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Aliases for OR51E1 Gene

Aliases for OR51E1 Gene

  • Olfactory Receptor Family 51 Subfamily E Member 1 2 3 5
  • Olfactory Receptor, Family 51, Subfamily E, Member 1 Pseudogene 2 3
  • Prostate-Overexpressed G Protein-Coupled Receptor 3 4
  • Prostate-Specific G Protein-Coupled Receptor 2 3 4
  • G-Protein Coupled Receptor 164 3 4
  • Olfactory Receptor 52A3 3 4
  • OR51E1P 3 4
  • OR52A3P 3 4
  • GPR164 3 4
  • D-GPCR 3 4
  • PSGR2 3 4
  • POGR 3 4
  • Olfactory Receptor, Family 52, Subfamily A, Member 3 Pseudogene 3
  • Olfactory Receptor, Family 51, Subfamily E, Member 1 2
  • Prostate Overexpressed G Protein-Coupled Receptor 3
  • Dresden-G-Protein-Coupled Receptor 3
  • Olfactory Receptor OR11-15 3
  • GPR136 3
  • DGPCR 3

External Ids for OR51E1 Gene

Previous HGNC Symbols for OR51E1 Gene

  • OR51E1P
  • OR52A3P
  • GPR164

Previous GeneCards Identifiers for OR51E1 Gene

  • GC11U990519
  • GC00U920624
  • GC11P004622

Summaries for OR51E1 Gene

Entrez Gene Summary for OR51E1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51E1 Gene

OR51E1 (Olfactory Receptor Family 51 Subfamily E Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51I1.

UniProtKB/Swiss-Prot for OR51E1 Gene

  • Odorant receptor.

Gene Wiki entry for OR51E1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR51E1 Gene

Genomics for OR51E1 Gene

Regulatory Elements for OR51E1 Gene

Enhancers for OR51E1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR51E1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR51E1 Gene

Chromosome:
11
Start:
4,643,420 bp from pter
End:
4,655,488 bp from pter
Size:
12,069 bases
Orientation:
Plus strand

Genomic View for OR51E1 Gene

Genes around OR51E1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51E1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51E1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51E1 Gene

Proteins for OR51E1 Gene

  • Protein details for OR51E1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCB6-O51E1_HUMAN
    Recommended name:
    Olfactory receptor 51E1
    Protein Accession:
    Q8TCB6
    Secondary Accessions:
    • A8KAM6
    • Q5S4P5
    • Q66X57
    • Q6IF93

    Protein attributes for OR51E1 Gene

    Size:
    317 amino acids
    Molecular mass:
    35271 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAU07996.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=DAA04767.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR51E1 Gene

Proteomics data for OR51E1 Gene at MOPED

Post-translational modifications for OR51E1 Gene

  • Glycosylation at Asn 7 and Asn 90

Other Protein References for OR51E1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51E1 Gene

Domains & Families for OR51E1 Gene

Gene Families for OR51E1 Gene

Protein Domains for OR51E1 Gene

Suggested Antigen Peptide Sequences for OR51E1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TCB6

UniProtKB/Swiss-Prot:

O51E1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51E1: view

Function for OR51E1 Gene

Molecular function for OR51E1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
genes like me logo Genes that share phenotypes with OR51E1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OR51E1

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51E1 Gene

Localization for OR51E1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51E1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR51E1 Gene COMPARTMENTS Subcellular localization image for OR51E1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR51E1: view

Pathways & Interactions for OR51E1 Gene

genes like me logo Genes that share pathways with OR51E1: view

Pathways by source for OR51E1 Gene

Interacting Proteins for OR51E1 Gene

Gene Ontology (GO) - Biological Process for OR51E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR51E1: view

No data available for SIGNOR curated interactions for OR51E1 Gene

Drugs & Compounds for OR51E1 Gene

No Compound Related Data Available

Transcripts for OR51E1 Gene

mRNA/cDNA for OR51E1 Gene

Unigene Clusters for OR51E1 Gene

Olfactory receptor, family 51, subfamily E, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OR51E1 Gene

No ASD Table

Relevant External Links for OR51E1 Gene

GeneLoc Exon Structure for
OR51E1
ECgene alternative splicing isoforms for
OR51E1

Expression for OR51E1 Gene

mRNA expression in normal human tissues for OR51E1 Gene

mRNA differential expression in normal tissues according to GTEx for OR51E1 Gene

This gene is overexpressed in Prostate (x7.0), Artery - Tibial (x6.6), and Heart - Left Ventricle (x6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR51E1 Gene



SOURCE GeneReport for Unigene cluster for OR51E1 Gene Hs.470038

mRNA Expression by UniProt/SwissProt for OR51E1 Gene

Q8TCB6-O51E1_HUMAN
Tissue specificity: Highly expressed in prostate. Very low levels may be detected in some other tissues, such as placenta, skeletal muscle, heart, ovary and testis. Up-regulated in prostate cancers.
genes like me logo Genes that share expression patterns with OR51E1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Protein tissue co-expression partners for OR51E1 Gene

Orthologs for OR51E1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR51E1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR51E1 35
  • 89.91 (n)
  • 93.38 (a)
OR51E1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC485235 35
  • 88.61 (n)
  • 92.41 (a)
OR51E1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr558 35
  • 87.87 (n)
  • 93.67 (a)
Olfr558 16
Olfr558 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC466342 35
  • 99.26 (n)
  • 99.68 (a)
OR51E1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr63 35
  • 87.62 (n)
  • 92.7 (a)
oppossum
(Monodelphis domestica)
Mammalia OR51E1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OR51E1 36
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01018874.1 36
  • 32 (a)
ManyToMany
or112-1 36
  • 31 (a)
ManyToMany
Species with no ortholog for OR51E1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OR51E1 Gene

ENSEMBL:
Gene Tree for OR51E1 (if available)
TreeFam:
Gene Tree for OR51E1 (if available)

Paralogs for OR51E1 Gene

(427) SIMAP similar genes for OR51E1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR51E1: view

Variants for OR51E1 Gene

Sequence variations from dbSNP and Humsavar for OR51E1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs17224476 -, - 4,652,558(+) ATCCA(A/C/G)TGCTA reference, missense
rs721758 -- 4,653,928(+) AAAAT(A/G)CTGTC utr-variant-3-prime
rs766282 -- 4,650,788(+) GAGTA(C/T)CCCTA intron-variant
rs1055262 -- 4,655,168(+) TCTGT(C/G)CTGAA utr-variant-3-prime
rs1354587 -- 4,650,297(+) ACGAA(A/C)CCAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OR51E1 Gene

Variant ID Type Subtype PubMed ID
nsv896911 CNV Gain 21882294
nsv832055 CNV Loss 17160897
nsv896915 CNV Gain 21882294
esv2670201 CNV Deletion 23128226
nsv832056 CNV Gain 17160897

Variation tolerance for OR51E1 Gene

Residual Variation Intolerance Score: 83.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.88; 59.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR51E1 Gene

Disorders for OR51E1 Gene

Relevant External Links for OR51E1

Genetic Association Database (GAD)
OR51E1
Human Genome Epidemiology (HuGE) Navigator
OR51E1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR51E1

No disorders were found for OR51E1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR51E1 Gene

Publications for OR51E1 Gene

  1. PSGR2, a novel G-protein coupled receptor, is overexpressed in human prostate cancer. (PMID: 16206286) Weng J. … Liu M. (Int. J. Cancer 2006) 3 4 67
  2. Olfactory receptor 51E1 protein as a potential novel tissue biomarker for small intestine neuroendocrine carcinomas. (PMID: 23184910) Cui T. … Giandomenico V. (Eur. J. Endocrinol. 2013) 3
  3. Olfactory receptor 51E1 as a novel target for diagnosis in somatostatin receptor-negative lung carcinoids. (PMID: 23969981) Giandomenico V. … Tsolakis A.V. (J. Mol. Endocrinol. 2013) 3
  4. Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas. (PMID: 18953328) Leja J. … Giandomenico V. (Mod. Pathol. 2009) 23
  5. The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl- CoA racemase. (PMID: 16491480) Wang J. … Ittmann M. (Prostate 2006) 3

Products for OR51E1 Gene

Sources for OR51E1 Gene

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