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Aliases for OR51T1 Gene

Aliases for OR51T1 Gene

  • Olfactory Receptor Family 51 Subfamily T Member 1 2 3 5
  • Olfactory Receptor OR11-26 3 4
  • Olfactory Receptor, Family 51, Subfamily T, Member 1 2
  • Olfactory Receptor 51T1 3
  • OR11-26 3

External Ids for OR51T1 Gene

Previous GeneCards Identifiers for OR51T1 Gene

  • GC11U990509
  • GC11P004867

Summaries for OR51T1 Gene

Entrez Gene Summary for OR51T1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51T1 Gene

OR51T1 (Olfactory Receptor Family 51 Subfamily T Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51F1.

UniProtKB/Swiss-Prot for OR51T1 Gene

  • Odorant receptor.

Gene Wiki entry for OR51T1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR51T1 Gene

Genomics for OR51T1 Gene

Regulatory Elements for OR51T1 Gene

Enhancers for OR51T1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F005328 0.3 FANTOM5 15 +447.4 447360 0.4 OR51G1 OR51T1 OR52N2 OR52N4 OR52D1 OR52J3 MMP26 OR51L1 OR51B2 OR51M1
GH11F005379 0.4 FANTOM5 11.1 +498.2 498173 0.0 ZNF316 OR51V1 OR51T1 HBB OR51B5 OR51G1 OR56B1 OR52J3 OR51L1 OR52N4 OR52D1
GH11F004881 0.7 ENCODE 0.8 +0.4 405 0.8 TBL1XR1 TAL1 FOXK2 GATA2 NCOR1 NR2F6 CREM MTA2 RNF2 NR2F1 OR51F2 OR51T1 OR51A6P
GH11F004484 0.3 FANTOM5 1.8 -397.3 -397345 0.1 OR52K1 TRIM21 OR51F2 OR52K2 OR51D1 OR51T1 OR51G1 OR52K3P
GH11F004492 0.3 FANTOM5 1.4 -389.4 -389404 0.1 OR52K2 OR51F1 OR52B4 OR51S1 OR51G2 OR51A4 OR52K1 C11orf40 OR52R1 OR51A7
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR51T1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR51T1 Gene

Chromosome:
11
Start:
4,881,819 bp from pter
End:
4,882,883 bp from pter
Size:
1,065 bases
Orientation:
Plus strand

Genomic View for OR51T1 Gene

Genes around OR51T1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51T1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51T1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51T1 Gene

Proteins for OR51T1 Gene

  • Protein details for OR51T1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGJ9-O51T1_HUMAN
    Recommended name:
    Olfactory receptor 51T1
    Protein Accession:
    Q8NGJ9
    Secondary Accessions:
    • Q6IFH9

    Protein attributes for OR51T1 Gene

    Size:
    327 amino acids
    Molecular mass:
    36998 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA04681.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR51T1 Gene

Post-translational modifications for OR51T1 Gene

Other Protein References for OR51T1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51T1 Gene

Domains & Families for OR51T1 Gene

Gene Families for OR51T1 Gene

Protein Domains for OR51T1 Gene

Suggested Antigen Peptide Sequences for OR51T1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGJ9

UniProtKB/Swiss-Prot:

O51T1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51T1: view

Function for OR51T1 Gene

Molecular function for OR51T1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR51T1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA,IBA --
genes like me logo Genes that share ontologies with OR51T1: view
genes like me logo Genes that share phenotypes with OR51T1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51T1 Gene

Localization for OR51T1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51T1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR51T1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51T1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR51T1: view

Pathways & Interactions for OR51T1 Gene

genes like me logo Genes that share pathways with OR51T1: view

Pathways by source for OR51T1 Gene

Interacting Proteins for OR51T1 Gene

Gene Ontology (GO) - Biological Process for OR51T1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA,IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR51T1: view

No data available for SIGNOR curated interactions for OR51T1 Gene

Transcripts for OR51T1 Gene

mRNA/cDNA for OR51T1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR51T1 Gene

No ASD Table

Relevant External Links for OR51T1 Gene

GeneLoc Exon Structure for
OR51T1
ECgene alternative splicing isoforms for
OR51T1

Expression for OR51T1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR51T1 Gene

Protein differential expression in normal tissues from HIPED for OR51T1 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR51T1 Gene



Protein tissue co-expression partners for OR51T1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR51T1 Gene:

OR51T1

SOURCE GeneReport for Unigene cluster for OR51T1 Gene:

Hs.553804
genes like me logo Genes that share expression patterns with OR51T1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR51T1 Gene

Orthologs for OR51T1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR51T1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466356 34
  • 99.15 (n)
OR51T1 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC610072 34
  • 84.71 (n)
OR51T1 35
  • 78 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC788825 34
  • 84 (n)
OR51T1 35
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or51t4 55 Olfr574 34 16 35
  • 81.37 (n)
rat
(Rattus norvegicus)
Mammalia Or51t1 34
  • 80 (n)
oppossum
(Monodelphis domestica)
Mammalia OR51T1 35
  • 61 (a)
OneToOne
Species where no ortholog for OR51T1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR51T1 Gene

ENSEMBL:
Gene Tree for OR51T1 (if available)
TreeFam:
Gene Tree for OR51T1 (if available)

Paralogs for OR51T1 Gene

(331) SIMAP similar genes for OR51T1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR51T1: view

Variants for OR51T1 Gene

Sequence variations from dbSNP and Humsavar for OR51T1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11034467 -- 4,880,169(+) TCCCC(A/G)TTGCC upstream-variant-2KB
rs11034472 -- 4,881,310(+) CATTC(C/T)AAGAA upstream-variant-2KB
rs111347642 -- 4,882,679(+) AGCCT(C/G/T)TCTTT reference, synonymous-codon
rs111874540 -- 4,881,805(+) ATTTA(A/C)AATTG upstream-variant-2KB
rs112003436 -- 4,880,649(+) ACTTT(C/T)AAGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR51T1 Gene

Variant ID Type Subtype PubMed ID
dgv1026n100 CNV loss 25217958
dgv1587n54 CNV loss 21841781
esv2673268 CNV deletion 23128226
esv2760633 CNV loss 21179565
esv3579253 CNV loss 25503493
esv3625193 CNV loss 21293372
esv3891914 CNV gain 25118596
nsv1054847 CNV gain 25217958
nsv467666 CNV loss 19166990
nsv7651 CNV insertion 18451855

Variation tolerance for OR51T1 Gene

Residual Variation Intolerance Score: 45.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR51T1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR51T1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR51T1 Gene

Disorders for OR51T1 Gene

Relevant External Links for OR51T1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR51T1

No disorders were found for OR51T1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR51T1 Gene

Publications for OR51T1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64

Products for OR51T1 Gene

Sources for OR51T1 Gene

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