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Aliases for OR52E8 Gene

Aliases for OR52E8 Gene

  • Olfactory Receptor Family 52 Subfamily E Member 8 2 3 5
  • Olfactory Receptor, Family 52, Subfamily E, Member 8 Pseudogene 2 3
  • Olfactory Receptor OR11-54 3 4
  • Olfactory Receptor, Family 52, Subfamily E, Member 8 2
  • OR11-54 3

External Ids for OR52E8 Gene

Previous GeneCards Identifiers for OR52E8 Gene

  • GC11U990497
  • GC11M005843

Summaries for OR52E8 Gene

Entrez Gene Summary for OR52E8 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52E8 Gene

OR52E8 (Olfactory Receptor Family 52 Subfamily E Member 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52D1.

UniProtKB/Swiss-Prot for OR52E8 Gene

  • Odorant receptor.

Gene Wiki entry for OR52E8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52E8 Gene

Genomics for OR52E8 Gene

Regulatory Elements for OR52E8 Gene

Enhancers for OR52E8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR52E8 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR52E8 Gene

5,856,674 bp from pter
5,857,734 bp from pter
1,061 bases
Minus strand

Genomic View for OR52E8 Gene

Genes around OR52E8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52E8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52E8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52E8 Gene

Proteins for OR52E8 Gene

  • Protein details for OR52E8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 52E8
    Protein Accession:
    Secondary Accessions:
    • B9EH38

    Protein attributes for OR52E8 Gene

    317 amino acids
    Molecular mass:
    35913 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52E8 Gene

Proteomics data for OR52E8 Gene at MOPED

Post-translational modifications for OR52E8 Gene

  • Glycosylation at Asn 9
  • Modification sites at PhosphoSitePlus

Other Protein References for OR52E8 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52E8 Gene

Domains & Families for OR52E8 Gene

Gene Families for OR52E8 Gene

Protein Domains for OR52E8 Gene

Suggested Antigen Peptide Sequences for OR52E8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52E8: view

Function for OR52E8 Gene

Molecular function for OR52E8 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes for OR52E8 Gene

GenomeRNAi human phenotypes for OR52E8:
genes like me logo Genes that share phenotypes with OR52E8: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52E8 Gene

Localization for OR52E8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52E8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR52E8 Gene COMPARTMENTS Subcellular localization image for OR52E8 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52E8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52E8: view

Pathways & Interactions for OR52E8 Gene

genes like me logo Genes that share pathways with OR52E8: view

Pathways by source for OR52E8 Gene

Interacting Proteins for OR52E8 Gene

Gene Ontology (GO) - Biological Process for OR52E8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52E8: view

No data available for SIGNOR curated interactions for OR52E8 Gene

Drugs & Compounds for OR52E8 Gene

No Compound Related Data Available

Transcripts for OR52E8 Gene

mRNA/cDNA for OR52E8 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR52E8 Gene

Olfactory receptor, family 52, subfamily E, member 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OR52E8 Gene

No ASD Table

Relevant External Links for OR52E8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR52E8 Gene

mRNA expression in normal human tissues for OR52E8 Gene

mRNA differential expression in normal tissues according to GTEx for OR52E8 Gene

This gene is overexpressed in Whole Blood (x10.9), Brain - Caudate (basal ganglia) (x6.3), Brain - Substantia nigra (x4.8), and Thyroid (x4.1).

SOURCE GeneReport for Unigene cluster for OR52E8 Gene Hs.553738

genes like me logo Genes that share expression patterns with OR52E8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR52E8 Gene

Orthologs for OR52E8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52E8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC613909 35
  • 85.17 (n)
  • 85.39 (a)
-- 36
  • 81 (a)
(Canis familiaris)
Mammalia OR52E8 35
  • 88.14 (n)
  • 90.06 (a)
-- 36
  • 86 (a)
-- 36
  • 88 (a)
-- 36
  • 89 (a)
(Mus musculus)
Mammalia Olfr671 35
  • 83.81 (n)
  • 84.66 (a)
Olfr675 16
Olfr671 36
  • 85 (a)
Olfr675 36
  • 84 (a)
(Pan troglodytes)
Mammalia LOC466399 35
  • 99.79 (n)
  • 99.68 (a)
OR52E8 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Olr184 35
  • 82.75 (n)
  • 84.23 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
-- 36
  • 73 (a)
-- 36
  • 74 (a)
-- 36
  • 73 (a)
-- 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
-- 36
  • 69 (a)
Species with no ortholog for OR52E8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52E8 Gene

Gene Tree for OR52E8 (if available)
Gene Tree for OR52E8 (if available)

Paralogs for OR52E8 Gene

(456) SIMAP similar genes for OR52E8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR52E8: view

Variants for OR52E8 Gene

Sequence variations from dbSNP and Humsavar for OR52E8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs61059077 -- 5,856,829(+) ATTGA(A/G)GGCTG reference, missense
rs112109519 -- 5,857,357(+) CTCCA(C/T)AGCAG reference, missense
rs112180979 -- 5,857,293(+) TGTAC(C/T)GAAGA reference, missense
rs66532636 -- 5,859,690(+) AAAAG(-/A)AAGAA upstream-variant-2KB
rs112494213 -- 5,859,204(+) CAACA(A/C)AAATG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR52E8 Gene

Variant ID Type Subtype PubMed ID
dgv341e1 CNV Complex 17122850
nsv832058 CNV Gain 17160897
nsv896952 CNV Loss 21882294
nsv515489 CNV Gain 19592680
dgv1028n71 CNV Gain 21882294
dgv345e1 CNV Complex 17122850
essv4941 CNV CNV 17122850
nsv8786 CNV Gain+Loss 18304495
dgv130n27 CNV Gain 19166990
dgv1029n71 CNV Gain 21882294
nsv442600 CNV CNV 18776908
nsv7655 CNV Loss 18451855
esv2673496 CNV Deletion 23128226
nsv498750 CNV Loss 21111241
nsv443002 CNV Loss 18674749
esv22550 CNV Loss 19812545
esv2421670 CNV Deletion 20811451
nsv514627 CNV Complex 21397061
dgv1030n71 CNV Gain 21882294

Variation tolerance for OR52E8 Gene

Residual Variation Intolerance Score: 91.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.21; 76.05% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR52E8 Gene

Disorders for OR52E8 Gene

Relevant External Links for OR52E8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR52E8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52E8 Gene

Publications for OR52E8 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4 67
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR52E8 Gene

Sources for OR52E8 Gene