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Aliases for OR56A1 Gene

Aliases for OR56A1 Gene

  • Olfactory Receptor Family 56 Subfamily A Member 1 2 3 5
  • Olfactory Receptor OR11-75 3 4
  • Olfactory Receptor, Family 56, Subfamily A, Member 1 2
  • Olfactory Receptor 56A1 3
  • OR11-75 3

External Ids for OR56A1 Gene

Previous GeneCards Identifiers for OR56A1 Gene

  • GC11U990305
  • GC11M006013
  • GC11M006004
  • GC11M006048

Summaries for OR56A1 Gene

Entrez Gene Summary for OR56A1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR56A1 Gene

OR56A1 (Olfactory Receptor Family 56 Subfamily A Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR56A4.

UniProtKB/Swiss-Prot for OR56A1 Gene

  • Odorant receptor.

Gene Wiki entry for OR56A1 Gene

Additional gene information for OR56A1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR56A1 Gene

Genomics for OR56A1 Gene

Regulatory Elements for OR56A1 Gene

Enhancers for OR56A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H006468 1.4 FANTOM5 Ensembl ENCODE 12.7 -435.0 -435034 1 HDGF PKNOX1 GLIS2 POLR2A ZBTB48 PATZ1 ATF7 CREM MAZ SP3 OR56A1 OR10A4 OR2AG2 OR10A2 OR56A4 OR52W1 OR2AG1 OR56B4 OR10A5 OR6A2
GH11H006317 1.1 ENCODE dbSUPER 9.8 -286.6 -286567 6 TBP PKNOX1 BATF RFX5 RCOR1 FOS ETV6 RUNX3 CREM IKZF2 CAVIN3 OR56A1 TAF10 GC11M006313
GH11H006249 1.1 Ensembl ENCODE 9.5 -215.8 -215788 1 TBP BRCA1 TCF12 ZNF766 GATA2 ELK1 RCOR1 FOS ZBTB11 USF2 C11orf42 OR52W1 CAVIN3 OR56A1 GC11M006236 CCKBR
GH11H006250 1 Ensembl ENCODE 9.5 -218.0 -218002 2 CTCF FOXA2 TAL1 ZNF175 RAD21 TCF12 POLR2A NCOR1 EGR1 SMC3 FAM160A2 CCKBR C11orf42 OR52W1 OR56A1 GC11M006236
GH11H006315 0.9 Ensembl ENCODE 10.1 -281.6 -281644 0 CTCF ZNF654 TRIM22 REST RAD21 SKIL EGR1 GATA2 ZNF143 SMC3 OR56A1 OR52B2 CAVIN3 LOC101927825 ENSG00000270435
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR56A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR56A1 Gene

Chromosome:
11
Start:
6,019,336 bp from pter
End:
6,034,338 bp from pter
Size:
15,003 bases
Orientation:
Minus strand

Genomic View for OR56A1 Gene

Genes around OR56A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR56A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR56A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR56A1 Gene

Proteins for OR56A1 Gene

  • Protein details for OR56A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGH5-O56A1_HUMAN
    Recommended name:
    Olfactory receptor 56A1
    Protein Accession:
    Q8NGH5
    Secondary Accessions:
    • B2RNI2
    • Q6IFL0

    Protein attributes for OR56A1 Gene

    Size:
    318 amino acids
    Molecular mass:
    35823 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR56A1 Gene

Post-translational modifications for OR56A1 Gene

  • Glycosylation at posLast=1010, Asn188, and Asn198
  • Modification sites at PhosphoSitePlus

Other Protein References for OR56A1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR56A1 Gene

Domains & Families for OR56A1 Gene

Gene Families for OR56A1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR56A1 Gene

Suggested Antigen Peptide Sequences for OR56A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGH5

UniProtKB/Swiss-Prot:

O56A1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR56A1: view

Function for OR56A1 Gene

Molecular function for OR56A1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR56A1 Gene

Gene Ontology (GO) - Molecular Function for OR56A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go IBA --
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004935 NOT adrenergic receptor activity IBA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR56A1: view
genes like me logo Genes that share phenotypes with OR56A1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR56A1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR56A1 Gene

Localization for OR56A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR56A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR56A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR56A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030672 synaptic vesicle membrane IBA --
genes like me logo Genes that share ontologies with OR56A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR56A1 Gene

Pathways & Interactions for OR56A1 Gene

genes like me logo Genes that share pathways with OR56A1: view

Pathways by source for OR56A1 Gene

Interacting Proteins for OR56A1 Gene

Gene Ontology (GO) - Biological Process for OR56A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001963 synaptic transmission, dopaminergic IBA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007194 negative regulation of adenylate cyclase activity IBA --
GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with OR56A1: view

No data available for SIGNOR curated interactions for OR56A1 Gene

Drugs & Compounds for OR56A1 Gene

No Compound Related Data Available

Transcripts for OR56A1 Gene

mRNA/cDNA for OR56A1 Gene

(1) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR56A1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR56A1 Gene

No ASD Table

Relevant External Links for OR56A1 Gene

GeneLoc Exon Structure for
OR56A1
ECgene alternative splicing isoforms for
OR56A1

Expression for OR56A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR56A1 Gene

mRNA differential expression in normal tissues according to GTEx for OR56A1 Gene

This gene is overexpressed in Testis (x53.0).

NURSA nuclear receptor signaling pathways regulating expression of OR56A1 Gene:

OR56A1

SOURCE GeneReport for Unigene cluster for OR56A1 Gene:

Hs.553543
genes like me logo Genes that share expression patterns with OR56A1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR56A1 Gene

Orthologs for OR56A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR56A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466406 33
  • 99.48 (n)
OR56A1 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR56A1 34
  • 92 (a)
OneToOne
LOC485323 33
  • 88.6 (n)
cow
(Bos Taurus)
Mammalia OR56A1 33 34
  • 86.47 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 85 (a)
OneToMany
-- 34
  • 84 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 72 (a)
ManyToMany
-- 34
  • 69 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr682-ps1 34
  • 68 (a)
ManyToMany
Or56a41-ps 52 Olfr680-ps1
  • chr7:105,090,705-105,091,367
Species where no ortholog for OR56A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR56A1 Gene

ENSEMBL:
Gene Tree for OR56A1 (if available)
TreeFam:
Gene Tree for OR56A1 (if available)

Paralogs for OR56A1 Gene

Paralogs for OR56A1 Gene

(440) SIMAP similar genes for OR56A1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR56A1 Gene

genes like me logo Genes that share paralogs with OR56A1: view

Variants for OR56A1 Gene

Sequence variations from dbSNP and Humsavar for OR56A1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000028919 -- 6,029,312(+) ATAAT(G/T)TGTAT intron-variant, upstream-variant-2KB
rs1000056703 -- 6,029,678(+) TACCT(C/T)CTGGT intron-variant, upstream-variant-2KB
rs1002687830 -- 6,028,668(+) GGGAA(A/C)TTTTA intron-variant, upstream-variant-2KB
rs1003724205 -- 6,027,781(+) AAGTA(A/T)CCCTT intron-variant, upstream-variant-2KB
rs1004503212 -- 6,027,518(+) CTGGT(A/G)CAGAG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR56A1 Gene

Variant ID Type Subtype PubMed ID
dgv1054n100 CNV gain 25217958
nsv1046068 CNV gain 25217958
nsv553241 CNV gain 21841781
nsv975146 CNV duplication 23825009

Variation tolerance for OR56A1 Gene

Residual Variation Intolerance Score: 47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 40.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR56A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR56A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR56A1 Gene

Disorders for OR56A1 Gene

Relevant External Links for OR56A1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR56A1

No disorders were found for OR56A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR56A1 Gene

Publications for OR56A1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for OR56A1 Gene

Sources for OR56A1 Gene

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