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OR51L1 Gene

protein-coding   GIFtS: 46
GCID: GC11P004976

Olfactory Receptor, Family 51, Subfamily L, Member 1
  See related disease
at
MalaCards
 

Aliases
for OR51L1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 51, Subfamily L, Member 11 2
Olfactory Receptor OR11-312 3
OR11-312
Olfactory Receptor 51L12

External Ids:    HGNC: 147591   Entrez Gene: 1196822   Ensembl: ENSG000001767987   UniProtKB: Q8NGJ53   

Export aliases for OR51L1 gene to outside databases

Previous GC identifers: GC11U990314 GC11P004985


Summaries
for OR51L1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR51L1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR51L1 Gene:
OR51L1 (olfactory receptor, family 51, subfamily L, member 1) is a protein-coding gene. Diseases associated with OR51L1 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51T1.

UniProtKB/Swiss-Prot: O51L1_HUMAN, Q8NGJ5
Function: Odorant receptor (Potential)

Gene Wiki entry for OR51L1 Gene


Genomic Views
for OR51L1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR51L1 gene promoter:
         RP58   AML1a   SREBP-1c   Nkx5-1   Ik-3   E47   SREBP-1b   RORalpha1   SREBP-1a   Meis-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OR51L1 promoter sequence
   Search Chromatin IP Primers for OR51L1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR51L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

OR51L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR51L1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P004976:  view genomic region     (about GC identifiers)

Start:
 5,020,213 bp from pter      End:
 5,021,157 bp from pter
Size:
 945 bases      Orientation:
 plus strand

Proteins
for OR51L1 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: O51L1_HUMAN, Q8NGJ5 (See protein sequence)
Recommended Name: Olfactory receptor 51L1  
Size: 315 amino acids; 35369 Da
Secondary accessions: Q6IFE5

Explore the universe of human proteins at neXtProt for OR51L1: NX_Q8NGJ5

Explore proteomics data for OR51L1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
    • HORDE protein sequence for OR51L1

    See OR51L1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004755.1  
    ENSEMBL proteins: 
     ENSP00000322156  
    Reactome Protein details: Q8NGJ5

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    Domains /
    Families
    for OR51L1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    OR51: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGJ5

    ProtoNet protein and cluster: Q8NGJ5

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O51L1_HUMAN, Q8NGJ5
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR51L1 for domains           About GeneDecksing


    Function
    for OR51L1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O51L1_HUMAN, Q8NGJ5
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR51L1 for ontologies           About GeneDecksing


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    Localization
    for OR51L1 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O51L1_HUMAN, Q8NGJ5: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR51L1 for ontologies           About GeneDecksing


    Pathways & Interactions
    for OR51L1 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR51L1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    		Olfactory Signaling Pathway0.82
    		Olfactory transduction0.82
    2Signaling by GPCR
    		Signaling by GPCR0.90
    		Signal Transduction0.58
    		GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR51L1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR51L1):
        Olfactory transduction


    OR51L1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR51L1
    Interactions:

        Search GeneGlobe Interaction Network for OR51L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR51L1 (ENSP000003221564) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    GNALENSP000003340514STRING: ENSP00000334051
    GNGT1ENSP000002485724STRING: ENSP00000248572
    OR10A3ENSP000003539884STRING: ENSP00000353988
    OR10A4ENSP000003691574STRING: ENSP00000369157
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR51L1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for OR51L1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR51L1 (O51L1)



    Transcripts
    for OR51L1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR51L1 gene: 
    NM_001004755.1  

    Unigene Cluster for OR51L1:

    Olfactory receptor, family 51, subfamily L, member 1
    Hs.553559
    Unigene Representative Sequence: NM_001004755
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000321543(uc010qyu.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat OR51L1

    1 AceView cDNA sequence:

    NM_001004755 

    GeneLoc Exon Structure


    Expression
    for OR51L1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR51L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGACATCT
    OR51L1 Expression
    About this image

    OR51L1 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    OR51L1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553559
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    In Situ
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    Orthologs
    for OR51L1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    ENSEMBL Gene Tree for OR51L1 (if available)
    TreeFam Gene Tree for OR51L1 (if available)

    Paralogs
    for OR51L1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR51L1 gene
    OR51T12  OR51A42  OR51F22  OR51G22  OR51I12  OR51A72  OR51G12  OR51H1P2  
    OR51I22  OR51A22  OR51F12  
    Selected SIMAP similar genes for OR51L1 using alignment to 1 protein entry:     O51L1_HUMAN(see all similar genes):
    OR51G1    OR51G2    OR51I1    OR51A4    OR51H1P    OR51A2
    OR51A7    OR51B5    OR51F2    OR51I2    OR51V1    OR52K1
    OR52K2    OR51D1    OR51E1    OR51E2    OR51Q1    OR51B2

    OR51L1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for OR51L1
    PGOHUM00000242132 PGOHUM00000242569


    Genomic Variants
    for OR51L1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR51L1 (see all 129)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1504765291,2
    		C--5018270(+) GGTAGC/TTGACT 1 -- us2k10--------
    rs562025291,2
    		C,F--5018472(+) GATTCT/GAAATC 1 -- us2k17Minor allele frequency- G:0.16NA WA CSA EA 366
    rs562666191,2
    		C,F--5018483(+) AAGTCC/TTCTTT 1 -- us2k16Minor allele frequency- T:0.16WA NA CSA EA 364
    rs1874519451,2
    		--5018527(+) GTCTTC/TACGGT 1 -- us2k10--------
    rs1142018621,2
    		F--5018656(+) CCACAT/GTTGGA 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs750222981,2
    		--5018683(+) GATGAC/GGCTAA 1 -- us2k10--------
    rs79330461,2
    		C,F,A,H--5018751(+) GAATTA/GCTGAG 1 -- us2k116Minor allele frequency- G:0.27NA NS EA WA CSA 906
    rs1412166121,2
    		--5018788(+) AGTCTA/GTGAGG 1 -- us2k10--------
    rs1152345301,2
    		C,F--5018834(+) TCTCAG/AGGGCA 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs113845051,2
    		C--5018853(+) ACTAGA/-ACAGG 1 -- us2k11Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for OR51L1 ( 5020213 - 5021157 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for OR51L1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv526998CNV Loss19592680
    esv33877CNV Gain17666407
    dgv340e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    Disorders / Diseases
    for OR51L1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus    		 1 disease for OR51L1:    About MalaCards
    neuronitis


    OR51L1 for disorders           About GeneDecksing


    Export disorders for OR51L1 gene to outside databases

    Publications
    for OR51L1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for OR51L1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR51L1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. Genetic determinants of haemolysis in sickle cell anaemia. (PubMed id 23406172)1 Milton J.N....Steinberg M.H. (Br. J. Haematol. 2013)
    3. (PubMed id )2 

    External Searches for OR51L1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing OR51L1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 119682 HGNC: 14759 AceView: OR51L1 Ensembl:ENSG00000176798 euGenes: HUgn119682
    ECgene: OR51L1 Kegg: 119682 H-InvDB: OR51L1

    Other Databases showing OR51L1 gene

    (According to HUGE)
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    Specialized Databases showing OR51L1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR51L1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR51L1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    Intellectual Property
    for OR51L1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for OR51L1 gene:
    Search GeneIP for patents involving OR51L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for OR51L1 gene

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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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