OR51L1 Gene

Aliases
for OR51L1 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC11U990314 GC11P004985

Summaries
for OR51L1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for OR51L1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000011.9  NC_018922.2  NT_009237.19  

SwitchGear Promoter luciferase reporter plasmid: OR51L1 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR51L1

OR51L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P004976:  view genomic region     (about GC identifiers)

Proteins
for OR51L1 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for OR51L1: NX_Q8NGJ5

Explore proteomics data for OR51L1 at MOPED

Post-translational modifications: 

OR51L1 Human Recombinant Protein Products:

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	antibodies-online peptides for OR51L1

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OR51L1 Assay Products:

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Domains /
Families
for OR51L1 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q8NGJ5

Find genes that share domains with OR51L1           About GenesLikeMe

Function
for OR51L1 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for OR51L1

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		Predesigned siRNA for gene silencing in human, mouse, rat OR51L1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for OR51L1

Clone Products:		OriGene clones in human, mouse for OR51L1 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for OR51L1
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		Addgene plasmids for OR51L1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for OR51L1
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR51L1

Localization
for OR51L1 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	5

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for OR51L1 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for OR51L1 About     See pathways by source

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	SuperPath	Contained pathways About
1	Olfactory Signaling Pathway	Olfactory Signaling Pathway 0.82 Olfactory transduction 0.82
2	Signaling by GPCR	Signaling by GPCR 0.90 Signal Transduction 0.58 GPCR downstream signaling 0.90

1 Reactome Pathway for OR51L1

Olfactory Signaling Pathway

1 Kegg Pathway  (Kegg details for OR51L1)

Olfactory transduction

Gene Ontology (GO): 1 biological process term:    About this table

Drugs & Compounds
for OR51L1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for OR51L1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for OR51L1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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OR51L1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCAGACATCT

About this image

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for OR51L1
		Pre-validated RT2 qPCR Primer Assay in human, mouse / rat OR51L1
		QuantiTect SYBR Green Assays in human, mouse, rat OR51L1
		QuantiFast Probe-based Assays in human, mouse, rat OR51L1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR51L1

Orthologs
for OR51L1 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for OR51L1 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for OR51L1 gene

OR51T1²  OR51A4²  OR51F2²  OR51G2²  OR51I1²  OR51A7²  OR51G1²  OR51H1P²  

OR51I2²  OR51A2²  OR51F1²  

Selected SIMAP similar genes for OR51L1 using alignment to 1 protein entry:     O51L1_HUMAN(see all similar genes):

OR51G1    OR51G2    OR51I1    OR51A4    OR51H1P    OR51A2

OR51A7    OR51B5    OR51F2    OR51I2    OR51V1    OR52K1

OR52K2    OR51D1    OR51E1    OR51E2    OR51Q1    OR51B2

Find genes that share paralogs with OR51L1           About GenesLikeMe


2 Pseudogenes.org Pseudogenes for OR51L1
PGOHUM00000242132 PGOHUM00000242569

Genomic Variants
for OR51L1 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for OR51L1 (see all 129)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1504765291,2	C	--	5018270(+)	GGTAGC/TTGACT	1	--	us2k1		0	--	--	--	--
rs562025291,2	C,F	--	5018472(+)	GATTCT/GAAATC	1	--	us2k1		7		NA WA CSA EA	366
rs562666191,2	C,F	--	5018483(+)	AAGTCC/TTCTTT	1	--	us2k1		6		WA NA CSA EA	364
rs1874519451,2		--	5018527(+)	GTCTTC/TACGGT	1	--	us2k1		0	--	--	--	--
rs1142018621,2	F	--	5018656(+)	CCACAT/GTTGGA	1	--	us2k1		1		WA	118
rs750222981,2		--	5018683(+)	GATGAC/GGCTAA	1	--	us2k1		0	--	--	--	--
rs79330461,2	C,F,A,H	--	5018751(+)	GAATTA/GCTGAG	1	--	us2k1		16		NA NS EA WA CSA	906
rs1412166121,2		--	5018788(+)	AGTCTA/GTGAGG	1	--	us2k1		0	--	--	--	--
rs1152345301,2	C,F	--	5018834(+)	TCTCAG/AGGGCA	1	--	us2k1		1		WA	118
rs113845051,2	C	--	5018853(+)	ACTAGA/-ACAGG	1	--	us2k1		1		NA	2

HapMap Linkage Disequilibrium report for OR51L1 ( 5020213 - 5021157 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for OR51L1:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv526998	CNV	Loss	19592680
esv33877	CNV	Gain	17666407
dgv340e1	CNV	Complex	17122850

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing OR51L1

DNA2.0 Custom Variant and Variant Library Synthesis for OR51L1

Disorders / Diseases
for OR51L1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for OR51L1 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. The human olfactory receptor gene family. (PubMed id 14983052)^{1, 2} Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
2. Genetic determinants of haemolysis in sickle cell anaemia. (PubMed id 23406172)¹ Milton J.N....Steinberg M.H. (Br. J. Haematol. 2013)
3. (PubMed id )² 

External Searches for OR51L1 gene

Genome Databases showing OR51L1 gene

Other Databases showing OR51L1 gene

Specialized Databases showing OR51L1 gene

Products
for OR51L1 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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