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OR51G2 Gene

protein-coding   GIFtS: 47
GCID: GC11M004936

Olfactory Receptor, Family 51, Subfamily G, Member 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 51, Subfamily G, Member 21 2
Olfactory Receptor OR11-282 3
OR11-282
Olfactory Receptor 51G22

External Ids:    HGNC: 151981   Entrez Gene: 812822   Ensembl: ENSG000001768937   UniProtKB: Q8NGK03   

Export aliases for OR51G2 gene to outside databases

Previous GC identifers: GC11U990516 GC11M004892


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR51G2 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR51G2 Gene:
OR51G2 (olfactory receptor, family 51, subfamily G, member 2) is a protein-coding gene. Diseases associated with OR51G2 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51L1.

UniProtKB/Swiss-Prot: O51G2_HUMAN, Q8NGK0
Function: Odorant receptor (Potential)

Gene Wiki entry for OR51G2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR51G2 gene promoter:
         COUP-TF1   COUP-TF   AP-1   POU2F1   POU2F1a   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR51G2 promoter sequence
   Search Chromatin IP Primers for OR51G2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR51G2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

OR51G2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR51G2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M004936:  view genomic region     (about GC identifiers)

Start:
4,935,952 bp from pter      End:
4,936,893 bp from pter
Size:
942 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: O51G2_HUMAN, Q8NGK0 (See protein sequence)
Recommended Name: Olfactory receptor 51G2  
Size: 314 amino acids; 35012 Da
Secondary accessions: Q6IFH7

Explore the universe of human proteins at neXtProt for OR51G2: NX_Q8NGK0

Explore proteomics data for OR51G2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn8
  • HORDE protein sequence for OR51G2

    See OR51G2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001005238.1  
    ENSEMBL proteins: 
     ENSP00000322593  
    Reactome Protein details: Q8NGK0

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR51: GPCR / Class A : Olfactory receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR019424 7TM_GPCR_olfarory/Srsx
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGK0

    ProtoNet protein and cluster: Q8NGK0

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O51G2_HUMAN, Q8NGK0
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR51G2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O51G2_HUMAN, Q8NGK0
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR51G2 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O51G2_HUMAN, Q8NGK0: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR51G2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR51G2 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR51G2
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR51G2):
        Olfactory transduction


    OR51G2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR51G2
    Interactions:

        Search GeneGlobe Interaction Network for OR51G2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR51G2 (ENSP000003225934) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10J1ENSP000003990784STRING: ENSP00000399078
    OR1B1ENSP000003031514STRING: ENSP00000303151
    OR2L13ENSP000003508364STRING: ENSP00000350836
    OR4C5ENSP000003213384STRING: ENSP00000321338
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR51G2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR51G2 (O51G2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR51G2 gene: 
    NM_001005238.1  

    Unigene Cluster for OR51G2:

    Olfactory receptor, family 51, subfamily G, member 2
    Hs.542302  [show with all ESTs]
    Unigene Representative Sequence: BC136830
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000322013(uc001lzr.1)
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    Additional mRNA sequence: 

    BC136830.1 BC136831.1 

    1 DOTS entry:

    DT.120758783 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR51G2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTTTGTTA
    OR51G2 Expression
    About this image

    OR51G2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR51G2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.542302
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR51G2 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr5771 , 5 olfactory receptor 5771, 5 85.62(n)1
    92.64(a)1
      7 (54.85 cM)5
    2591131  NM_147109.11  NP_667320.11 
     1029730525 


    ENSEMBL Gene Tree for OR51G2 (if available)
    TreeFam Gene Tree for OR51G2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR51G2 gene
    OR51L12  OR51T12  OR51A42  OR51F22  OR51I12  OR51A72  OR51G12  OR51H1P2  
    OR51I22  OR51A22  OR51F12  
    Selected SIMAP similar genes for OR51G2 using alignment to 1 protein entry:     O51G2_HUMAN(see all similar genes):
    OR51L1    OR52K3P    OR51G1    OR51A7    OR51E1    OR51E2
    OR51F2    OR51H1P    OR51I2    OR52K1    OR51D1    OR51Q1
    OR52K2    OR51F1    OR51I1    OR51V1    OR52M1    OR51A4

    OR51G2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for OR51G2
    PGOHUM00000242564 PGOHUM00000242570


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR51G2 (see all 143)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs71121011,2
    C,F,A,H--4935470(+) gggccT/Ctctcc 1 -- ds500132Minor allele frequency- C:0.45NS EA NA WA CSA 3189
    rs1857625161,2
    --4935480(+) CACGTC/TGCCTG 1 -- ds50010--------
    rs1431037171,2
    --4935545(+) ACAGAA/GACAGT 1 -- ds50010--------
    rs128029221,2
    C,F,A,H--4935610(+) caataC/Ttcaat 1 -- ds500121Minor allele frequency- T:0.06NS EA NA 2206
    rs1482176571,2
    --4935636(+) AAATTC/GTATCC 1 -- ds50010--------
    rs1411823661,2
    --4935684(+) TGAGGA/GGTAGC 1 -- ds50010--------
    rs1912092121,2
    --4935685(+) GAGGAA/GTAGCA 1 -- ds50010--------
    rs1838199741,2
    --4935688(+) GAGTAA/GCAAGT 1 -- ds50010--------
    rs1136512321,2
    F--4935717(+) GTTTAC/GAATTA 1 -- ds50011Minor allele frequency- G:0.00CSA 1
    rs113780881,2
    C--4935774(+) TTTTA-/CCCCCC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for OR51G2 ( 4935952 - 4936893 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for OR51G2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv507580CNV Insertion20534489
    dgv340e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for OR51G2:    
    About MalaCards
    neuronitis


    OR51G2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): OR51G2

    Export disorders for OR51G2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR51G2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR51G2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (BMC Med. Genet. 2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Natural selection on the olfactory receptor gene family in humans and chimpanzees. (PubMed id 12908129)1 Gilad Y.... Paabo S. (Am. J. Hum. Genet. 2003)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81282 HGNC: 15198 Ensembl:ENSG00000176893 euGenes: HUgn81282 ECgene: OR51G2 Kegg: 81282
    H-InvDB: OR51G2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR51G2 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR51G2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR51G2 gene:
    Search GeneIP for patents involving OR51G2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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