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OR52M1 Gene

protein-coding   GIFtS: 42
GCID: GC11P004523

Olfactory Receptor, Family 52, Subfamily M, Member 1

(Previous names: olfactory receptor, family 52, subfamily M, member 1 pseudogene)
(Previous symbol: OR52M1P)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 52, Subfamily M, Member 11 2     OR11-112
OR52M1P1 2 3     OR52M3P2
Olfactory Receptor, Family 52, Subfamily M, Member 1 Pseudogene1 2     Olfactory Receptor 52M12
Olfactory Receptor OR11-112 3     Olfactory Receptor, Family 52, Subfamily M, Member 3 Pseudogene2

External Ids:    HGNC: 152251   Entrez Gene: 1197722   Ensembl: ENSG000001977907   UniProtKB: Q8NGK53   

Export aliases for OR52M1 gene to outside databases

Previous GC identifers: GC11U900029 GC11P004529


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR52M1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR52M1 Gene:
OR52M1 (olfactory receptor, family 52, subfamily M, member 1) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52L1.

UniProtKB/Swiss-Prot: O52M1_HUMAN, Q8NGK5
Function: Odorant receptor (Potential)

Gene Wiki entry for OR52M1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR52M1 gene promoter:
         Nkx3-1   E2F-4   E2F-3a   E2F-5   E2F-2   NF-kappaB   AREB6   E2F   E2F-1   NF-kappaB1   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR52M1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

OR52M1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR52M1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P004523:  view genomic region     (about GC identifiers)

Start:
4,566,421 bp from pter      End:
4,567,371 bp from pter
Size:
951 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB/Swiss-Prot: O52M1_HUMAN, Q8NGK5 (See protein sequence)
Recommended Name: Olfactory receptor 52M1  
Size: 317 amino acids; 35037 Da

Explore the universe of human proteins at neXtProt for OR52M1: NX_Q8NGK5

Explore proteomics data for OR52M1 at MOPED

HORDE protein sequence for OR52M1

See OR52M1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001004137.1  
ENSEMBL proteins: 
 ENSP00000353343  
Reactome Protein details: Q8NGK5

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
OR52: GPCR / Class A : Olfactory receptors

4 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR019424 7TM_GPCR_olfarory/Srsx
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8NGK5

ProtoNet protein and cluster: Q8NGK5

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: O52M1_HUMAN, Q8NGK5
Similarity: Belongs to the G-protein coupled receptor 1 family


Find genes that share domains with OR52M1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: O52M1_HUMAN, Q8NGK5
Function: Odorant receptor (Potential)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--
     
Find genes that share ontologies with OR52M1           About GenesLikeMe


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
O52M1_HUMAN, Q8NGK5: Cell membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral component of membrane IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for OR52M1 About    
See pathways by source

SuperPathContained pathways About
1Olfactory Signaling Pathway
Olfactory Signaling Pathway0.82
Olfactory transduction0.82
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90


Find genes that share SuperPaths with OR52M1           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for OR52M1
    Olfactory Signaling Pathway


1 Kegg Pathway  (Kegg details for OR52M1):
    Olfactory transduction

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Interactions:

    Search GeneGlobe Interaction Network for OR52M1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for OR52M1 (ENSP000003533434) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
InteractantInteraction Details
GeneCardExternal ID(s)
OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
OR10AD1ENSP000003086894STRING: ENSP00000308689
OR10G4ENSP000003250764STRING: ENSP00000325076
OR10J5ENSP000003344414STRING: ENSP00000334441
OR10P1ENSP000003080824STRING: ENSP00000308082
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for OR52M1 (O52M1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for OR52M1 gene: 
NM_001004137.1  

Unigene Cluster for OR52M1:

Olfactory receptor, family 52, subfamily M, member 1
Hs.553567
Unigene Representative Sequence: NM_001004137
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000360213(uc010qyf.2)
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1 AceView cDNA sequence:

NM_001004137 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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OR52M1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CGCTTCTCAC
OR52M1 Expression
About this image

OR52M1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

OR52M1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.553567
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for OR52M1 gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Olfr5541 , 5 olfactory receptor 5541, 5 87.07(n)1
90.22(a)1
  7 (54.79 cM)5
2583221  NM_146325.21  NP_666437.21 
 1026402485 


ENSEMBL Gene Tree for OR52M1 (if available)
TreeFam Gene Tree for OR52M1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for OR52M1 gene
OR52L12  OR52A12  OR52N42  OR52N52  OR52K12  OR52K22  OR52R12  OR52N12  
OR52N22  OR52A52  
Selected SIMAP similar genes for OR52M1 using alignment to 1 protein entry:     O52M1_HUMAN(see all similar genes):
OR52K3P    OR51E1    OR52D1    OR52K2    OR51E2    OR51G2
OR52E8    OR52K1    OR52L1    OR51A4    OR51D1    OR51G1
OR52A1    OR52B2    OR52E1    OR52E2    OR52E4    OR52E6

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1 Pseudogenes.org Pseudogene for OR52M1
PGOHUM00000242131


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for OR52M1 (see all 198)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1486197691,2
--4564425(+) TTATAC/TACTGT 1 -- us2k10--------
rs1931700391,2
--4564446(+) TCTGAC/TATATT 1 -- us2k10--------
rs1411434751,2
C--4564447(+) CTGATA/GTATTC 1 -- us2k10--------
rs1507103821,2
--4564552(+) CACTGC/GGACTA 1 -- us2k10--------
rs1391055381,2
--4564636(+) CACTTC/TAGGAG 1 -- us2k10--------
rs1440175241,2
--4564654(+) CTTTGA/GTAGAA 1 -- us2k10--------
rs27091851,2
C,F,H--4564662(-) TCTTGG/ATCTTC 1 -- us2k115Minor allele frequency- A:0.47NS EA NA WA CSA 790
rs1468504501,2
--4564688(+) CTGGTA/GGGAAG 1 -- us2k10--------
rs15052121,2
C,F,H--4564698(-) CTCTAG/CTTCCC 1 -- us2k111Minor allele frequency- C:0.28NA EA MN NS CSA WA 714
rs2005271161,2
--4564715(+) TCTCT-/AATCTC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for OR52M1 ( 4566421 - 4567371 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for OR52M1:    About this table    
Variant IDTypeSubtypePubMed ID
esv2751024CNV Loss17911159
dgv1022n71CNV Loss21882294
nsv832055CNV Loss17160897
nsv896911CNV Gain21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with OR52M1           About GenesLikeMe

Genetic Association Database (GAD): OR52M1

Export disorders for OR52M1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for OR52M1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with OR52M1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
  2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
  3. Population differences in the human functional olfactory repertoire. (PubMed id 12644552)1 Gilad Y. and Lancet D. (Mol. Biol. Evol. 2003)
  4. Novel human G-protein-coupled receptors. (PubMed id 12732197)1 Vanti W.B....O'Dowd B.F. (Biochem. Biophys. Res. Commun. 2003)
  5. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 119772 HGNC: 15225 AceView: OR52M1 Ensembl:ENSG00000197790 euGenes: HUgn119772
ECgene: OR52M1 Kegg: 119772 H-InvDB: OR52M1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for OR52M1 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR52M1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for OR52M1 gene:
Search GeneIP for patents involving OR52M1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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