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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR52A4 Gene

pseudogene   GIFtS: 35
GCID: GC11M005141

olfactory receptor, family 52, subfamily A, member 4
 Explore 3 diseases affiliated with
OR52A4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for OR52A4    

Aliases
for OR52A4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Olfactory Receptor, Family 52, Subfamily A, Member 41 2

External Ids:    HGNC: 195791   Entrez Gene: 3900532   Ensembl: ENSG000002054947   UniProtKB: A6NMU13   

Export aliases for OR52A4 gene to outside databases

Previous GC identifers: GC00U903046 GC11M005098


Summaries
for OR52A4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for OR52A4:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors
(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many
neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of
odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the
olfactory receptor genes and proteins for this organism is independent of other organisms. Although originally
considered to be a functional olfactory receptor, this family member is now considered to be pseudogene due to the
presence of a C-terminal frameshift compared to other family members; this is also consistent with the Classifier for
Olfactory Receptor Pseudogenes (CORP), as described in PMID:16939646. (provided by RefSeq, Jun 2011)




Genomic Views
for OR52A4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR52A4 gene promoter:
         Max1   USF1   XBP-1   Evi-1   AREB6   USF-1   LyF-1   c-Myc   
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR52A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

OR52A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR52A4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M005141:  view genomic region     (about GC identifiers)

Start:
 5,141,897 bp from pter      End:
 5,142,808 bp from pter
Size:
 912 bases      Orientation:
 minus strand

Proteins
for OR52A4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: O52A4_HUMAN, A6NMU1 (See protein sequence)
Recommended Name: Putative olfactory receptor 52A4  
Size: 304 amino acids; 34901 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Caution: Could be the product of a pseudogene. Has a truncated and frameshifted C-terminal region

Explore the universe of human proteins at neXtProt for OR52A4: NX_A6NMU1

HORDE protein sequence for OR52A4
OR52A4 Protein expression data from MOPED and PaxDb: --
Reactome Protein details: A6NMU1
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Uscn Proteins for OR52A4

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0016021integral to membrane IEA--


OR52A4 for ontologies           About GeneDecksing



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Protein Domains /
Families
for OR52A4 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
OR52A4 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR019424 7TM_GPCR_olfarory/Srsx
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry A6NMU1

ProtoNet protein and cluster: A6NMU1

UniProtKB/Swiss-Prot: O52A4_HUMAN, A6NMU1
Similarity: Belongs to the G-protein coupled receptor 1 family


Function
for OR52A4 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
miRNA
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In Situ Assay
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--


OR52A4 for ontologies           About GeneDecksing



Pathways & Interactions
for OR52A4 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Signaling by GPCR
Signaling by GPCR1.00
Signal Transduction0.56
GPCR downstream signaling0.89
2Olfactory transduction
Olfactory Signaling Pathway0.77

Pathway sources
See GeneCards unified pathways
Show all pathways


4        Reactome Pathways for OR52A4
    GPCR downstream signaling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR



OR52A4 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR52A4

Drugs & Compounds
for OR52A4 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
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Browse Tocris compounds for OR52A4
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Transcripts
for OR52A4 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for OR52A4 gene: 
NM_001005222.2  

Unigene Cluster for OR52A4:

Olfactory receptor, family 52, subfamily A, member 4
Hs.553729
Unigene Representative Sequence: DQ656008
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000472867 ENST00000498233(uc001maa.3) ENST00000481634 ENST00000380369


miRNA
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Inhib. RNA
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Clone
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Primer
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Additional cDNA sequence: 

BC140752.1 DQ656008.2 DQ656009.2 

1 DOTS entry:

DT.120727315 

1 AceView cDNA sequence:

NM_001005222 

GeneLoc Exon Structure


Expression
for OR52A4 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OR52A4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTCCCCAT

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image
SOURCE GeneReport for Unigene cluster: Hs.553729
    SABiosciences Custom PCR Arrays for OR52A4
Primer
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In Situ
Assay Products: 
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Orthologs
for OR52A4 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
   --

ENSEMBL Gene Tree for OR52A4 (if available)
TreeFam Gene Tree for OR52A4 (if available) 

Paralogs
for OR52A4 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

Genomic Variants
for OR52A4 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
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Disorders / Diseases
for OR52A4 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OR52A4 for disorders           About GeneDecksing

3 diseases for OR52A4:    About MalaCards
beta thalassemia    thalassemia    neuronitis


Export disorders for OR52A4 gene to outside databases

Publications
for OR52A4 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for OR52A4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR52A4)		    Utopia: connect your pdf to the dynamic
world of online information

  1. A probabilistic classifier for olfactory receptor pseudogenes. (PubMed id 16939646)1 Menashe I....Lancet D. (2006)
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

External Searches for OR52A4 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing OR52A4 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 390053 HGNC: 19579 AceView: OR52A4 Ensembl:ENSG00000205494 euGenes: HUgn390053
ECgene: OR52A4 H-InvDB: OR52A4

Other Databases showing OR52A4 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing OR52A4 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for OR52A4 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR52A4 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

Intellectual Property
for OR52A4 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for OR52A4 gene:
Search GeneIP for patents involving OR52A4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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About This Section

 
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