Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR52A1 Gene

Aliases for OR52A1 Gene

  • Olfactory Receptor Family 52 Subfamily A Member 1 2 3 5
  • Olfactory Receptor, Family 52, Subfamily A, Member 1 2 3
  • Olfactory Receptor OR11-319 3 4
  • Odorant Receptor HOR3beta4 3 4
  • HPFH1OR 3 4

External Ids for OR52A1 Gene

Previous GeneCards Identifiers for OR52A1 Gene

  • GC11U990203
  • GC11M005474
  • GC11M005131
  • GC11M005136
  • GC11M005129

Summaries for OR52A1 Gene

Entrez Gene Summary for OR52A1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52A1 Gene

OR52A1 (Olfactory Receptor Family 52 Subfamily A Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR52A5.

UniProtKB/Swiss-Prot for OR52A1 Gene

  • Odorant receptor.

Gene Wiki entry for OR52A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52A1 Gene

Genomics for OR52A1 Gene

Regulatory Elements for OR52A1 Gene

Enhancers for OR52A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR52A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR52A1 Gene

5,151,009 bp from pter
5,186,382 bp from pter
35,374 bases
Minus strand

Genomic View for OR52A1 Gene

Genes around OR52A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52A1 Gene

Proteins for OR52A1 Gene

  • Protein details for OR52A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 52A1
    Protein Accession:
    Secondary Accessions:
    • Q6IF31

    Protein attributes for OR52A1 Gene

    312 amino acids
    Molecular mass:
    35322 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52A1 Gene

Proteomics data for OR52A1 Gene at MOPED

Post-translational modifications for OR52A1 Gene

Other Protein References for OR52A1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52A1 Gene

Domains & Families for OR52A1 Gene

Gene Families for OR52A1 Gene

Protein Domains for OR52A1 Gene

Suggested Antigen Peptide Sequences for OR52A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52A1: view

Function for OR52A1 Gene

Molecular function for OR52A1 Gene

GENATLAS Biochemistry:
olfactory receptor family 52,subfamily A,member 1,expressed in primary tissues containing erythroid cells,and in erythroid tissues cell lines,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.
genes like me logo Genes that share phenotypes with OR52A1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52A1 Gene

Localization for OR52A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR52A1 Gene COMPARTMENTS Subcellular localization image for OR52A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52A1: view

Pathways & Interactions for OR52A1 Gene

genes like me logo Genes that share pathways with OR52A1: view

Pathways by source for OR52A1 Gene

Interacting Proteins for OR52A1 Gene

Gene Ontology (GO) - Biological Process for OR52A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell TAS 10512676
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52A1: view

No data available for SIGNOR curated interactions for OR52A1 Gene

Drugs & Compounds for OR52A1 Gene

No Compound Related Data Available

Transcripts for OR52A1 Gene

mRNA/cDNA for OR52A1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR52A1 Gene

No ASD Table

Relevant External Links for OR52A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR52A1 Gene

mRNA expression in normal human tissues for OR52A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR52A1 Gene

SOURCE GeneReport for Unigene cluster for OR52A1 Gene Hs.553520

genes like me logo Genes that share expression patterns with OR52A1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR52A1 Gene

Orthologs for OR52A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC781403 35
  • 85.68 (n)
  • 83.33 (a)
-- 36
  • 83 (a)
-- 36
  • 83 (a)
-- 36
  • 83 (a)
-- 36
  • 83 (a)
-- 36
  • 82 (a)
-- 36
  • 83 (a)
(Canis familiaris)
Mammalia LOC485248 35
  • 87.61 (n)
  • 87.18 (a)
OR52A1 36
  • 87 (a)
(Mus musculus)
Mammalia Olfr68 35
  • 73.38 (n)
  • 72.73 (a)
Olfr68 16
Olfr628 36
  • 74 (a)
(Pan troglodytes)
Mammalia LOC466371 35
  • 98.93 (n)
  • 98.08 (a)
OR52A1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Olr127 35
  • 72.08 (n)
  • 72.08 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
-- 36
  • 69 (a)
-- 36
  • 73 (a)
-- 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 52 (a)
Species with no ortholog for OR52A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52A1 Gene

Gene Tree for OR52A1 (if available)
Gene Tree for OR52A1 (if available)

Paralogs for OR52A1 Gene

Paralogs for OR52A1 Gene

(313) SIMAP similar genes for OR52A1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR52A1: view

Variants for OR52A1 Gene

Sequence variations from dbSNP and Humsavar for OR52A1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs7482505 -- 5,151,168(+) TTAGA(A/G)GAATA downstream-variant-500B
rs112098990 -- 5,151,565(+) GACCC(-/C)AAACC reference, frameshift-variant
rs143372683 -- 5,151,920(+) AGTAC(A/G/T)ACCAT reference, synonymous-codon
rs112884296 -- 5,151,461(+) TGAAT(A/G/T)CGAAT reference, synonymous-codon
rs7940626 -- 5,154,247(+) AGCAG(A/G)GTTGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR52A1 Gene

Variant ID Type Subtype PubMed ID
nsv896920 CNV Loss 21882294
dgv1023n71 CNV Loss 21882294
nsv896925 CNV Gain 21882294
dgv1024n71 CNV Loss 21882294

Variation tolerance for OR52A1 Gene

Residual Variation Intolerance Score: 58.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.55; 82.41% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR52A1 Gene

Disorders for OR52A1 Gene

Relevant External Links for OR52A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR52A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52A1 Gene

Publications for OR52A1 Gene

  1. An olfactory receptor gene is located in the extended human beta- globin gene cluster and is expressed in erythroid cells. (PMID: 10512676) Feingold E.A. … Forget B.G. (Genomics 1999) 2 3 4 67
  2. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G. … White R.L. (Alcohol. Clin. Exp. Res. 2010) 3
  3. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3
  4. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for OR52A1 Gene

Sources for OR52A1 Gene