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OR52K2 Gene

protein-coding   GIFtS: 45
GCID: GC11P004470

Olfactory Receptor, Family 52, Subfamily K, Member 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 52, Subfamily K, Member 21 2
Olfactory Receptor OR11-72 3
OR11-72
Olfactory Receptor 52K22

External Ids:    HGNC: 152231   Entrez Gene: 1197742   Ensembl: ENSG000001819637   UniProtKB: Q8NGK33   

Export aliases for OR52K2 gene to outside databases

Previous GC identifers: GC11U990491 GC11P004435 GC11P004427


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR52K2 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR52K2 Gene:
OR52K2 (olfactory receptor, family 52, subfamily K, member 2) is a protein-coding gene. Diseases associated with OR52K2 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52L1.

UniProtKB/Swiss-Prot: O52K2_HUMAN, Q8NGK3
Function: Odorant receptor (Potential)

Gene Wiki entry for OR52K2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR52K2 gene promoter:
         AML1a   Pax-6   ARP-1   HNF-4alpha2   LCR-F1   Tal-1beta   E47   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR52K2 promoter sequence
   Search Chromatin IP Primers for OR52K2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR52K2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

OR52K2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR52K2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P004470:  view genomic region     (about GC identifiers)

Start:
4,470,570 bp from pter      End:
4,471,511 bp from pter
Size:
942 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: O52K2_HUMAN, Q8NGK3 (See protein sequence)
Recommended Name: Olfactory receptor 52K2  
Size: 314 amino acids; 34926 Da
Secondary accessions: A8MUY8 B2RP35 Q6IFK4

Explore the universe of human proteins at neXtProt for OR52K2: NX_Q8NGK3

Explore proteomics data for OR52K2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR52K2

    See OR52K2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001005172.2  
    ENSEMBL proteins: 
     ENSP00000318956  
    Reactome Protein details: Q8NGK3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR52: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGK3

    ProtoNet protein and cluster: Q8NGK3

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O52K2_HUMAN, Q8NGK3
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR52K2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O52K2_HUMAN, Q8NGK3
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR52K2 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O52K2_HUMAN, Q8NGK3: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR52K2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR52K2 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR52K2
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR52K2):
        Olfactory transduction


    OR52K2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR52K2
    Interactions:

        Search GeneGlobe Interaction Network for OR52K2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for OR52K2 (ENSP000003189564) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRBK2ENSP000003175784STRING: ENSP00000317578
    ARRB2ENSP000002692604STRING: ENSP00000269260
    GNALENSP000003340514STRING: ENSP00000334051
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR52K2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for OR52K2 (O52K2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR52K2 gene: 
    NM_001005172.2  

    Unigene Cluster for OR52K2:

    Olfactory receptor, family 52, subfamily K, member 2
    Hs.553568
    Unigene Representative Sequence: NM_001005172
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000325719(uc001lyz.2)
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      QuantiFast Probe-based Assays in human, mouse, rat OR52K2

    Additional mRNA sequence: 

    BC137247.1 BC137248.1 

    1 AceView cDNA sequence:

    NM_001005172 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR52K2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCAATCCCA
    OR52K2 Expression
    About this image


    OR52K2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    OR52K2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR52K2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553568
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR52K2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr5521 , 5 olfactory receptor 5521, 5 84.08(n)1
    87.9(a)1
      7 (54.78 cM)5
    2591061  NM_147102.21  NP_667313.21 
     1026043565 


    ENSEMBL Gene Tree for OR52K2 (if available)
    TreeFam Gene Tree for OR52K2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR52K2 gene
    OR52L12  OR52A12  OR52M12  OR52N42  OR52N52  OR52K12  OR52R12  OR52N12  
    OR52N22  OR52A52  
    Selected SIMAP similar genes for OR52K2 using alignment to 1 protein entry:     O52K2_HUMAN(see all similar genes):
    OR52K1    OR52K3P    OR51E2    OR51G2    OR52M1    OR51L1
    OR52J3    OR52R1    OR51A7    OR51D1    OR51H1P    OR52D1
    OR52E2    OR52E8    OR52L1    OR52P1P    OR51B5    OR52B6

    OR52K2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR52K2 (see all 183)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1122737841,2
    F--4468586(+) CACCCC/TGGGTT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs754764471,2
    F--4468601(+) ACCTAA/GCTATA 1 -- us2k11Minor allele frequency- G:0.00NA 2
    rs1387223601,2
    --4468612(+) GGATGA/GATGGT 1 -- us2k10--------
    rs1858868131,2
    --4468670(+) GGAGAC/TAGATT 1 -- us2k10--------
    rs13673091,2
    C,F,A--4468706(-) ACTTTA/GAAGTC 1 -- us2k19Minor allele frequency- G:0.42NA WA CSA EA 370
    rs13673081,2
    C,F,A,H--4468715(-) GATAGT/CTCCAC 1 -- us2k111Minor allele frequency- C:0.36EA NS NA WA CSA 536
    rs1493391451,2
    --4468783(+) ATTCCC/GTGAAT 1 -- us2k10--------
    rs1164639121,2
    F--4468814(+) TTACCA/TCCTAA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1895691191,2
    --4468842(+) TATGAA/GAATAA 1 -- us2k10--------
    rs1447528671,2
    C--4468853(+) AAGGGC/GAACAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR52K2 ( 4470570 - 4471511 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for OR52K2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832054CNV Gain17160897
    nsv467664CNV Gain19166990
    nsv896911CNV Gain21882294
    nsv896908CNV Gain21882294
    nsv469934CNV Gain18288195
    nsv428248CNV Gain+Loss18775914
    dgv338e1CNV Complex17122850
    nsv469800CNV Complex16826518

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for OR52K2:    
    About MalaCards
    neuronitis


    OR52K2 for disorders           About GeneDecksing


    Export disorders for OR52K2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR52K2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR52K2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 119774 HGNC: 15223 AceView: OR52K2 Ensembl:ENSG00000181963 euGenes: HUgn119774
    ECgene: OR52K2 Kegg: 119774 H-InvDB: OR52K2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR52K2 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR52K2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR52K2 gene:
    Search GeneIP for patents involving OR52K2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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