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Aliases for OR56A1 Gene

Aliases for OR56A1 Gene

  • Olfactory Receptor Family 56 Subfamily A Member 1 2 3 5
  • Olfactory Receptor OR11-75 3 4
  • Olfactory Receptor, Family 56, Subfamily A, Member 1 2
  • Olfactory Receptor 56A1 3
  • OR11-75 3

External Ids for OR56A1 Gene

Previous GeneCards Identifiers for OR56A1 Gene

  • GC11U990305
  • GC11M006013
  • GC11M006004
  • GC11M006048

Summaries for OR56A1 Gene

Entrez Gene Summary for OR56A1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR56A1 Gene

OR56A1 (Olfactory Receptor Family 56 Subfamily A Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR56A4.

UniProtKB/Swiss-Prot for OR56A1 Gene

  • Odorant receptor.

Gene Wiki entry for OR56A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR56A1 Gene

Genomics for OR56A1 Gene

Regulatory Elements for OR56A1 Gene

Enhancers for OR56A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F005546 0.6 FANTOM5 21.4 +481.5 481496 0.1 OR56A1 OR56A3 OR51Q1 OR52E8 OR52N1 OR56A4 OR52N4 OR52E2 OR52E4 OR52A1
GH11F006468 1.4 FANTOM5 Ensembl ENCODE 12.7 -441.6 -441631 1.5 HDGF PKNOX1 WRNIP1 GLIS2 ZBTB48 POLR2A PATZ1 CREM ZNF263 SP3 OR56A1 OR10A4 OR2AG2 OR10A2 OR56A4 OR52W1 OR2AG1 OR56B4 OR10A5 OR6A2
GH11F006094 0.3 FANTOM5 12.6 -66.7 -66679 0.1 OR56A1 OR52W1 FAM160A2 C11orf42 TRIM5 TRIM34 OR52N1 OR56A3 OR52E8 TRIM22
GH11F006315 0.8 Ensembl ENCODE 10.1 -288.2 -288241 0.5 CTCF ZNF654 TRIM22 REST ZNF48 RAD21 JUND SMARCA4 GATA2 ZNF143 OR56A1 OR52B2 PRKCDBP LOC101927825 ENSG00000270435
GH11F006129 0.4 Ensembl 10 -102.1 -102060 1.2 OR52B2 OR56A1 OR56B3P OR52B1P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR56A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR56A1 Gene

6,026,671 bp from pter
6,027,741 bp from pter
1,071 bases
Minus strand

Genomic View for OR56A1 Gene

Genes around OR56A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR56A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR56A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR56A1 Gene

Proteins for OR56A1 Gene

  • Protein details for OR56A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 56A1
    Protein Accession:
    Secondary Accessions:
    • B2RNI2
    • Q6IFL0

    Protein attributes for OR56A1 Gene

    318 amino acids
    Molecular mass:
    35823 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR56A1 Gene

Post-translational modifications for OR56A1 Gene

  • Glycosylation at Asn 10, Asn 188, and Asn 198
  • Modification sites at PhosphoSitePlus

Other Protein References for OR56A1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR56A1 Gene

Domains & Families for OR56A1 Gene

Gene Families for OR56A1 Gene

Protein Domains for OR56A1 Gene

Suggested Antigen Peptide Sequences for OR56A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR56A1: view

Function for OR56A1 Gene

Molecular function for OR56A1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR56A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004935 NOT adrenergic receptor activity IBA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR56A1: view
genes like me logo Genes that share phenotypes with OR56A1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR56A1 Gene

Localization for OR56A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR56A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR56A1 Gene COMPARTMENTS Subcellular localization image for OR56A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR56A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR56A1: view

Pathways & Interactions for OR56A1 Gene

genes like me logo Genes that share pathways with OR56A1: view

Pathways by source for OR56A1 Gene

Gene Ontology (GO) - Biological Process for OR56A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007267 cell-cell signaling IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OR56A1: view

No data available for SIGNOR curated interactions for OR56A1 Gene

Transcripts for OR56A1 Gene

mRNA/cDNA for OR56A1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR56A1 Gene

No ASD Table

Relevant External Links for OR56A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR56A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR56A1 Gene

mRNA differential expression in normal tissues according to GTEx for OR56A1 Gene

This gene is overexpressed in Testis (x53.0).

NURSA nuclear receptor signaling pathways regulating expression of OR56A1 Gene:


SOURCE GeneReport for Unigene cluster for OR56A1 Gene:

genes like me logo Genes that share expression patterns with OR56A1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR56A1 Gene

Orthologs for OR56A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR56A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466406 34
  • 99.48 (n)
OR56A1 35
  • 99 (a)
(Canis familiaris)
Mammalia OR56A1 35
  • 92 (a)
LOC485323 34
  • 88.6 (n)
(Bos Taurus)
Mammalia OR56A1 34 35
  • 86.47 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 85 (a)
-- 35
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 72 (a)
-- 35
  • 69 (a)
(Mus musculus)
Mammalia Olfr682-ps1 35
  • 68 (a)
Or56a41-ps 55 Olfr680-ps1
  • chr7:105,090,705-105,091,367
Species where no ortholog for OR56A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR56A1 Gene

Gene Tree for OR56A1 (if available)
Gene Tree for OR56A1 (if available)

Paralogs for OR56A1 Gene

Paralogs for OR56A1 Gene

(440) SIMAP similar genes for OR56A1 Gene using alignment to 1 proteins: Pseudogenes for OR56A1 Gene

genes like me logo Genes that share paralogs with OR56A1: view

Variants for OR56A1 Gene

Sequence variations from dbSNP and Humsavar for OR56A1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10839266 -- 6,028,301(+) AAACT(A/G)AAAAA intron-variant, upstream-variant-2KB
rs11040335 -- 6,026,826(+) TTCAA(C/T)GCAGG intron-variant, reference, synonymous-codon
rs111685831 -- 6,027,939(+) AGTTT(-/A)AAAAA intron-variant, upstream-variant-2KB
rs111987979 -- 6,026,808(+) ACCCC(A/G)TACAC intron-variant, reference, synonymous-codon
rs114928564 -- 6,028,449(+) TCATT(G/T)TTTTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR56A1 Gene

Variant ID Type Subtype PubMed ID
dgv1054n100 CNV gain 25217958
nsv1046068 CNV gain 25217958
nsv553241 CNV gain 21841781
nsv975146 CNV duplication 23825009

Variation tolerance for OR56A1 Gene

Residual Variation Intolerance Score: 47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 40.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR56A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR56A1 Gene

Disorders for OR56A1 Gene

Relevant External Links for OR56A1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR56A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR56A1 Gene

Publications for OR56A1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR56A1 Gene

Sources for OR56A1 Gene

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