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Aliases for OR52N1 Gene

Aliases for OR52N1 Gene

  • Olfactory Receptor, Family 52, Subfamily N, Member 1 2 3
  • Olfactory Receptor OR11-61 3 4
  • Olfactory Receptor 52N1 3
  • OR11-61 3

External Ids for OR52N1 Gene

Previous GeneCards Identifiers for OR52N1 Gene

  • GC11U990333
  • GC11M005767

Summaries for OR52N1 Gene

Entrez Gene Summary for OR52N1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52N1 Gene

OR52N1 (Olfactory Receptor, Family 52, Subfamily N, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52R1.

UniProtKB/Swiss-Prot for OR52N1 Gene

  • Odorant receptor.

Gene Wiki entry for OR52N1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52N1 Gene

Genomics for OR52N1 Gene

Regulatory Elements for OR52N1 Gene

Genomic Location for OR52N1 Gene

Start:
5,787,854 bp from pter
End:
5,788,816 bp from pter
Size:
963 bases
Orientation:
Minus strand

Genomic View for OR52N1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR52N1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52N1 Gene

Proteins for OR52N1 Gene

  • Protein details for OR52N1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH53-O52N1_HUMAN
    Recommended name:
    Olfactory receptor 52N1
    Protein Accession:
    Q8NH53
    Secondary Accessions:
    • Q6IFF6

    Protein attributes for OR52N1 Gene

    Size:
    320 amino acids
    Molecular mass:
    35785 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52N1 Gene

Proteomics data for OR52N1 Gene at MOPED

Post-translational modifications for OR52N1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR52N1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for OR52N1

No data available for DME Specific Peptides for OR52N1 Gene

Domains for OR52N1 Gene

Gene Families for OR52N1 Gene

HGNC:
  • OR52 :GPCR / Class A : Olfactory receptors

Protein Domains for OR52N1 Gene

Suggested Antigen Peptide Sequences for OR52N1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH53

UniProtKB/Swiss-Prot:

O52N1_HUMAN :
  • Q8NH53
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52N1: view

Function for OR52N1 Gene

Molecular function for OR52N1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR52N1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR52N1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR52N1 Gene

Localization for OR52N1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52N1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR52N1 Gene COMPARTMENTS Subcellular localization image for OR52N1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52N1: view

Pathways for OR52N1 Gene

genes like me logo Genes that share pathways with OR52N1: view

Pathways by source for OR52N1 Gene

Interacting Proteins for OR52N1 Gene

Gene Ontology (GO) - Biological Process for OR52N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52N1: view

Transcripts for OR52N1 Gene

mRNA/cDNA for OR52N1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR52N1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR52N1 Gene

No ASD Table

Relevant External Links for OR52N1 Gene

GeneLoc Exon Structure for
OR52N1
ECgene alternative splicing isoforms for
OR52N1

Expression for OR52N1 Gene

mRNA expression in normal human tissues for OR52N1 Gene

mRNA differential expression in normal tissues according to GTEx for OR52N1 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (17.0).

Protein differential expression in normal tissues for OR52N1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR52N1 Gene

SOURCE GeneReport for Unigene cluster for OR52N1 Gene Hs.690209

genes like me logo Genes that share expressions with OR52N1: view

Expression partners for OR52N1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OR52N1 Gene

Orthologs for OR52N1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52N1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC618803 35
  • 88.4 (n)
  • 87.46 (a)
OR52N1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr669 35
  • 72.31 (n)
  • 72.52 (a)
Olfr669 16
Olfr659 36
  • 68 (a)
ManyToMany
Olfr686 36
  • 48 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC466395 35
  • 98.96 (n)
  • 98.12 (a)
OR52N1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr170 35
  • 85.17 (n)
  • 87.7 (a)
dog
(Canis familiaris)
Mammalia OR52N1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
Species with no ortholog for OR52N1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52N1 Gene

ENSEMBL:
Gene Tree for OR52N1 (if available)
TreeFam:
Gene Tree for OR52N1 (if available)

Paralogs for OR52N1 Gene

Selected SIMAP similar genes for OR52N1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR52N1: view

Variants for OR52N1 Gene

Sequence variations from dbSNP and Humsavar for OR52N1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1453432 -- 5,789,116(-) CCAAC(A/G)TTGGC upstream-variant-2KB
rs2198446 -- 5,790,736(-) AACAC(A/G)TATGT upstream-variant-2KB
rs4758093 -- 5,790,770(+) TATCC(C/T)TTTCC upstream-variant-2KB
rs7924810 -- 5,790,225(+) AAAAT(G/T)TTTAT upstream-variant-2KB
rs7924824 -- 5,790,259(+) GGCTG(A/T)ATAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR52N1 Gene

Variant ID Type Subtype PubMed ID
nsv896939 CNV Loss 21882294
dgv341e1 CNV Complex 17122850
nsv896950 CNV Gain 21882294
nsv832058 CNV Gain 17160897
nsv896951 CNV Gain 21882294
dgv342e1 CNV Complex 17122850
dgv11n50 CNV Loss 21212237
nsv65 CNV Loss 15895083
nsv7654 CNV Loss 18451855
esv2507539 CNV Loss 19546169
dgv5n31 CNV Deletion 19718026
esv2631490 CNV Deletion 19546169
nsv435927 CNV Deletion 17901297
dgv189e199 CNV Deletion 23128226
esv2144298 CNV Deletion 18987734
nsv8784 CNV Gain+Loss 18304495
esv33544 CNV Gain+Loss 17666407
esv2744067 CNV Deletion 23290073
nsv498749 CNV Loss 21111241
nsv443001 CNV Loss 18674749
dgv20e180 CNV Gain 20482838
dgv197n67 CNV Loss 20364138
nsv821028 CNV Deletion 20802225
nsv819430 CNV Gain 19587683
esv28265 CNV Gain 19812545
nsv514624 CNV Loss 21397061
esv2421614 CNV Deletion 20811451
dgv343e1 CNV Complex 17122850
dgv344e1 CNV Complex 17122850
essv14800 CNV CNV 17122850
nsv442598 CNV CNV 18776908
nsv471361 CNV Deletion 19718026
esv32705 CNV Gain 17666407

Relevant External Links for OR52N1 Gene

HapMap Linkage Disequilibrium report
OR52N1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52N1 Gene

Disorders for OR52N1 Gene

No disorders were found for OR52N1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for OR52N1 Gene

Publications for OR52N1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4

Products for OR52N1 Gene

Sources for OR52N1 Gene

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