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Aliases for OR52K1 Gene

Aliases for OR52K1 Gene

  • Olfactory Receptor, Family 52, Subfamily K, Member 1 2 3
  • Olfactory Receptor OR11-8 3 4
  • Olfactory Receptor 52K1 3
  • OR11-8 3

External Ids for OR52K1 Gene

Previous GeneCards Identifiers for OR52K1 Gene

  • GC11U990492
  • GC11P004475
  • GC11P004466

Summaries for OR52K1 Gene

Entrez Gene Summary for OR52K1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52K1 Gene

OR52K1 (Olfactory Receptor, Family 52, Subfamily K, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52R1.

UniProtKB/Swiss-Prot for OR52K1 Gene

  • Odorant receptor.

Gene Wiki entry for OR52K1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52K1 Gene

Genomics for OR52K1 Gene

Regulatory Elements for OR52K1 Gene

Genomic Location for OR52K1 Gene

4,488,879 bp from pter
4,489,908 bp from pter
1,030 bases
Plus strand

Genomic View for OR52K1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR52K1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52K1 Gene

Proteins for OR52K1 Gene

  • Protein details for OR52K1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 52K1
    Protein Accession:
    Secondary Accessions:
    • B9EH54
    • Q6IFK5

    Protein attributes for OR52K1 Gene

    314 amino acids
    Molecular mass:
    35231 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52K1 Gene

Proteomics data for OR52K1 Gene at MOPED

Post-translational modifications for OR52K1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR52K1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52K1 Gene

Domains for OR52K1 Gene

Gene Families for OR52K1 Gene

Protein Domains for OR52K1 Gene

Suggested Antigen Peptide Sequences for OR52K1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52K1: view

Function for OR52K1 Gene

Molecular function for OR52K1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR52K1: view

Phenotypes for OR52K1 Gene

genes like me logo Genes that share phenotypes with OR52K1: view

Animal Model Products

CRISPR Products

miRNA for OR52K1 Gene

miRTarBase miRNAs that target OR52K1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR52K1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for OR52K1 Gene

Localization for OR52K1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52K1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR52K1 Gene COMPARTMENTS Subcellular localization image for OR52K1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52K1: view

Pathways for OR52K1 Gene

genes like me logo Genes that share pathways with OR52K1: view

Pathways by source for OR52K1 Gene

Interacting Proteins for OR52K1 Gene

Gene Ontology (GO) - Biological Process for OR52K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52K1: view

Transcripts for OR52K1 Gene

mRNA/cDNA for OR52K1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR52K1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR52K1 Gene

No ASD Table

Relevant External Links for OR52K1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR52K1 Gene

mRNA expression in normal human tissues for OR52K1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR52K1 Gene

SOURCE GeneReport for Unigene cluster for OR52K1 Gene Hs.553726

genes like me logo Genes that share expressions with OR52K1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for OR52K1 Gene

Orthologs for OR52K1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52K1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OR52K1 35
  • 87.79 (n)
  • 92.68 (a)
OR52K1 36
  • 93 (a)
(Canis familiaris)
Mammalia cOR52K6 35
  • 89.78 (n)
  • 91.94 (a)
OR52K1 36
  • 90 (a)
(Rattus norvegicus)
Mammalia Olr46 35
  • 86.24 (n)
  • 89.68 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
-- 36
  • 78 (a)
(Mus musculus)
Mammalia Olfr656 36
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
Species with no ortholog for OR52K1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52K1 Gene

Gene Tree for OR52K1 (if available)
Gene Tree for OR52K1 (if available)

Paralogs for OR52K1 Gene

(456) SIMAP similar genes for OR52K1 Gene using alignment to 1 proteins: Pseudogenes for OR52K1 Gene

genes like me logo Genes that share paralogs with OR52K1: view

Variants for OR52K1 Gene

Sequence variations from dbSNP and Humsavar for OR52K1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs96489 - 4,489,055(-) CAGCC(C/T)GGATA reference, missense
rs331508 -- 4,487,175(+) gtttc(A/G)ctgta upstream-variant-2KB
rs331509 -- 4,487,875(-) CCAAG(A/C)CTGTT upstream-variant-2KB
rs331510 - 4,489,357(-) AGCCC(A/G)GGCCA reference, missense
rs3889581 -- 4,489,323(+) GGGTC(C/T)CTCAT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for OR52K1 Gene

Variant ID Type Subtype PubMed ID
nsv428248 CNV Gain+Loss 18775914
dgv338e1 CNV Complex 17122850
nsv896908 CNV Gain 21882294
nsv896911 CNV Gain 21882294
dgv55n21 CNV Loss 19592680
esv2668112 CNV Deletion 23128226
nsv825722 CNV Loss 20364138
nsv442215 CNV CNV 18776908
dgv38e55 CNV Loss 17911159
dgv339e1 CNV Complex 17122850

Relevant External Links for OR52K1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52K1 Gene

Disorders for OR52K1 Gene

No disorders were found for OR52K1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for OR52K1 Gene

Publications for OR52K1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. A high-density genome-wide association screen of sporadic ALS in US veterans. (PMID: 22470424) Kwee L.C. … Hauser M.A. (PLoS ONE 2012) 3
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4

Products for OR52K1 Gene

Sources for OR52K1 Gene

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