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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

OR51L1 Gene

protein-coding GIFtS: 45
GCID: GC11P004976

Olfactory Receptor, Family 51, Subfamily L, Member 1

See related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 51, Subfamily L, Member 1¹ ²
Olfactory Receptor OR11-31² ³
OR11-31²
Olfactory Receptor 51L1²

External Ids:	HGNC: 14759¹	Entrez Gene: 119682²	Ensembl: ENSG00000176798⁷	UniProtKB: Q8NGJ5³

Export aliases for OR51L1 gene to outside databases

Previous GC identifers: GC11U990314 GC11P004985

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR51L1 Gene:

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the

perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled

receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain

structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G

protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the

genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent

of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR51L1 Gene:

OR51L1 (olfactory receptor, family 51, subfamily L, member 1) is a protein-coding gene. Diseases associated with OR51L1 include neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51M1.

UniProtKB/Swiss-Prot: O51L1_HUMAN, Q8NGJ5

Function: Odorant receptor (Potential)

Gene Wiki entry for OR51L1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.2 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the OR51L1 gene promoter:
RP58 AML1a SREBP-1c Nkx5-1 Ik-3 E47 SREBP-1b RORalpha1 SREBP-1a Meis-1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OR51L1 promoter sequence

Search SABiosciences Chromatin IP Primers for OR51L1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR51L1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.4

OR51L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR51L1 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P004976: view genomic region (about GC identifiers)

Start:	5,020,213 bp from pter	End:	5,021,157 bp from pter
Size:	945 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: O51L1_HUMAN, Q8NGJ5 (See protein sequence)

Recommended Name: Olfactory receptor 51L1

Size: 315 amino acids; 35369 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q6IFE5

Explore the universe of human proteins at neXtProt for OR51L1: NX_Q8NGJ5

Explore proteomics data for OR51L1 at MOPED

HORDE protein sequence for OR51L1
OR51L1 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_001004755.1

ENSEMBL proteins:

ENSP00000322156

Reactome Protein details: Q8NGJ5
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

OR51L1 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

OR51: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:

IPR017452 GPCR_Rhodpsn_7TM

IPR000725 Olfact_rcpt

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8NGJ5

ProtoNet protein and cluster: Q8NGJ5

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: O51L1_HUMAN, Q8NGJ5

Similarity: Belongs to the G-protein coupled receptor 1 family

OR51L1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: O51L1_HUMAN, Q8NGJ5

Function: Odorant receptor (Potential)

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004984	olfactory receptor activity	IEA	--

OR51L1 for ontologies About GeneDecksing

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for OR51L1 About

See pathways by source

SuperPath

Contained pathways About

Olfactory transduction

Olfactory Signaling Pathway

0.81

Olfactory transduction

0.81

Signaling by GPCR

	Signaling by GPCR	0.90			Signal Transduction	0.55
	GPCR downstream signaling	0.90

Pathways by source See SuperPaths
Show all pathways

4 Reactome Pathways for OR51L1

	GPCR downstream signaling
	Olfactory Signaling Pathway
	Signal Transduction
	Signaling by GPCR

1 Kegg Pathway (Kegg details for OR51L1):

Olfactory transduction

OR51L1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for OR51L1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/273 Interacting proteins for OR51L1 (ENSP00000322156⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 273)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
OR52E6	ENSP00000328878⁴	STRING: ENSP00000369279 STRING: ENSP00000328878
GNAL	ENSP00000334051⁴	STRING: ENSP00000334051
GNGT1	ENSP00000248572⁴	STRING: ENSP00000248572
OR10A3	ENSP00000353988⁴	STRING: ENSP00000353988
OR10A4	ENSP00000369157⁴	STRING: ENSP00000369157

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007186	G-protein coupled receptor signaling pathway	--	--

OR51L1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OR51L1 (O51L1)

Search CenterWatch for drugs/clinical trials and news about OR51L1 / O51L1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for OR51L1 gene:

NM_001004755.1

Unigene Cluster for OR51L1:

Olfactory receptor, family 51, subfamily L, member 1

Hs.553559

Unigene Representative Sequence: NM_001004755

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000321543(uc010qyu.2)

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1 AceView cDNA sequence:

NM_001004755

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OR51L1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCAGACATCT

About this image

See OR51L1 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.553559

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for OR51L1 gene from 1/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
rat (Rattus norvegicus)	Mammalia	Olr78¹	olfactory receptor 78	84.44(n) 87.94(a)		293221 NM_001000135.1 NP_001000135.1

ENSEMBL Gene Tree for OR51L1 (if available)
TreeFam Gene Tree for OR51L1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for OR51L1 gene

OR51M1² OR51T1² OR51C1P² OR51A4² OR51F2² OR51G2² OR51I1² OR51A7²

OR51G1² OR51H1P² OR51A2² OR51I2² OR51F1²

18/418 SIMAP similar genes for OR51L1 using alignment to 1 protein entry: O51L1_HUMAN(see all similar genes):

OR51G1 OR51G2 OR51I1 OR51A4 OR51H1P OR51A2

OR51A7 OR51B5 OR51F2 OR51I2 OR51V1 OR52K1

OR52K2 OR51D1 OR51E1 OR51E2 OR51Q1 OR51B2

OR51L1 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for OR51L1
PGOHUM00000242132 PGOHUM00000242569

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150476529^1,2	C	--	5018270(+)	`GGTAGC/TTGACT`	1	--	us2k¹		0	--	--	--	--
rs56202529^1,2	C,F	--	5018472(+)	`GATTCT/GAAATC`	1	--	us2k¹		7		NA WA CSA EA	366
rs56266619^1,2	C,F	--	5018483(+)	`AAGTCC/TTCTTT`	1	--	us2k¹		6		WA NA CSA EA	364
rs187451945^1,2		--	5018527(+)	`GTCTTC/TACGGT`	1	--	us2k¹		0	--	--	--	--
rs114201862^1,2	F	--	5018656(+)	`CCACAT/GTTGGA`	1	--	us2k¹		1		WA	118
rs75022298^1,2		--	5018683(+)	`GATGAC/GGCTAA`	1	--	us2k¹		0	--	--	--	--
rs7933046^1,2	C,F,A,H	--	5018751(+)	`GAATTA/GCTGAG`	1	--	us2k¹		16		NA NS EA WA CSA	906
rs141216612^1,2		--	5018788(+)	`AGTCTA/GTGAGG`	1	--	us2k¹		0	--	--	--	--
rs115234530^1,2	C,F	--	5018834(+)	`TCTCAG/AGGGCA`	1	--	us2k¹		1		WA	118
rs11384505^1,2	C	--	5018853(+)	`ACTAGA/-ACAGG`	1	--	us2k¹		1		NA	2

HapMap Linkage Disequilibrium report for OR51L1 ( 5020213 - 5021157 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for OR51L1: About this table

Variant ID	Type	Subtype	PubMed ID
nsv526998	CNV	Loss	19592680
esv33877	CNV	Gain	17666407
dgv340e1	CNV	Complex	17122850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

2 diseases for OR51L1: About MalaCards

neuronitis

OR51L1 for disorders About GeneDecksing

Export disorders for OR51L1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for OR51L1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR51L1)

Utopia: connect your pdf to the dynamic
world of online information

The human olfactory receptor gene family. (PubMed id 14983052)^{1, 2} Malnic B.... Buck L.B. (2004)
Genetic determinants of haemolysis in sickle cell anae mia. (PubMed id 23406172)¹ Milton J.N....Steinberg M.H. (2013)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 119682	HGNC: 14759	AceView: OR51L1	Ensembl:ENSG00000176798	euGenes: HUgn119682
ECgene: OR51L1	Kegg: 119682	H-InvDB: OR51L1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for OR51L1	Pharmacogenomics, SNPs, Pathways
HORDE entry for OR51L1	The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

Intellectual Property for OR51L1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for OR51L1 gene:
Search GeneIP for patents involving OR51L1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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Search Tocris compounds for OR51L1 (O51L1)

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	inGenious Targeting Laboratory - Custom generated mouse model solutions for OR51L1
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes OR51L1 gene at Home site.

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OR51L1 Gene

Olfactory Receptor, Family 51, Subfamily L, Member 1

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OR51L1 Gene

Olfactory Receptor, Family 51, Subfamily L, Member 1

Aliasesfor OR51L1 gene

Summariesfor OR51L1 gene

Genomic Viewsfor OR51L1 gene

Proteinsfor OR51L1 gene

Protein Domains /Familiesfor OR51L1 gene

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Genome Databases showing OR51L1 gene

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Specialized Databases showing OR51L1 gene

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for OR51L1 gene

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for OR51L1 gene

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for OR51L1 gene

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for OR51L1 gene

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for OR51L1 gene

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for OR51L1 gene

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for OR51L1 gene

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for OR51L1 gene

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for OR51L1 gene

Expression
for OR51L1 gene

Orthologs
for OR51L1 gene

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for OR51L1 gene

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for OR51L1 gene

Publications
for OR51L1 gene

Intellectual Property
for OR51L1 gene

Products
for OR51L1 gene