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Aliases for OR52N4 Gene

Aliases for OR52N4 Gene

  • Olfactory Receptor Family 52 Subfamily N Member 4 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 52, Subfamily N, Member 4 2 3
  • Olfactory Receptor OR11-64 3 4
  • Olfactory Receptor, Family 52, Subfamily N, Member 4 (Gene/Pseudogene) 2
  • OR11-64 3

External Ids for OR52N4 Gene

Previous GeneCards Identifiers for OR52N4 Gene

  • GC11U990484
  • GC11P005741
  • GC11P005732

Summaries for OR52N4 Gene

Entrez Gene Summary for OR52N4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52N4 Gene

OR52N4 (Olfactory Receptor Family 52 Subfamily N Member 4 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is ENSG00000279270.

UniProtKB/Swiss-Prot for OR52N4 Gene

  • Odorant receptor.

Gene Wiki entry for OR52N4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52N4 Gene

Genomics for OR52N4 Gene

Regulatory Elements for OR52N4 Gene

Enhancers for OR52N4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR52N4 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR52N4 Gene

5,722,259 bp from pter
5,755,958 bp from pter
33,700 bases
Plus strand

Genomic View for OR52N4 Gene

Genes around OR52N4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52N4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52N4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52N4 Gene

Proteins for OR52N4 Gene

  • Protein details for OR52N4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 52N4
    Protein Accession:
    Secondary Accessions:
    • B2RNP8
    • Q6IF77

    Protein attributes for OR52N4 Gene

    321 amino acids
    Molecular mass:
    36080 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52N4 Gene

Proteomics data for OR52N4 Gene at MOPED

Post-translational modifications for OR52N4 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR52N4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52N4 Gene

Domains & Families for OR52N4 Gene

Gene Families for OR52N4 Gene

Protein Domains for OR52N4 Gene

Suggested Antigen Peptide Sequences for OR52N4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52N4: view

Function for OR52N4 Gene

Molecular function for OR52N4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes for OR52N4 Gene

genes like me logo Genes that share phenotypes with OR52N4: view

Animal Model Products

CRISPR Products

miRNA for OR52N4 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR52N4 Gene

Localization for OR52N4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52N4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR52N4 Gene COMPARTMENTS Subcellular localization image for OR52N4 gene
Compartment Confidence
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for OR52N4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52N4: view

Pathways & Interactions for OR52N4 Gene

genes like me logo Genes that share pathways with OR52N4: view

Pathways by source for OR52N4 Gene

Interacting Proteins for OR52N4 Gene

Gene Ontology (GO) - Biological Process for OR52N4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52N4: view

No data available for SIGNOR curated interactions for OR52N4 Gene

Drugs & Compounds for OR52N4 Gene

No Compound Related Data Available

Transcripts for OR52N4 Gene

mRNA/cDNA for OR52N4 Gene

(2) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR52N4 Gene

No ASD Table

Relevant External Links for OR52N4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR52N4 Gene

mRNA expression in normal human tissues for OR52N4 Gene

mRNA differential expression in normal tissues according to GTEx for OR52N4 Gene

This gene is overexpressed in Nerve - Tibial (x4.3) and Spleen (x4.1).

SOURCE GeneReport for Unigene cluster for OR52N4 Gene Hs.553735

genes like me logo Genes that share expression patterns with OR52N4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR52N4 Gene

Orthologs for OR52N4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR52N4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OR52N4 35
  • 85.46 (n)
  • 86.6 (a)
OR52N4 36
  • 86 (a)
(Canis familiaris)
Mammalia LOC485294 35
  • 87.75 (n)
  • 89.1 (a)
OR52N4 36
  • 89 (a)
(Mus musculus)
Mammalia Olfr658 35
  • 84.94 (n)
  • 87.85 (a)
Olfr658 16
Olfr503 36
  • 83 (a)
Olfr658 36
  • 87 (a)
(Pan troglodytes)
Mammalia LOC466392 35
  • 99.17 (n)
  • 97.51 (a)
OR52N4 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Olr159 35
  • 84.11 (n)
  • 88.47 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
-- 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
-- 36
  • 75 (a)
-- 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490566 35
  • 58.55 (n)
  • 51.95 (a)
Species with no ortholog for OR52N4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52N4 Gene

Gene Tree for OR52N4 (if available)
Gene Tree for OR52N4 (if available)

Paralogs for OR52N4 Gene

(432) SIMAP similar genes for OR52N4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR52N4: view

Variants for OR52N4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR52N4 Gene

A stop codon at position Arg-172 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans.

Sequence variations from dbSNP and Humsavar for OR52N4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs7936512 - 5,755,057(+) CTTCA(C/G/T)CCACA reference, missense
rs7396938 - 5,755,393(+) CACCA(A/T)CTCCT reference, missense
rs7394584 - 5,755,240(+) CAAGC(A/C/G/T)CCTGC reference, missense
rs12363178 - 5,755,365(+) TGATT(G/T)GGGGC reference, missense
rs868380 -- 5,741,194(-) AATCA(C/T)ACTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OR52N4 Gene

Variant ID Type Subtype PubMed ID
nsv896939 CNV Loss 21882294
dgv341e1 CNV Complex 17122850
nsv896950 CNV Gain 21882294
nsv832058 CNV Gain 17160897
esv33342 CNV Loss 17666407
nsv896951 CNV Gain 21882294
dgv342e1 CNV Complex 17122850

Variation tolerance for OR52N4 Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.60; 86.20% of all genes are more intolerant (likely to be disease-causing)

No data available for Relevant External Links for OR52N4 Gene

Disorders for OR52N4 Gene

Relevant External Links for OR52N4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR52N4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52N4 Gene

Publications for OR52N4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR52N4 Gene

Sources for OR52N4 Gene