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OR51F1 Gene

protein-coding   GIFtS: 42
GCID: GC11M004790

Olfactory Receptor, Family 51, Subfamily F, Member 1


(Previous symbol: OR51F1P)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 51, Subfamily F, Member 11 2
OR51F1P1 2 3
OR11-212
Olfactory Receptor 51F12
Olfactory Receptor OR11-21 Pseudogene2
Olfactory Receptor, Family 51, Subfamily F, Member 1 Pseudogene2

External Ids:    HGNC: 151961   Entrez Gene: 2568922   Ensembl: ENSG000001880697   UniProtKB: A6NGY53   

Export aliases for OR51F1 gene to outside databases

Previous GC identifers: GC11M004756 GC11M004746


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR51F1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR51F1 Gene:
OR51F1 (olfactory receptor, family 51, subfamily F, member 1) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51L1.

UniProtKB/Swiss-Prot: O51F1_HUMAN, A6NGY5
Function: Odorant receptor (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR51F1 gene promoter:
         RP58   Nkx6-1   HSF2   HSF1short   HSF1 (long)   Ik-3   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR51F1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

OR51F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR51F1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M004790:  view genomic region     (about GC identifiers)

Start:
4,790,212 bp from pter      End:
4,791,147 bp from pter
Size:
936 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB/Swiss-Prot: O51F1_HUMAN, A6NGY5 (See protein sequence)
Recommended Name: Olfactory receptor 51F1  
Size: 319 amino acids; 35849 Da

Explore the universe of human proteins at neXtProt for OR51F1: NX_A6NGY5

Explore proteomics data for OR51F1 at MOPED

HORDE protein sequence for OR51F1

See OR51F1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001004752.1  
ENSEMBL proteins: 
 ENSP00000345163   ENSP00000369744  
Reactome Protein details: A6NGY5

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
OR51: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry A6NGY5

ProtoNet protein and cluster: A6NGY5

UniProtKB/Swiss-Prot: O51F1_HUMAN, A6NGY5
Similarity: Belongs to the G-protein coupled receptor 1 family


Find genes that share domains with OR51F1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: O51F1_HUMAN, A6NGY5
Function: Odorant receptor (Potential)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--
     
Find genes that share ontologies with OR51F1           About GenesLikeMe


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
O51F1_HUMAN, A6NGY5: Cell membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral component of membrane IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for OR51F1 About    
See pathways by source

SuperPathContained pathways About
1Olfactory Signaling Pathway
Olfactory Signaling Pathway0.82
Olfactory transduction0.82
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90


Find genes that share SuperPaths with OR51F1           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for OR51F1
    Olfactory Signaling Pathway


1 Kegg Pathway  (Kegg details for OR51F1):
    Olfactory transduction

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Interactions:

    Search GeneGlobe Interaction Network for OR51F1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for OR51F1 (ENSP000003451634) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
InteractantInteraction Details
GeneCardExternal ID(s)
OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
OR10J5ENSP000003344414STRING: ENSP00000334441
OR2G3ENSP000003263014STRING: ENSP00000326301
OR6Y1ENSP000003048074STRING: ENSP00000304807
GNALENSP000003340514STRING: ENSP00000334051
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for OR51F1 (O51F1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for OR51F1 gene: 
NM_001004752.1  

Unigene Cluster for OR51F1:

Olfactory receptor, family 51, subfamily F, member 1
Hs.553659
Unigene Representative Sequence: NM_001004752
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000343430(uc010qyl.2) ENST00000380383
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1 AceView cDNA sequence:

NM_001004752 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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OR51F1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTGAGCCTGT
OR51F1 Expression
About this image

OR51F1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

OR51F1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.553659
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for OR51F1 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Olfr5855 olfactory receptor 585   --   7 (54.85 cM) 103097743 


ENSEMBL Gene Tree for OR51F1 (if available)
TreeFam Gene Tree for OR51F1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for OR51F1 gene
OR51L12  OR51T12  OR51A42  OR51F22  OR51G22  OR51I12  OR51A72  OR51G12  
OR51H1P2  OR51A22  OR51I22  
Selected SIMAP similar genes for OR51F1 using alignment to 2 protein entries:     O51F1_HUMAN (see all proteins) (see all similar genes):
OR51F2    OR51G2    OR51I1    OR51T1    OR51I2    OR51B2
OR51G1    OR51A1P    OR51A4    OR51B5    OR51B6    OR51E2
OR51L1    OR52N1    OR51M1    OR51V1    OR51A2    OR51E1

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Polymorphic Variants from UniProtKB/Swiss-Prot
O51F1_HUMAN, A6NGY5: A single nucleotide deletion at position Arg-92 in the gene coding for this protein is responsible
for functional diversity thus producing a pseudogene. The deletion is more frequent in African-Americans than in
non-Africans


Selected SNPs for OR51F1 (see all 152)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs792901141,2
--4789745(+) GAAGAA/GCATAG 1 -- ds50010--------
rs1398201891,2
C--4789769(+) GAACAC/TCTGGG 1 -- ds50010--------
rs14339151,2
C,F,A,H--4789862(-) attagC/Tgatat 1 -- ds500110Minor allele frequency- T:0.23NS EA WA CSA NA 623
rs14339141,2
C,F,A,H--4789887(-) acagcG/Aaaatg 1 -- ds500128Minor allele frequency- A:0.23NS EA NA WA CSA 2744
rs1431215071,2
--4789991(+) ATTTAC/TCATTT 1 -- ds50010--------
rs10307271,2
C,F,A,H--4790070(-) TTGTAT/CATTTG 1 -- ds500116Minor allele frequency- C:0.21NS EA NA WA CSA 781
rs79247271,2
H--4790112(+) TATTTT/AAAAAA 1 -- ds50014Minor allele frequency- A:0.00NS EA 410
rs2015822721,2
--4790182(+) GCCAGC/GTTTGT 1 -- ds50010--------
rs1474711851,2
C,F--4790214(+) TCATTT/CTGTAA 2 /K /E mis11Minor allele frequency- C:0.00NA 4536
rs10307261,2,,4
C,F,A,H--4790268(-) TCATCG/TACAGT 2 D Y mis1 ese326Minor allele frequency- T:0.31NS EA NA WA CSA EU 8157

HapMap Linkage Disequilibrium report for OR51F1 ( 4790212 - 4791147 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for OR51F1:    About this table    
Variant IDTypeSubtypePubMed ID
esv29053CNV Loss19812545
nsv896916CNV Loss21882294
nsv896911CNV Gain21882294
nsv832056CNV Gain17160897
nsv896915CNV Gain21882294

Human Gene Mutation Database (HGMD): OR51F1
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with OR51F1           About GenesLikeMe


Export disorders for OR51F1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for OR51F1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with OR51F1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Imputation-based meta-analysis of severe malaria in three African populations. (PubMed id 23717212)1 Band G.... . (PLoS Genet. 2013)
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
  3. The human olfactory receptor gene family. (PubMed id 14983052)1 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
  4. Population differences in the human functional olfactory repertoire. (PubMed id 12644552)1 Gilad Y. and Lancet D. (Mol. Biol. Evol. 2003)
  5. Different noses for different people. (PubMed id 12730696)2 Menashe I.... Gilad Y. (Nat. Genet. 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 256892 HGNC: 15196 AceView: OR51F1 Ensembl:ENSG00000188069 euGenes: HUgn256892
ECgene: OR51F1 Kegg: 256892 H-InvDB: OR51F1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for OR51F1 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR51F1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for OR51F1 gene:
Search GeneIP for patents involving OR51F1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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