Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR52H1 Gene

Aliases for OR52H1 Gene

  • Olfactory Receptor Family 52 Subfamily H Member 1 2 3 5
  • Olfactory Receptor OR11-45 3 4
  • Olfactory Receptor, Family 52, Subfamily H, Member 1 2
  • Olfactory Receptor OR11-41 Pseudogene 3
  • Olfactory Receptor 52H1 3
  • OR11-41 3
  • OR11-45 3

External Ids for OR52H1 Gene

Previous GeneCards Identifiers for OR52H1 Gene

  • GC11U990496
  • GC11M005531
  • GC11M005522
  • GC11M005526
  • GC11M005534
  • GC11M005555
  • GC11M005559
  • GC11M005563
  • GC11M005566
  • GC11M005570
  • GC11M005577
  • GC11M005582
  • GC11M005586
  • GC11M005599
  • GC11M005606

Summaries for OR52H1 Gene

Entrez Gene Summary for OR52H1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52H1 Gene

OR52H1 (Olfactory Receptor Family 52 Subfamily H Member 1) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52B2.

UniProtKB/Swiss-Prot for OR52H1 Gene

  • Odorant receptor.

Gene Wiki entry for OR52H1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52H1 Gene

Genomics for OR52H1 Gene

Regulatory Elements for OR52H1 Gene

Enhancers for OR52H1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G005595 1 ENCODE 9.9 -51.6 -51563 3.2 PKNOX1 FOXA2 ATF1 ARNT E2F7 SIN3A TCF12 GLIS2 GATA2 FOS TRIM6 OR52H1 TRIM6-TRIM34 PIR57907
GH11G005546 0.3 FANTOM5 5 -0.7 -723 0.1 OR56A1 OR56A3 OR51Q1 OR52E8 OR52N1 OR56A4 OR52N4 OR52E2 OR52E4 OR52A1
GH11G005550 0.9 Ensembl ENCODE 0.4 -5.4 -5389 1.1 SMARCE1 STAT1 MTA2 BHLHE40 JUN DPF2 FOSL1 ARID1B JUND ATF3 HBE1 ENSG00000167355 HBG2 TRIM6 OR52D1 OR51I2 OLFM5P OR52H2P OR52H1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR52H1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR52H1 Gene

Chromosome:
11
Start:
5,544,561 bp from pter
End:
5,545,523 bp from pter
Size:
963 bases
Orientation:
Minus strand

Genomic View for OR52H1 Gene

Genes around OR52H1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52H1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52H1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52H1 Gene

Proteins for OR52H1 Gene

  • Protein details for OR52H1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGJ2-O52H1_HUMAN
    Recommended name:
    Olfactory receptor 52H1
    Protein Accession:
    Q8NGJ2
    Secondary Accessions:
    • B9EH26
    • Q6IF79

    Protein attributes for OR52H1 Gene

    Size:
    320 amino acids
    Molecular mass:
    35592 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52H1 Gene

Post-translational modifications for OR52H1 Gene

  • Glycosylation at posLast=1111 and Asn275
  • Modification sites at PhosphoSitePlus

Other Protein References for OR52H1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52H1 Gene

Domains & Families for OR52H1 Gene

Gene Families for OR52H1 Gene

Protein Domains for OR52H1 Gene

Suggested Antigen Peptide Sequences for OR52H1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGJ2

UniProtKB/Swiss-Prot:

O52H1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52H1: view

Function for OR52H1 Gene

Molecular function for OR52H1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR52H1: view
genes like me logo Genes that share phenotypes with OR52H1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52H1 Gene

Localization for OR52H1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52H1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR52H1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52H1: view

Pathways & Interactions for OR52H1 Gene

genes like me logo Genes that share pathways with OR52H1: view

Pathways by source for OR52H1 Gene

Interacting Proteins for OR52H1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000326259%0d%0a9606.ENSP00000334051%0d%0a9606.ENSP00000248572%0d%0a9606.ENSP00000367869%0d%0a9606.ENSP00000359719%0d%0a9606.ENSP00000409581%0d%0a
Selected Interacting proteins: ENSP00000326259 Q8NGJ2-O52H1_HUMAN for OR52H1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR52H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA,IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52H1: view

No data available for SIGNOR curated interactions for OR52H1 Gene

Drugs & Compounds for OR52H1 Gene

No Compound Related Data Available

Transcripts for OR52H1 Gene

mRNA/cDNA for OR52H1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR52H1 Gene

No ASD Table

Relevant External Links for OR52H1 Gene

GeneLoc Exon Structure for
OR52H1
ECgene alternative splicing isoforms for
OR52H1

Expression for OR52H1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR52H1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR52H1 Gene:

OR52H1

SOURCE GeneReport for Unigene cluster for OR52H1 Gene:

Hs.554540
genes like me logo Genes that share expression patterns with OR52H1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52H1 Gene

Orthologs for OR52H1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52H1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OR52H1 34 35
  • 97.92 (n)
cow
(Bos Taurus)
Mammalia LOC515619 34
  • 90.11 (n)
-- 35
  • 89 (a)
OneToMany
-- 35
  • 88 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 89 (a)
OneToMany
LOC100684706 34
  • 88.15 (n)
-- 35
  • 88 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Or52h1 55 Olfr648 34 16 35
  • 86.56 (n)
Or52h7 55 Olfr652
  • chr7:104,564,223-104,565,176
Or52h9 55 Olfr651
  • chr7:104,552,921-104,553,859
rat
(Rattus norvegicus)
Mammalia Olr149 34
  • 86.02 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 80 (a)
OneToMany
-- 35
  • 77 (a)
OneToMany
Species where no ortholog for OR52H1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52H1 Gene

ENSEMBL:
Gene Tree for OR52H1 (if available)
TreeFam:
Gene Tree for OR52H1 (if available)

Paralogs for OR52H1 Gene

(410) SIMAP similar genes for OR52H1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR52H1 Gene

genes like me logo Genes that share paralogs with OR52H1: view

Variants for OR52H1 Gene

Sequence variations from dbSNP and Humsavar for OR52H1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1002322931 -- 5,544,399(+) AAGAG(A/G)TCATC downstream-variant-500B
rs1002529773 -- 5,544,688(+) GGAAG(A/G)TGCGA reference, missense
rs1002738507 -- 5,547,354(+) TTGAG(G/T)GATAT upstream-variant-2KB
rs1003734633 -- 5,545,585(+) TCAAA(A/C)TTTCA upstream-variant-2KB
rs1003756772 -- 5,545,918(+) CCTTA(C/T)GGACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR52H1 Gene

Variant ID Type Subtype PubMed ID
esv3625230 CNV loss 21293372
esv3625235 CNV loss 21293372
esv3625236 CNV loss 21293372
esv3891919 CNV loss 25118596
nsv1046068 CNV gain 25217958
nsv1048608 CNV gain 25217958
nsv510997 OTHER complex 20534489
nsv553241 CNV gain 21841781
nsv832057 CNV loss 17160897

Variation tolerance for OR52H1 Gene

Residual Variation Intolerance Score: 95.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.44; 98.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR52H1 Gene

Human Gene Mutation Database (HGMD)
OR52H1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR52H1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52H1 Gene

Disorders for OR52H1 Gene

Relevant External Links for OR52H1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR52H1

No disorders were found for OR52H1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52H1 Gene

Publications for OR52H1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR52H1 Gene

Sources for OR52H1 Gene

Content
Loading form....