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Aliases for OR52E1 Gene

Aliases for OR52E1 Gene

  • Olfactory Receptor Family 52 Subfamily E Member 1 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 52, Subfamily E, Member 1 Pseudogene 2 3
  • OR52E1P 3 4
  • Olfactory Receptor, Family 52, Subfamily E, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 52, Subfamily E, Member 1 Gene/Pseudogene 2
  • Seven Transmembrane Helix Receptor 3
  • Olfactory Receptor 52E1 3

External Ids for OR52E1 Gene

Previous HGNC Symbols for OR52E1 Gene

  • OR52E1P

Previous GeneCards Identifiers for OR52E1 Gene

  • GC11U990310
  • GC11P005048

Summaries for OR52E1 Gene

Entrez Gene Summary for OR52E1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]

GeneCards Summary for OR52E1 Gene

OR52E1 (Olfactory Receptor Family 52 Subfamily E Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52E2.

UniProtKB/Swiss-Prot for OR52E1 Gene

  • Odorant receptor.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52E1 Gene

Genomics for OR52E1 Gene

Genomic Location for OR52E1 Gene

Chromosome:
11
Start:
5,069,472 bp from pter
End:
5,070,596 bp from pter
Size:
1,125 bases
Orientation:
Plus strand

Genomic View for OR52E1 Gene

Genes around OR52E1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52E1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52E1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52E1 Gene

No data available for Regulatory Elements for OR52E1 Gene

Proteins for OR52E1 Gene

  • Protein details for OR52E1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGJ3-O52E1_HUMAN
    Recommended name:
    Olfactory receptor 52E1
    Protein Accession:
    Q8NGJ3

    Protein attributes for OR52E1 Gene

    Size:
    308 amino acids
    Molecular mass:
    34714 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52E1 Gene

Post-translational modifications for OR52E1 Gene

Other Protein References for OR52E1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OR52E1 Gene

Domains & Families for OR52E1 Gene

Gene Families for OR52E1 Gene

Protein Domains for OR52E1 Gene

Suggested Antigen Peptide Sequences for OR52E1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGJ3

UniProtKB/Swiss-Prot:

O52E1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52E1: view

Function for OR52E1 Gene

Molecular function for OR52E1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR52E1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52E1 Gene

Localization for OR52E1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52E1 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR52E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52E1: view

No data available for Subcellular locations from COMPARTMENTS for OR52E1 Gene

Pathways & Interactions for OR52E1 Gene

genes like me logo Genes that share pathways with OR52E1: view

Pathways by source for OR52E1 Gene

Interacting Proteins for OR52E1 Gene

Gene Ontology (GO) - Biological Process for OR52E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52E1: view

No data available for SIGNOR curated interactions for OR52E1 Gene

Transcripts for OR52E1 Gene

mRNA/cDNA for OR52E1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR52E1 Gene

No ASD Table

Relevant External Links for OR52E1 Gene

GeneLoc Exon Structure for
OR52E1
ECgene alternative splicing isoforms for
OR52E1

Expression for OR52E1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR52E1 Gene

Protein differential expression in normal tissues from HIPED for OR52E1 Gene

This gene is overexpressed in Milk (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR52E1 Gene



Protein tissue co-expression partners for OR52E1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR52E1 Gene:

OR52E1
genes like me logo Genes that share expression patterns with OR52E1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52E1 Gene

Orthologs for OR52E1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52E1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 35
  • 71 (a)
OneToMany
-- 35
  • 71 (a)
OneToMany
-- 35
  • 68 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 62 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr594 35
  • 61 (a)
ManyToMany
Or52c1-ps 55 Olfr590-ps1
  • chr7:103,165,907-103,166,747
Or52e51-ps 55 Olfr595-ps1
  • chr7:103,235,686-103,236,582
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 54 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
Species where no ortholog for OR52E1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52E1 Gene

ENSEMBL:
Gene Tree for OR52E1 (if available)
TreeFam:
Gene Tree for OR52E1 (if available)

Paralogs for OR52E1 Gene

(428) SIMAP similar genes for OR52E1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR52E1: view

Variants for OR52E1 Gene

Sequence variations from dbSNP and Humsavar for OR52E1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs145482335 -- 5,070,051(+) GTTCT(A/G/T)TTTAT nc-transcript-variant, reference, synonymous-codon
rs182633272 -- 5,068,234(+) CCAAA(C/G/T)AGTTA upstream-variant-2KB
rs2219231 -- 5,069,283(+) CAGTC(A/C/G)CAGCA upstream-variant-2KB
rs530443683 -- 5,069,564(+) AAGAA(A/C/T)AGCCT nc-transcript-variant, utr-variant-5-prime
rs532265111 -- 5,067,491(+) AAGAT(A/G/T)AGATA upstream-variant-2KB

Relevant External Links for OR52E1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR52E1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for OR52E1 Gene

Disorders for OR52E1 Gene

No disorders were found for OR52E1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for OR52E1 Gene

Publications for OR52E1 Gene

  1. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T. … Lancet D. (BMC Genomics 2012) 3 64

Products for OR52E1 Gene

Sources for OR52E1 Gene

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