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OR51V1 Gene

protein-coding   GIFtS: 46
GCID: GC11M005220

Olfactory Receptor, Family 51, Subfamily V, Member 1


(Previous symbol: OR51A12)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 51, Subfamily V, Member 11 2     Olfactory Receptor OR11-362 3
OR51A121 2 3     OR11-362
Odorant Receptor HOR3'Beta12 3     Olfactory Receptor 51V12
Olfactory Receptor 51A122 3     

External Ids:    HGNC: 195971   Entrez Gene: 2831112   Ensembl: ENSG000001767427   UniProtKB: Q9H2C83   

Export aliases for OR51V1 gene to outside databases

Previous GC identifers: GC00U903061 GC11M005187 GC11M005177


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR51V1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR51V1 Gene:
OR51V1 (olfactory receptor, family 51, subfamily V, member 1) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51M1.

UniProtKB/Swiss-Prot: O51V1_HUMAN, Q9H2C8
Function: Odorant receptor (Potential)

Gene Wiki entry for OR51V1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR51V1 gene promoter:
         CHOP-10   NRSF form 1   HOXA5   NRSF form 2   LCR-F1   YY1   C/EBPalpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR51V1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

OR51V1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR51V1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M005220:  view genomic region     (about GC identifiers)

Start:
5,220,968 bp from pter      End:
5,221,912 bp from pter
Size:
945 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: O51V1_HUMAN, Q9H2C8 (See protein sequence)
Recommended Name: Olfactory receptor 51V1  
Size: 321 amino acids; 36749 Da

Explore the universe of human proteins at neXtProt for OR51V1: NX_Q9H2C8

Explore proteomics data for OR51V1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn18
  • HORDE protein sequence for OR51V1

    See OR51V1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004760.2  
    ENSEMBL proteins: 
     ENSP00000321729  
    Reactome Protein details: Q9H2C8

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR51: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9H2C8

    ProtoNet protein and cluster: Q9H2C8

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O51V1_HUMAN, Q9H2C8
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR51V1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O51V1_HUMAN, Q9H2C8
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity NAS11121057
         
    Find genes that share ontologies with OR51V1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for OR51V1:
     Synthetic lethal with c-Myc af 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OR51V1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O51V1_HUMAN, Q9H2C8: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane NAS11121057

    Find genes that share ontologies with OR51V1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR51V1 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR51V1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR51V1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR51V1):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR51V1
    Interactions:

        Search GeneGlobe Interaction Network for OR51V1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR51V1 (ENSP000003217294) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR1A1ENSP000003052074STRING: ENSP00000305207
    OR1A2ENSP000003713774STRING: ENSP00000371377
    OR1D2ENSP000003275854STRING: ENSP00000327585
    OR51B2ENSP000003275404STRING: ENSP00000327540
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007608sensory perception of smell NAS11121057
    GO:0050911detection of chemical stimulus involved in sensory perception of smell NAS11121057

    Find genes that share ontologies with OR51V1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for OR51V1 (O51V1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR51V1 gene: 
    NM_001004760.2  

    Unigene Cluster for OR51V1:

    Olfactory receptor, family 51, subfamily V, member 1
    Hs.553670
    Unigene Representative Sequence: NM_001004760
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000321255(uc010qyz.2)
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      QuantiFast Probe-based Assays in human, mouse, rat OR51V1

    1 AceView cDNA sequence:

    NM_001004760 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR51V1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OR51V1 Expression
    About this image

    OR51V1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR51V1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553670
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OR51V1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr6245 olfactory receptor 624   --   7 (54.85 cM) 103670103 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    49(a)
    1 → many
    1(193679670-193680620) ENSGALG00000026571


    ENSEMBL Gene Tree for OR51V1 (if available)
    TreeFam Gene Tree for OR51V1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR51V1 gene
    OR51M12  OR51D12  OR51B62  OR51B52  OR51J12  OR51Q12  OR51E22  OR51B42  
    OR51B22  OR51E12  
    Selected SIMAP similar genes for OR51V1 using alignment to 1 protein entry:     O51V1_HUMAN(see all similar genes):
    OR51B5    OR51A4    OR51A7    OR51B6    OR51G1    OR51G2
    OR51H1P    OR51I2    OR51L1    OR51B2    OR51A2    OR51E2
    OR51Q1    OR51F2    OR51I1    OR51D1    OR51E1    OR52K1

    Find genes that share paralogs with OR51V1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR51V1 (see all 155)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs740493211,2
    C--5220549(+) GATATC/TACAAC 1 -- ds50012Minor allele frequency- T:0.10WA 120
    rs1403185601,2
    --5220640(+) TACTTG/TGAAAC 1 -- ds50010--------
    rs1148512281,2
    F--5220707(+) GTACAT/CTTCAG 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs79309681,2
    C,F,A,H--5220710(+) CATTTC/GAGGCA 1 -- ds500114Minor allele frequency- G:0.18NS EA NA WA CSA 788
    rs79456521,2
    C,F,A,H--5220743(+) CTTAAA/GTATGG 1 -- ds500123Minor allele frequency- G:0.19NS EA NA WA CSA 2273
    rs79330981,2
    C,F,A,H--5220837(+) TTTAAG/AGTCAT 1 -- ds500119Minor allele frequency- A:0.16NS EA NA WA CSA 1915
    rs79515871,2
    C,F--5220842(+) GGTCAT/CTTGTC 1 -- ds50013Minor allele frequency- C:0.26WA CSA 122
    rs1836254791,2
    C--5220879(+) TAATAA/TTTTTT 1 -- ds50010--------
    rs1135279811,2
    C,F--5220954(+) TACATC/TTCAAT 1 -- ds50013Minor allele frequency- T:0.01CSA WA EU 1443
    rs1881758801,2
    C--5220964(+) TATCTC/TTCAAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for OR51V1 ( 5220968 - 5221912 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for OR51V1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv523914CNV Loss19592680
    dgv1023n71CNV Loss21882294
    nsv896920CNV Loss21882294
    nsv896929CNV Loss21882294
    nsv896925CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with OR51V1           About GenesLikeMe

    Genetic Association Database (GAD): OR51V1

    Export disorders for OR51V1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR51V1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR51V1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PubMed id 11121057)1, 2 Bulger M.... Hardison R. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    3. Genome-wide and fine-resolution association analysis of malaria in West Africa. (PubMed id 19465909)4 Jallow M.... . (Nat. Genet. 2009)
    4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 283111 HGNC: 19597 AceView: OR51V1 Ensembl:ENSG00000176742 euGenes: HUgn283111
    ECgene: OR51V1 Kegg: 283111 H-InvDB: OR51V1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR51V1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR51V1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR51V1 gene:
    Search GeneIP for patents involving OR51V1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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