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Aliases for OR52M1 Gene

Aliases for OR52M1 Gene

  • Olfactory Receptor Family 52 Subfamily M Member 1 2 3 5
  • Olfactory Receptor, Family 52, Subfamily M, Member 1 Pseudogene 2 3
  • Olfactory Receptor OR11-11 3 4
  • OR52M1P 3 4
  • Olfactory Receptor, Family 52, Subfamily M, Member 3 Pseudogene 3
  • Olfactory Receptor, Family 52, Subfamily M, Member 1 2
  • Olfactory Receptor 52M1 3
  • OR11-11 3
  • OR52M3P 3

External Ids for OR52M1 Gene

Previous HGNC Symbols for OR52M1 Gene

  • OR52M1P

Previous GeneCards Identifiers for OR52M1 Gene

  • GC11U900029
  • GC11P004529

Summaries for OR52M1 Gene

Entrez Gene Summary for OR52M1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52M1 Gene

OR52M1 (Olfactory Receptor Family 52 Subfamily M Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52R1.

UniProtKB/Swiss-Prot for OR52M1 Gene

  • Odorant receptor.

Gene Wiki entry for OR52M1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52M1 Gene

Genomics for OR52M1 Gene

Regulatory Elements for OR52M1 Gene

Enhancers for OR52M1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F004636 0.8 Ensembl ENCODE 10.1 +92.0 91959 0.5 ZBTB10 CTCF ZNF654 TEAD4 MAX TRIM22 REST ZNF2 RAD21 ZBTB48 TRIM68 OR52M1 OR51D1 GC11P004628
GH11F004458 1.7 FANTOM5 Ensembl ENCODE 9.8 -84.9 -84869 3.7 JUN DPF2 ZNF264 FOSL1 ZNF316 JUND ZNF692 ATF3 NFE2 FOS OR52K3P OR52K1 OR52M1 TRIM21 OR52K2 GC11M004470
GH11F004492 0.9 FANTOM5 3.8 -52.8 -52776 0.1 OR52K2 OR51F1 OR52B4 OR51S1 OR51G2 OR51A4 OR52K1 C11orf40 OR52R1 OR51A7
GH11F004210 1.1 FANTOM5 2.5 -334.2 -334241 0.3 OR52K2 C11orf40 OR52I1 OR51D1 OR52K1 OR52M1 GC11M004210 LOC100506082
GH11F004108 0.3 FANTOM5 1.6 -436.4 -436371 0.3 RRM1-AS1 ART1 ART5 C11orf40 OR52I1 OR52K2 OR52K1 OR52M1 RRM1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR52M1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR52M1 Gene

Chromosome:
11
Start:
4,545,191 bp from pter
End:
4,546,144 bp from pter
Size:
954 bases
Orientation:
Plus strand

Genomic View for OR52M1 Gene

Genes around OR52M1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52M1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52M1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52M1 Gene

Proteins for OR52M1 Gene

  • Protein details for OR52M1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGK5-O52M1_HUMAN
    Recommended name:
    Olfactory receptor 52M1
    Protein Accession:
    Q8NGK5

    Protein attributes for OR52M1 Gene

    Size:
    317 amino acids
    Molecular mass:
    35037 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52M1 Gene

Post-translational modifications for OR52M1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR52M1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52M1 Gene

Domains & Families for OR52M1 Gene

Gene Families for OR52M1 Gene

Protein Domains for OR52M1 Gene

Suggested Antigen Peptide Sequences for OR52M1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGK5

UniProtKB/Swiss-Prot:

O52M1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52M1: view

Function for OR52M1 Gene

Molecular function for OR52M1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR52M1: view

Phenotypes for OR52M1 Gene

genes like me logo Genes that share phenotypes with OR52M1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52M1 Gene

Localization for OR52M1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52M1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR52M1 Gene COMPARTMENTS Subcellular localization image for OR52M1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52M1: view

Pathways & Interactions for OR52M1 Gene

genes like me logo Genes that share pathways with OR52M1: view

Pathways by source for OR52M1 Gene

Gene Ontology (GO) - Biological Process for OR52M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA,IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52M1: view

No data available for SIGNOR curated interactions for OR52M1 Gene

Transcripts for OR52M1 Gene

mRNA/cDNA for OR52M1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR52M1 Gene

No ASD Table

Relevant External Links for OR52M1 Gene

GeneLoc Exon Structure for
OR52M1
ECgene alternative splicing isoforms for
OR52M1

Expression for OR52M1 Gene

mRNA expression in normal human tissues for OR52M1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR52M1 Gene:

OR52M1

SOURCE GeneReport for Unigene cluster for OR52M1 Gene:

Hs.553567
genes like me logo Genes that share expression patterns with OR52M1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR52M1 Gene

Orthologs for OR52M1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52M1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466337 34
  • 98.63 (n)
OR52M1 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR52M1 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or52m1 55 Olfr554 34 16 35
  • 87.07 (n)
rat
(Rattus norvegicus)
Mammalia Olr48 34
  • 87.07 (n)
cow
(Bos Taurus)
Mammalia OR52M1 34 35
  • 86.23 (n)
oppossum
(Monodelphis domestica)
Mammalia OR52M1 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 45 (a)
ManyToMany
Species where no ortholog for OR52M1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52M1 Gene

ENSEMBL:
Gene Tree for OR52M1 (if available)
TreeFam:
Gene Tree for OR52M1 (if available)

Paralogs for OR52M1 Gene

(418) SIMAP similar genes for OR52M1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR52M1 Gene

genes like me logo Genes that share paralogs with OR52M1: view

Variants for OR52M1 Gene

Sequence variations from dbSNP and Humsavar for OR52M1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10557754 -- 4,546,387(+) GACAA(-/GCT)GCTAA downstream-variant-500B
rs10836254 -- 4,546,615(+) AAATT(A/T)AAAAA downstream-variant-500B
rs11032738 -- 4,545,283(+) TCCAT(A/C/G)CCCTT reference, synonymous-codon, missense
rs111748026 -- 4,545,963(+) TCCCA(C/T)TGCTG reference, missense
rs112010454 -- 4,545,172(+) GAGAA(A/G)GTTCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR52M1 Gene

Variant ID Type Subtype PubMed ID
dgv1583n54 CNV loss 21841781
esv2751024 CNV loss 17911159
esv2762892 CNV loss 21179565
esv3579247 CNV loss 25503493
esv3579248 CNV loss 25503493
esv3625188 CNV loss 21293372
esv3625191 CNV loss 21293372
nsv1039206 CNV loss 25217958
nsv1044093 CNV loss 25217958
nsv1047280 CNV loss 25217958
nsv1047344 CNV loss 25217958
nsv1050498 CNV loss 25217958
nsv553159 CNV gain 21841781
nsv832055 CNV loss 17160897

Variation tolerance for OR52M1 Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.48; 64.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR52M1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR52M1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52M1 Gene

Disorders for OR52M1 Gene

Relevant External Links for OR52M1

Genetic Association Database (GAD)
OR52M1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR52M1

No disorders were found for OR52M1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52M1 Gene

Publications for OR52M1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64
  3. Population differences in the human functional olfactory repertoire. (PMID: 12644552) Gilad Y. … Lancet D. (Mol. Biol. Evol. 2003) 3 64
  4. Novel human G-protein-coupled receptors. (PMID: 12732197) Vanti W.B. … O'Dowd B.F. (Biochem. Biophys. Res. Commun. 2003) 3 64

Products for OR52M1 Gene

Sources for OR52M1 Gene

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