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Aliases for OR51E2 Gene

Aliases for OR51E2 Gene

  • Olfactory Receptor Family 51 Subfamily E Member 2 2 3 5
  • Olfactory Receptor, Family 51, Subfamily E, Member 2 2 3
  • Prostate-Specific G-Protein Coupled Receptor 3 4
  • Olfactory Receptor OR11-16 3 4
  • HPRAJ 3 4
  • PSGR 3 4
  • Olfactory Receptor, Family 51, Subfamily E, Member 3 Pseudogene 3
  • Olfactory Receptor, Family 52, Subfamily A, Member 2 3
  • Prostate Specific G-Protein Coupled Receptor 3
  • OR51E3P 3
  • OR52A2 3

External Ids for OR51E2 Gene

Previous GeneCards Identifiers for OR51E2 Gene

  • GC11M005267
  • GC11M005003
  • GC11M004660
  • GC11M004665
  • GC11M004657
  • GC11M004701

Summaries for OR51E2 Gene

Entrez Gene Summary for OR51E2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51E2 Gene

OR51E2 (Olfactory Receptor Family 51 Subfamily E Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and steroid hormone receptor activity. An important paralog of this gene is OR51E1.

UniProtKB/Swiss-Prot for OR51E2 Gene

  • Probable G protein-coupled receptor that is activated by the short chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702). May also function as an olfactory receptor being activated by beta-ionone (PubMed:19389702).

Gene Wiki entry for OR51E2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR51E2 Gene

Genomics for OR51E2 Gene

Regulatory Elements for OR51E2 Gene

Genomic Location for OR51E2 Gene

Chromosome:
11
Start:
4,680,171 bp from pter
End:
4,697,854 bp from pter
Size:
17,684 bases
Orientation:
Minus strand

Genomic View for OR51E2 Gene

Genes around OR51E2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51E2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51E2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51E2 Gene

Proteins for OR51E2 Gene

  • Protein details for OR51E2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H255-O51E2_HUMAN
    Recommended name:
    Olfactory receptor 51E2
    Protein Accession:
    Q9H255
    Secondary Accessions:
    • B2RA63
    • Q6IF94

    Protein attributes for OR51E2 Gene

    Size:
    320 amino acids
    Molecular mass:
    35493 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51E2 Gene

Proteomics data for OR51E2 Gene at MOPED

Post-translational modifications for OR51E2 Gene

Other Protein References for OR51E2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for OR51E2

No data available for DME Specific Peptides for OR51E2 Gene

Domains & Families for OR51E2 Gene

Gene Families for OR51E2 Gene

Protein Domains for OR51E2 Gene

Suggested Antigen Peptide Sequences for OR51E2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H255

UniProtKB/Swiss-Prot:

O51E2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51E2: view

Function for OR51E2 Gene

Molecular function for OR51E2 Gene

UniProtKB/Swiss-Prot Function:
Probable G protein-coupled receptor that is activated by the short chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702). May also function as an olfactory receptor being activated by beta-ionone (PubMed:19389702).

Gene Ontology (GO) - Molecular Function for OR51E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003707 steroid hormone receptor activity IDA 19389702
GO:0038023 signaling receptor activity IEA,ISS --
genes like me logo Genes that share ontologies with OR51E2: view
genes like me logo Genes that share phenotypes with OR51E2: view

Animal Models for OR51E2 Gene

MGI Knock Outs for OR51E2:

Animal Model Products

  • Taconic Biosciences Mouse Models for OR51E2

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OR51E2 Gene

Localization for OR51E2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51E2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR51E2 Gene COMPARTMENTS Subcellular localization image for OR51E2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR51E2: view

Pathways & Interactions for OR51E2 Gene

genes like me logo Genes that share pathways with OR51E2: view

Pathways by source for OR51E2 Gene

Interacting Proteins for OR51E2 Gene

Gene Ontology (GO) - Biological Process for OR51E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045777 positive regulation of blood pressure IEA,ISS --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
GO:1900135 positive regulation of renin secretion into blood stream IEA,ISS --
genes like me logo Genes that share ontologies with OR51E2: view

No data available for SIGNOR curated interactions for OR51E2 Gene

Drugs & Compounds for OR51E2 Gene

No Compound Related Data Available

Transcripts for OR51E2 Gene

mRNA/cDNA for OR51E2 Gene

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR51E2 Gene

No ASD Table

Relevant External Links for OR51E2 Gene

GeneLoc Exon Structure for
OR51E2
ECgene alternative splicing isoforms for
OR51E2

Expression for OR51E2 Gene

mRNA expression in normal human tissues for OR51E2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OR51E2 Gene

This gene is overexpressed in Prostate (x20.5), Colon - Sigmoid (x9.6), Artery - Tibial (x8.3), and Colon - Transverse (x4.0).

SOURCE GeneReport for Unigene cluster for OR51E2 Gene Hs.501758

mRNA Expression by UniProt/SwissProt for OR51E2 Gene

Q9H255-O51E2_HUMAN
Tissue specificity: Mainly expressed in the prostate. Also expressed in spleen, liver, olfactory epithelium and medulla oblongata.
genes like me logo Genes that share expression patterns with OR51E2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for OR51E2 Gene

Orthologs for OR51E2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR51E2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466344 35
  • 99.17 (n)
  • 99.69 (a)
OR51E2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR51E2 36
  • 92 (a)
OneToOne
OR51E2 35
  • 89.37 (n)
  • 91.56 (a)
dog
(Canis familiaris)
Mammalia LOC100856052 35
  • 89.79 (n)
  • 92.81 (a)
OR51E2 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr78 16
Olfr78 36
  • 93 (a)
OneToOne
Olfr78 35
  • 86.94 (n)
  • 93.1 (a)
oppossum
(Monodelphis domestica)
Mammalia OR51E2 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr59 35
  • 86.83 (n)
  • 93.42 (a)
lizard
(Anolis carolinensis)
Reptilia OR51E2 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia or51e1 35
  • 62.84 (n)
  • 57.7 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01018874.1 36
  • 31 (a)
ManyToMany
or112-1 36
  • 30 (a)
ManyToMany
Species with no ortholog for OR51E2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OR51E2 Gene

ENSEMBL:
Gene Tree for OR51E2 (if available)
TreeFam:
Gene Tree for OR51E2 (if available)

Paralogs for OR51E2 Gene

(420) SIMAP similar genes for OR51E2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for OR51E2 Gene

genes like me logo Genes that share paralogs with OR51E2: view

Variants for OR51E2 Gene

Sequence variations from dbSNP and Humsavar for OR51E2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs903156 -- 4,684,411(+) TAGAA(A/C)TTTAA intron-variant
rs977210 -- 4,687,699(+) GGCCC(C/T)GAGAA intron-variant
rs1072893 -- 4,688,742(+) GTAGA(C/G)ATGGT intron-variant
rs1123990 -- 4,682,091(-) ATGGG(C/T)GTGGA reference, synonymous-codon
rs1505210 -- 4,692,581(-) TTCTC(C/T)ACTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OR51E2 Gene

Variant ID Type Subtype PubMed ID
nsv896911 CNV Gain 21882294
nsv832055 CNV Loss 17160897
nsv896915 CNV Gain 21882294
nsv832056 CNV Gain 17160897
nsv896916 CNV Loss 21882294

Variation tolerance for OR51E2 Gene

Residual Variation Intolerance Score: 56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR51E2 Gene

HapMap Linkage Disequilibrium report
OR51E2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR51E2 Gene

Disorders for OR51E2 Gene

Relevant External Links for OR51E2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR51E2

No disorders were found for OR51E2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR51E2 Gene

Publications for OR51E2 Gene

  1. PSGR, a novel prostate-specific gene with homology to a G protein- coupled receptor, is overexpressed in prostate cancer. (PMID: 11118034) Xu L.L. … Srivastava S. (Cancer Res. 2000) 2 3 4 23 67
  2. Activation of an olfactory receptor inhibits proliferation of prostate cancer cells. (PMID: 19389702) Neuhaus E.M. … Hatt H. (J. Biol. Chem. 2009) 3 23
  3. The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl- CoA racemase. (PMID: 16491480) Wang J. … Ittmann M. (Prostate 2006) 3 23
  4. Increased expression of prostate-specific G-protein-coupled receptor in human prostate intraepithelial neoplasia and prostate cancers. (PMID: 15499628) Weng J. … Liu M. (Int. J. Cancer 2005) 3 23
  5. Regulation of human prostate-specific G-protein coupled receptor, PSGR, by two distinct promoters and growth factors. (PMID: 16149059) Weng J. … Liu M. (J. Cell. Biochem. 2005) 3 23

Products for OR51E2 Gene

Sources for OR51E2 Gene

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