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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR52M1 Gene

protein-coding   GIFtS: 43
GCID: GC11P004523

Olfactory Receptor, Family 52, Subfamily M, Member 1

(Previous names: olfactory receptor, family 52, subfamily M, member 1 pseudogene)
(Previous symbol: OR52M1P)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 52, Subfamily M, Member 11 2     OR11-112
OR52M1P1 2 3     OR52M3P2
Olfactory Receptor, Family 52, Subfamily M, Member 1 Pseudogene1 2     Olfactory Receptor 52M12
Olfactory Receptor OR11-112 3     Olfactory Receptor, Family 52, Subfamily M, Member 3 Pseudogene2

External Ids:    HGNC: 152251   Entrez Gene: 1197722   Ensembl: ENSG000001977907   UniProtKB: Q8NGK53   

Export aliases for OR52M1 gene to outside databases

Previous GC identifers: GC11U900029 GC11P004529


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR52M1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR52M1 Gene: 
OR52M1 (olfactory receptor, family 52, subfamily M, member 1) is a protein-coding gene. Diseases associated with OR52M1 include neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52L1.

UniProtKB/Swiss-Prot: O52M1_HUMAN, Q8NGK5
Function: Odorant receptor (Potential)

Gene Wiki entry for OR52M1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR52M1 gene promoter:
         Nkx3-1   E2F-4   E2F-3a   E2F-5   E2F-2   NF-kappaB   AREB6   E2F   E2F-1   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for OR52M1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR52M1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

OR52M1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR52M1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P004523:  view genomic region     (about GC identifiers)

Start:
4,566,421 bp from pter      End:
4,567,371 bp from pter
Size:
951 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: O52M1_HUMAN, Q8NGK5 (See protein sequence)
Recommended Name: Olfactory receptor 52M1  
Size: 317 amino acids; 35037 Da
Subcellular location: Cell membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for OR52M1: NX_Q8NGK5

Explore proteomics data for OR52M1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NGK5

  • HORDE protein sequence for OR52M1
    OR52M1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OR52M1 Protein Expression
    REFSEQ proteins: NP_001004137.1  
    ENSEMBL proteins: 
     ENSP00000353343  
    Reactome Protein details: Q8NGK5
    Human Recombinant Protein Products for OR52M1: 
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    Browse Sino Biological Recombinant Proteins
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OR52M1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    OR52M1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for OR52M1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    OR52: GPCR / Class A : Olfactory receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR019424 7TM_GPCR_olfarory/Srsx
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGK5

    ProtoNet protein and cluster: Q8NGK5

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O52M1_HUMAN, Q8NGK5
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR52M1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O52M1_HUMAN, Q8NGK5
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR52M1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for OR52M1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OR52M1 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR52M1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for OR52M1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Olfactory transduction
    Olfactory Signaling Pathway0.81
    Olfactory transduction0.81
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for OR52M1
        GPCR downstream signaling
    Olfactory Signaling Pathway
    Signal Transduction
    Signaling by GPCR


    1         Kegg Pathway  (Kegg details for OR52M1):
        Olfactory transduction


    OR52M1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR52M1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/273 Interacting proteins for OR52M1 (ENSP000003533434) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10AD1ENSP000003086894STRING: ENSP00000308689
    OR10P1ENSP000003080824STRING: ENSP00000308082
    OR10W1ENSP000003785164STRING: ENSP00000378516
    OR11G2ENSP000003499304STRING: ENSP00000349930
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR52M1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OR52M1 (O52M1)

    Search CenterWatch for drugs/clinical trials and news about OR52M1 / O52M1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OR52M1 gene: 
    NM_001004137.1  

    Unigene Cluster for OR52M1:

    Olfactory receptor, family 52, subfamily M, member 1
    Hs.553567
    Unigene Representative Sequence: NM_001004137
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000360213(uc010qyf.2)
    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OR52M1
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OR52M1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR52M1
    Sirion Biotech Customized lentivirus for stable overexpression of OR52M1 
                         Customized lentivirus expression plasmids for stable overexpression of OR52M1 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR52M1

    1 AceView cDNA sequence:

    NM_001004137 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OR52M1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGCTTCTCAC
    OR52M1 Expression
    About this image


    See OR52M1 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.553567
        SABiosciences Custom PCR Arrays for OR52M1
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR52M1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for OR52M1 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr5541 , 5 olfactory receptor 5541, 5 87.07(n)1
    90.22(a)1
      7 (54.79 cM)5
    2583221  NM_146325.21  NP_666437.21 
     1026402485 
    chicken
    (Gallus gallus)
    Aves OR52M16
    olfactory receptor, family 52, subfamily M, member...
    45(a)
    1 ↔ 1
    1(193750603-193751568)


    ENSEMBL Gene Tree for OR52M1 (if available)
    TreeFam Gene Tree for OR52M1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OR52M1 gene
    OR52L12  OR52A12  OR52N42  OR52N52  OR52K12  OR52K22  OR52R12  OR52N12  
    OR52N22  OR52A52  
    18/418 SIMAP similar genes for OR52M1 using alignment to 1 protein entry:     O52M1_HUMAN(see all similar genes):
    OR52K3P    OR51E1    OR52D1    OR52K2    OR51E2    OR51G2
    OR52E8    OR52K1    OR52L1    OR51A4    OR51C1P    OR51D1
    OR51G1    OR52A1    OR52B2    OR52E1    OR52E2    OR52E4

    OR52M1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OR52M1
    PGOHUM00000242131


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/198 SNPs in OR52M1 are shown (see all 198)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1486197691,2
    --4564425(+) TTATAC/TACTGT 1 -- us2k10--------
    rs1931700391,2
    --4564446(+) TCTGAC/TATATT 1 -- us2k10--------
    rs1411434751,2
    C--4564447(+) CTGATA/GTATTC 1 -- us2k10--------
    rs1507103821,2
    --4564552(+) CACTGC/GGACTA 1 -- us2k10--------
    rs1391055381,2
    --4564636(+) CACTTC/TAGGAG 1 -- us2k10--------
    rs1440175241,2
    --4564654(+) CTTTGA/GTAGAA 1 -- us2k10--------
    rs27091851,2
    C,F,H--4564662(-) TCTTGG/ATCTTC 1 -- us2k115Minor allele frequency- A:0.47NS EA NA WA CSA 790
    rs1468504501,2
    --4564688(+) CTGGTA/GGGAAG 1 -- us2k10--------
    rs15052121,2
    C,F,H--4564698(-) CTCTAG/CTTCCC 1 -- us2k111Minor allele frequency- C:0.28NA EA MN NS CSA WA 714
    rs2005271161,2
    --4564715(+) TCTCT-/AATCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR52M1 ( 4566421 - 4567371 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for OR52M1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2751024CNV Loss17911159
    dgv1022n71CNV Loss21882294
    nsv832055CNV Loss17160897
    nsv896911CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for OR52M1:    About MalaCards
    neuronitis    


    OR52M1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): OR52M1

    Export disorders for OR52M1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OR52M1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with OR52M1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
    2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    3. Population differences in the human functional olfactory repertoire. (PubMed id 12644552)1 Gilad Y. and Lancet D. (2003)
    4. Novel human G-protein-coupled receptors. (PubMed id 12732197)1 Vanti W.B....O'Dowd B.F. (2003)
    5. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 119772 HGNC: 15225 AceView: OR52M1 Ensembl:ENSG00000197790 euGenes: HUgn119772
    ECgene: OR52M1 Kegg: 119772 H-InvDB: OR52M1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OR52M1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR52M1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OR52M1 gene:
    Search GeneIP for patents involving OR52M1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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