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Aliases for OR52K2 Gene

Aliases for OR52K2 Gene

  • Olfactory Receptor, Family 52, Subfamily K, Member 2 2 3
  • Olfactory Receptor OR11-7 3 4
  • Olfactory Receptor 52K2 3
  • OR11-7 3

External Ids for OR52K2 Gene

Summaries for OR52K2 Gene

Entrez Gene Summary for OR52K2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52K2 Gene

OR52K2 (Olfactory Receptor, Family 52, Subfamily K, Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52R1.

UniProtKB/Swiss-Prot for OR52K2 Gene

  • Odorant receptor.

Gene Wiki entry for OR52K2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52K2 Gene

Genomics for OR52K2 Gene

Genomic Location for OR52K2 Gene

Start:
4,449,295 bp from pter
End:
4,450,361 bp from pter
Size:
1,067 bases
Orientation:
Plus strand

Genomic View for OR52K2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR52K2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52K2 Gene

Regulatory Elements for OR52K2 Gene

Proteins for OR52K2 Gene

  • Protein details for OR52K2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGK3-O52K2_HUMAN
    Recommended name:
    Olfactory receptor 52K2
    Protein Accession:
    Q8NGK3
    Secondary Accessions:
    • A8MUY8
    • B2RP35
    • Q6IFK4

    Protein attributes for OR52K2 Gene

    Size:
    314 amino acids
    Molecular mass:
    34926 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52K2 Gene

Proteomics data for OR52K2 Gene at MOPED

Post-translational modifications for OR52K2 Gene

Other Protein References for OR52K2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR52K2 Gene

Domains for OR52K2 Gene

Gene Families for OR52K2 Gene

HGNC:
  • OR52 :GPCR / Class A : Olfactory receptors

Protein Domains for OR52K2 Gene

UniProtKB/Swiss-Prot:

O52K2_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q8NGK3
genes like me logo Genes that share domains with OR52K2: view

Function for OR52K2 Gene

Molecular function for OR52K2 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR52K2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR52K2 Gene

Localization for OR52K2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52K2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR52K2 Gene COMPARTMENTS Subcellular localization image for OR52K2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52K2: view

Pathways for OR52K2 Gene

genes like me logo Genes that share pathways with OR52K2: view

Pathways by source for OR52K2 Gene

Interacting Proteins for OR52K2 Gene

Gene Ontology (GO) - Biological Process for OR52K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52K2: view

Transcripts for OR52K2 Gene

mRNA/cDNA for OR52K2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR52K2 Gene

No ASD Table

Relevant External Links for OR52K2 Gene

GeneLoc Exon Structure for
OR52K2
ECgene alternative splicing isoforms for
OR52K2

Expression for OR52K2 Gene

mRNA expression in normal human tissues for OR52K2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for OR52K2 Gene Hs.553568

genes like me logo Genes that share expressions with OR52K2: view

Orthologs for OR52K2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52K2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466334 36
  • 98.2 (n)
  • 97.77 (a)
OR52K2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR52K2 36
  • 87.26 (n)
  • 89.81 (a)
OR52K2 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 89 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr552 36
  • 84.08 (n)
  • 87.9 (a)
Olfr552 16
Olfr552 37
  • 87 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 75 (a)
ManyToMany
-- 37
  • 79 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 49 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr45 36
  • 85.03 (n)
  • 87.58 (a)
Species with no ortholog for OR52K2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52K2 Gene

ENSEMBL:
Gene Tree for OR52K2 (if available)
TreeFam:
Gene Tree for OR52K2 (if available)

Paralogs for OR52K2 Gene

Selected SIMAP similar genes for OR52K2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR52K2: view

Variants for OR52K2 Gene

Sequence variations from dbSNP and Humsavar for OR52K2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs331537 - 4,450,046(-) TGTAG(C/T)GGGCC missense, reference
rs1367308 -- 4,447,485(-) GATAG(C/T)TCCAC upstream-variant-2KB
rs1367309 -- 4,447,476(-) ACTTT(A/G)AAGTC upstream-variant-2KB
rs7934336 - 4,450,243(+) AAATC(C/T)GTGAG reference, missense
rs11032296 - 4,449,709(+) TTGAC(C/T)GCTAT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR52K2 Gene

Variant ID Type Subtype PubMed ID
nsv428248 CNV Gain+Loss 18775914
dgv338e1 CNV Complex 17122850
nsv832054 CNV Gain 17160897
nsv469800 CNV Complex 16826518
nsv896908 CNV Gain 21882294
nsv896911 CNV Gain 21882294
nsv469934 CNV Gain 18288195
nsv467664 CNV Gain 19166990

Relevant External Links for OR52K2 Gene

HapMap Linkage Disequilibrium report
OR52K2

Disorders for OR52K2 Gene

No disorders were found for OR52K2 Gene.

No data available for UniProtKB/Swiss-Prot for OR52K2 Gene

Publications for OR52K2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR52K2 Gene

Sources for OR52K2 Gene

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