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OR52E8 Gene

protein-coding   GIFtS: 42
GCID: GC11M005834

Olfactory Receptor, Family 52, Subfamily E, Member 8

(Previous names: olfactory receptor, family 52, subfamily E, member 8 pseudogene)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 52, Subfamily E, Member 81 2
Olfactory Receptor, Family 52, Subfamily E, Member 8 Pseudogene1 2
Olfactory Receptor OR11-542 3
OR11-542
Olfactory Receptor 52E82

External Ids:    HGNC: 152171   Entrez Gene: 3900792   Ensembl: ENSG000001832697   UniProtKB: Q6IFG13   

Export aliases for OR52E8 gene to outside databases

Previous GC identifers: GC11U990497 GC11M005843


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR52E8 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR52E8 Gene:
OR52E8 (olfactory receptor, family 52, subfamily E, member 8) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52D1.

UniProtKB/Swiss-Prot: O52E8_HUMAN, Q6IFG1
Function: Odorant receptor (Potential)

Gene Wiki entry for OR52E8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR52E8 gene promoter:
         HOXA9B   HOXA9   E2F-4   E2F-3a   E2F-5   E2F-2   Meis-1b   E2F   E2F-1   Meis-1   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR52E8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

OR52E8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR52E8 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M005834:  view genomic region     (about GC identifiers)

Start:
5,877,982 bp from pter      End:
5,878,920 bp from pter
Size:
939 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: O52E8_HUMAN, Q6IFG1 (See protein sequence)
Recommended Name: Olfactory receptor 52E8  
Size: 317 amino acids; 35913 Da
Caution: It is uncertain whether Met-1 or Met-5 is the initiator
Secondary accessions: B9EH38

Explore the universe of human proteins at neXtProt for OR52E8: NX_Q6IFG1

Post-translational modifications: 

  • Glycosylation2 at Asn9
  • Modification sites at PhosphoSitePlus
  • HORDE protein sequence for OR52E8
    REFSEQ proteins: NP_001005168.1  
    ENSEMBL proteins: 
     ENSP00000444054  
    Reactome Protein details: Q6IFG1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR52: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q6IFG1

    ProtoNet protein and cluster: Q6IFG1

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O52E8_HUMAN, Q6IFG1
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR52E8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O52E8_HUMAN, Q6IFG1
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR52E8           About GenesLikeMe


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O52E8_HUMAN, Q6IFG1: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR52E8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR52E8 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR52E8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR52E8
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR52E8):
        Olfactory transduction

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    Interactions:

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    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR52E8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for OR52E8 (O52E8)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR52E8 gene: 
    NM_001005168.1  

    Unigene Cluster for OR52E8:

    Olfactory receptor, family 52, subfamily E, member 8
    Hs.553738  [show with all ESTs]
    Unigene Representative Sequence: BC137041
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000537935(uc010qzr.2)
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    Additional mRNA sequence: 

    BC137030.1 BC137041.1 

    1 DOTS entry:

    DT.120723375 

    1 AceView cDNA sequence:

    NM_001005168 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR52E8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OR52E8 Expression
    About this image

    OR52E8 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.553738
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR52E8 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr6711 olfactory receptor 671 83.81(n)
    84.66(a)
      257910  NM_001011755.1  NP_001011755.1 


    ENSEMBL Gene Tree for OR52E8 (if available)
    TreeFam Gene Tree for OR52E8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR52E8 gene
    OR52D12  OR52B1P2  OR52E42  ENSG000002730852  OR52B62  OR52E22  OR52B22  OR52J32  
    OR52E62  OR52B42  OR52H12  
    Selected SIMAP similar genes for OR52E8 using alignment to 1 protein entry:     O52E8_HUMAN(see all similar genes):
    OR52E6    OR52E4    OR52E1    OR52E5    OR52E2    OR52J3
    OR52D1    OR52Z1    OR52B2    OR52H1    OR52N2    OR52M1
    OR52R1    OR52K2    OR52L1    OR52L2P    OR52N1    OR52N5

    Find genes that share paralogs with OR52E8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR52E8 (see all 150)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs670316671,2
    C--5877548(+) TAAGC-/TATTATTA 1 -- ds50010--------
    rs710567111,2
    C--5877549(+) TTATT-/ATTTTAAG 2 -- ds5001 cds11Minor allele frequency- ATT:0.00NA 2
    rs1998331201,2
    --5877554(+) ATTAT-/TATTATT 1 -- ds50010--------
    rs1999362531,2
    --5877556(+) TATTA-/TTATTTT 1 -- ds50010--------
    rs1511989031,2
    --5877625(+) CCGTAC/TTCTGT 1 -- ds50010--------
    rs767722591,2
    F--5877703(+) AACATG/ATAGTT 1 -- ds50011Minor allele frequency- A:0.10WA 118
    rs1403314121,2
    --5877704(+) ACATGA/TAGTTT 1 -- ds50010--------
    rs110393161,2
    C,F,A,H--5877751(+) TAATCA/CCAAGA 1 -- ds500110Minor allele frequency- C:0.37NA WA CSA EA 375
    rs595802791,2
    C,F--5877820(+) AAGAAC/TTTGGA 1 -- ds50011Minor allele frequency- T:0.04WA 118
    rs799727441,2
    C,F--5877874(+) AAGTCA/GAAAGC 1 -- ds50011Minor allele frequency- G:0.01WA 118

    HapMap Linkage Disequilibrium report for OR52E8 ( 5877982 - 5878920 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for OR52E8 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673496CNV Deletion23128226
    esv2421670CNV Deletion20811451
    nsv896952CNV Loss21882294
    nsv443002CNV Loss18674749
    nsv498750CNV Loss21111241
    nsv7655CNV Loss18451855
    esv22550CNV Loss19812545
    dgv1029n71CNV Gain21882294
    dgv130n27CNV Gain19166990
    dgv1028n71CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR52E8 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR52E8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (Nature 2006)
    2. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 390079 HGNC: 15217 AceView: OR52E8 Ensembl:ENSG00000183269 euGenes: HUgn390079
    ECgene: OR52E8 Kegg: 390079 H-InvDB: OR52E8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR52E8 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR52E8 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR52E8 gene:
    Search GeneIP for patents involving OR52E8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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