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Aliases for OR52R1 Gene

Aliases for OR52R1 Gene

  • Olfactory Receptor, Family 52, Subfamily R, Member 1 (Gene/Pseudogene) 2 3
  • Olfactory Receptor OR11-22 3 4
  • Olfactory Receptor 52R1 3
  • OR11-22 3

External Ids for OR52R1 Gene

Previous GeneCards Identifiers for OR52R1 Gene

  • GC11U990479
  • GC11M004789
  • GC11M004781

Summaries for OR52R1 Gene

Entrez Gene Summary for OR52R1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52R1 Gene

OR52R1 (Olfactory Receptor, Family 52, Subfamily R, Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52N5.

UniProtKB/Swiss-Prot for OR52R1 Gene

  • Odorant receptor.

Gene Wiki entry for OR52R1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52R1 Gene

Genomics for OR52R1 Gene

Regulatory Elements for OR52R1 Gene

Genomic Location for OR52R1 Gene

Start:
4,803,433 bp from pter
End:
4,804,380 bp from pter
Size:
948 bases
Orientation:
Minus strand

Genomic View for OR52R1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR52R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52R1 Gene

Proteins for OR52R1 Gene

  • Protein details for OR52R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGF1-O52R1_HUMAN
    Recommended name:
    Olfactory receptor 52R1
    Protein Accession:
    Q8NGF1
    Secondary Accessions:
    • Q6IFI0

    Protein attributes for OR52R1 Gene

    Size:
    315 amino acids
    Molecular mass:
    34943 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA04680.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR52R1 Gene

Proteomics data for OR52R1 Gene at MOPED

Post-translational modifications for OR52R1 Gene

Other Protein References for OR52R1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52R1 Gene

Domains for OR52R1 Gene

Gene Families for OR52R1 Gene

HGNC:
  • OR52 :GPCR / Class A : Olfactory receptors

Protein Domains for OR52R1 Gene

Suggested Antigen Peptide Sequences for OR52R1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGF1

UniProtKB/Swiss-Prot:

O52R1_HUMAN :
  • Q8NGF1
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52R1: view

Function for OR52R1 Gene

Molecular function for OR52R1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR52R1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR52R1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR52R1 Gene

Localization for OR52R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52R1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR52R1 Gene COMPARTMENTS Subcellular localization image for OR52R1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52R1: view

Pathways for OR52R1 Gene

genes like me logo Genes that share pathways with OR52R1: view

Pathways by source for OR52R1 Gene

Interacting Proteins for OR52R1 Gene

Gene Ontology (GO) - Biological Process for OR52R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52R1: view

Transcripts for OR52R1 Gene

mRNA/cDNA for OR52R1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR52R1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR52R1 Gene

No ASD Table

Relevant External Links for OR52R1 Gene

GeneLoc Exon Structure for
OR52R1
ECgene alternative splicing isoforms for
OR52R1

Expression for OR52R1 Gene

mRNA expression in normal human tissues for OR52R1 Gene

SOURCE GeneReport for Unigene cluster for OR52R1 Gene Hs.553563

genes like me logo Genes that share expressions with OR52R1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for OR52R1 Gene

Orthologs for OR52R1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR52R1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC782046 35
  • 85.21 (n)
  • 81.99 (a)
-- 36
  • 81 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC100684682 35
  • 85.03 (n)
  • 81.53 (a)
-- 36
  • 80 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr569 35
  • 84.96 (n)
  • 82.47 (a)
Olfr569 16
Olfr569 36
  • 81 (a)
OneToMany
Olfr582 36
  • 79 (a)
OneToMany
Olfr584 36
  • 80 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC466351 35
  • 99.15 (n)
  • 98.1 (a)
OR52R1 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr50 35
  • 84.42 (n)
  • 81.49 (a)
oppossum
(Monodelphis domestica)
Mammalia OR52R1 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857813 35
  • 66.78 (n)
  • 61.18 (a)
Species with no ortholog for OR52R1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52R1 Gene

ENSEMBL:
Gene Tree for OR52R1 (if available)
TreeFam:
Gene Tree for OR52R1 (if available)

Paralogs for OR52R1 Gene

Selected SIMAP similar genes for OR52R1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for OR52R1 Gene

genes like me logo Genes that share paralogs with OR52R1: view

Variants for OR52R1 Gene

Sequence variations from dbSNP and Humsavar for OR52R1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs919899 -- 4,806,053(-) CAGGA(A/T)TTTTT upstream-variant-2KB
rs934485 -- 4,806,092(-) AAAGA(C/T)AAGGC upstream-variant-2KB
rs1865284 -- 4,805,862(-) GATTC(A/T)GAGAT upstream-variant-2KB
rs1865285 -- 4,804,935(-) TGGAG(C/T)GCAGT upstream-variant-2KB
rs2053116 - 4,803,648(-) CACGT(G/T)CCTCC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for OR52R1 Gene

Variant ID Type Subtype PubMed ID
nsv896915 CNV Gain 21882294
nsv832056 CNV Gain 17160897
esv2673268 CNV Deletion 23128226
nsv467666 CNV Loss 19166990

Relevant External Links for OR52R1 Gene

HapMap Linkage Disequilibrium report
OR52R1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52R1 Gene

Disorders for OR52R1 Gene

No disorders were found for OR52R1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for OR52R1 Gene

Publications for OR52R1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4

Products for OR52R1 Gene

Sources for OR52R1 Gene

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