Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR51G2 Gene

Aliases for OR51G2 Gene

  • Olfactory Receptor, Family 51, Subfamily G, Member 2 2 3
  • Olfactory Receptor OR11-28 3 4
  • OR11-28 3

External Ids for OR51G2 Gene

Previous GeneCards Identifiers for OR51G2 Gene

  • GC11U990516
  • GC11M004892
  • GC11M004936

Summaries for OR51G2 Gene

Entrez Gene Summary for OR51G2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51G2 Gene

OR51G2 (Olfactory Receptor, Family 51, Subfamily G, Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51I2.

UniProtKB/Swiss-Prot for OR51G2 Gene

  • Odorant receptor.

Gene Wiki entry for OR51G2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR51G2 Gene

Genomics for OR51G2 Gene

Regulatory Elements for OR51G2 Gene

Genomic Location for OR51G2 Gene

Chromosome:
11
Start:
4,914,719 bp from pter
End:
4,915,663 bp from pter
Size:
945 bases
Orientation:
Minus strand

Genomic View for OR51G2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR51G2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51G2 Gene

Proteins for OR51G2 Gene

  • Protein details for OR51G2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGK0-O51G2_HUMAN
    Recommended name:
    Olfactory receptor 51G2
    Protein Accession:
    Q8NGK0
    Secondary Accessions:
    • Q6IFH7

    Protein attributes for OR51G2 Gene

    Size:
    314 amino acids
    Molecular mass:
    35012 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51G2 Gene

Proteomics data for OR51G2 Gene at MOPED

Post-translational modifications for OR51G2 Gene

  • Glycosylation at Asn 8
  • Modification sites at PhosphoSitePlus

Other Protein References for OR51G2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51G2 Gene

Domains & Families for OR51G2 Gene

Gene Families for OR51G2 Gene

Protein Domains for OR51G2 Gene

Suggested Antigen Peptide Sequences for OR51G2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGK0

UniProtKB/Swiss-Prot:

O51G2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51G2: view

Function for OR51G2 Gene

Molecular function for OR51G2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR51G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR51G2: view
genes like me logo Genes that share phenotypes with OR51G2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR51G2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51G2 Gene

Localization for OR51G2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51G2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR51G2 Gene COMPARTMENTS Subcellular localization image for OR51G2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR51G2: view

Pathways & Interactions for OR51G2 Gene

genes like me logo Genes that share pathways with OR51G2: view

Pathways by source for OR51G2 Gene

Interacting Proteins for OR51G2 Gene

Gene Ontology (GO) - Biological Process for OR51G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IBA --
genes like me logo Genes that share ontologies with OR51G2: view

No data available for SIGNOR curated interactions for OR51G2 Gene

Drugs & Compounds for OR51G2 Gene

No Compound Related Data Available

Transcripts for OR51G2 Gene

mRNA/cDNA for OR51G2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR51G2 Gene

Olfactory receptor, family 51, subfamily G, member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR51G2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR51G2 Gene

No ASD Table

Relevant External Links for OR51G2 Gene

GeneLoc Exon Structure for
OR51G2
ECgene alternative splicing isoforms for
OR51G2

Expression for OR51G2 Gene

mRNA expression in normal human tissues for OR51G2 Gene

SOURCE GeneReport for Unigene cluster for OR51G2 Gene Hs.542302

genes like me logo Genes that share expression patterns with OR51G2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR51G2 Gene

Orthologs for OR51G2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR51G2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC508595 35
  • 88.14 (n)
  • 89.74 (a)
-- 36
  • 90 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
dog
(Canis familiaris)
Mammalia OR51G2 35
  • 89.71 (n)
  • 93.29 (a)
OR51G2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr577 35
  • 85.62 (n)
  • 92.64 (a)
Olfr577 16
Olfr577 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr69 35
  • 86.18 (n)
  • 92.64 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 50 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 54 (a)
ManyToMany
Species with no ortholog for OR51G2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR51G2 Gene

ENSEMBL:
Gene Tree for OR51G2 (if available)
TreeFam:
Gene Tree for OR51G2 (if available)

Paralogs for OR51G2 Gene

(413) SIMAP similar genes for OR51G2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR51G2 Gene

genes like me logo Genes that share paralogs with OR51G2: view

Variants for OR51G2 Gene

Sequence variations from dbSNP and Humsavar for OR51G2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs919900 -- 4,915,908(+) TGAGC(C/T)AAACT upstream-variant-2KB
rs956917 -- 4,916,222(+) ggcag(G/T)ggctg upstream-variant-2KB
rs2570580 -- 4,917,122(+) GAACA(C/T)GCCCC upstream-variant-2KB
rs2595976 -- 4,917,183(-) TTAGC(G/T)AAATA upstream-variant-2KB
rs2595977 -- 4,916,089(-) CGCCC(A/G)CCTCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR51G2 Gene

Variant ID Type Subtype PubMed ID
dgv340e1 CNV Complex 17122850
nsv507580 CNV Insertion 20534489

Variation tolerance for OR51G2 Gene

Residual Variation Intolerance Score: 80.94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.42; 71.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR51G2 Gene

HapMap Linkage Disequilibrium report
OR51G2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR51G2 Gene

Disorders for OR51G2 Gene

Relevant External Links for OR51G2

Genetic Association Database (GAD)
OR51G2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR51G2
genes like me logo Genes that share disorders with OR51G2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR51G2 Gene

Publications for OR51G2 Gene

  1. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel D.P. … Karasik D. (BMC Med. Genet. 2007) 67
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 67
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  4. Natural selection on the olfactory receptor gene family in humans and chimpanzees. (PMID: 12908129) Gilad Y. … Paabo S. (Am. J. Hum. Genet. 2003) 67
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for OR51G2 Gene

Sources for OR51G2 Gene

Back to Top

Content