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Aliases for OR51D1 Gene

Aliases for OR51D1 Gene

  • Olfactory Receptor Family 51 Subfamily D Member 1 2 3 5
  • Olfactory Receptor OR11-14 3 4
  • Olfactory Receptor, Family 51, Subfamily D, Member 1 2
  • Olfactory Receptor 51D1 3
  • OR11-14 3
  • OR51D1Q 3

External Ids for OR51D1 Gene

Previous GeneCards Identifiers for OR51D1 Gene

  • GC11U990520
  • GC11P004627
  • GC11P004616

Summaries for OR51D1 Gene

Entrez Gene Summary for OR51D1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51D1 Gene

OR51D1 (Olfactory Receptor Family 51 Subfamily D Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51E1.

UniProtKB/Swiss-Prot for OR51D1 Gene

  • Odorant receptor.

Gene Wiki entry for OR51D1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR51D1 Gene

Genomics for OR51D1 Gene

Regulatory Elements for OR51D1 Gene

Enhancers for OR51D1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F004682 0.5 ENCODE 11.1 +43.5 43538 1.4 PKNOX1 ZNF652 ZBTB40 TRIM28 OR51E1 OR51D1 OR51C1P LOC105376528
GH11F004609 1.3 Ensembl ENCODE 10.4 -29.4 -29424 1.1 IRF2 IKZF1 IRF1 SPI1 OR51D1 OR51E1 TRIM68 GC11M004616
GH11F004210 1.1 FANTOM5 6.4 -428.8 -428765 0.3 OR52K2 C11orf40 OR52I1 OR51D1 OR52K1 OR52M1 GC11M004210 LOC100506082
GH11F004492 0.9 FANTOM5 5.3 -147.3 -147300 0.1 OR52K2 OR51F1 OR52B4 OR51S1 OR51G2 OR51A4 OR52K1 C11orf40 OR52R1 OR51A7
GH11F004484 0.3 FANTOM5 1.8 -155.2 -155241 0.1 OR52K1 TRIM21 OR51F2 OR52K2 OR51D1 OR51T1 OR51G1 OR52K3P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR51D1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR51D1 Gene

Chromosome:
11
Start:
4,639,715 bp from pter
End:
4,640,838 bp from pter
Size:
1,124 bases
Orientation:
Plus strand

Genomic View for OR51D1 Gene

Genes around OR51D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51D1 Gene

Proteins for OR51D1 Gene

  • Protein details for OR51D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGF3-O51D1_HUMAN
    Recommended name:
    Olfactory receptor 51D1
    Protein Accession:
    Q8NGF3
    Secondary Accessions:
    • B9EIK4

    Protein attributes for OR51D1 Gene

    Size:
    324 amino acids
    Molecular mass:
    35839 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51D1 Gene

Post-translational modifications for OR51D1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR51D1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51D1 Gene

Domains & Families for OR51D1 Gene

Gene Families for OR51D1 Gene

Protein Domains for OR51D1 Gene

Suggested Antigen Peptide Sequences for OR51D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGF3

UniProtKB/Swiss-Prot:

O51D1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51D1: view

Function for OR51D1 Gene

Molecular function for OR51D1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR51D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR51D1: view
genes like me logo Genes that share phenotypes with OR51D1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51D1 Gene

Localization for OR51D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51D1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR51D1 Gene COMPARTMENTS Subcellular localization image for OR51D1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR51D1: view

Pathways & Interactions for OR51D1 Gene

genes like me logo Genes that share pathways with OR51D1: view

Pathways by source for OR51D1 Gene

Gene Ontology (GO) - Biological Process for OR51D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR51D1: view

No data available for SIGNOR curated interactions for OR51D1 Gene

Transcripts for OR51D1 Gene

mRNA/cDNA for OR51D1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR51D1 Gene

No ASD Table

Relevant External Links for OR51D1 Gene

GeneLoc Exon Structure for
OR51D1
ECgene alternative splicing isoforms for
OR51D1

Expression for OR51D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR51D1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR51D1 Gene:

OR51D1

SOURCE GeneReport for Unigene cluster for OR51D1 Gene:

Hs.553728
genes like me logo Genes that share expression patterns with OR51D1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR51D1 Gene

Orthologs for OR51D1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR51D1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100614707 34
  • 98.87 (n)
OR51D1 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR51D1 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC684208 34
  • 86.29 (n)
mouse
(Mus musculus)
Mammalia Or51d1 55 Olfr557 34 16 35
  • 86.19 (n)
cow
(Bos Taurus)
Mammalia OR51D1 35
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OR51D1 35
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01018874.1 35
  • 29 (a)
ManyToMany
or112-1 35
  • 27 (a)
ManyToMany
Species where no ortholog for OR51D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OR51D1 Gene

ENSEMBL:
Gene Tree for OR51D1 (if available)
TreeFam:
Gene Tree for OR51D1 (if available)

Paralogs for OR51D1 Gene

(404) SIMAP similar genes for OR51D1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR51D1: view

Variants for OR51D1 Gene

Sequence variations from dbSNP and Humsavar for OR51D1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10836399 -- 4,639,491(+) ACTGT(C/G)TTACA upstream-variant-2KB
rs11033126 -- 4,638,628(+) GATGG(C/T)AGATG upstream-variant-2KB
rs11033127 -- 4,638,790(+) TGTTT(A/G)TTTGT upstream-variant-2KB
rs11033128 -- 4,638,863(+) TCTCG(G/T)CTCAC upstream-variant-2KB
rs11033129 -- 4,639,004(+) GCCTG(G/T)CTGGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR51D1 Gene

Variant ID Type Subtype PubMed ID
dgv1025n100 CNV loss 25217958
dgv1586n54 CNV loss 21841781
nsv1041633 CNV gain 25217958
nsv1054705 CNV loss 25217958
nsv1054847 CNV gain 25217958
nsv832055 CNV loss 17160897

Variation tolerance for OR51D1 Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.35; 63.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR51D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR51D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR51D1 Gene

Disorders for OR51D1 Gene

Relevant External Links for OR51D1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR51D1

No disorders were found for OR51D1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR51D1 Gene

Publications for OR51D1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  3. Novel human G-protein-coupled receptors. (PMID: 12732197) Vanti W.B. … O'Dowd B.F. (Biochem. Biophys. Res. Commun. 2003) 3 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR51D1 Gene

Sources for OR51D1 Gene

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