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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR51F1 Gene

protein-coding   GIFtS: 43
GCID: GC11M004790

Olfactory Receptor, Family 51, Subfamily F, Member 1


(Previous symbol: OR51F1P)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 51, Subfamily F, Member 11 2
OR51F1P1 2 3
OR11-212
Olfactory Receptor 51F12
Olfactory Receptor OR11-21 Pseudogene2
Olfactory Receptor, Family 51, Subfamily F, Member 1 Pseudogene2

External Ids:    HGNC: 151961   Entrez Gene: 2568922   Ensembl: ENSG000001880697   UniProtKB: A6NGY53   

Export aliases for OR51F1 gene to outside databases

Previous GC identifers: GC11M004756 GC11M004746


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR51F1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR51F1 Gene: 
OR51F1 (olfactory receptor, family 51, subfamily F, member 1) is a protein-coding gene. Diseases associated with OR51F1 include neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51M1.

UniProtKB/Swiss-Prot: O51F1_HUMAN, A6NGY5
Function: Odorant receptor (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR51F1 gene promoter:
         RP58   Nkx6-1   HSF2   HSF1short   HSF1 (long)   Ik-3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for OR51F1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR51F1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

OR51F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR51F1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M004790:  view genomic region     (about GC identifiers)

Start:
4,790,212 bp from pter      End:
4,791,147 bp from pter
Size:
936 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: O51F1_HUMAN, A6NGY5 (See protein sequence)
Recommended Name: Olfactory receptor 51F1  
Size: 319 amino acids; 35849 Da
Subcellular location: Cell membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for OR51F1: NX_A6NGY5

Explore proteomics data for OR51F1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A6NGY5

  • HORDE protein sequence for OR51F1
    OR51F1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OR51F1 Protein Expression
    REFSEQ proteins: NP_001004752.1  
    ENSEMBL proteins: 
     ENSP00000345163   ENSP00000369744  
    Reactome Protein details: A6NGY5
    Human Recombinant Protein Products for OR51F1: 
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    Cloud-Clone Corp. Proteins for OR51F1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    OR51F1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    OR51: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry A6NGY5

    ProtoNet protein and cluster: A6NGY5

    UniProtKB/Swiss-Prot: O51F1_HUMAN, A6NGY5
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR51F1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O51F1_HUMAN, A6NGY5
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR51F1 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for OR51F1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Olfactory transduction
    Olfactory Signaling Pathway0.81
    Olfactory transduction0.81
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for OR51F1
        GPCR downstream signaling
    Olfactory Signaling Pathway
    Signal Transduction
    Signaling by GPCR


    1         Kegg Pathway  (Kegg details for OR51F1):
        Olfactory transduction


    OR51F1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR51F1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/273 Interacting proteins for OR51F1 (ENSP000003451634) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10J5ENSP000003344414STRING: ENSP00000334441
    OR2G3ENSP000003263014STRING: ENSP00000326301
    OR6Y1ENSP000003048074STRING: ENSP00000304807
    GNALENSP000003340514STRING: ENSP00000334051
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR51F1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OR51F1 (O51F1)

    Search CenterWatch for drugs/clinical trials and news about OR51F1 / O51F1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OR51F1 gene: 
    NM_001004752.1  

    Unigene Cluster for OR51F1:

    Olfactory receptor, family 51, subfamily F, member 1
    Hs.553659
    Unigene Representative Sequence: NM_001004752
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343430(uc010qyl.2) ENST00000380383
    miRNA
    Products:
         
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate OR51F1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OR51F1
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                         Customized lentivirus expression plasmids for stable overexpression of OR51F1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR51F1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR51F1

    1 AceView cDNA sequence:

    NM_001004752 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OR51F1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAGCCTGT
    OR51F1 Expression
    About this image


    See OR51F1 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.553659
        SABiosciences Custom PCR Arrays for OR51F1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR51F1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR51F1 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr5855
    Olfr5661
    olfactory receptor 5855
    olfactory receptor 5661
    83.07(n)1
    81.99(a)1
      7 (54.85 cM)5
    2581681  NM_001011536.11  NP_001011536.11 
     1030977435 


    ENSEMBL Gene Tree for OR51F1 (if available)
    TreeFam Gene Tree for OR51F1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OR51F1 gene
    OR51M12  OR51L12  OR51T12  OR51C1P2  OR51A42  OR51F22  OR51G22  OR51I12  
    OR51A72  OR51G12  OR51H1P2  OR51A22  OR51I22  
    18/358 SIMAP similar genes for OR51F1 using alignment to 2 protein entries:     O51F1_HUMAN (see all proteins) (see all similar genes):
    OR51F2    OR51C1P    OR51G2    OR51I1    OR51T1    OR51I2
    OR51B2    OR51G1    OR51A1P    OR51A4    OR51B5    OR51B6
    OR51E2    OR51L1    OR52N1    OR51M1    OR51V1    OR51A2

    OR51F1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: O51F1_HUMAN, A6NGY5
    Polymorphism: A single nucleotide deletion at position Arg-92 in the gene coding for this protein is responsible
    for functional diversity thus producing a pseudogene. The deletion is more frequent in African-Americans than in
    non-Africans


    10/152 SNPs in OR51F1 are shown (see all 152)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs792901141,2
    --4789745(+) GAAGAA/GCATAG 1 -- ds50010--------
    rs1398201891,2
    C--4789769(+) GAACAC/TCTGGG 1 -- ds50010--------
    rs14339151,2
    C,F,A,H--4789862(-) attagC/Tgatat 1 -- ds500110Minor allele frequency- T:0.23NS EA WA CSA NA 623
    rs14339141,2
    C,F,A,H--4789887(-) acagcG/Aaaatg 1 -- ds500128Minor allele frequency- A:0.23NS EA NA WA CSA 2744
    rs1431215071,2
    --4789991(+) ATTTAC/TCATTT 1 -- ds50010--------
    rs10307271,2
    C,F,A,H--4790070(-) TTGTAT/CATTTG 1 -- ds500116Minor allele frequency- C:0.21NS EA NA WA CSA 781
    rs79247271,2
    H--4790112(+) TATTTT/AAAAAA 1 -- ds50014Minor allele frequency- A:0.00NS EA 410
    rs2015822721,2
    --4790182(+) GCCAGC/GTTTGT 1 -- ds50010--------
    rs1474711851,2
    C,F--4790214(+) TCATTT/CTGTAA 2 /K /E mis11Minor allele frequency- C:0.00NA 4536
    rs10307261,2,4
    C,F,A,H--4790268(-) TCATCG/TACAGT 2 D Y mis1 ese326Minor allele frequency- T:0.31NS EA NA WA CSA EU 8157

    HapMap Linkage Disequilibrium report for OR51F1 ( 4790212 - 4791147 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for OR51F1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv29053CNV Loss19812545
    nsv896916CNV Loss21882294
    nsv896911CNV Gain21882294
    nsv832056CNV Gain17160897
    nsv896915CNV Gain21882294


    Human Gene Mutation Database (HGMD): OR51F1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for OR51F1:    About MalaCards
    neuronitis    


    OR51F1 for disorders           About GeneDecksing


    Export disorders for OR51F1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OR51F1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with OR51F1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    2. The human olfactory receptor gene family. (PubMed id 14983052)1 Malnic B.... Buck L.B. (2004)
    3. Population differences in the human functional olfactory repertoire. (PubMed id 12644552)1 Gilad Y. and Lancet D. (2003)
    4. Different noses for different people. (PubMed id 12730696)2 Menashe I.... Gilad Y. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 256892 HGNC: 15196 AceView: OR51F1 Ensembl:ENSG00000188069 euGenes: HUgn256892
    ECgene: OR51F1 Kegg: 256892 H-InvDB: OR51F1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OR51F1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR51F1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OR51F1 gene:
    Search GeneIP for patents involving OR51F1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Proteins for OR51F1
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     Search ThermoFisher Antibodies for OR51F1
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     inGenious Targeting Laboratory - Custom generated mouse model solutions for OR51F1
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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