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Aliases for OR51E2 Gene

Aliases for OR51E2 Gene

  • Olfactory Receptor, Family 51, Subfamily E, Member 2 2 3
  • PSGR 3 4 6
  • Prostate-Specific G-Protein Coupled Receptor 3 4
  • Olfactory Receptor OR11-16 3 4
  • HPRAJ 3 4
  • Olfactory Receptor, Family 51, Subfamily E, Member 3 Pseudogene 3
  • Olfactory Receptor, Family 52, Subfamily A, Member 2 3
  • Prostate Specific G-Protein Coupled Receptor 3
  • Olfactory Receptor 51E2 3
  • OR51E3P 3
  • OR52A2 3

External Ids for OR51E2 Gene

Summaries for OR51E2 Gene

Entrez Gene Summary for OR51E2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51E2 Gene

OR51E2 (Olfactory Receptor, Family 51, Subfamily E, Member 2) is a Protein Coding gene. Diseases associated with OR51E2 include prostate cancer. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51E1.

UniProtKB/Swiss-Prot for OR51E2 Gene

  • Probable G protein-coupled receptor that is activated by the short chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702). May also function as an olfactory receptor being activated by beta-ionone (PubMed:19389702).

Gene Wiki entry for OR51E2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR51E2 Gene

Genomics for OR51E2 Gene

Genomic Location for OR51E2 Gene

Start:
4,680,171 bp from pter
End:
4,697,854 bp from pter
Size:
17,684 bases
Orientation:
Minus strand

Genomic View for OR51E2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR51E2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51E2 Gene

Regulatory Elements for OR51E2 Gene

Proteins for OR51E2 Gene

  • Protein details for OR51E2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H255-O51E2_HUMAN
    Recommended name:
    Olfactory receptor 51E2
    Protein Accession:
    Q9H255
    Secondary Accessions:
    • B2RA63
    • Q6IF94

    Protein attributes for OR51E2 Gene

    Size:
    320 amino acids
    Molecular mass:
    35493 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51E2 Gene

Proteomics data for OR51E2 Gene at MOPED

Post-translational modifications for OR51E2 Gene

Other Protein References for OR51E2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR51E2 Gene

Domains for OR51E2 Gene

Gene Families for OR51E2 Gene

HGNC:
  • OR51 :GPCR / Class A : Olfactory receptors

Protein Domains for OR51E2 Gene

UniProtKB/Swiss-Prot:

O51E2_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q9H255
genes like me logo Genes that share domains with OR51E2: view

Function for OR51E2 Gene

Molecular function for OR51E2 Gene

UniProtKB/Swiss-Prot Function: Probable G protein-coupled receptor that is activated by the short chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702). May also function as an olfactory receptor being activated by beta-ionone (PubMed:19389702).

Gene Ontology (GO) - Molecular Function for OR51E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003707 steroid hormone receptor activity IDA 19389702
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IDA 19389702
GO:0038023 signaling receptor activity ISS --
genes like me logo Genes that share ontologies with OR51E2: view
genes like me logo Genes that share phenotypes with OR51E2: view

Animal Models for OR51E2 Gene

MGI Knock Outs for OR51E2:

miRNA for OR51E2 Gene

miRTarBase miRNAs that target OR51E2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for OR51E2 Gene

Localization for OR51E2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51E2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR51E2 Gene COMPARTMENTS Subcellular localization image for OR51E2 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for OR51E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR51E2: view

Pathways for OR51E2 Gene

genes like me logo Genes that share pathways with OR51E2: view

Pathways by source for OR51E2 Gene

Interacting Proteins for OR51E2 Gene

Gene Ontology (GO) - Biological Process for OR51E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0043401 steroid hormone mediated signaling pathway IDA 19389702
GO:0045777 positive regulation of blood pressure ISS --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
GO:0071398 cellular response to fatty acid ISS --
genes like me logo Genes that share ontologies with OR51E2: view

Transcripts for OR51E2 Gene

mRNA/cDNA for OR51E2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for OR51E2 Gene

No ASD Table

Relevant External Links for OR51E2 Gene

GeneLoc Exon Structure for
OR51E2
ECgene alternative splicing isoforms for
OR51E2

Expression for OR51E2 Gene

mRNA expression in normal human tissues for OR51E2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OR51E2 Gene

This gene is overexpressed in Prostate (20.5), Colon - Sigmoid (9.6), Artery - Tibial (8.3), and Colon - Transverse (4.0).

SOURCE GeneReport for Unigene cluster for OR51E2 Gene Hs.501758

mRNA Expression by UniProt/SwissProt for OR51E2 Gene

Q9H255-O51E2_HUMAN
Tissue specificity: Mainly expressed in the prostate. Also expressed in spleen, liver, olfactory epithelium and medulla oblongata.
genes like me logo Genes that share expressions with OR51E2: view

Orthologs for OR51E2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR51E2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466344 36
  • 99.17 (n)
  • 99.69 (a)
OR51E2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR51E2 36
  • 89.37 (n)
  • 91.56 (a)
OR51E2 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100856052 36
  • 89.79 (n)
  • 92.81 (a)
OR51E2 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr78 36
  • 86.94 (n)
  • 93.1 (a)
Olfr78 16
Olfr78 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OR51E2 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr59 36
  • 86.83 (n)
  • 93.42 (a)
lizard
(Anolis carolinensis)
Reptilia OR51E2 37
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia or51e1 36
  • 62.84 (n)
  • 57.7 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01018874.1 37
  • 31 (a)
ManyToMany
or112-1 37
  • 30 (a)
ManyToMany
Species with no ortholog for OR51E2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OR51E2 Gene

ENSEMBL:
Gene Tree for OR51E2 (if available)
TreeFam:
Gene Tree for OR51E2 (if available)

Paralogs for OR51E2 Gene

Paralogs for OR51E2 Gene

Selected SIMAP similar genes for OR51E2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for OR51E2 Gene

genes like me logo Genes that share paralogs with OR51E2: view

Variants for OR51E2 Gene

Sequence variations from dbSNP and Humsavar for OR51E2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1685 -- 4,680,280(+) AGACA(C/T)GATCA utr-variant-3-prime
rs903156 -- 4,684,411(+) TAGAA(A/C)TTTAA intron-variant
rs977210 -- 4,687,699(+) GGCCC(C/T)GAGAA intron-variant
rs993636 -- 4,686,905(-) CTGTC(C/T)AACAG intron-variant
rs1072893 -- 4,688,742(+) GTAGA(C/G)ATGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OR51E2 Gene

Variant ID Type Subtype PubMed ID
nsv896911 CNV Gain 21882294
nsv832055 CNV Loss 17160897
nsv896915 CNV Gain 21882294
nsv832056 CNV Gain 17160897
nsv896916 CNV Loss 21882294

Relevant External Links for OR51E2 Gene

HapMap Linkage Disequilibrium report
OR51E2

Disorders for OR51E2 Gene

(1) MalaCards Diseases for OR51E2 Gene

Search for OR51E2 Gene in MalaCards »

(2) Novoseek inferred disease relationships for OR51E2 Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 54.6 17
tumors 8.26 8
genes like me logo Genes that share disorders with OR51E2: view

No data available for UniProtKB/Swiss-Prot for OR51E2 Gene

Publications for OR51E2 Gene

  1. PSGR, a novel prostate-specific gene with homology to a G protein- coupled receptor, is overexpressed in prostate cancer. (PMID: 11118034) Xu L.L. … Srivastava S. (Cancer Res. 2000) 2 3 4 23
  2. The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl- CoA racemase. (PMID: 16491480) Wang J. … Ittmann M. (Prostate 2006) 3 4 23
  3. Activation of an olfactory receptor inhibits proliferation of prostate cancer cells. (PMID: 19389702) Neuhaus E.M. … Hatt H. (J. Biol. Chem. 2009) 3 4 23
  4. Identification of a prostate-specific G-protein coupled receptor in prostate cancer. (PMID: 11593396) Xia C. … Liu M. (Oncogene 2001) 3 23
  5. Increased expression of prostate-specific G-protein-coupled receptor in human prostate intraepithelial neoplasia and prostate cancers. (PMID: 15499628) Weng J. … Liu M. (Int. J. Cancer 2005) 3 23

Products for OR51E2 Gene

  • antibodies-online peptides for OR51E2
  • antibodies-online antibodies for OR51E2
  • antibodies-online kits for OR51E2

Sources for OR51E2 Gene

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