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Aliases for OR52E6 Gene

Aliases for OR52E6 Gene

  • Olfactory Receptor, Family 52, Subfamily E, Member 6 2 3
  • Olfactory Receptor OR11-58 3 4
  • Olfactory Receptor 52E6 3
  • OR11-58 3

External Ids for OR52E6 Gene

Summaries for OR52E6 Gene

Entrez Gene Summary for OR52E6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52E6 Gene

OR52E6 (Olfactory Receptor, Family 52, Subfamily E, Member 6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52D1.

UniProtKB/Swiss-Prot for OR52E6 Gene

  • Odorant receptor.

Gene Wiki entry for OR52E6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52E6 Gene

Genomics for OR52E6 Gene

Genomic Location for OR52E6 Gene

Start:
5,840,928 bp from pter
End:
5,841,952 bp from pter
Size:
1,025 bases
Orientation:
Minus strand

Genomic View for OR52E6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR52E6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52E6 Gene

Regulatory Elements for OR52E6 Gene

Proteins for OR52E6 Gene

  • Protein details for OR52E6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RD3-O52E6_HUMAN
    Recommended name:
    Olfactory receptor 52E6
    Protein Accession:
    Q96RD3
    Secondary Accessions:
    • Q6IFF8

    Protein attributes for OR52E6 Gene

    Size:
    313 amino acids
    Molecular mass:
    35524 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52E6 Gene

Proteomics data for OR52E6 Gene at MOPED

Post-translational modifications for OR52E6 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn5

Other Protein References for OR52E6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR52E6 Gene

Domains for OR52E6 Gene

Gene Families for OR52E6 Gene

HGNC:
  • OR52 :GPCR / Class A : Olfactory receptors

Protein Domains for OR52E6 Gene

Suggested Antigen Peptide Sequences for OR52E6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RD3

UniProtKB/Swiss-Prot:

O52E6_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q96RD3
genes like me logo Genes that share domains with OR52E6: view

Function for OR52E6 Gene

Molecular function for OR52E6 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52E6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR52E6: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR52E6 Gene

Localization for OR52E6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52E6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR52E6 Gene COMPARTMENTS Subcellular localization image for OR52E6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52E6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52E6: view

Pathways for OR52E6 Gene

genes like me logo Genes that share pathways with OR52E6: view

Pathways by source for OR52E6 Gene

Interacting Proteins for OR52E6 Gene

Gene Ontology (GO) - Biological Process for OR52E6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52E6: view

Transcripts for OR52E6 Gene

mRNA/cDNA for OR52E6 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR52E6 Gene

Olfactory receptor, family 52, subfamily E, member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OR52E6 Gene

No ASD Table

Relevant External Links for OR52E6 Gene

GeneLoc Exon Structure for
OR52E6
ECgene alternative splicing isoforms for
OR52E6

Expression for OR52E6 Gene

mRNA expression in normal human tissues for OR52E6 Gene

SOURCE GeneReport for Unigene cluster for OR52E6 Gene Hs.534693

genes like me logo Genes that share expressions with OR52E6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR52E6 Gene

Orthologs for OR52E6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52E6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466398 35
  • 98.83 (n)
  • 97.76 (a)
OR52E6 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 78 (a)
OneToMany
LOC528515 35
  • 71.49 (n)
  • 70.72 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 82 (a)
ManyToMany
-- 36
  • 84 (a)
ManyToMany
-- 36
  • 85 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr671 36
  • 81 (a)
ManyToMany
Olfr675 16
Olfr675 36
  • 82 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 69 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
Species with no ortholog for OR52E6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52E6 Gene

ENSEMBL:
Gene Tree for OR52E6 (if available)
TreeFam:
Gene Tree for OR52E6 (if available)

Paralogs for OR52E6 Gene

Selected SIMAP similar genes for OR52E6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR52E6: view

Variants for OR52E6 Gene

Sequence variations from dbSNP and Humsavar for OR52E6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs4247301 -- 5,842,849(+) ggtat(A/G)tatgt upstream-variant-2KB
rs4357719 - 5,841,423(+) TGGAA(C/T)GACCA reference, missense
rs4362172 -- 5,841,550(+) ACCAA(C/T)ACGAT reference, synonymous-codon
rs4362173 - 5,841,783(+) TGCAA(C/T)AAGAT reference, missense
rs4363637 -- 5,842,076(+) CATAT(A/C/G)AGCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR52E6 Gene

Variant ID Type Subtype PubMed ID
dgv341e1 CNV Complex 17122850
nsv832058 CNV Gain 17160897
nsv896952 CNV Loss 21882294
nsv515489 CNV Gain 19592680
dgv1028n71 CNV Gain 21882294

Relevant External Links for OR52E6 Gene

HapMap Linkage Disequilibrium report
OR52E6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52E6 Gene

Disorders for OR52E6 Gene

Relevant External Links for OR52E6

Genetic Association Database (GAD)
OR52E6
Human Genome Epidemiology (HuGE) Navigator
OR52E6
genes like me logo Genes that share disorders with OR52E6: view

No data available for UniProtKB/Swiss-Prot for OR52E6 Gene

Publications for OR52E6 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 48

Products for OR52E6 Gene

  • antibodies-online proteins for OR52E6
  • antibodies-online antibodies for OR52E6
  • antibodies-online kits for OR52E6

Sources for OR52E6 Gene

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