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Aliases for OR52A5 Gene

Aliases for OR52A5 Gene

  • Olfactory Receptor Family 52 Subfamily A Member 5 2 3 5
  • Olfactory Receptor, Family 52, Subfamily A, Member 5 2 3
  • Odorant Receptor HOR3beta5 3 4
  • Olfactory Receptor OR11-33 3 4
  • OR11-33 3

External Ids for OR52A5 Gene

Previous GeneCards Identifiers for OR52A5 Gene

  • GC00U903047
  • GC11M005118
  • GC11M005109

Summaries for OR52A5 Gene

Entrez Gene Summary for OR52A5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52A5 Gene

OR52A5 (Olfactory Receptor Family 52 Subfamily A Member 5) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52A1.

UniProtKB/Swiss-Prot for OR52A5 Gene

  • Odorant receptor.

Gene Wiki entry for OR52A5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52A5 Gene

Genomics for OR52A5 Gene

Regulatory Elements for OR52A5 Gene

Enhancers for OR52A5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR52A5 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR52A5 Gene

Chromosome:
11
Start:
5,131,692 bp from pter
End:
5,132,642 bp from pter
Size:
951 bases
Orientation:
Minus strand

Genomic View for OR52A5 Gene

Genes around OR52A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52A5 Gene

Proteins for OR52A5 Gene

  • Protein details for OR52A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2C5-O52A5_HUMAN
    Recommended name:
    Olfactory receptor 52A5
    Protein Accession:
    Q9H2C5

    Protein attributes for OR52A5 Gene

    Size:
    316 amino acids
    Molecular mass:
    35955 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52A5 Gene

Proteomics data for OR52A5 Gene at MOPED

Post-translational modifications for OR52A5 Gene

Other Protein References for OR52A5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52A5 Gene

Domains & Families for OR52A5 Gene

Gene Families for OR52A5 Gene

Protein Domains for OR52A5 Gene

Suggested Antigen Peptide Sequences for OR52A5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H2C5

UniProtKB/Swiss-Prot:

O52A5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52A5: view

Function for OR52A5 Gene

Molecular function for OR52A5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
genes like me logo Genes that share phenotypes with OR52A5: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52A5 Gene

Localization for OR52A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52A5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR52A5 Gene COMPARTMENTS Subcellular localization image for OR52A5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,NAS 11121057
genes like me logo Genes that share ontologies with OR52A5: view

Pathways & Interactions for OR52A5 Gene

genes like me logo Genes that share pathways with OR52A5: view

Pathways by source for OR52A5 Gene

Interacting Proteins for OR52A5 Gene

Gene Ontology (GO) - Biological Process for OR52A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 11121057
GO:0050911 detection of chemical stimulus involved in sensory perception of smell NAS 11121057
genes like me logo Genes that share ontologies with OR52A5: view

No data available for SIGNOR curated interactions for OR52A5 Gene

Drugs & Compounds for OR52A5 Gene

No Compound Related Data Available

Transcripts for OR52A5 Gene

mRNA/cDNA for OR52A5 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR52A5 Gene

No ASD Table

Relevant External Links for OR52A5 Gene

GeneLoc Exon Structure for
OR52A5
ECgene alternative splicing isoforms for
OR52A5

Expression for OR52A5 Gene

mRNA expression in normal human tissues for OR52A5 Gene

Protein differential expression in normal tissues from HIPED for OR52A5 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR52A5 Gene



SOURCE GeneReport for Unigene cluster for OR52A5 Gene Hs.546593

genes like me logo Genes that share expression patterns with OR52A5: view

Protein tissue co-expression partners for OR52A5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR52A5 Gene

Orthologs for OR52A5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52A5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC781324 35
  • 84.41 (n)
  • 84.84 (a)
-- 36
  • 83 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr69 35
  • 81.1 (n)
  • 81.21 (a)
Olfr69 16
Olfr68 36
  • 81 (a)
OneToMany
Olfr69 36
  • 81 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC466370 35
  • 98.63 (n)
  • 98.42 (a)
-- 36
  • 98 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr126 35
  • 80.04 (n)
  • 80.89 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 79 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
ManyToMany
-- 36
  • 78 (a)
ManyToMany
-- 36
  • 79 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
OneToMany
Species with no ortholog for OR52A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52A5 Gene

ENSEMBL:
Gene Tree for OR52A5 (if available)
TreeFam:
Gene Tree for OR52A5 (if available)

Paralogs for OR52A5 Gene

Paralogs for OR52A5 Gene

(324) SIMAP similar genes for OR52A5 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR52A5 Gene

genes like me logo Genes that share paralogs with OR52A5: view

Variants for OR52A5 Gene

Sequence variations from dbSNP and Humsavar for OR52A5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs7120612 -- 5,132,927(+) GGTTC(A/G)TGACT upstream-variant-2KB
rs61880362 -- 5,134,312(+) CCAGC(C/G)TCATC upstream-variant-2KB
rs112604883 -- 5,131,761(+) CCATA(A/G)ACAAT reference, synonymous-codon
rs12282896 -- 5,131,268(+) CAATA(A/T)AATTG downstream-variant-500B
rs12289086 -- 5,131,690(+) CTAAC(A/G)ATCAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR52A5 Gene

Variant ID Type Subtype PubMed ID
nsv896920 CNV Loss 21882294
dgv1023n71 CNV Loss 21882294
nsv896925 CNV Gain 21882294
nsv896926 CNV Loss 21882294

Variation tolerance for OR52A5 Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.13; 51.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR52A5 Gene

HapMap Linkage Disequilibrium report
OR52A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52A5 Gene

Disorders for OR52A5 Gene

Relevant External Links for OR52A5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR52A5

No disorders were found for OR52A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52A5 Gene

Publications for OR52A5 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PMID: 11121057) Bulger M. … Hardison R. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3

Products for OR52A5 Gene

Sources for OR52A5 Gene

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