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Aliases for OR52B4 Gene

Aliases for OR52B4 Gene

  • Olfactory Receptor Family 52 Subfamily B Member 4 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor OR11-3 3 4
  • Olfactory Receptor, Family 52, Subfamily B, Member 4 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 52, Subfamily B, Member 4 3
  • OR11-3 3

External Ids for OR52B4 Gene

Previous GeneCards Identifiers for OR52B4 Gene

  • GC11U990505
  • GC11M004353
  • GC11M004345

Summaries for OR52B4 Gene

Entrez Gene Summary for OR52B4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR52B4 Gene

OR52B4 (Olfactory Receptor Family 52 Subfamily B Member 4 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52D1.

UniProtKB/Swiss-Prot for OR52B4 Gene

  • Odorant receptor.

Gene Wiki entry for OR52B4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52B4 Gene

Genomics for OR52B4 Gene

Regulatory Elements for OR52B4 Gene

Enhancers for OR52B4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR52B4 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR52B4 Gene

4,367,263 bp from pter
4,368,386 bp from pter
1,124 bases
Minus strand

Genomic View for OR52B4 Gene

Genes around OR52B4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52B4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52B4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52B4 Gene

Proteins for OR52B4 Gene

  • Protein details for OR52B4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 52B4
    Protein Accession:
    Secondary Accessions:
    • A6NP68
    • Q6IFK6

    Protein attributes for OR52B4 Gene

    314 amino acids
    Molecular mass:
    35584 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52B4 Gene

Proteomics data for OR52B4 Gene at MOPED

Post-translational modifications for OR52B4 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR52B4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52B4 Gene

Domains & Families for OR52B4 Gene

Gene Families for OR52B4 Gene

Protein Domains for OR52B4 Gene

Suggested Antigen Peptide Sequences for OR52B4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52B4: view

Function for OR52B4 Gene

Molecular function for OR52B4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes for OR52B4 Gene

GenomeRNAi human phenotypes for OR52B4:
genes like me logo Genes that share phenotypes with OR52B4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52B4 Gene

Localization for OR52B4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52B4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR52B4 Gene COMPARTMENTS Subcellular localization image for OR52B4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52B4: view

Pathways & Interactions for OR52B4 Gene

genes like me logo Genes that share pathways with OR52B4: view

Pathways by source for OR52B4 Gene

Interacting Proteins for OR52B4 Gene

Gene Ontology (GO) - Biological Process for OR52B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52B4: view

No data available for SIGNOR curated interactions for OR52B4 Gene

Drugs & Compounds for OR52B4 Gene

No Compound Related Data Available

Transcripts for OR52B4 Gene

mRNA/cDNA for OR52B4 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR52B4 Gene

Olfactory receptor, family 52, subfamily B, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OR52B4 Gene

No ASD Table

Relevant External Links for OR52B4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR52B4 Gene

mRNA expression in normal human tissues for OR52B4 Gene

SOURCE GeneReport for Unigene cluster for OR52B4 Gene Hs.447463

genes like me logo Genes that share expression patterns with OR52B4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR52B4 Gene

Orthologs for OR52B4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52B4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OR52B4 35
  • 84.39 (n)
  • 82.17 (a)
OR52B4 36
  • 80 (a)
(Canis familiaris)
Mammalia OR52B4 35
  • 87.47 (n)
  • 86.31 (a)
OR52B4 36
  • 86 (a)
(Mus musculus)
Mammalia Olfr547 35
  • 85.27 (n)
  • 85.16 (a)
Olfr547 16
Olfr547 36
  • 85 (a)
Olfr548-ps1 36
  • 79 (a)
(Pan troglodytes)
Mammalia LOC466330 35
  • 98.94 (n)
  • 97.13 (a)
OR52B4 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Olr41 35
  • 82.75 (n)
  • 77 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
-- 36
  • 67 (a)
-- 36
  • 70 (a)
Species with no ortholog for OR52B4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52B4 Gene

Gene Tree for OR52B4 (if available)
Gene Tree for OR52B4 (if available)

Paralogs for OR52B4 Gene

(355) SIMAP similar genes for OR52B4 Gene using alignment to 2 proteins: Pseudogenes for OR52B4 Gene

genes like me logo Genes that share paralogs with OR52B4: view

Variants for OR52B4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR52B4 Gene

A stop codon at position Ala-40 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans.

Sequence variations from dbSNP and Humsavar for OR52B4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11031961 - 4,367,880(+) CATTT(A/G)TAAGA reference, missense
rs61732898 -- 4,367,649(+) TAAAA(A/G)TTAGT reference, missense
rs11828363 -- 4,369,538(+) GTAAA(C/T)AGATT upstream-variant-2KB
rs61885767 -- 4,367,297(+) CTTTC(A/T)TACCC utr-variant-3-prime
rs7929171 -- 4,368,357(+) AATCT(C/G)CAACA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for OR52B4 Gene

Variant ID Type Subtype PubMed ID
essv17026 CNV CNV 17122850
nsv428248 CNV Gain+Loss 18775914
dgv338e1 CNV Complex 17122850
nsv832054 CNV Gain 17160897
nsv469800 CNV Complex 16826518
dgv1021n71 CNV Gain 21882294
nsv896908 CNV Gain 21882294

Variation tolerance for OR52B4 Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.44; 88.63% of all genes are more intolerant (likely to be disease-causing)

No data available for Relevant External Links for OR52B4 Gene

Disorders for OR52B4 Gene

Relevant External Links for OR52B4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR52B4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52B4 Gene

Publications for OR52B4 Gene

  1. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 48 67
  2. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T. … Lancet D. (BMC Genomics 2012) 3
  3. Analysis of copy number variation in Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. (PMID: 23227193) Swaminathan S. … Saykin A.J. (PLoS ONE 2012) 3
  4. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I. … Lancet D. (BMC Bioinformatics 2006) 3
  5. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3

Products for OR52B4 Gene

Sources for OR52B4 Gene