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Aliases for OR51I2 Gene

Aliases for OR51I2 Gene

  • Olfactory Receptor Family 51 Subfamily I Member 2 2 3 5
  • Odorant Receptor HOR5beta12 3 4
  • Olfactory Receptor OR11-38 3 4
  • Olfactory Receptor, Family 51, Subfamily I, Member 2 2
  • Olfactory Receptor 51I2 3
  • HOR5Beta12 3
  • OR11-38 3

External Ids for OR51I2 Gene

Previous GeneCards Identifiers for OR51I2 Gene

  • GC11U990513
  • GC11P005439
  • GC11P005431

Summaries for OR51I2 Gene

Entrez Gene Summary for OR51I2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51I2 Gene

OR51I2 (Olfactory Receptor Family 51 Subfamily I Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51I1.

UniProtKB/Swiss-Prot for OR51I2 Gene

  • Odorant receptor.

Gene Wiki entry for OR51I2 Gene

Additional gene information for OR51I2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR51I2 Gene

Genomics for OR51I2 Gene

Regulatory Elements for OR51I2 Gene

Enhancers for OR51I2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H005361 1.1 Ensembl ENCODE 9.3 -83.8 -83790 7 HINFP JUN CHAMP1 RELA IRF9 CC2D1A ZNF316 POLR2A NFE2 MAFK ENSG00000224091 OR51B5 OR51B4 OR51J1 OR51V1 OR52A4P HBB ENSG00000221031 OR51I2 ENSG00000167355
GH11H005550 0.9 Ensembl ENCODE 9.7 +101.6 101589 1 SMARCE1 JUN DPF2 FOSL1 JUND SMARCA4 CUX1 FOS HBE1 ENSG00000167355 HBG2 TRIM6 OR52D1 OR51I2 OLFM5P OR52H1 OR52H2P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR51I2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR51I2 Gene

Chromosome:
11
Start:
5,449,323 bp from pter
End:
5,456,518 bp from pter
Size:
7,196 bases
Orientation:
Plus strand

Genomic View for OR51I2 Gene

Genes around OR51I2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51I2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51I2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51I2 Gene

Proteins for OR51I2 Gene

  • Protein details for OR51I2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H344-O51I2_HUMAN
    Recommended name:
    Olfactory receptor 51I2
    Protein Accession:
    Q9H344
    Secondary Accessions:
    • Q6IF81

    Protein attributes for OR51I2 Gene

    Size:
    312 amino acids
    Molecular mass:
    35002 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51I2 Gene

Post-translational modifications for OR51I2 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR51I2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51I2 Gene

Domains & Families for OR51I2 Gene

Gene Families for OR51I2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR51I2 Gene

Suggested Antigen Peptide Sequences for OR51I2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H344

UniProtKB/Swiss-Prot:

O51I2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51I2: view

Function for OR51I2 Gene

Molecular function for OR51I2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR51I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 11121057
genes like me logo Genes that share ontologies with OR51I2: view

Phenotypes for OR51I2 Gene

genes like me logo Genes that share phenotypes with OR51I2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR51I2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51I2 Gene

Localization for OR51I2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51I2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR51I2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 11121057
genes like me logo Genes that share ontologies with OR51I2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR51I2 Gene

Pathways & Interactions for OR51I2 Gene

genes like me logo Genes that share pathways with OR51I2: view

Pathways by source for OR51I2 Gene

Interacting Proteins for OR51I2 Gene

Gene Ontology (GO) - Biological Process for OR51I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 11121057
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR51I2: view

No data available for SIGNOR curated interactions for OR51I2 Gene

Drugs & Compounds for OR51I2 Gene

No Compound Related Data Available

Transcripts for OR51I2 Gene

mRNA/cDNA for OR51I2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR51I2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR51I2 Gene

No ASD Table

Relevant External Links for OR51I2 Gene

GeneLoc Exon Structure for
OR51I2
ECgene alternative splicing isoforms for
OR51I2

Expression for OR51I2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR51I2 Gene

Protein differential expression in normal tissues from HIPED for OR51I2 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR51I2 Gene



Protein tissue co-expression partners for OR51I2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR51I2 Gene:

OR51I2

SOURCE GeneReport for Unigene cluster for OR51I2 Gene:

Hs.553733
genes like me logo Genes that share expression patterns with OR51I2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR51I2 Gene

Orthologs for OR51I2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR51I2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466379 33
  • 99.79 (n)
OR51I2 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR51I2 34
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC508808 33
  • 89.1 (n)
OR51I2 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr143 33
  • 88.35 (n)
mouse
(Mus musculus)
Mammalia Or51i2 52 Olfr641 33 16 34
  • 88.03 (n)
oppossum
(Monodelphis domestica)
Mammalia OR51I2 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 50 (a)
ManyToMany
Species where no ortholog for OR51I2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR51I2 Gene

ENSEMBL:
Gene Tree for OR51I2 (if available)
TreeFam:
Gene Tree for OR51I2 (if available)

Paralogs for OR51I2 Gene

Paralogs for OR51I2 Gene

(429) SIMAP similar genes for OR51I2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for OR51I2 Gene

genes like me logo Genes that share paralogs with OR51I2: view

Variants for OR51I2 Gene

Sequence variations from dbSNP and Humsavar for OR51I2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1002141931 -- 5,451,970(+) TAAGA(-/AAT)AATAT intron-variant, upstream-variant-2KB
rs1002851102 -- 5,452,233(+) GGCAC(A/G/T)GTGGC intron-variant, upstream-variant-2KB
rs1003367486 -- 5,453,222(+) TTATT(A/G)AAGTA intron-variant, upstream-variant-2KB
rs1003809537 -- 5,453,168(+) TATAT(A/G)CAAGT intron-variant, upstream-variant-2KB
rs1004091135 -- 5,452,905(+) GAAAA(-/G)CTCAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR51I2 Gene

Variant ID Type Subtype PubMed ID
dgv1042n100 CNV gain 25217958
esv2664205 CNV deletion 23128226
esv2759800 CNV loss 17122850
esv2761647 CNV loss 21179565
esv34391 CNV loss 17911159
esv3625225 CNV loss 21293372
esv3625227 CNV loss 21293372
nsv1039047 CNV gain 25217958
nsv1046068 CNV gain 25217958
nsv1048608 CNV gain 25217958
nsv832057 CNV loss 17160897

Variation tolerance for OR51I2 Gene

Residual Variation Intolerance Score: 93.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.06; 96.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR51I2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR51I2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR51I2 Gene

Disorders for OR51I2 Gene

Relevant External Links for OR51I2

Genetic Association Database (GAD)
OR51I2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR51I2

No disorders were found for OR51I2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR51I2 Gene

Publications for OR51I2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  2. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PMID: 11121057) Bulger M … Hardison R (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 60
  3. Genetic determinants of haemolysis in sickle cell anaemia. (PMID: 23406172) Milton JN … Steinberg MH (British journal of haematology 2013) 3 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60
  5. Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. (PMID: 10220430) Bulger M … von Doorninck JH (Proceedings of the National Academy of Sciences of the United States of America 1999) 3 60

Products for OR51I2 Gene

Sources for OR51I2 Gene

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