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Aliases for OR51B6 Gene

Aliases for OR51B6 Gene

  • Olfactory Receptor, Family 51, Subfamily B, Member 6 2 3
  • Odorant Receptor HOR5beta6 3 4
  • Olfactory Receptor 51B5 3
  • HOR5Beta6 3

External Ids for OR51B6 Gene

Previous GeneCards Identifiers for OR51B6 Gene

  • GC00U903063
  • GC11P005338
  • GC11P005301
  • GC11P005372

Summaries for OR51B6 Gene

Entrez Gene Summary for OR51B6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51B6 Gene

OR51B6 (Olfactory Receptor, Family 51, Subfamily B, Member 6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51E1.

UniProtKB/Swiss-Prot for OR51B6 Gene

  • Odorant receptor.

Gene Wiki entry for OR51B6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR51B6 Gene

Genomics for OR51B6 Gene

Regulatory Elements for OR51B6 Gene

Genomic Location for OR51B6 Gene

Chromosome:
11
Start:
5,351,508 bp from pter
End:
5,352,446 bp from pter
Size:
939 bases
Orientation:
Plus strand

Genomic View for OR51B6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR51B6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51B6 Gene

Proteins for OR51B6 Gene

  • Protein details for OR51B6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H340-O51B6_HUMAN
    Recommended name:
    Olfactory receptor 51B6
    Protein Accession:
    Q9H340

    Protein attributes for OR51B6 Gene

    Size:
    312 amino acids
    Molecular mass:
    35269 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51B6 Gene

Proteomics data for OR51B6 Gene at MOPED

Post-translational modifications for OR51B6 Gene

  • Glycosylation at Asn 4
  • Modification sites at PhosphoSitePlus

Other Protein References for OR51B6 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51B6 Gene

Domains & Families for OR51B6 Gene

Gene Families for OR51B6 Gene

Protein Domains for OR51B6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OR51B6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H340

UniProtKB/Swiss-Prot:

O51B6_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51B6: view

Function for OR51B6 Gene

Molecular function for OR51B6 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR51B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 11121057
genes like me logo Genes that share ontologies with OR51B6: view

Phenotypes for OR51B6 Gene

GenomeRNAi human phenotypes for OR51B6:
genes like me logo Genes that share phenotypes with OR51B6: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR51B6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51B6 Gene

Localization for OR51B6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51B6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR51B6 Gene COMPARTMENTS Subcellular localization image for OR51B6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane NAS 11121057
genes like me logo Genes that share ontologies with OR51B6: view

Pathways & Interactions for OR51B6 Gene

genes like me logo Genes that share pathways with OR51B6: view

Pathways by source for OR51B6 Gene

Interacting Proteins for OR51B6 Gene

Gene Ontology (GO) - Biological Process for OR51B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 11121057
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IBA --
genes like me logo Genes that share ontologies with OR51B6: view

No data available for SIGNOR curated interactions for OR51B6 Gene

Drugs & Compounds for OR51B6 Gene

No Compound Related Data Available

Transcripts for OR51B6 Gene

mRNA/cDNA for OR51B6 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR51B6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR51B6 Gene

No ASD Table

Relevant External Links for OR51B6 Gene

GeneLoc Exon Structure for
OR51B6
ECgene alternative splicing isoforms for
OR51B6

Expression for OR51B6 Gene

mRNA expression in normal human tissues for OR51B6 Gene

SOURCE GeneReport for Unigene cluster for OR51B6 Gene Hs.553730

genes like me logo Genes that share expression patterns with OR51B6: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR51B6 Gene

Orthologs for OR51B6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR51B6 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC100683227 35
  • 77.14 (n)
  • 75.96 (a)
OR51B6 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr65 35
  • 84.83 (n)
  • 85.9 (a)
Olfr65 16
Olfr623 36
  • 81 (a)
OneToMany
Olfr65 36
  • 85 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC466375 35
  • 98.18 (n)
  • 96.15 (a)
OR51B6 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr132 35
  • 84.72 (n)
  • 85.9 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 51 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia OR51B6 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 45 (a)
OneToMany
Species with no ortholog for OR51B6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR51B6 Gene

ENSEMBL:
Gene Tree for OR51B6 (if available)
TreeFam:
Gene Tree for OR51B6 (if available)

Paralogs for OR51B6 Gene

Paralogs for OR51B6 Gene

(359) SIMAP similar genes for OR51B6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR51B6: view

Variants for OR51B6 Gene

Sequence variations from dbSNP and Humsavar for OR51B6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_053312 -
VAR_053313 -
VAR_053314 -
VAR_053315 -
VAR_053316 -

Structural Variations from Database of Genomic Variants (DGV) for OR51B6 Gene

Variant ID Type Subtype PubMed ID
nsv524400 CNV Loss 19592680
nsv896931 CNV Loss 21882294
esv26010 CNV Gain 19812545
dgv56n21 CNV Loss 19592680

Variation tolerance for OR51B6 Gene

Residual Variation Intolerance Score: 98.53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 26.38; 99.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR51B6 Gene

HapMap Linkage Disequilibrium report
OR51B6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR51B6 Gene

Disorders for OR51B6 Gene

Relevant External Links for OR51B6

Genetic Association Database (GAD)
OR51B6
Human Genome Epidemiology (HuGE) Navigator
OR51B6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR51B6
genes like me logo Genes that share disorders with OR51B6: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR51B6 Gene

Publications for OR51B6 Gene

  1. Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster. (PMID: 20018918) Solovieff N. … Steinberg M.H. (Blood 2010) 67
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 67
  3. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PMID: 11121057) Bulger M. … Hardison R. (Proc. Natl. Acad. Sci. U.S.A. 2000) 67
  4. Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. (PMID: 10220430) Bulger M. … Groudine M. (Proc. Natl. Acad. Sci. U.S.A. 1999) 67

Products for OR51B6 Gene

Sources for OR51B6 Gene

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