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Aliases for OR52I2 Gene

Aliases for OR52I2 Gene

  • Olfactory Receptor Family 52 Subfamily I Member 2 2 3 5
  • Olfactory Receptor, Family 52, Subfamily I, Member 2 2 3
  • Olfactory Receptor OR11-12 3 4
  • OR11-12 3
  • OR52I1 3

External Ids for OR52I2 Gene

Previous GeneCards Identifiers for OR52I2 Gene

  • GC11U990493
  • GC11P004573

Summaries for OR52I2 Gene

Entrez Gene Summary for OR52I2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52I2 Gene

OR52I2 (Olfactory Receptor Family 52 Subfamily I Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52I1.

UniProtKB/Swiss-Prot for OR52I2 Gene

  • Odorant receptor.

Gene Wiki entry for OR52I2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52I2 Gene

Genomics for OR52I2 Gene

Genomic Location for OR52I2 Gene

4,586,791 bp from pter
4,587,905 bp from pter
1,115 bases
Plus strand

Genomic View for OR52I2 Gene

Genes around OR52I2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52I2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52I2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52I2 Gene

No data available for Regulatory Elements for OR52I2 Gene

Proteins for OR52I2 Gene

  • Protein details for OR52I2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 52I2
    Protein Accession:
    Secondary Accessions:
    • B2RNJ5
    • B9EKV8
    • Q6IFJ8

    Protein attributes for OR52I2 Gene

    350 amino acids
    Molecular mass:
    38353 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05770.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR52I2 Gene

Proteomics data for OR52I2 Gene at MOPED

Post-translational modifications for OR52I2 Gene

  • Glycosylation at Asn 33
  • Modification sites at PhosphoSitePlus

Other Protein References for OR52I2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52I2 Gene

Domains & Families for OR52I2 Gene

Gene Families for OR52I2 Gene

Protein Domains for OR52I2 Gene

Suggested Antigen Peptide Sequences for OR52I2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52I2: view

Function for OR52I2 Gene

Molecular function for OR52I2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
genes like me logo Genes that share phenotypes with OR52I2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52I2 Gene

Localization for OR52I2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52I2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR52I2 Gene COMPARTMENTS Subcellular localization image for OR52I2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52I2: view

Pathways & Interactions for OR52I2 Gene

genes like me logo Genes that share pathways with OR52I2: view

Pathways by source for OR52I2 Gene

Interacting Proteins for OR52I2 Gene

Gene Ontology (GO) - Biological Process for OR52I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52I2: view

No data available for SIGNOR curated interactions for OR52I2 Gene

Drugs & Compounds for OR52I2 Gene

No Compound Related Data Available

Transcripts for OR52I2 Gene

mRNA/cDNA for OR52I2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR52I2 Gene

No ASD Table

Relevant External Links for OR52I2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR52I2 Gene

mRNA expression in normal human tissues for OR52I2 Gene

SOURCE GeneReport for Unigene cluster for OR52I2 Gene Hs.553607

genes like me logo Genes that share expression patterns with OR52I2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR52I2 Gene

Orthologs for OR52I2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR52I2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OR52I2 35
  • 85.55 (n)
  • 82.35 (a)
-- 36
  • 79 (a)
-- 36
  • 78 (a)
-- 36
  • 78 (a)
(Canis familiaris)
Mammalia LOC100683809 35
  • 86.32 (n)
  • 82.72 (a)
(Mus musculus)
Mammalia Olfr556 35
  • 81.58 (n)
  • 79.63 (a)
Olfr556 16
Olfr556 36
  • 80 (a)
(Pan troglodytes)
Mammalia LOC466338 35
  • 98.29 (n)
  • 96.57 (a)
OR52I2 36
  • 97 (a)
(Rattus norvegicus)
Mammalia LOC684179 35
  • 83.01 (n)
  • 79.49 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 72 (a)
-- 36
  • 70 (a)
-- 36
  • 68 (a)
-- 36
  • 72 (a)
-- 36
  • 66 (a)
-- 36
  • 45 (a)
-- 36
  • 45 (a)
(Gallus gallus)
Aves LOC428119 35
  • 61.11 (n)
  • 50.65 (a)
-- 36
  • 51 (a)
Species with no ortholog for OR52I2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52I2 Gene

Gene Tree for OR52I2 (if available)
Gene Tree for OR52I2 (if available)

Paralogs for OR52I2 Gene

Paralogs for OR52I2 Gene

(448) SIMAP similar genes for OR52I2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR52I2: view

Variants for OR52I2 Gene

Sequence variations from dbSNP and Humsavar for OR52I2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs7128702 - 4,586,886(+) CTCAC(C/T)TGTGA reference, missense
rs12793957 - 4,587,032(+) ACACC(A/C)TCATC reference, missense
rs1847632 - 4,587,312(-) GAGGC(A/G)TGAGA reference, missense
rs7947426 - 4,587,344(+) TGGCC(A/G)TCACC reference, missense
rs7947432 - 4,587,359(+) GAGCT(A/C/G)TCATA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR52I2 Gene

Variant ID Type Subtype PubMed ID
nsv896911 CNV Gain 21882294
nsv832055 CNV Loss 17160897
nsv896914 CNV Gain 21882294

Variation tolerance for OR52I2 Gene

Residual Variation Intolerance Score: 93.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.40; 95.42% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR52I2 Gene

Disorders for OR52I2 Gene

Relevant External Links for OR52I2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR52I2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52I2 Gene

Publications for OR52I2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. Novel human G-protein-coupled receptors. (PMID: 12732197) Vanti W.B. … O'Dowd B.F. (Biochem. Biophys. Res. Commun. 2003) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR52I2 Gene

Sources for OR52I2 Gene