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OR51I1 Gene

protein-coding   GIFtS: 48
GCID: GC11M005418

Olfactory Receptor, Family 51, Subfamily I, Member 1

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 51, Subfamily I, Member 11 2
Odorant Receptor HOR5'Beta112 3
Olfactory Receptor OR11-392 3
HOR5'Beta112
Olfactory Receptor 51I12

External Ids:    HGNC: 152001   Entrez Gene: 3900632   Ensembl: ENSG000001673597   UniProtKB: Q9H3433   

Export aliases for OR51I1 gene to outside databases

Previous GC identifers: GC11U990514 GC11M005427 GC11M005409 GC11M005400


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR51I1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR51I1 Gene:
OR51I1 (olfactory receptor, family 51, subfamily I, member 1) is a protein-coding gene. Diseases associated with OR51I1 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51L1.

UniProtKB/Swiss-Prot: O51I1_HUMAN, Q9H343
Function: Odorant receptor (Potential)

Gene Wiki entry for OR51I1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR51I1 gene promoter:
         HOXA9   Max1   p53   Evi-1   C/EBPalpha   POU2F1   POU2F1a   FOXO1a   FOXO1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR51I1 promoter sequence
   Search Chromatin IP Primers for OR51I1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR51I1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

OR51I1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR51I1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M005418:  view genomic region     (about GC identifiers)

Start:
5,461,803 bp from pter      End:
5,462,744 bp from pter
Size:
942 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: O51I1_HUMAN, Q9H343 (See protein sequence)
Recommended Name: Olfactory receptor 51I1  
Size: 314 amino acids; 35484 Da
Secondary accessions: B9EKW2 Q6IF33

Explore the universe of human proteins at neXtProt for OR51I1: NX_Q9H343

Explore proteomics data for OR51I1 at MOPED

HORDE protein sequence for OR51I1

See OR51I1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001005288.1  
ENSEMBL proteins: 
 ENSP00000369559  
Reactome Protein details: Q9H343

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
OR51: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q9H343

ProtoNet protein and cluster: Q9H343

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: O51I1_HUMAN, Q9H343
Similarity: Belongs to the G-protein coupled receptor 1 family


OR51I1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: O51I1_HUMAN, Q9H343
Function: Odorant receptor (Potential)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity NAS11121057
     
OR51I1 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
O51I1_HUMAN, Q9H343: Cell membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral component of membrane NAS11121057

OR51I1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for OR51I1 About                                                                                                See pathways by source

SuperPathContained pathways About
1Olfactory Signaling Pathway
Olfactory Signaling Pathway0.82
Olfactory transduction0.82
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for OR51I1
    Olfactory Signaling Pathway


1 Kegg Pathway  (Kegg details for OR51I1):
    Olfactory transduction


OR51I1 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR51I1
Interactions:

    Search GeneGlobe Interaction Network for OR51I1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for OR51I1 (ENSP000003695594) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
InteractantInteraction Details
GeneCardExternal ID(s)
OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
OR10H2ENSP000003060954STRING: ENSP00000306095
OR10H3ENSP000003071304STRING: ENSP00000307130
OR10H4ENSP000003188344STRING: ENSP00000318834
OR1A1ENSP000003052074STRING: ENSP00000305207
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----
GO:0007608sensory perception of smell NAS11121057
GO:0050911detection of chemical stimulus involved in sensory perception of smell NAS11121057

OR51I1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for OR51I1 (O51I1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for OR51I1 gene: 
NM_001005288.2  

Unigene Cluster for OR51I1:

Olfactory receptor, family 51, subfamily I, member 1
Hs.553732
Unigene Representative Sequence: NM_001005288
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000380211(uc010qze.2)
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Additional mRNA sequence: BC151148.1 
GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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OR51I1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTCAACCCTA
OR51I1 Expression
About this image

OR51I1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

OR51I1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.553732
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for OR51I1 gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Olfr6401 , 5 olfactory receptor 6401, 5 83.71(n)1
88.18(a)1
  7 (54.85 cM)5
2588191  NM_146822.21  NP_667033.21 
 1040213725 


ENSEMBL Gene Tree for OR51I1 (if available)
TreeFam Gene Tree for OR51I1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for OR51I1 gene
OR51L12  OR51T12  OR51A42  OR51F22  OR51G22  OR51A72  OR51G12  OR51H1P2  
OR51A22  OR51I22  OR51F12  
Selected SIMAP similar genes for OR51I1 using alignment to 1 protein entry:     O51I1_HUMAN(see all similar genes):
OR51I2    OR51L1    OR51H1P    OR51F1    OR51F2    OR51G1
OR51G2    OR51Q1    OR51A7    OR51B5    OR51A4    OR51M1
OR51V1    OR51A2    OR51B2    OR51D1    OR51E1    OR51E2

OR51I1 for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for OR51I1
PGOHUM00000242143 PGOHUM00000262862


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for OR51I1 (see all 139)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs108381081,2
C,F,A,H--5461297(+) CTTCAC/GAAGCT 1 -- ds500127Minor allele frequency- G:0.29NS EA NA WA CSA 2770
rs1176700631,2
F--5461398(+) TGTCTC/TTCTTT 1 -- ds50011Minor allele frequency- T:0.01NA 120
rs1926331761,2
--5461409(+) AATATC/TTATTA 1 -- ds50010--------
rs1843304881,2
--5461421(+) CTCCTC/TCACTC 1 -- ds50010--------
rs777885431,2
C,F--5461441(+) GCAGAA/GTTATT 1 -- ds50011Minor allele frequency- G:0.03NA 120
rs1147795451,2
C,F--5461488(+) TTCCCG/ATATAT 1 -- ds50011Minor allele frequency- A:0.03WA 118
rs1891073731,2
--5461495(+) ATATGC/TCAAAC 1 -- ds50010--------
rs1815792731,2
--5461572(+) GACAAC/TATTTC 1 -- ds50010--------
rs1408187841,2
--5461685(+) AGTGAC/TACATT 1 -- ds50010--------
rs2006727871,2
C--5461752(+) TTAACA/GTGTCC 1 -- ds50010--------

HapMap Linkage Disequilibrium report for OR51I1 ( 5461803 - 5462744 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for OR51I1:    About this table    
Variant IDTypeSubtypePubMed ID
esv2664205CNV Deletion23128226
nsv832057CNV Loss17160897
nsv896931CNV Loss21882294
esv34391CNV Loss17911159
dgv1025n71CNV Loss21882294
essv3627CNV CNV17122850

Human Gene Mutation Database (HGMD): OR51I1
Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for OR51I1:    About MalaCards
neuronitis


OR51I1 for disorders           About GeneDecksing

Genetic Association Database (GAD): OR51I1

Export disorders for OR51I1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for OR51I1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with OR51I1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
  2. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PubMed id 11121057)1, 2 Bulger M.... Hardison R. (Proc. Natl. Acad. Sci. U.S.A. 2000)
  3. Genetic determinants of haemolysis in sickle cell anaemia. (PubMed id 23406172)1 Milton J.N....Steinberg M.H. (Br. J. Haematol. 2013)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  6. Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. (PubMed id 10220430)1 Bulger M.... Groudine M. (Proc. Natl. Acad. Sci. U.S.A. 1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 390063 HGNC: 15200 Ensembl:ENSG00000167359 euGenes: HUgn390063 ECgene: OR51I1 Kegg: 390063
H-InvDB: OR51I1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for OR51I1 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR51I1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for OR51I1 gene:
Search GeneIP for patents involving OR51I1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR51I1
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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