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OR52I1 Gene

protein-coding   GIFtS: 44
GCID: GC11P004568

Olfactory Receptor, Family 52, Subfamily I, Member 1

  See OR52I1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 52, Subfamily I, Member 11 2
Olfactory Receptor OR11-132 3
OR11-132
Olfactory Receptor 52I12

External Ids:    HGNC: 152201   Entrez Gene: 3900372   Ensembl: ENSG000002322687   UniProtKB: Q8NGK63   

Export aliases for OR52I1 gene to outside databases

Previous GC identifers: GC11U990494 GC11P004580


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR52I1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR52I1 Gene:
OR52I1 (olfactory receptor, family 52, subfamily I, member 1) is a protein-coding gene. Diseases associated with OR52I1 include type 2 diabetes mellitus. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52I2.

UniProtKB/Swiss-Prot: O52I1_HUMAN, Q8NGK6
Function: Odorant receptor (Potential)

Gene Wiki entry for OR52I1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR52I1 gene promoter:
         NRSF form 1   NRSF form 2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for OR52I1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR52I1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

OR52I1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR52I1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P004568:  view genomic region     (about GC identifiers)

Start:
4,615,296 bp from pter      End:
4,616,240 bp from pter
Size:
945 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: O52I1_HUMAN, Q8NGK6 (See protein sequence)
Recommended Name: Olfactory receptor 52I1  
Size: 324 amino acids; 35386 Da
Sequence caution: Sequence=BAC06007.1; Type=Erroneous initiation;
Secondary accessions: Q6IF91

Explore the universe of human proteins at neXtProt for OR52I1: NX_Q8NGK6

Explore proteomics data for OR52I1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn7
  • HORDE protein sequence for OR52I1

    See OR52I1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001005169.1  
    ENSEMBL proteins: 
     ENSP00000436453   ENSP00000409094  
    Reactome Protein details: Q8NGK6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR52: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGK6

    ProtoNet protein and cluster: Q8NGK6

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O52I1_HUMAN, Q8NGK6
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR52I1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O52I1_HUMAN, Q8NGK6
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR52I1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OR52I1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O52I1_HUMAN, Q8NGK6: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR52I1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR52I1 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR52I1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR52I1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR52I1):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR52I1
    Interactions:

        Search GeneGlobe Interaction Network for OR52I1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for OR52I1 (ENSP000004090944) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRBK2ENSP000003175784STRING: ENSP00000317578
    ARRB2ENSP000002692604STRING: ENSP00000269260
    GNALENSP000003340514STRING: ENSP00000334051
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR52I1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR52I1 (O52I1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR52I1 gene: 
    NM_001005169.1  

    Unigene Cluster for OR52I1:

    Olfactory receptor, family 52, subfamily I, member 1
    Hs.553727
    Unigene Representative Sequence: NM_001005169
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000530443(uc010qyi.2) ENST00000450052
    miRNA
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    1 AceView cDNA sequence:

    NM_001005169 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR52I1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OR52I1 Expression
    About this image

    OR52I1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR52I1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553727
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OR52I1 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    49(a)
    1 → many
    1(193745527-193746487) ENSGALG00000019030
            Species with no ortholog for OR52I1

    ENSEMBL Gene Tree for OR52I1 (if available)
    TreeFam Gene Tree for OR52I1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR52I1 gene
    OR52I22  
    Selected SIMAP similar genes for OR52I1 using alignment to 2 protein entries:     O52I1_HUMAN (see all proteins) (see all similar genes):
    OR52I2    OR52D1    OR52J3    OR52M1    OR52E8    OR51E2
    OR52E5    OR52K3P    OR52B6    OR52E2    OR52E4    OR52L1
    OR52L2P    OR52N4    OR52P1P    OR52Z1    OR52N2    OR52B2

    Find genes that share paralogs with OR52I1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR52I1 (see all 119)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs110329681,2
    C,F,A,H--4613352(+) AGAATT/CAGGCA 1 -- us2k116Minor allele frequency- C:0.46EA NS NA WA CSA 672
    rs1123177181,2
    C,F--4613355(+) ATCAGG/ACAGGG 1 -- us2k11Minor allele frequency- A:0.07NA 120
    rs9058721,2
    C,F,A,H--4613366(+) AAAACT/CGTCTT 1 -- us2k125Minor allele frequency- C:0.21NS EA NA WA CSA 2266
    rs49106321,2
    C,F,A,H--4613424(+) AGCATC/TACACT 1 -- us2k118Minor allele frequency- T:0.02NS EA NA WA CSA 799
    rs71247461,2
    C,F,H--4613466(+) TCAAAA/GTATCT 1 -- us2k14Minor allele frequency- G:0.00NS EA 420
    rs49106331,2
    C,F,A,H--4613559(+) AAGCGA/GTAGAG 1 -- us2k120Minor allele frequency- G:0.25NA NS EA 2362
    rs1500904791,2
    C--4613615(+) GCCACA/TTTGCT 1 -- us2k10--------
    rs1385240311,2
    C--4613667(+) GTAGGG/TTACAC 1 -- us2k10--------
    rs49106341,2
    C,F,A,H--4613693(+) TTGTAT/CGCTCT 1 -- us2k118Minor allele frequency- C:0.43NA WA CSA EA 704
    rs1874068301,2
    --4613785(+) GGAGCA/CTCCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR52I1 ( 4615296 - 4616240 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for OR52I1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832055CNV Loss17160897
    nsv896914CNV Gain21882294
    nsv896911CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for OR52I1:    
    About MalaCards
    type 2 diabetes mellitus


    Find genes that share disorders with OR52I1           About GenesLikeMe

    Genetic Association Database (GAD): OR52I1
    Human Genome Epidemiology (HuGE) Navigator: OR52I1 (1 document)

    Export disorders for OR52I1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR52I1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR52I1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group. (PubMed id 19795399)1, 4 Malhotra A....Hanson R.L. (Diabetes Metab. Res. Rev. 2009)
    2. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. Novel human G-protein-coupled receptors. (PubMed id 12732197)1 Vanti W.B....O'Dowd B.F. (Biochem. Biophys. Res. Commun. 2003)
    4. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 390037 HGNC: 15220 AceView: OR52I1 Ensembl:ENSG00000232268 euGenes: HUgn390037
    ECgene: OR52I1 Kegg: 390037 H-InvDB: OR52I1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR52I1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR52I1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR52I1 gene:
    Search GeneIP for patents involving OR52I1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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