OR52E4 Gene
protein-coding GIFtS: 45
GCID: GC11P005905
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|
olfactory receptor, family 52, subfamily E, member 4
| |
Aliases
for OR52E4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Olfactory Receptor, Family 52, Subfamily E, Member 41 2 | | Olfactory Receptor OR11-552 3 | | OR11-552 | | Olfactory Receptor 52E42 |
Export aliases for OR52E4 gene to outside databasesPrevious GC identifers: GC11U990501 GC11P005870 GC11P005862 |
Summaries
for OR52E4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OR52E4:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: O52E4_HUMAN, Q8NGH9Function: Odorant receptor (Potential)
Gene Wiki entry for OR52E4
|
Genomic Views
for OR52E4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OR52E4 gene promoter:
HOXA9B HOXA9 E2F-3a E2F-4 E2F-5 E2F-2 Meis-1b E2F E2F-1 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for OR52E4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR52E4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.4OR52E4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P005905: view genomic region
(about GC identifiers)
Start:
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5,905,523 bp from pter |
End:
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5,906,458 bp from pter |
Size:
|
936 bases |
Orientation:
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plus strand |
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Proteins
for OR52E4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: O52E4_HUMAN, Q8NGH9 (See
protein sequence)Recommended Name: Olfactory receptor 52E4 Size: 312 amino acids; 35480 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q6IFG0Explore the universe of human proteins at neXtProt for OR52E4: NX_Q8NGH9
HORDE protein sequence for OR52E4
OR52E4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001005165.1
ENSEMBL proteins: ENSP00000321426 Reactome Protein details: Q8NGH9
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
OR52E4 for ontologies About GeneDecksing
OR52E4 Antibody Products:
Assay Products for OR52E4: |
Protein
Domains /
Families
for OR52E4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR52E4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NGH9ProtoNet protein and cluster: Q8NGH9 1 Blocks protein family: IPB000725 Olfactory receptor signature
UniProtKB/Swiss-Prot: O52E4_HUMAN, Q8NGH9Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for OR52E4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: O52E4_HUMAN, Q8NGH9Function: Odorant receptor (Potential)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR52E4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR52E4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for OR52E4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR52E4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR52E4 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0004984 | olfactory receptor activity |
IEA | -- |
OR52E4 for ontologies About GeneDecksing
|
Pathways & Interactions
for OR52E4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | Olfactory transduction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for OR52E4
1 
Kegg Pathway (Kegg details for OR52E4):
OR52E4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR52E4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/273 Interacting proteins for OR52E4 (ENSP000003214264) via UniProtKB, MINT, STRING, and/or I2D (see all 273)About this table
|
Drugs & Compounds
for OR52E4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OR52E4
Search CenterWatch for drugs/clinical trials and news about OR52E4 / O52E4
|
Transcripts
for OR52E4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OR52E4 gene: NM_001005165.1 Unigene Cluster for OR52E4: Olfactory receptor, family 52, subfamily E, member 4 Hs.553739 Unigene Representative Sequence: BC1369721 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000316987(uc010qzs.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR52E4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR52E4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OR52E4 (NM_001005165) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR52E4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR52E4 |
Additional cDNA sequence: BC136972.1 BC136974.1 1 AceView cDNA sequence: NM_001005165
GeneLoc Exon Structure
|
Expression
for OR52E4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR52E4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTGTGTTAT
About this image
See OR52E4 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.553739
SABiosciences Custom PCR Arrays for OR52E4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR52E4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OR52E4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR52E4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR52E4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR52E4 |
Orthologs
for OR52E4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OR52E4 gene from 1/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
CABZ01018874.16 |
-- |
35(a) |
1 → many |
15(5202740-5204422) |
ENSEMBL Gene Tree for OR52E4 (if available)
TreeFam Gene Tree for OR52E4 (if available) |
Paralogs
for OR52E4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OR52E4 gene
- OR52N42 OR52D12 OR52K12 OR52B22 OR52J32 OR52E62 OR52B42 OR52N22
- OR52L12 OR52A12 OR52M12 OR52N52 OR52B1P2 OR52K22 OR52B62 OR52E22
- OR52R12 OR52N12 OR52E82 OR52H12 OR52A52
18/457 SIMAP similar genes for OR52E4 using alignment to 2 protein entries: O52E4_HUMAN (see all proteins)
(see all similar genes):OR52E8 OR52E2 OR52E6 OR52E1 OR52J3 OR52E5
OR52Z1 OR52D1 OR52R1 OR52B2 OR52N2 OR52L1
OR52H1 OR51E1 OR51G2 OR52B6 OR52K3P OR52L2P
OR52E4 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for OR52E4
PGOHUM00000242582 PGOHUM00000242583
|
Genomic Variants
for OR52E4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OR52E4 ( 5905523 - 5906458 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 14 variations for OR52E4
14 CNVs: 34458 48859 3836 48860 8677 53917 30541 53792 37668 2903 53856 9650 8676 29603 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR52E4 |
|
Disorders
/ Diseases
for OR52E4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OR52E4 for disorders About GeneDecksing
1  disease for OR52E4: About MalaCardsneuronitis
Export disorders for OR52E4 gene to outside databases
|
Publications
for OR52E4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OR52E4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR52E4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for OR52E4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OR52E4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR52E4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR52E4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OR52E4 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR52E4 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
|
| | |
About This Section
| Patent Information for OR52E4 gene:
Search GeneIP for patents involving OR52E4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OR52E4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OR52E4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OR52E4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR52E4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OR52E4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR52E4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR52E4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OR52E4 | | OriGene Custom Protein Services for OR52E4 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OR52E4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR52E4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR52E4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OR52E4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR52E4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR52E4 |
| |
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| |  |  |  |  | | | | |
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 | | | OR52E4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR52E4 |
|  |  |  | | | | Search ThermoFisher Antibodies for OR52E4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR52E4 |
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