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OR51Q1 Gene

protein-coding   GIFtS: 48
GCID: GC11P005443

Olfactory Receptor, Family 51, Subfamily Q, Member 1 (Gene/Pseudogene)

(Previous names: olfactory receptor, family 51, subfamily Q, member 1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 51, Subfamily Q, Member 1
(Gene/Pseudogene)1
Olfactory Receptor, Family 51, Subfamily Q, Member 11 2
Olfactory Receptor 51Q12

External Ids:    HGNC: 148511   Entrez Gene: 3900612   Ensembl: ENSG000001673607   UniProtKB: Q8NH593   

Export aliases for OR51Q1 gene to outside databases

Previous GC identifers: GC11U990335 GC11P005409 GC11P005400


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR51Q1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR51Q1 Gene:
OR51Q1 (olfactory receptor, family 51, subfamily Q, member 1 (gene/pseudogene)) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51M1.

UniProtKB/Swiss-Prot: O51Q1_HUMAN, Q8NH59
Function: Odorant receptor (Potential)

Gene Wiki entry for OR51Q1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR51Q1 gene promoter:
         Max1   p53   POU3F1   RelA   NF-kappaB   CP2   Sox9   c-Myb   NF-kappaB1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR51Q1 promoter sequence
   Search Chromatin IP Primers for OR51Q1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR51Q1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

OR51Q1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR51Q1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P005443:  view genomic region     (about GC identifiers)

Start:
5,443,431 bp from pter      End:
5,444,381 bp from pter
Size:
951 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: O51Q1_HUMAN, Q8NH59 (See protein sequence)
Recommended Name: Olfactory receptor 51Q1  
Size: 317 amino acids; 35747 Da
Secondary accessions: B2RNN1

Explore the universe of human proteins at neXtProt for OR51Q1: NX_Q8NH59

Explore proteomics data for OR51Q1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn6
  • HORDE protein sequence for OR51Q1

    See OR51Q1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004757.1  
    ENSEMBL proteins: 
     ENSP00000300778  
    Reactome Protein details: Q8NH59

    OR51Q1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR51: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NH59

    ProtoNet protein and cluster: Q8NH59

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O51Q1_HUMAN, Q8NH59
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR51Q1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O51Q1_HUMAN, Q8NH59
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR51Q1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OR51Q1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O51Q1_HUMAN, Q8NH59: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR51Q1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR51Q1 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR51Q1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR51Q1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR51Q1):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR51Q1
    Interactions:

        Search GeneGlobe Interaction Network for OR51Q1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR51Q1 (ENSP000003007784) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    GNALENSP000003340514STRING: ENSP00000334051
    GNGT1ENSP000002485724STRING: ENSP00000248572
    OR10A3ENSP000003539884STRING: ENSP00000353988
    OR10A4ENSP000003691574STRING: ENSP00000369157
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR51Q1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR51Q1 (O51Q1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR51Q1 gene: 
    NM_001004757.2  

    Unigene Cluster for OR51Q1:

    Olfactory receptor, family 51, subfamily Q, member 1
    Hs.528592
    Unigene Representative Sequence: NM_001004757
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000300778(uc010qzd.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat OR51Q1

    Additional mRNA sequence: BC136999.1 

    1 DOTS entry:

    DT.91968703 

    1 AceView cDNA sequence:

    NM_001004757 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR51Q1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAATATCT
    OR51Q1 Expression
    About this image

    OR51Q1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR51Q1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.528592
        Custom PCR Arrays for OR51Q1
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OR51Q1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr6355 olfactory receptor 635   --   7 (54.85 cM) 103979176 
    chicken
    (Gallus gallus)
    Aves OR51M11 olfactory receptor, family 51, subfamily M, member more 59.3(n)
    50.5(a)
      428116  NM_001008754.1  NP_001008754.1 


    ENSEMBL Gene Tree for OR51Q1 (if available)
    TreeFam Gene Tree for OR51Q1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR51Q1 gene
    OR51M12  OR51D12  OR51V12  OR51B62  OR51B52  OR51J12  OR51E22  OR51B42  
    OR51B22  OR51E12  
    Selected SIMAP similar genes for OR51Q1 using alignment to 1 protein entry:     O51Q1_HUMAN(see all similar genes):
    OR51I2    OR51A4    OR51G2    OR51H1P    OR51A2    OR51I1
    OR51A7    OR51L1    OR51V1    OR51B5    OR51E2    OR51M1
    OR52E2    OR52K3P    OR52M1    OR51D1    OR51F2    OR51G1

    Find genes that share paralogs with OR51Q1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    O51Q1_HUMAN, Q8NH59: A stop codon at position Arg-236 in the gene coding for this protein is responsible for functional
    diversity thus producing a pseudogene


    Selected SNPs for OR51Q1 (see all 137)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs79351081,2
    C,F,A--5441355(+) AGTCTA/GTTTTC 1 -- us2k18Minor allele frequency- G:0.27NA WA CSA EA 368
    rs1906632181,2
    --5441501(+) TGTTTC/TTACAC 1 -- us2k10--------
    rs1449646841,2
    --5441504(+) TTCTAC/TACTGC 1 -- us2k10--------
    rs1815765741,2
    --5441513(+) GCCATC/TTCCTT 1 -- us2k10--------
    rs24719911,2
    C,F,A,H--5441623(-) CAATGT/CTCAAC 1 -- us2k122Minor allele frequency- C:0.15NS EA NA WA 2760
    rs26475761,2
    C,A,H--5441703(-) CAAGAT/AAAATA 1 -- us2k17Minor allele frequency- A:0.41NA WA EA 366
    rs2012228331,2
    --5441751(+) AGTAA-/TCTCTTC 1 -- us2k10--------
    rs27365921,2
    C,A,H--5441842(-) GACAAA/GTAGAT 1 -- us2k19Minor allele frequency- G:0.28NA WA CSA EA 371
    rs1402745741,2
    --5441851(+) TCTTTA/CTCTGT 1 -- us2k10--------
    rs1442247641,2
    C--5441869(+) GTCTAC/TTGCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR51Q1 ( 5443431 - 5444381 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for OR51Q1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664205CNV Deletion23128226
    nsv896934CNV Loss21882294
    nsv832057CNV Loss17160897
    nsv896931CNV Loss21882294
    esv34391CNV Loss17911159
    dgv1025n71CNV Loss21882294
    essv3627CNV CNV17122850

    Human Gene Mutation Database (HGMD): OR51Q1
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with OR51Q1           About GenesLikeMe


    Export disorders for OR51Q1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR51Q1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR51Q1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (Nature 2006)
    2. Genetic elucidation of human hyperosmia to isovaleric acid. (PubMed id 17973576)2 Menashe I....Lancet D. (PLoS Biol. 2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 390061 HGNC: 14851 AceView: OR51Q1 Ensembl:ENSG00000167360 euGenes: HUgn390061
    ECgene: OR51Q1 Kegg: 390061 H-InvDB: OR51Q1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR51Q1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR51Q1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR51Q1 gene:
    Search GeneIP for patents involving OR51Q1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Block miRNA regulation of human, mouse, rat OR51Q1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OR51Q1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR51Q1 Predesigned siRNA for gene silencing in human, mouse, rat OR51Q1
     QuantiFast Probe-based Assays in human, mouse, rat OR51Q1 QuantiTect SYBR Green Assays in human, mouse, rat OR51Q1
     Custom PCR Arrays for OR51Q1 Search Chromatin IP Primers for OR51Q1
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for OR51Q1
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     antibodies-online antibodies for OR51Q1 (16 products)
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