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Aliases for OR51Q1 Gene

Aliases for OR51Q1 Gene

  • Olfactory Receptor Family 51 Subfamily Q Member 1 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 51, Subfamily Q, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 51, Subfamily Q, Member 1 2

External Ids for OR51Q1 Gene

Previous GeneCards Identifiers for OR51Q1 Gene

  • GC11U990335
  • GC11P005409
  • GC11P005400

Summaries for OR51Q1 Gene

Entrez Gene Summary for OR51Q1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51Q1 Gene

OR51Q1 (Olfactory Receptor Family 51 Subfamily Q Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51G2.

UniProtKB/Swiss-Prot for OR51Q1 Gene

  • Odorant receptor.

Gene Wiki entry for OR51Q1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR51Q1 Gene

Genomics for OR51Q1 Gene

Regulatory Elements for OR51Q1 Gene

Enhancers for OR51Q1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G005546 0.3 FANTOM5 17.9 +124.1 124135 0.1 OR56A1 OR56A3 OR51Q1 OR52E8 OR52N1 OR56A4 OR52N4 OR52E2 OR52E4 OR52A1
GH11G005623 1.2 FANTOM5 ENCODE 1.3 +203.3 203325 3.2 HDAC1 TBP PKNOX1 TBL1XR1 SREBF2 WRNIP1 SIN3A ZBTB40 RAD21 RFX5 TRIM5 TRIM34 TRIM22 OR51B2 OR56B4 OR56A1 OR56A3 OR52N4 OR51Q1 OR52E6
GH11G005379 0.4 FANTOM5 1.7 -42.1 -42120 0.0 ZNF316 OR51V1 OR51T1 HBB OR51B5 OR51G1 OR56B1 OR52J3 OR51L1 OR52N4 OR52D1
GH11G005328 0.3 FANTOM5 1.6 -92.9 -92933 0.4 OR51G1 OR51T1 OR52N2 OR52N4 OR52D1 OR52J3 MMP26 OR51L1 OR51B2 OR51M1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR51Q1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR51Q1 Gene

Chromosome:
11
Start:
5,422,111 bp from pter
End:
5,423,206 bp from pter
Size:
1,096 bases
Orientation:
Plus strand

Genomic View for OR51Q1 Gene

Genes around OR51Q1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51Q1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51Q1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51Q1 Gene

Proteins for OR51Q1 Gene

  • Protein details for OR51Q1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH59-O51Q1_HUMAN
    Recommended name:
    Olfactory receptor 51Q1
    Protein Accession:
    Q8NH59
    Secondary Accessions:
    • B2RNN1

    Protein attributes for OR51Q1 Gene

    Size:
    317 amino acids
    Molecular mass:
    35747 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51Q1 Gene

Post-translational modifications for OR51Q1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR51Q1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51Q1 Gene

Domains & Families for OR51Q1 Gene

Gene Families for OR51Q1 Gene

Protein Domains for OR51Q1 Gene

Suggested Antigen Peptide Sequences for OR51Q1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH59

UniProtKB/Swiss-Prot:

O51Q1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51Q1: view

Function for OR51Q1 Gene

Molecular function for OR51Q1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR51Q1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR51Q1: view
genes like me logo Genes that share phenotypes with OR51Q1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51Q1 Gene

Localization for OR51Q1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51Q1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR51Q1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51Q1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR51Q1: view

Pathways & Interactions for OR51Q1 Gene

genes like me logo Genes that share pathways with OR51Q1: view

Pathways by source for OR51Q1 Gene

Interacting Proteins for OR51Q1 Gene

Gene Ontology (GO) - Biological Process for OR51Q1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA,IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR51Q1: view

No data available for SIGNOR curated interactions for OR51Q1 Gene

Drugs & Compounds for OR51Q1 Gene

No Compound Related Data Available

Transcripts for OR51Q1 Gene

mRNA/cDNA for OR51Q1 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR51Q1 Gene

Olfactory receptor, family 51, subfamily Q, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR51Q1 Gene

No ASD Table

Relevant External Links for OR51Q1 Gene

GeneLoc Exon Structure for
OR51Q1
ECgene alternative splicing isoforms for
OR51Q1

Expression for OR51Q1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR51Q1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR51Q1 Gene



NURSA nuclear receptor signaling pathways regulating expression of OR51Q1 Gene:

OR51Q1

SOURCE GeneReport for Unigene cluster for OR51Q1 Gene:

Hs.528592
genes like me logo Genes that share expression patterns with OR51Q1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR51Q1 Gene

Orthologs for OR51Q1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR51Q1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466380 34
  • 98 (n)
OR51Q1 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR51Q1 34 35
  • 85.71 (n)
rat
(Rattus norvegicus)
Mammalia Olr137 34
  • 83.7 (n)
cow
(Bos Taurus)
Mammalia OR51Q1 34 35
  • 83.28 (n)
mouse
(Mus musculus)
Mammalia Or51q1 55 Olfr635 35
  • 83 (a)
OneToMany
Or51q1c 55 Olfr638 35
  • 81 (a)
OneToMany
Or51q1b-ps 55 Olfr1397-ps1
  • chr11:108,687,077-108,688,017
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 77 (a)
OneToMany
-- 35
  • 75 (a)
OneToMany
-- 35
  • 73 (a)
OneToMany
chicken
(Gallus gallus)
Aves OR51M1 34
  • 59.3 (n)
Species where no ortholog for OR51Q1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR51Q1 Gene

ENSEMBL:
Gene Tree for OR51Q1 (if available)
TreeFam:
Gene Tree for OR51Q1 (if available)

Paralogs for OR51Q1 Gene

(272) SIMAP similar genes for OR51Q1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR51Q1: view

Variants for OR51Q1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR51Q1 Gene

O51Q1_HUMAN-Q8NH59
A stop codon at position Arg-236 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene.

Sequence variations from dbSNP and Humsavar for OR51Q1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000628252 -- 5,420,117(+) TACAT(A/G)AAAGT intron-variant, upstream-variant-2KB
rs1001417440 -- 5,420,346(+) ACACC(A/T)ATTAT intron-variant, upstream-variant-2KB
rs1002046728 -- 5,420,860(+) CATAT(A/G)TATAA intron-variant, upstream-variant-2KB
rs1002246071 -- 5,421,098(+) ATTCA(A/G)TATGG intron-variant, upstream-variant-2KB
rs1002906938 -- 5,423,243(+) AAAAC(G/T)TCATC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR51Q1 Gene

Variant ID Type Subtype PubMed ID
dgv1042n100 CNV gain 25217958
esv2664205 CNV deletion 23128226
esv2759800 CNV loss 17122850
esv2761646 CNV loss 21179565
esv34391 CNV loss 17911159
esv3625225 CNV loss 21293372
esv3625226 CNV loss 21293372
nsv1046068 CNV gain 25217958
nsv1048608 CNV gain 25217958
nsv832057 CNV loss 17160897

Variation tolerance for OR51Q1 Gene

Residual Variation Intolerance Score: 96.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 23.67; 99.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR51Q1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR51Q1

Disorders for OR51Q1 Gene

Relevant External Links for OR51Q1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR51Q1

No disorders were found for OR51Q1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR51Q1 Gene

Publications for OR51Q1 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4 64
  2. Genetic elucidation of human hyperosmia to isovaleric acid. (PMID: 17973576) Menashe I. … Lancet D. (PLoS Biol. 2007) 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR51Q1 Gene

Sources for OR51Q1 Gene

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