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Aliases for OR51G2 Gene

Aliases for OR51G2 Gene

  • Olfactory Receptor Family 51 Subfamily G Member 2 2 3 5
  • Olfactory Receptor OR11-28 3 4
  • Olfactory Receptor, Family 51, Subfamily G, Member 2 2
  • Olfactory Receptor 51G2 3
  • OR11-28 3

External Ids for OR51G2 Gene

Previous GeneCards Identifiers for OR51G2 Gene

  • GC11U990516
  • GC11M004892
  • GC11M004936

Summaries for OR51G2 Gene

Entrez Gene Summary for OR51G2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51G2 Gene

OR51G2 (Olfactory Receptor Family 51 Subfamily G Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51G1.

UniProtKB/Swiss-Prot for OR51G2 Gene

  • Odorant receptor.

Gene Wiki entry for OR51G2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR51G2 Gene

Genomics for OR51G2 Gene

Regulatory Elements for OR51G2 Gene

Enhancers for OR51G2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F004492 0.3 FANTOM5 8.4 +423.2 423248 0.1 OR52K2 OR51F1 OR52B4 OR51S1 OR51G2 OR51A4 OR52K1 C11orf40 OR52R1 OR51A7
GH11F005379 0.4 FANTOM5 1.9 -464.3 -464329 0.0 ZNF316 OR51V1 OR51T1 HBB OR51B5 OR51G1 OR56B1 OR52J3 OR51L1 OR52N4 OR52D1
GH11F005328 0.3 FANTOM5 2.2 -413.5 -413516 0.4 OR51G1 OR51T1 OR52N2 OR52N4 OR52D1 OR52J3 MMP26 OR51L1 OR51B2 OR51M1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR51G2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR51G2 Gene

Chromosome:
11
Start:
4,914,719 bp from pter
End:
4,915,663 bp from pter
Size:
945 bases
Orientation:
Minus strand

Genomic View for OR51G2 Gene

Genes around OR51G2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51G2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51G2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51G2 Gene

Proteins for OR51G2 Gene

  • Protein details for OR51G2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGK0-O51G2_HUMAN
    Recommended name:
    Olfactory receptor 51G2
    Protein Accession:
    Q8NGK0
    Secondary Accessions:
    • Q6IFH7

    Protein attributes for OR51G2 Gene

    Size:
    314 amino acids
    Molecular mass:
    35012 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51G2 Gene

Post-translational modifications for OR51G2 Gene

  • Glycosylation at Asn 8
  • Modification sites at PhosphoSitePlus

Other Protein References for OR51G2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51G2 Gene

Domains & Families for OR51G2 Gene

Gene Families for OR51G2 Gene

Protein Domains for OR51G2 Gene

Suggested Antigen Peptide Sequences for OR51G2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGK0

UniProtKB/Swiss-Prot:

O51G2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51G2: view

Function for OR51G2 Gene

Molecular function for OR51G2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR51G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR51G2: view
genes like me logo Genes that share phenotypes with OR51G2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51G2 Gene

Localization for OR51G2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51G2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR51G2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR51G2: view

Pathways & Interactions for OR51G2 Gene

genes like me logo Genes that share pathways with OR51G2: view

Pathways by source for OR51G2 Gene

Gene Ontology (GO) - Biological Process for OR51G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA,IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR51G2: view

No data available for SIGNOR curated interactions for OR51G2 Gene

Transcripts for OR51G2 Gene

mRNA/cDNA for OR51G2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR51G2 Gene

Olfactory receptor, family 51, subfamily G, member 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR51G2 Gene

No ASD Table

Relevant External Links for OR51G2 Gene

GeneLoc Exon Structure for
OR51G2
ECgene alternative splicing isoforms for
OR51G2

Expression for OR51G2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR51G2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR51G2 Gene:

OR51G2

SOURCE GeneReport for Unigene cluster for OR51G2 Gene:

Hs.542302
genes like me logo Genes that share expression patterns with OR51G2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR51G2 Gene

Orthologs for OR51G2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR51G2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 35
  • 90 (a)
OneToMany
LOC508595 34
  • 88.14 (n)
-- 35
  • 87 (a)
OneToMany
dog
(Canis familiaris)
Mammalia OR51G2 34 35
  • 89.71 (n)
rat
(Rattus norvegicus)
Mammalia Olr69 34
  • 86.18 (n)
mouse
(Mus musculus)
Mammalia Or51g2 55 Olfr577 34 16 35
  • 85.62 (n)
Or51aa2 55 Olfr612
  • chr7:103,538,264-103,539,232
Or51aa5 55 Olfr611
  • chr7:103,517,414-103,518,382
Or51ac3 55 Olfr616
  • chr7:103,564,327-103,565,277
Or51af1 55 Olfr609
  • chr7:103,491,920-103,492,876
Or51ag1 55 Olfr610
  • chr7:103,506,000-103,506,944
Or51l14 55 Olfr606
  • chr7:103,451,339-103,452,295
Or51l4 55 Olfr630
  • chr7:103,754,627-103,755,583
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 54 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 50 (a)
ManyToMany
Species where no ortholog for OR51G2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR51G2 Gene

ENSEMBL:
Gene Tree for OR51G2 (if available)
TreeFam:
Gene Tree for OR51G2 (if available)

Paralogs for OR51G2 Gene

(413) SIMAP similar genes for OR51G2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR51G2 Gene

genes like me logo Genes that share paralogs with OR51G2: view

Variants for OR51G2 Gene

Sequence variations from dbSNP and Humsavar for OR51G2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10500625 -- 4,917,388(-) AAAGA(A/G)TAATC upstream-variant-2KB
rs10500626 -- 4,916,649(-) ACTTG(A/G)ACAAG upstream-variant-2KB
rs111557850 -- 4,915,755(+) TAAAG(-/A)AAAAA upstream-variant-2KB
rs113119333 -- 4,915,896(+) ATTGT(C/G)AAGTG upstream-variant-2KB
rs11318208 -- 4,914,545(+) TTTTA(-/C)CCCCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR51G2 Gene

Variant ID Type Subtype PubMed ID
esv2759799 CNV loss 17122850
esv3891914 CNV gain 25118596
nsv1054847 CNV gain 25217958
nsv507580 OTHER sequence alteration 20534489

Variation tolerance for OR51G2 Gene

Residual Variation Intolerance Score: 80.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.42; 71.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR51G2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR51G2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR51G2 Gene

Disorders for OR51G2 Gene

Relevant External Links for OR51G2

Genetic Association Database (GAD)
OR51G2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR51G2

No disorders were found for OR51G2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR51G2 Gene

Publications for OR51G2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel D.P. … Karasik D. (BMC Med. Genet. 2007) 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Natural selection on the olfactory receptor gene family in humans and chimpanzees. (PMID: 12908129) Gilad Y. … Paabo S. (Am. J. Hum. Genet. 2003) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR51G2 Gene

Sources for OR51G2 Gene

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