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OR51D1 Gene

protein-coding   GIFtS: 44
GCID: GC11P004616

Olfactory Receptor, Family 51, Subfamily D, Member 1

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 51, Subfamily D, Member 11 2
Olfactory Receptor OR11-142 3
OR11-142
OR51D1Q2
Olfactory Receptor 51D12

External Ids:    HGNC: 151931   Entrez Gene: 3900382   Ensembl: ENSG000001974287   UniProtKB: Q8NGF33   

Export aliases for OR51D1 gene to outside databases

Previous GC identifers: GC11U990520 GC11P004627


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR51D1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR51D1 Gene:
OR51D1 (olfactory receptor, family 51, subfamily D, member 1) is a protein-coding gene. Diseases associated with OR51D1 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51M1.

UniProtKB/Swiss-Prot: O51D1_HUMAN, Q8NGF3
Function: Odorant receptor (Potential)

Gene Wiki entry for OR51D1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR51D1 gene promoter:
         HOXA9   HOXA9B   AML1a   Brachyury   Tal-1beta   E47   C/EBPalpha   Evi-1   Meis-1b   Meis-1   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR51D1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

OR51D1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR51D1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P004616:  view genomic region     (about GC identifiers)

Start:
4,661,021 bp from pter      End:
4,661,992 bp from pter
Size:
972 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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UniProtKB/Swiss-Prot: O51D1_HUMAN, Q8NGF3 (See protein sequence)
Recommended Name: Olfactory receptor 51D1  
Size: 324 amino acids; 35839 Da
Secondary accessions: B9EIK4

Explore the universe of human proteins at neXtProt for OR51D1: NX_Q8NGF3

Explore proteomics data for OR51D1 at MOPED

HORDE protein sequence for OR51D1

See OR51D1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001004751.1  
ENSEMBL proteins: 
 ENSP00000350222  
Reactome Protein details: Q8NGF3

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
OR51: GPCR / Class A : Olfactory receptors

4 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR019424 7TM_GPCR_olfarory/Srsx
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8NGF3

ProtoNet protein and cluster: Q8NGF3

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: O51D1_HUMAN, Q8NGF3
Similarity: Belongs to the G-protein coupled receptor 1 family


OR51D1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: O51D1_HUMAN, Q8NGF3
Function: Odorant receptor (Potential)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--
     
OR51D1 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
O51D1_HUMAN, Q8NGF3: Cell membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral component of membrane IEA--

OR51D1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for OR51D1 About    
See pathways by source

SuperPathContained pathways About
1Olfactory Signaling Pathway
Olfactory Signaling Pathway0.82
Olfactory transduction0.82
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for OR51D1
    Olfactory Signaling Pathway


1 Kegg Pathway  (Kegg details for OR51D1):
    Olfactory transduction


OR51D1 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR51D1
Interactions:

    Search GeneGlobe Interaction Network for OR51D1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for OR51D1 (ENSP000003502224) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
InteractantInteraction Details
GeneCardExternal ID(s)
OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
GNALENSP000003340514STRING: ENSP00000334051
GNGT1ENSP000002485724STRING: ENSP00000248572
OR10A3ENSP000003539884STRING: ENSP00000353988
OR10A4ENSP000003691574STRING: ENSP00000369157
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

OR51D1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for OR51D1 (O51D1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for OR51D1 gene: 
NM_001004751.2  

Unigene Cluster for OR51D1:

Olfactory receptor, family 51, subfamily D, member 1
Hs.553728
Unigene Representative Sequence: NM_001004751
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000357605(uc010qyk.2)
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Additional mRNA sequence: BC140717.1 

1 AceView cDNA sequence:

NM_001004751 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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OR51D1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGGTTATGGC
OR51D1 Expression
About this image

OR51D1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

OR51D1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.553728
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for OR51D1 gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Olfr5571 , 5 olfactory receptor 5571, 5 86.19(n)1
89.1(a)1
  7 (54.81 cM)5
2583581  NM_146361.21  NP_666473.21 
 1026982165 
zebrafish
(Danio rerio)
Actinopterygii CABZ01018874.16
or112-16
Uncharacterized protein
odorant receptor, family A, subfamily 112, member ...
29(a)
27(a)
many ↔ many
many ↔ many
15(5202740-5204422) ENSDARG00000077146
15(5221640-5223327) ENSDARG00000077211


ENSEMBL Gene Tree for OR51D1 (if available)
TreeFam Gene Tree for OR51D1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for OR51D1 gene
OR51M12  OR51V12  OR51B62  OR51B52  OR51J12  OR51Q12  OR51E22  OR51B42  
OR51B22  OR51E12  
Selected SIMAP similar genes for OR51D1 using alignment to 1 protein entry:     O51D1_HUMAN(see all similar genes):
OR51E1    OR51E2    OR51G2    OR51G1    OR51L1    OR52K2
OR52M1    OR51A7    OR51I2    OR52K1    OR52R1    OR51A2
OR51A4    OR51F2    OR51H1P    OR51I1    OR51V1    OR52L1

OR51D1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for OR51D1 (see all 127)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1449474791,2
--4317548(+) AGGACA/GGGACT 1 -- us2k10--------
rs783593581,2
C,F--4659000(+) TACTTT/CACCAG 1 -- us2k11Minor allele frequency- C:0.01NA 120
rs348732481,2
C,F--4659067(+) TGGTGC/GTGGTG 1 -- us2k15Minor allele frequency- G:0.41NA 128
rs169234841,2
C,F,H--4659085(+) GTGATG/TAAGAA 1 -- us2k1 trp322Minor allele frequency- T:0.14NA NS EA WA 2896
rs79248531,2
H--4659123(+) AGTTAG/AAGGAA 1 -- us2k14Minor allele frequency- A:0.00NS EA 410
rs46254571,2
C,F,A,H--4659187(+) TGGAAA/CGCTAT 1 -- us2k124Minor allele frequency- C:0.49NS EA NA WA 2762
rs1175179551,2
F--4659343(+) GTGGAT/AAATAT 1 -- us2k11Minor allele frequency- A:0.02NA 120
rs19081771,2
C,F,H--4659419(-) ACCCCC/AACATG 1 -- us2k124Minor allele frequency- A:0.14NS EA NA WA 2668
rs1490477611,2
C--4659429(+) TGAAAA/GAGGAG 1 -- us2k10--------
rs352416441,2
C,F--4659436(+) GGAGAC/GGGGTC 1 -- us2k19Minor allele frequency- G:0.16NA WA EA 370

HapMap Linkage Disequilibrium report for OR51D1 ( 4661021 - 4661992 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for OR51D1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv832055CNV Loss17160897
nsv896911CNV Gain21882294
nsv896915CNV Gain21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for OR51D1:    
About MalaCards
neuronitis


OR51D1 for disorders           About GeneDecksing


Export disorders for OR51D1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for OR51D1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with OR51D1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Novel human G-protein-coupled receptors. (PubMed id 12732197)1 Vanti W.B....O'Dowd B.F. (Biochem. Biophys. Res. Commun. 2003)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  5. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 390038 HGNC: 15193 AceView: OR51D1 Ensembl:ENSG00000197428 euGenes: HUgn390038
ECgene: OR51D1 Kegg: 390038 H-InvDB: OR51D1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for OR51D1 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR51D1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for OR51D1 gene:
Search GeneIP for patents involving OR51D1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Custom PCR Arrays for OR51D1 Search Chromatin IP Primers for OR51D1
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 Search Tocris compounds for OR51D1 (O51D1)
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
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 Search ThermoFisher Antibodies for OR51D1
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR51D1
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR51D1
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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