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Aliases for OR52D1 Gene

Aliases for OR52D1 Gene

  • Olfactory Receptor Family 52 Subfamily D Member 1 2 3 5
  • Odorant Receptor HOR5beta14 3 4
  • Olfactory Receptor OR11-43 3 4
  • Olfactory Receptor, Family 52, Subfamily D, Member 1 2
  • Olfactory Receptor 52D1 3
  • HOR 5Beta14 3
  • OR11-43 3

External Ids for OR52D1 Gene

Previous GeneCards Identifiers for OR52D1 Gene

  • GC11U990502
  • GC11P005475
  • GC11P005466

Summaries for OR52D1 Gene

Entrez Gene Summary for OR52D1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52D1 Gene

OR52D1 (Olfactory Receptor Family 52 Subfamily D Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52E8.

UniProtKB/Swiss-Prot for OR52D1 Gene

  • Odorant receptor.

Gene Wiki entry for OR52D1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52D1 Gene

Genomics for OR52D1 Gene

Regulatory Elements for OR52D1 Gene

Enhancers for OR52D1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F005683 1 ENCODE 9.5 +196.4 196353 2.7 ATF1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 GATA2 CBX5 TRIM22 TRIM5 HBG2 TRIM6 OR52D1 OR52N3P
GH11F005688 0.8 ENCODE 9 +202.1 202057 4.5 TBP RAD21 CEBPB REST TBX21 IKZF1 HMBOX1 NBN IRF1 CTCF TRIM22 TRIM5 OR52N1 TRIM6 OR52D1 HBG2 GC11M005696
GH11F005550 0.7 ENCODE 10.1 +62.2 62227 1.1 SMARCE1 STAT1 MTA2 BHLHE40 JUN ARID1B JUND ATF3 SMARCA4 NFYB ENSG00000167355 HBE1 HBG2 TRIM6 OR52D1 OR51I2 OLFM5P OR52H2P OR52H1
GH11F005379 0.4 FANTOM5 5 -108.7 -108694 0.0 ZNF316 OR51V1 OR51T1 HBB OR51B5 OR51G1 OR56B1 OR52J3 OR51L1 OR52N4 OR52D1
GH11F005328 0.3 FANTOM5 6.5 -159.5 -159507 0.4 OR51G1 OR51T1 OR52N2 OR52N4 OR52D1 OR52J3 MMP26 OR51L1 OR51B2 OR51M1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR52D1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR52D1 Gene

Chromosome:
11
Start:
5,488,685 bp from pter
End:
5,489,749 bp from pter
Size:
1,065 bases
Orientation:
Plus strand

Genomic View for OR52D1 Gene

Genes around OR52D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52D1 Gene

Proteins for OR52D1 Gene

  • Protein details for OR52D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H346-O52D1_HUMAN
    Recommended name:
    Olfactory receptor 52D1
    Protein Accession:
    Q9H346
    Secondary Accessions:
    • B9EGY9
    • Q6IFI6

    Protein attributes for OR52D1 Gene

    Size:
    318 amino acids
    Molecular mass:
    35122 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52D1 Gene

Post-translational modifications for OR52D1 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR52D1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52D1 Gene

Domains & Families for OR52D1 Gene

Gene Families for OR52D1 Gene

Protein Domains for OR52D1 Gene

Suggested Antigen Peptide Sequences for OR52D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H346

UniProtKB/Swiss-Prot:

O52D1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52D1: view

Function for OR52D1 Gene

Molecular function for OR52D1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 11121057
genes like me logo Genes that share ontologies with OR52D1: view
genes like me logo Genes that share phenotypes with OR52D1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52D1 Gene

Localization for OR52D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52D1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR52D1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 11121057
genes like me logo Genes that share ontologies with OR52D1: view

Pathways & Interactions for OR52D1 Gene

genes like me logo Genes that share pathways with OR52D1: view

Pathways by source for OR52D1 Gene

Gene Ontology (GO) - Biological Process for OR52D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 11121057
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52D1: view

No data available for SIGNOR curated interactions for OR52D1 Gene

Transcripts for OR52D1 Gene

mRNA/cDNA for OR52D1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR52D1 Gene

No ASD Table

Relevant External Links for OR52D1 Gene

GeneLoc Exon Structure for
OR52D1
ECgene alternative splicing isoforms for
OR52D1

Expression for OR52D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR52D1 Gene

mRNA differential expression in normal tissues according to GTEx for OR52D1 Gene

This gene is overexpressed in Testis (x33.0).

NURSA nuclear receptor signaling pathways regulating expression of OR52D1 Gene:

OR52D1

SOURCE GeneReport for Unigene cluster for OR52D1 Gene:

Hs.553734
genes like me logo Genes that share expression patterns with OR52D1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR52D1 Gene

Orthologs for OR52D1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52D1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466383 34
  • 99.27 (n)
OR52D1 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 89 (a)
OneToMany
-- 35
  • 87 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 87 (a)
OneToMany
OR52D1 34
  • 85.95 (n)
-- 35
  • 85 (a)
OneToMany
-- 35
  • 84 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Or52d1 55 Olfr646 34 16 35
  • 85.61 (n)
Or52d3 55 Olfr653
  • chr7:104,579,648-104,580,598
rat
(Rattus norvegicus)
Mammalia Olr148 34
  • 85.3 (n)
oppossum
(Monodelphis domestica)
Mammalia OR52D1 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OR52D1 35
  • 69 (a)
OneToOne
Species where no ortholog for OR52D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52D1 Gene

ENSEMBL:
Gene Tree for OR52D1 (if available)
TreeFam:
Gene Tree for OR52D1 (if available)

Paralogs for OR52D1 Gene

(428) SIMAP similar genes for OR52D1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR52D1 Gene

genes like me logo Genes that share paralogs with OR52D1: view

Variants for OR52D1 Gene

Sequence variations from dbSNP and Humsavar for OR52D1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11037758 -- 5,489,616(+) AGATT(C/T)GGAGT intron-variant, reference, missense
rs111729368 -- 5,487,239(+) TTATC(A/G)AGAGT intron-variant, upstream-variant-2KB
rs111735812 -- 5,489,116(+) CACAA(A/C)CATTC intron-variant, reference, missense
rs114302667 -- 5,487,826(+) CAGTA(G/T)CCTCA intron-variant, upstream-variant-2KB
rs115005003 -- 5,487,327(+) TCCAT(G/T)AATAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR52D1 Gene

Variant ID Type Subtype PubMed ID
dgv1043n100 CNV loss 25217958
esv3625230 CNV loss 21293372
esv3625232 CNV loss 21293372
nsv1046068 CNV gain 25217958
nsv1048608 CNV gain 25217958
nsv553240 CNV loss 21841781
nsv553241 CNV gain 21841781
nsv832057 CNV loss 17160897

Variation tolerance for OR52D1 Gene

Residual Variation Intolerance Score: 62.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.64; 91.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR52D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR52D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52D1 Gene

Disorders for OR52D1 Gene

Relevant External Links for OR52D1

Genetic Association Database (GAD)
OR52D1
Human Genome Epidemiology (HuGE) Navigator
OR52D1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR52D1

No disorders were found for OR52D1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52D1 Gene

Publications for OR52D1 Gene

  1. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 46 64
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  3. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PMID: 11121057) Bulger M. … Hardison R. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR52D1 Gene

Sources for OR52D1 Gene

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