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Aliases for OR52M1 Gene

Aliases for OR52M1 Gene

  • Olfactory Receptor, Family 52, Subfamily M, Member 1 2 3
  • Olfactory Receptor, Family 52, Subfamily M, Member 1 Pseudogene 2 3
  • Olfactory Receptor OR11-11 3 4
  • OR52M1P 3 4
  • Olfactory Receptor, Family 52, Subfamily M, Member 3 Pseudogene 3
  • Olfactory Receptor 52M1 3
  • OR11-11 3
  • OR52M3P 3

External Ids for OR52M1 Gene

Previous Symbols for OR52M1 Gene

  • OR52M1P

Summaries for OR52M1 Gene

Entrez Gene Summary for OR52M1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52M1 Gene

OR52M1 (Olfactory Receptor, Family 52, Subfamily M, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52R1.

UniProtKB/Swiss-Prot for OR52M1 Gene

  • Odorant receptor.

Gene Wiki entry for OR52M1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52M1 Gene

Genomics for OR52M1 Gene

Genomic Location for OR52M1 Gene

Start:
4,545,191 bp from pter
End:
4,546,144 bp from pter
Size:
954 bases
Orientation:
Plus strand

Genomic View for OR52M1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR52M1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52M1 Gene

Regulatory Elements for OR52M1 Gene

Proteins for OR52M1 Gene

  • Protein details for OR52M1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGK5-O52M1_HUMAN
    Recommended name:
    Olfactory receptor 52M1
    Protein Accession:
    Q8NGK5
    Secondary Accessions:

    Protein attributes for OR52M1 Gene

    Size:
    317 amino acids
    Molecular mass:
    35037 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52M1 Gene

Proteomics data for OR52M1 Gene at MOPED

Post-translational modifications for OR52M1 Gene

No Post-translational modifications

Other Protein References for OR52M1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR52M1 Gene

Domains for OR52M1 Gene

Gene Families for OR52M1 Gene

HGNC:
  • OR52 :GPCR / Class A : Olfactory receptors

Protein Domains for OR52M1 Gene

UniProtKB/Swiss-Prot:

O52M1_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q8NGK5
genes like me logo Genes that share domains with OR52M1: view

Function for OR52M1 Gene

Molecular function for OR52M1 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR52M1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR52M1 Gene

Localization for OR52M1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52M1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR52M1 Gene COMPARTMENTS Subcellular localization image for OR52M1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52M1: view

Pathways for OR52M1 Gene

genes like me logo Genes that share pathways with OR52M1: view

Pathways by source for OR52M1 Gene

Interacting Proteins for OR52M1 Gene

Gene Ontology (GO) - Biological Process for OR52M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52M1: view

Transcripts for OR52M1 Gene

mRNA/cDNA for OR52M1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR52M1 Gene

No ASD Table

Relevant External Links for OR52M1 Gene

GeneLoc Exon Structure for
OR52M1
ECgene alternative splicing isoforms for
OR52M1

Expression for OR52M1 Gene

mRNA expression in normal human tissues for OR52M1 Gene

SOURCE GeneReport for Unigene cluster for OR52M1 Gene Hs.553567

genes like me logo Genes that share expressions with OR52M1: view

Orthologs for OR52M1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52M1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466337 36
  • 98.63 (n)
  • 97.48 (a)
OR52M1 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR52M1 36
  • 86.23 (n)
  • 86.75 (a)
OR52M1 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR52M1 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr554 36
  • 87.07 (n)
  • 90.22 (a)
Olfr554 16
Olfr554 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OR52M1 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 45 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr48 36
  • 87.07 (n)
  • 90.85 (a)
Species with no ortholog for OR52M1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52M1 Gene

ENSEMBL:
Gene Tree for OR52M1 (if available)
TreeFam:
Gene Tree for OR52M1 (if available)

Paralogs for OR52M1 Gene

Selected SIMAP similar genes for OR52M1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR52M1 Gene

genes like me logo Genes that share paralogs with OR52M1: view

Variants for OR52M1 Gene

Sequence variations from dbSNP and Humsavar for OR52M1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1505211 -- 4,543,640(-) CTTCA(C/T)TTGCA upstream-variant-2KB
rs1505212 -- 4,543,468(-) CTCTA(C/G)TTCCC upstream-variant-2KB
rs2566270 -- 4,544,200(-) GTTGA(C/T)TACAG upstream-variant-2KB
rs2641412 -- 4,544,260(-) GAATA(C/T)GAAAG upstream-variant-2KB
rs2657167 - 4,546,105(-) AGAAG(C/G)CTCTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR52M1 Gene

Variant ID Type Subtype PubMed ID
nsv896911 CNV Gain 21882294
dgv1022n71 CNV Loss 21882294
esv2751024 CNV Loss 17911159
nsv832055 CNV Loss 17160897

Relevant External Links for OR52M1 Gene

HapMap Linkage Disequilibrium report
OR52M1

Disorders for OR52M1 Gene

Relevant External Links for OR52M1

Genetic Association Database (GAD)
OR52M1
genes like me logo Genes that share disorders with OR52M1: view

No data available for UniProtKB/Swiss-Prot for OR52M1 Gene

Publications for OR52M1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  3. Population differences in the human functional olfactory repertoire. (PMID: 12644552) Gilad Y. … Lancet D. (Mol. Biol. Evol. 2003) 3
  4. Novel human G-protein-coupled receptors. (PMID: 12732197) Vanti W.B. … O'Dowd B.F. (Biochem. Biophys. Res. Commun. 2003) 3

Products for OR52M1 Gene

Sources for OR52M1 Gene

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