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Aliases for OR52B6 Gene

Aliases for OR52B6 Gene

  • Olfactory Receptor, Family 52, Subfamily B, Member 6 2 3
  • Olfactory Receptor OR11-47 3 4
  • Olfactory Receptor 52B6 3
  • OR11-47 3

External Ids for OR52B6 Gene

Previous GeneCards Identifiers for OR52B6 Gene

  • GC11U990503
  • GC11P005566
  • GC11P005558
  • GC11P005603

Summaries for OR52B6 Gene

Entrez Gene Summary for OR52B6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52B6 Gene

OR52B6 (Olfactory Receptor, Family 52, Subfamily B, Member 6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52D1.

UniProtKB/Swiss-Prot for OR52B6 Gene

  • Odorant receptor.

Gene Wiki entry for OR52B6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52B6 Gene

Genomics for OR52B6 Gene

Regulatory Elements for OR52B6 Gene

Genomic Location for OR52B6 Gene

Start:
5,580,877 bp from pter
End:
5,581,884 bp from pter
Size:
1,008 bases
Orientation:
Plus strand

Genomic View for OR52B6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR52B6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52B6 Gene

Proteins for OR52B6 Gene

  • Protein details for OR52B6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGF0-O52B6_HUMAN
    Recommended name:
    Olfactory receptor 52B6
    Protein Accession:
    Q8NGF0
    Secondary Accessions:
    • Q6IFI7

    Protein attributes for OR52B6 Gene

    Size:
    335 amino acids
    Molecular mass:
    36963 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52B6 Gene

Proteomics data for OR52B6 Gene at MOPED

Post-translational modifications for OR52B6 Gene

  • Glycosylation at Asn23
  • Modification sites at PhosphoSitePlus

Other Protein References for OR52B6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52B6 Gene

Domains for OR52B6 Gene

Gene Families for OR52B6 Gene

HGNC:
  • OR52 :GPCR / Class A : Olfactory receptors

Protein Domains for OR52B6 Gene

Suggested Antigen Peptide Sequences for OR52B6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGF0

UniProtKB/Swiss-Prot:

O52B6_HUMAN :
  • Q8NGF0
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52B6: view

Function for OR52B6 Gene

Molecular function for OR52B6 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR52B6: view

Phenotypes for OR52B6 Gene

GenomeRNAi human phenotypes for OR52B6:
genes like me logo Genes that share phenotypes with OR52B6: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR52B6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR52B6 Gene

Localization for OR52B6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52B6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR52B6 Gene COMPARTMENTS Subcellular localization image for OR52B6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52B6: view

Pathways for OR52B6 Gene

genes like me logo Genes that share pathways with OR52B6: view

Pathways by source for OR52B6 Gene

Interacting Proteins for OR52B6 Gene

Gene Ontology (GO) - Biological Process for OR52B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52B6: view

Transcripts for OR52B6 Gene

mRNA/cDNA for OR52B6 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR52B6

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR52B6
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR52B6 Gene

No ASD Table

Relevant External Links for OR52B6 Gene

GeneLoc Exon Structure for
OR52B6
ECgene alternative splicing isoforms for
OR52B6

Expression for OR52B6 Gene

mRNA expression in normal human tissues for OR52B6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OR52B6 Gene

This gene is overexpressed in Ovary (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR52B6 Gene

SOURCE GeneReport for Unigene cluster for OR52B6 Gene Hs.553704

genes like me logo Genes that share expressions with OR52B6: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for OR52B6 Gene

Orthologs for OR52B6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR52B6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR52B6 35
  • 85.27 (n)
  • 82.09 (a)
OR52B6 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR52B6 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr618 35
  • 63.94 (n)
  • 58.17 (a)
Olfr618 16
Olfr618 36
  • 57 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia OR52B6 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OR52B6 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr111 35
  • 62.9 (n)
  • 58.06 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 56 (a)
OneToMany
Species with no ortholog for OR52B6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52B6 Gene

ENSEMBL:
Gene Tree for OR52B6 (if available)
TreeFam:
Gene Tree for OR52B6 (if available)

Paralogs for OR52B6 Gene

Selected SIMAP similar genes for OR52B6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR52B6: view

Variants for OR52B6 Gene

Sequence variations from dbSNP and Humsavar for OR52B6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs892336 -- 5,581,449(+) ATCAA(C/T)ATCAT synonymous-codon, reference
rs1077126 - 5,581,045(+) ACATC(A/G)CTGCC reference, missense
rs2163946 -- 5,581,560(+) GGCCT(A/G)GACAT reference, synonymous-codon
rs2341432 - 5,581,208(+) TAGCC(A/T)CATTT missense, reference
rs2341433 - 5,581,375(+) CTGCC(A/G)CCCTG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for OR52B6 Gene

Variant ID Type Subtype PubMed ID
nsv896939 CNV Loss 21882294
dgv1027n71 CNV Loss 21882294
nsv896945 CNV Loss 21882294

Relevant External Links for OR52B6 Gene

HapMap Linkage Disequilibrium report
OR52B6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52B6 Gene

Disorders for OR52B6 Gene

Relevant External Links for OR52B6

Genetic Association Database (GAD)
OR52B6
genes like me logo Genes that share disorders with OR52B6: view

No data available for UniProtKB/Swiss-Prot for OR52B6 Gene

Publications for OR52B6 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4

Products for OR52B6 Gene

Sources for OR52B6 Gene

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