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Aliases for OR52A1 Gene

Aliases for OR52A1 Gene

  • Olfactory Receptor, Family 52, Subfamily A, Member 1 2 3
  • Olfactory Receptor OR11-319 3 4
  • Odorant Receptor HOR3beta4 3 4
  • HPFH1OR 3 4
  • Olfactory Receptor 52A1 3

External Ids for OR52A1 Gene

Summaries for OR52A1 Gene

Entrez Gene Summary for OR52A1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52A1 Gene

OR52A1 (Olfactory Receptor, Family 52, Subfamily A, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR52R1.

UniProtKB/Swiss-Prot for OR52A1 Gene

  • Odorant receptor.

Gene Wiki entry for OR52A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52A1 Gene

Genomics for OR52A1 Gene

Genomic Location for OR52A1 Gene

Start:
5,151,009 bp from pter
End:
5,186,382 bp from pter
Size:
35,374 bases
Orientation:
Minus strand

Genomic View for OR52A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR52A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52A1 Gene

Regulatory Elements for OR52A1 Gene

Proteins for OR52A1 Gene

  • Protein details for OR52A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKL2-O52A1_HUMAN
    Recommended name:
    Olfactory receptor 52A1
    Protein Accession:
    Q9UKL2
    Secondary Accessions:
    • Q6IF31

    Protein attributes for OR52A1 Gene

    Size:
    312 amino acids
    Molecular mass:
    35322 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52A1 Gene

Proteomics data for OR52A1 Gene at MOPED

Post-translational modifications for OR52A1 Gene

Other Protein References for OR52A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR52A1 Gene

Domains for OR52A1 Gene

Gene Families for OR52A1 Gene

HGNC:
  • OR52 :GPCR / Class A : Olfactory receptors

Protein Domains for OR52A1 Gene

UniProtKB/Swiss-Prot:

O52A1_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q9UKL2
genes like me logo Genes that share domains with OR52A1: view

Function for OR52A1 Gene

Molecular function for OR52A1 Gene

GENATLAS Biochemistry: olfactory receptor family 52,subfamily A,member 1,expressed in primary tissues containing erythroid cells,and in erythroid tissues cell lines,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 10512676
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR52A1: view

Phenotypes for OR52A1 Gene

GenomeRNAi human phenotypes for OR52A1:
genes like me logo Genes that share phenotypes with OR52A1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR52A1 Gene

Localization for OR52A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR52A1 Gene COMPARTMENTS Subcellular localization image for OR52A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10512676
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with OR52A1: view

Pathways for OR52A1 Gene

genes like me logo Genes that share pathways with OR52A1: view

Pathways by source for OR52A1 Gene

Interacting Proteins for OR52A1 Gene

Gene Ontology (GO) - Biological Process for OR52A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10512676
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell TAS 10512676
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52A1: view

Transcripts for OR52A1 Gene

mRNA/cDNA for OR52A1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR52A1 Gene

No ASD Table

Relevant External Links for OR52A1 Gene

GeneLoc Exon Structure for
OR52A1
ECgene alternative splicing isoforms for
OR52A1

Expression for OR52A1 Gene

mRNA expression in normal human tissues for OR52A1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR52A1 Gene

SOURCE GeneReport for Unigene cluster for OR52A1 Gene Hs.553520

genes like me logo Genes that share expressions with OR52A1: view

Orthologs for OR52A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466371 36
  • 98.93 (n)
  • 98.08 (a)
OR52A1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 83 (a)
OneToMany
-- 37
  • 83 (a)
OneToMany
-- 37
  • 83 (a)
OneToMany
-- 37
  • 83 (a)
OneToMany
-- 37
  • 82 (a)
OneToMany
-- 37
  • 83 (a)
OneToMany
LOC781403 36
  • 85.68 (n)
  • 83.33 (a)
dog
(Canis familiaris)
Mammalia LOC485248 36
  • 87.61 (n)
  • 87.18 (a)
OR52A1 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr628 37
  • 74 (a)
ManyToMany
Olfr68 36
  • 73.38 (n)
  • 72.73 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 62 (a)
ManyToMany
-- 37
  • 69 (a)
ManyToMany
-- 37
  • 73 (a)
ManyToMany
-- 37
  • 74 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 52 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr127 36
  • 72.08 (n)
  • 72.08 (a)
Species with no ortholog for OR52A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52A1 Gene

ENSEMBL:
Gene Tree for OR52A1 (if available)
TreeFam:
Gene Tree for OR52A1 (if available)

Paralogs for OR52A1 Gene

Selected SIMAP similar genes for OR52A1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR52A1: view

Variants for OR52A1 Gene

Sequence variations from dbSNP and Humsavar for OR52A1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs7482505 -- 5,151,168(+) TTAGA(A/G)GAATA downstream-variant-500B
rs7940626 -- 5,154,247(+) AGCAG(A/G)GTTGC upstream-variant-2KB
rs10768611 -- 5,151,556(+) AGGGG(A/G)GATGT missense, reference
rs36060295 -- 5,151,859(+) TAAAA(-/A)TTGAA reference, frameshift-variant
rs58039145 -- 5,153,820(+) TTTTT(-/TT)GAAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR52A1 Gene

Variant ID Type Subtype PubMed ID
nsv896920 CNV Loss 21882294
dgv1023n71 CNV Loss 21882294
nsv896925 CNV Gain 21882294
dgv1024n71 CNV Loss 21882294

Relevant External Links for OR52A1 Gene

HapMap Linkage Disequilibrium report
OR52A1

Disorders for OR52A1 Gene

Relevant External Links for OR52A1

Genetic Association Database (GAD)
OR52A1
Human Genome Epidemiology (HuGE) Navigator
OR52A1
genes like me logo Genes that share disorders with OR52A1: view

No data available for UniProtKB/Swiss-Prot for OR52A1 Gene

Publications for OR52A1 Gene

  1. An olfactory receptor gene is located in the extended human beta- globin gene cluster and is expressed in erythroid cells. (PMID: 10512676) Feingold E.A. … Forget B.G. (Genomics 1999) 2 3 4
  2. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PMID: 11121057) Bulger M. … Hardison R. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G. … White R.L. (Alcohol. Clin. Exp. Res. 2010) 3 49

Products for OR52A1 Gene

Sources for OR52A1 Gene

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