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Aliases for OR52I1 Gene

Aliases for OR52I1 Gene

  • Olfactory Receptor Family 52 Subfamily I Member 1 2 3 5
  • Olfactory Receptor OR11-13 3 4
  • Olfactory Receptor, Family 52, Subfamily I, Member 1 2
  • Olfactory Receptor 52I1 3
  • OR11-13 3

External Ids for OR52I1 Gene

Previous GeneCards Identifiers for OR52I1 Gene

  • GC11U990494
  • GC11P004580

Summaries for OR52I1 Gene

Entrez Gene Summary for OR52I1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52I1 Gene

OR52I1 (Olfactory Receptor Family 52 Subfamily I Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52I2.

UniProtKB/Swiss-Prot for OR52I1 Gene

  • Odorant receptor.

Gene Wiki entry for OR52I1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52I1 Gene

Genomics for OR52I1 Gene

Regulatory Elements for OR52I1 Gene

Enhancers for OR52I1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F004210 1.1 FANTOM5 7.6 -382.8 -382800 0.3 OR52K2 C11orf40 OR52I1 OR51D1 OR52K1 OR52M1 GC11M004210 LOC100506082
GH11F004492 0.9 FANTOM5 4.8 -101.3 -101335 0.1 OR52K2 OR51F1 OR52B4 OR51S1 OR51G2 OR51A4 OR52K1 C11orf40 OR52R1 OR51A7
GH11F004108 0.3 FANTOM5 3.2 -484.9 -484930 0.3 RRM1-AS1 ART1 ART5 C11orf40 OR52I1 OR52K2 OR52K1 OR52M1 RRM1
GH11F004606 0.9 ENCODE 0.4 +14.2 14249 2.3 ATF1 PKNOX1 CREB3L1 SIN3A ZNF2 YY1 GLIS2 FOS CEBPZ SP3 TRIM68 OR52I1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR52I1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR52I1 Gene

4,593,750 bp from pter
4,595,013 bp from pter
1,264 bases
Plus strand

Genomic View for OR52I1 Gene

Genes around OR52I1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52I1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52I1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52I1 Gene

Proteins for OR52I1 Gene

  • Protein details for OR52I1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 52I1
    Protein Accession:
    Secondary Accessions:
    • Q6IF91

    Protein attributes for OR52I1 Gene

    324 amino acids
    Molecular mass:
    35386 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC06007.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR52I1 Gene

Post-translational modifications for OR52I1 Gene

  • Glycosylation at Asn 7
  • Modification sites at PhosphoSitePlus

Other Protein References for OR52I1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52I1 Gene

Domains & Families for OR52I1 Gene

Gene Families for OR52I1 Gene

Protein Domains for OR52I1 Gene

Suggested Antigen Peptide Sequences for OR52I1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52I1: view

Function for OR52I1 Gene

Molecular function for OR52I1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA,IBA --
genes like me logo Genes that share ontologies with OR52I1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52I1 Gene

Localization for OR52I1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52I1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR52I1 Gene COMPARTMENTS Subcellular localization image for OR52I1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52I1: view

Pathways & Interactions for OR52I1 Gene

genes like me logo Genes that share pathways with OR52I1: view

Pathways by source for OR52I1 Gene

Interacting Proteins for OR52I1 Gene

Gene Ontology (GO) - Biological Process for OR52I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA,IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52I1: view

No data available for SIGNOR curated interactions for OR52I1 Gene

Transcripts for OR52I1 Gene

mRNA/cDNA for OR52I1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR52I1 Gene

No ASD Table

Relevant External Links for OR52I1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR52I1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR52I1 Gene

mRNA differential expression in normal tissues according to GTEx for OR52I1 Gene

This gene is overexpressed in Brain - Cerebellum (x5.5) and Brain - Cerebellar Hemisphere (x5.2).

NURSA nuclear receptor signaling pathways regulating expression of OR52I1 Gene:


SOURCE GeneReport for Unigene cluster for OR52I1 Gene:

genes like me logo Genes that share expression patterns with OR52I1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR52I1 Gene

Orthologs for OR52I1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR52I1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466339 34
  • 98.56 (n)
OR52I1 35
  • 90 (a)
(Mus musculus)
Mammalia Olfr556 35
  • 78 (a)
(Bos Taurus)
Mammalia -- 35
  • 76 (a)
-- 35
  • 76 (a)
-- 35
  • 74 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 71 (a)
-- 35
  • 69 (a)
-- 35
  • 66 (a)
-- 35
  • 66 (a)
-- 35
  • 65 (a)
(Gallus gallus)
Aves -- 35
  • 49 (a)
Species where no ortholog for OR52I1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52I1 Gene

Gene Tree for OR52I1 (if available)
Gene Tree for OR52I1 (if available)

Paralogs for OR52I1 Gene

Paralogs for OR52I1 Gene

(444) SIMAP similar genes for OR52I1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR52I1: view

Variants for OR52I1 Gene

Sequence variations from dbSNP and Humsavar for OR52I1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10836328 -- 4,595,182(+) ATGTT(G/T)CTAAT downstream-variant-500B
rs11032968 -- 4,592,122(+) AGAAT(C/T)AGGCA upstream-variant-2KB
rs112317718 -- 4,592,125(+) ATCAG(A/G)CAGGG upstream-variant-2KB
rs113315148 -- 4,594,607(+) GGCCA(A/G)GTTAG reference, missense
rs114288632 -- 4,595,511(+) ATGGT(C/T)TACTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR52I1 Gene

Variant ID Type Subtype PubMed ID
dgv1586n54 CNV loss 21841781
esv2762892 CNV loss 21179565
nsv1047344 CNV loss 25217958
nsv1054705 CNV loss 25217958
nsv832055 CNV loss 17160897
nsv971982 CNV duplication 23825009

Variation tolerance for OR52I1 Gene

Residual Variation Intolerance Score: 96.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.09; 84.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR52I1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52I1 Gene

Disorders for OR52I1 Gene

Relevant External Links for OR52I1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR52I1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52I1 Gene

Publications for OR52I1 Gene

  1. Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group. (PMID: 19795399) Malhotra A. … Hanson R.L. (Diabetes Metab. Res. Rev. 2009) 3 46 64
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  3. Novel human G-protein-coupled receptors. (PMID: 12732197) Vanti W.B. … O'Dowd B.F. (Biochem. Biophys. Res. Commun. 2003) 3 64

Products for OR52I1 Gene

Sources for OR52I1 Gene

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