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Aliases for OR52A1 Gene

Aliases for OR52A1 Gene

  • Olfactory Receptor Family 52 Subfamily A Member 1 2 3 5
  • Olfactory Receptor OR11-319 3 4
  • Odorant Receptor HOR3beta4 3 4
  • HPFH1OR 3 4
  • Olfactory Receptor, Family 52, Subfamily A, Member 1 2
  • Olfactory Receptor 52A1 3

External Ids for OR52A1 Gene

Previous GeneCards Identifiers for OR52A1 Gene

  • GC11U990203
  • GC11M005474
  • GC11M005131
  • GC11M005136
  • GC11M005129

Summaries for OR52A1 Gene

Entrez Gene Summary for OR52A1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52A1 Gene

OR52A1 (Olfactory Receptor Family 52 Subfamily A Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR52A5.

UniProtKB/Swiss-Prot for OR52A1 Gene

  • Odorant receptor.

Gene Wiki entry for OR52A1 Gene

Additional gene information for OR52A1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52A1 Gene

Genomics for OR52A1 Gene

Regulatory Elements for OR52A1 Gene

Enhancers for OR52A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H005546 0.3 FANTOM5 10.3 -391.5 -391489 0 OR56A1 OR56A3 OR51Q1 OR52E8 OR52N1 OR56A4 OR52N4 OR52E2 OR52E4 OR52A1
GH11H005328 0.3 FANTOM5 2 -174.4 -174422 0 OR51G1 OR51T1 OR52N2 OR52N4 OR52D1 OR52J3 MMP26 OR51L1 OR51B2 OR51M1
GH11H005379 0.3 FANTOM5 1.7 -225.2 -225235 0 OR51V1 OR51T1 HBB OR51B5 OR51G1 OR56B1 OR52J3 OR51L1 OR52N4 OR52D1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR52A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR52A1 Gene

Chromosome:
11
Start:
5,143,219 bp from pter
End:
5,154,757 bp from pter
Size:
11,539 bases
Orientation:
Minus strand

Genomic View for OR52A1 Gene

Genes around OR52A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52A1 Gene

Proteins for OR52A1 Gene

  • Protein details for OR52A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKL2-O52A1_HUMAN
    Recommended name:
    Olfactory receptor 52A1
    Protein Accession:
    Q9UKL2
    Secondary Accessions:
    • Q6IF31

    Protein attributes for OR52A1 Gene

    Size:
    312 amino acids
    Molecular mass:
    35322 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52A1 Gene

Post-translational modifications for OR52A1 Gene

Other Protein References for OR52A1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52A1 Gene

Domains & Families for OR52A1 Gene

Gene Families for OR52A1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR52A1 Gene

Suggested Antigen Peptide Sequences for OR52A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKL2

UniProtKB/Swiss-Prot:

O52A1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52A1: view

Function for OR52A1 Gene

Molecular function for OR52A1 Gene

GENATLAS Biochemistry:
olfactory receptor family 52,subfamily A,member 1,expressed in primary tissues containing erythroid cells,and in erythroid tissues cell lines,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR52A1 Gene

Gene Ontology (GO) - Molecular Function for OR52A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 10512676
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR52A1: view
genes like me logo Genes that share phenotypes with OR52A1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR52A1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52A1 Gene

Localization for OR52A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR52A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10512676
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR52A1 Gene

Pathways & Interactions for OR52A1 Gene

genes like me logo Genes that share pathways with OR52A1: view

Pathways by source for OR52A1 Gene

Interacting Proteins for OR52A1 Gene

Gene Ontology (GO) - Biological Process for OR52A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10512676
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell TAS 10512676
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52A1: view

No data available for SIGNOR curated interactions for OR52A1 Gene

Drugs & Compounds for OR52A1 Gene

No Compound Related Data Available

Transcripts for OR52A1 Gene

mRNA/cDNA for OR52A1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR52A1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR52A1 Gene

No ASD Table

Relevant External Links for OR52A1 Gene

GeneLoc Exon Structure for
OR52A1
ECgene alternative splicing isoforms for
OR52A1

Expression for OR52A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR52A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR52A1 Gene



NURSA nuclear receptor signaling pathways regulating expression of OR52A1 Gene:

OR52A1

SOURCE GeneReport for Unigene cluster for OR52A1 Gene:

Hs.553520
genes like me logo Genes that share expression patterns with OR52A1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52A1 Gene

Orthologs for OR52A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466371 33
  • 98.93 (n)
OR52A1 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC485248 33
  • 87.61 (n)
OR52A1 34
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC781403 33
  • 85.68 (n)
-- 34
  • 83 (a)
OneToMany
-- 34
  • 83 (a)
OneToMany
-- 34
  • 83 (a)
OneToMany
-- 34
  • 83 (a)
OneToMany
-- 34
  • 83 (a)
OneToMany
-- 34
  • 82 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 74 (a)
ManyToMany
-- 34
  • 73 (a)
ManyToMany
-- 34
  • 69 (a)
ManyToMany
-- 34
  • 62 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr628 34
  • 74 (a)
ManyToMany
Olfr68 33 16
  • 73.38 (n)
Or52ab2 52 Olfr597
  • chr7:103,320,401-103,321,357
Or52ab7 52 Olfr598
  • chr7:103,328,488-103,329,444
Or52ab8-ps 52 Olfr602-ps1
  • chr7:103,367,523-103,368,479
rat
(Rattus norvegicus)
Mammalia Olr127 33
  • 72.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 52 (a)
OneToMany
Species where no ortholog for OR52A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52A1 Gene

ENSEMBL:
Gene Tree for OR52A1 (if available)
TreeFam:
Gene Tree for OR52A1 (if available)

Paralogs for OR52A1 Gene

Paralogs for OR52A1 Gene

(313) SIMAP similar genes for OR52A1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR52A1: view

Variants for OR52A1 Gene

Sequence variations from dbSNP and Humsavar for OR52A1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000245039 -- 5,152,008(+) CCAGG(A/G)CCATG reference, missense
rs1000497123 -- 5,153,801(+) CTGTT(C/T)TTTGA upstream-variant-2KB
rs1001514678 -- 5,153,748(+) TCAGC(-/T)TAACC upstream-variant-2KB
rs1001967010 -- 5,153,356(+) CTTAT(A/C)TAATT upstream-variant-2KB
rs1003308315 -- 5,152,467(+) TATTG(A/C)GTCTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR52A1 Gene

Variant ID Type Subtype PubMed ID
esv2760169 CNV gain+loss 21179565
esv3625206 CNV loss 21293372
esv3625208 CNV loss 21293372
esv3891917 CNV loss 25118596
nsv1054847 CNV gain 25217958
nsv553219 CNV gain 21841781
nsv553224 CNV loss 21841781

Variation tolerance for OR52A1 Gene

Residual Variation Intolerance Score: 58.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.55; 82.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR52A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR52A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52A1 Gene

Disorders for OR52A1 Gene

Relevant External Links for OR52A1

Genetic Association Database (GAD)
OR52A1
Human Genome Epidemiology (HuGE) Navigator
OR52A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR52A1

No disorders were found for OR52A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52A1 Gene

Publications for OR52A1 Gene

  1. An olfactory receptor gene is located in the extended human beta-globin gene cluster and is expressed in erythroid cells. (PMID: 10512676) Feingold EA … Forget BG (Genomics 1999) 2 3 4 60
  2. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 45 60
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PMID: 11121057) Bulger M … Hardison R (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 60

Products for OR52A1 Gene

Sources for OR52A1 Gene

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