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OR52A5 Gene

protein-coding   GIFtS: 48
GCID: GC11M005152

Olfactory Receptor, Family 52, Subfamily A, Member 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 52, Subfamily A, Member 51 2
Odorant Receptor HOR3'Beta52 3
Olfactory Receptor OR11-332 3
OR11-332
Olfactory Receptor 52A52

External Ids:    HGNC: 195801   Entrez Gene: 3900542   Ensembl: ENSG000001719447   UniProtKB: Q9H2C53   

Export aliases for OR52A5 gene to outside databases

Previous GC identifers: GC00U903047 GC11M005118 GC11M005109


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR52A5 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR52A5 Gene:
OR52A5 (olfactory receptor, family 52, subfamily A, member 5) is a protein-coding gene. Diseases associated with OR52A5 include thalassemia, and neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52L1.

UniProtKB/Swiss-Prot: O52A5_HUMAN, Q9H2C5
Function: Odorant receptor (Potential)

Gene Wiki entry for OR52A5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR52A5 gene promoter:
         Max1   USF1   Tal-1beta   Evi-1   PPAR-gamma1   USF-1   PPAR-gamma2   ITF-2   LyF-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR52A5 promoter sequence
   Search Chromatin IP Primers for OR52A5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR52A5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

OR52A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR52A5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M005152:  view genomic region     (about GC identifiers)

Start:
5,152,925 bp from pter      End:
5,153,872 bp from pter
Size:
948 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: O52A5_HUMAN, Q9H2C5 (See protein sequence)
Recommended Name: Olfactory receptor 52A5  
Size: 316 amino acids; 35955 Da

Explore the universe of human proteins at neXtProt for OR52A5: NX_Q9H2C5

Explore proteomics data for OR52A5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR52A5

    See OR52A5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001005160.1  
    ENSEMBL proteins: 
     ENSP00000303469  
    Reactome Protein details: Q9H2C5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR52: GPCR / Class A : Olfactory receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR019424 7TM_GPCR_olfarory/Srsx
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9H2C5

    ProtoNet protein and cluster: Q9H2C5

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O52A5_HUMAN, Q9H2C5
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR52A5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O52A5_HUMAN, Q9H2C5
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity NAS11121057
         
    OR52A5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OR52A5:
     Increased G2M DNA content 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O52A5_HUMAN, Q9H2C5: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane NAS11121057

    OR52A5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR52A5 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR52A5
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR52A5):
        Olfactory transduction


    OR52A5 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR52A5
    Interactions:

        Search GeneGlobe Interaction Network for OR52A5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR52A5 (ENSP000003034694) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR1A1ENSP000003052074STRING: ENSP00000305207
    OR1A2ENSP000003713774STRING: ENSP00000371377
    OR1D2ENSP000003275854STRING: ENSP00000327585
    OR51V1ENSP000003217294STRING: ENSP00000321729
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007608sensory perception of smell NAS11121057
    GO:0050911detection of chemical stimulus involved in sensory perception of smell NAS11121057

    OR52A5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR52A5 (O52A5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR52A5 gene: 
    NM_001005160.2  

    Unigene Cluster for OR52A5:

    Olfactory receptor, family 52, subfamily A, member 5
    Hs.546593
    Unigene Representative Sequence: NM_001005160
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000307388(uc010qyx.2)
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      QuantiFast Probe-based Assays in human, mouse, rat OR52A5

    Additional mRNA sequence: AY726590.1 

    1 DOTS entry:

    DT.120727316 

    1 AceView cDNA sequence:

    NM_001005160 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR52A5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTGCCCAC
    OR52A5 Expression
    About this image

    OR52A5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR52A5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.546593
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR52A5 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr691 , 5 olfactory receptor 691, 5 81.1(n)1
    81.21(a)1
      7 (54.85 cM)5
    183701  NM_013621.31  NP_038649.21 
     1037674455 


    ENSEMBL Gene Tree for OR52A5 (if available)
    TreeFam Gene Tree for OR52A5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR52A5 gene
    OR52L12  OR52A12  OR52M12  OR52N42  OR52N52  OR52K12  OR52K22  OR52R12  
    OR52N12  OR52N22  
    Selected SIMAP similar genes for OR52A5 using alignment to 1 protein entry:     O52A5_HUMAN(see all similar genes):
    OR52A1    OR52A4    OR52D1    OR52E2    OR52J3    OR52N1
    OR51E1    OR52B2    OR52E8    OR52N2    OR52N4    OR52R1
    OR52Z1    OR51E2    OR52B6    OR52E1    OR52E4    OR52E5

    OR52A5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OR52A5
    PGOHUM00000262031


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR52A5 (see all 113)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs122828961,2
    C,F,H--5152498(+) CAATAA/TAATTG 1 -- ds50016Minor allele frequency- T:0.03NS EA CSA WA NA 540
    rs794762561,2
    C,F--5152503(+) AAATTG/TTGTGG 1 -- ds50014Minor allele frequency- T:0.24WA CSA 124
    rs799688271,2
    F--5152504(+) AATTGT/CGTGGT 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1824278221,2
    C--5152567(+) AAATGA/GTATTT 1 -- ds50010--------
    rs122890861,2
    C,F,H--5152920(+) CTAACG/AATCAA 1 -- ds500114Minor allele frequency- A:0.08NS EA NA EU 6909
    rs740513261,2
    C,F--5152957(+) CACAAT/CATGGT 2 /I /V mis15Minor allele frequency- C:0.04WA CSA NA EU 5991
    rs740513301,2
    C,F--5152966(+) GTCACG/AAATTT 2 /R /C mis14Minor allele frequency- A:0.01WA CSA NA 4670
    rs1126048831,2
    C,F--5152991(+) CCATAG/AACAAT 2 /V syn11Minor allele frequency- A:0.50CSA 4
    rs1390296371,2
    C--5153015(+) GGTGGA/GACTAA 2 V syn10--------
    rs1176953411,2
    C,F--5153053(+) AATATA/GTGGTG 2 H Y mis13Minor allele frequency- G:0.00NA EU 5993

    HapMap Linkage Disequilibrium report for OR52A5 ( 5152925 - 5153872 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for OR52A5:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1023n71CNV Loss21882294
    nsv896920CNV Loss21882294
    nsv896926CNV Loss21882294
    nsv896925CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for OR52A5:    
    About MalaCards
    thalassemia    neuronitis


    OR52A5 for disorders           About GeneDecksing


    Export disorders for OR52A5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR52A5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR52A5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PubMed id 11121057)1, 2 Bulger M.... Hardison R. (Proc. Natl. Acad. Sci. U.S.A. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 390054 HGNC: 19580 AceView: OR52A5 Ensembl:ENSG00000171944 euGenes: HUgn390054
    ECgene: OR52A5 Kegg: 390054 H-InvDB: OR52A5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR52A5 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR52A5 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR52A5 gene:
    Search GeneIP for patents involving OR52A5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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