment to 1 proteins: Pseudogenes for OR56A4 Gene

genes like me logo Genes that share paralogs with OR56A4: view

Variants for OR56A4 Gene

Sequence variations from dbSNP and Humsavar for OR56A4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11602093 -- 6,005,062(+) AAGCA(G/T)AAACA upstream-variant-2KB
rs7926146 -- 6,004,522(+) TATTT(A/C)TTTAA upstream-variant-2KB
rs112591914 -- 6,003,922(+) TGTAA(G/T)CTACA upstream-variant-2KB
rs143488149 -- 6,002,801(+) AGCAG(A/G)TAGTA reference, synonymous-codon
rs143505962 -- 6,002,387(+) ACAAA(C/T)TGGTA reference, synonymous-codon

Variation tolerance for OR56A4 Gene

Residual Variation Intolerance Score: 44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.04; 75.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for OR56A4 Gene

Disorders for OR56A4 Gene

Relevant External Links for OR56A4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR56A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR56A4 Gene

Publications for OR56A4 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 67
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR56A4 Gene

Sources for OR56A4 Gene