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Aliases for OR52E4 Gene

Aliases for OR52E4 Gene

  • Olfactory Receptor, Family 52, Subfamily E, Member 4 2 3
  • Olfactory Receptor OR11-55 3 4
  • Olfactory Receptor 52E4 3
  • OR11-55 3

External Ids for OR52E4 Gene

Summaries for OR52E4 Gene

Entrez Gene Summary for OR52E4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52E4 Gene

OR52E4 (Olfactory Receptor, Family 52, Subfamily E, Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52D1.

UniProtKB/Swiss-Prot for OR52E4 Gene

  • Odorant receptor.

Gene Wiki entry for OR52E4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52E4 Gene

Genomics for OR52E4 Gene

Genomic Location for OR52E4 Gene

Start:
5,884,271 bp from pter
End:
5,885,300 bp from pter
Size:
1,030 bases
Orientation:
Plus strand

Genomic View for OR52E4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR52E4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52E4 Gene

Regulatory Elements for OR52E4 Gene

Proteins for OR52E4 Gene

  • Protein details for OR52E4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGH9-O52E4_HUMAN
    Recommended name:
    Olfactory receptor 52E4
    Protein Accession:
    Q8NGH9
    Secondary Accessions:
    • Q6IFG0

    Protein attributes for OR52E4 Gene

    Size:
    312 amino acids
    Molecular mass:
    35480 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52E4 Gene

Proteomics data for OR52E4 Gene at MOPED

Post-translational modifications for OR52E4 Gene

Other Protein References for OR52E4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR52E4 Gene

Domains for OR52E4 Gene

Gene Families for OR52E4 Gene

HGNC:
  • OR52 :GPCR / Class A : Olfactory receptors

Protein Domains for OR52E4 Gene

Suggested Antigen Peptide Sequences for OR52E4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGH9

UniProtKB/Swiss-Prot:

O52E4_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q8NGH9
genes like me logo Genes that share domains with OR52E4: view

Function for OR52E4 Gene

Molecular function for OR52E4 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52E4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR52E4: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR52E4 Gene

Localization for OR52E4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52E4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR52E4 Gene COMPARTMENTS Subcellular localization image for OR52E4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52E4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52E4: view

Pathways for OR52E4 Gene

genes like me logo Genes that share pathways with OR52E4: view

Pathways by source for OR52E4 Gene

Interacting Proteins for OR52E4 Gene

Gene Ontology (GO) - Biological Process for OR52E4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52E4: view

Transcripts for OR52E4 Gene

mRNA/cDNA for OR52E4 Gene

(2) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR52E4 Gene

No ASD Table

Relevant External Links for OR52E4 Gene

GeneLoc Exon Structure for
OR52E4
ECgene alternative splicing isoforms for
OR52E4

Expression for OR52E4 Gene

mRNA expression in normal human tissues for OR52E4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR52E4 Gene

SOURCE GeneReport for Unigene cluster for OR52E4 Gene Hs.553739

genes like me logo Genes that share expressions with OR52E4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR52E4 Gene

Orthologs for OR52E4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52E4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466400 35
  • 99.15 (n)
  • 98.72 (a)
OR52E4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR52E4 35
  • 88.24 (n)
  • 89.64 (a)
OR52E4 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cOR52E4 35
  • 88.96 (n)
  • 90.03 (a)
OR52E4 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr677 35
  • 84.62 (n)
  • 85.58 (a)
Olfr677 16
Olfr677 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OR52E4 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr188 35
  • 85.36 (n)
  • 86.86 (a)
Species with no ortholog for OR52E4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52E4 Gene

ENSEMBL:
Gene Tree for OR52E4 (if available)
TreeFam:
Gene Tree for OR52E4 (if available)

Paralogs for OR52E4 Gene

Selected SIMAP similar genes for OR52E4 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for OR52E4 Gene

genes like me logo Genes that share paralogs with OR52E4: view

Variants for OR52E4 Gene

Sequence variations from dbSNP and Humsavar for OR52E4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs935955 -- 5,885,636(-) GAAAC(A/G)GACAC downstream-variant-500B
rs935956 -- 5,882,697(-) GAGAC(A/G)GAGAA upstream-variant-2KB
rs935957 -- 5,882,580(-) ACACA(A/G)GCAAA upstream-variant-2KB
rs935958 -- 5,882,552(-) ATTCT(A/G)TATGA upstream-variant-2KB
rs1349766 -- 5,883,817(-) CCATT(C/T)TCACT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR52E4 Gene

Variant ID Type Subtype PubMed ID
dgv341e1 CNV Complex 17122850
nsv832058 CNV Gain 17160897
nsv515489 CNV Gain 19592680
dgv1028n71 CNV Gain 21882294
dgv345e1 CNV Complex 17122850
essv4941 CNV CNV 17122850
nsv8786 CNV Gain+Loss 18304495
dgv130n27 CNV Gain 19166990
dgv1029n71 CNV Gain 21882294
dgv1030n71 CNV Gain 21882294
nsv442217 CNV CNV 18776908
dgv346e1 CNV Complex 17122850
dgv39e55 CNV Gain 17911159
essv5015 CNV CNV 17122850
dgv40e55 CNV Gain 17911159
nsv825754 CNV Gain 20364138
nsv896961 CNV Gain 21882294
dgv1031n71 CNV Gain 21882294
nsv469935 CNV Gain 18288195
dgv131n27 CNV Gain 19166990
nsv818796 CNV Gain 17921354
dgv1032n71 CNV Gain 21882294
dgv132n27 CNV Gain 19166990
nsv896965 CNV Gain 21882294
nsv471362 CNV Duplication 19718026

Relevant External Links for OR52E4 Gene

HapMap Linkage Disequilibrium report
OR52E4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52E4 Gene

Disorders for OR52E4 Gene

No disorders were found for OR52E4 Gene.

No data available for UniProtKB/Swiss-Prot for OR52E4 Gene

Publications for OR52E4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR52E4 Gene

  • antibodies-online proteins for OR52E4
  • antibodies-online antibodies for OR52E4
  • antibodies-online kits for OR52E4

Sources for OR52E4 Gene

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