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Aliases for OR52I2 Gene

Aliases for OR52I2 Gene

  • Olfactory Receptor, Family 52, Subfamily I, Member 2 2 3
  • Olfactory Receptor OR11-12 3 4
  • Olfactory Receptor 52I2 3
  • OR11-12 3

External Ids for OR52I2 Gene

Summaries for OR52I2 Gene

Entrez Gene Summary for OR52I2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52I2 Gene

OR52I2 (Olfactory Receptor, Family 52, Subfamily I, Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52I1.

UniProtKB/Swiss-Prot for OR52I2 Gene

  • Odorant receptor.

Gene Wiki entry for OR52I2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52I2 Gene

Genomics for OR52I2 Gene

Genomic Location for OR52I2 Gene

Start:
4,586,791 bp from pter
End:
4,587,905 bp from pter
Size:
1,115 bases
Orientation:
Plus strand

Genomic View for OR52I2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR52I2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52I2 Gene

No data available for Regulatory Elements for OR52I2 Gene

Proteins for OR52I2 Gene

  • Protein details for OR52I2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH67-O52I2_HUMAN
    Recommended name:
    Olfactory receptor 52I2
    Protein Accession:
    Q8NH67
    Secondary Accessions:
    • B2RNJ5
    • B9EKV8
    • Q6IFJ8

    Protein attributes for OR52I2 Gene

    Size:
    350 amino acids
    Molecular mass:
    38353 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05770.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR52I2 Gene

Proteomics data for OR52I2 Gene at MOPED

Post-translational modifications for OR52I2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn33

Other Protein References for OR52I2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR52I2 Gene

Domains for OR52I2 Gene

Gene Families for OR52I2 Gene

HGNC:
  • OR52 :GPCR / Class A : Olfactory receptors

Protein Domains for OR52I2 Gene

UniProtKB/Swiss-Prot:

O52I2_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q8NH67
genes like me logo Genes that share domains with OR52I2: view

Function for OR52I2 Gene

Molecular function for OR52I2 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR52I2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR52I2 Gene

Localization for OR52I2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52I2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR52I2 Gene COMPARTMENTS Subcellular localization image for OR52I2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52I2: view

Pathways for OR52I2 Gene

genes like me logo Genes that share pathways with OR52I2: view

Pathways by source for OR52I2 Gene

Interacting Proteins for OR52I2 Gene

Gene Ontology (GO) - Biological Process for OR52I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52I2: view

Transcripts for OR52I2 Gene

mRNA/cDNA for OR52I2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR52I2 Gene

No ASD Table

Relevant External Links for OR52I2 Gene

GeneLoc Exon Structure for
OR52I2
ECgene alternative splicing isoforms for
OR52I2

Expression for OR52I2 Gene

mRNA expression in normal human tissues for OR52I2 Gene

SOURCE GeneReport for Unigene cluster for OR52I2 Gene Hs.553607

genes like me logo Genes that share expressions with OR52I2: view

Orthologs for OR52I2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR52I2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466338 36
  • 98.29 (n)
  • 96.57 (a)
OR52I2 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 79 (a)
ManyToMany
-- 37
  • 78 (a)
ManyToMany
-- 37
  • 78 (a)
ManyToMany
OR52I2 36
  • 85.55 (n)
  • 82.35 (a)
dog
(Canis familiaris)
Mammalia LOC100683809 36
  • 86.32 (n)
  • 82.72 (a)
mouse
(Mus musculus)
Mammalia Olfr556 36
  • 81.58 (n)
  • 79.63 (a)
Olfr556 16
Olfr556 37
  • 80 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 72 (a)
ManyToMany
-- 37
  • 70 (a)
ManyToMany
-- 37
  • 68 (a)
ManyToMany
-- 37
  • 72 (a)
ManyToMany
-- 37
  • 66 (a)
ManyToMany
-- 37
  • 45 (a)
ManyToMany
-- 37
  • 45 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC684179 36
  • 83.01 (n)
  • 79.49 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 51 (a)
OneToMany
LOC428119 36
  • 61.11 (n)
  • 50.65 (a)
Species with no ortholog for OR52I2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52I2 Gene

ENSEMBL:
Gene Tree for OR52I2 (if available)
TreeFam:
Gene Tree for OR52I2 (if available)

Paralogs for OR52I2 Gene

Paralogs for OR52I2 Gene

Selected SIMAP similar genes for OR52I2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR52I2: view

Variants for OR52I2 Gene

Sequence variations from dbSNP and Humsavar for OR52I2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1847632 - 4,587,312(-) GAGGC(A/G)TGAGA reference, missense
rs2115929 -- 4,586,872(+) AACAG(A/G)AAAAA synonymous-codon, reference
rs2201338 -- 4,587,175(-) CTGAT(G/T)GAGCT reference, synonymous-codon
rs7108599 -- 4,586,683(+) ACAAT(A/G)AATAC upstream-variant-2KB
rs7124305 -- 4,585,722(+) CCATA(C/T)TGGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR52I2 Gene

Variant ID Type Subtype PubMed ID
nsv896911 CNV Gain 21882294
nsv832055 CNV Loss 17160897
nsv896914 CNV Gain 21882294

Relevant External Links for OR52I2 Gene

HapMap Linkage Disequilibrium report
OR52I2

Disorders for OR52I2 Gene

No disorders were found for OR52I2 Gene.

No data available for UniProtKB/Swiss-Prot for OR52I2 Gene

Publications for OR52I2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Novel human G-protein-coupled receptors. (PMID: 12732197) Vanti W.B. … O'Dowd B.F. (Biochem. Biophys. Res. Commun. 2003) 3

Products for OR52I2 Gene

Sources for OR52I2 Gene

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