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OR51B5 Gene

protein-coding   GIFtS: 47
GCID: GC11M005363

Olfactory Receptor, Family 51, Subfamily B, Member 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 51, Subfamily B, Member 51 2
Odorant Receptor HOR5'Beta52 3
Olfactory Receptor OR11-372 3
HOR5'Beta52
OR11-372
Olfactory Receptor 51B52

External Ids:    HGNC: 195991   Entrez Gene: 2827632   Ensembl: ENSG000002421807   UniProtKB: Q9H3393   

Export aliases for OR51B5 gene to outside databases

Previous GC identifers: GC00U903062 GC11U900610 GC11M005321 GC11M005323


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR51B5 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR51B5 Gene:
OR51B5 (olfactory receptor, family 51, subfamily B, member 5) is a protein-coding gene. Diseases associated with OR51B5 include sickle cell anemia, and beta thalassemia. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51M1.

UniProtKB/Swiss-Prot: O51B5_HUMAN, Q9H339
Function: Odorant receptor (Potential)

Gene Wiki entry for OR51B5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the OR51B5 gene promoter:
         Max1   GATA-3   AML1a   POU3F2 (N-Oct-5a)   POU3F2   LCR-F1   GATA-1   GATA-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR51B5 promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR51B5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

OR51B5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR51B5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M005363:  view genomic region     (about GC identifiers)

Start:
5,363,819 bp from pter      End:
5,364,754 bp from pter
Size:
936 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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UniProtKB/Swiss-Prot: O51B5_HUMAN, Q9H339 (See protein sequence)
Recommended Name: Olfactory receptor 51B5  
Size: 312 amino acids; 35241 Da
Secondary accessions: B2RN59

Explore the universe of human proteins at neXtProt for OR51B5: NX_Q9H339

Explore proteomics data for OR51B5 at MOPED

HORDE protein sequence for OR51B5

See OR51B5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001005567.2  
ENSEMBL proteins: 
 ENSP00000300773  
Reactome Protein details: Q9H339

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
OR51: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q9H339

ProtoNet protein and cluster: Q9H339

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: O51B5_HUMAN, Q9H339
Similarity: Belongs to the G-protein coupled receptor 1 family


OR51B5 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: O51B5_HUMAN, Q9H339
Function: Odorant receptor (Potential)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity NAS11121057
     
OR51B5 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for OR51B5:
 Increased G1 DNA content 

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
O51B5_HUMAN, Q9H339: Cell membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral component of membrane NAS11121057

OR51B5 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for OR51B5 About    
See pathways by source

SuperPathContained pathways About
1Olfactory Signaling Pathway
Olfactory Signaling Pathway0.82
Olfactory transduction0.82
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for OR51B5
    Olfactory Signaling Pathway


1 Kegg Pathway  (Kegg details for OR51B5):
    Olfactory transduction


OR51B5 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR51B5
Interactions:

    Search GeneGlobe Interaction Network for OR51B5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for OR51B5 (ENSP000003007734) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
InteractantInteraction Details
GeneCardExternal ID(s)
OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
OR51B2ENSP000003275404STRING: ENSP00000327540
OR51B4ENSP000003695734STRING: ENSP00000369573
OR51B6ENSP000003695684STRING: ENSP00000369568
OR51M1ENSP000003331964STRING: ENSP00000333196
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----
GO:0007608sensory perception of smell NAS11121057
GO:0050911detection of chemical stimulus involved in sensory perception of smell NAS11121057

OR51B5 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for OR51B5 (O51B5)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for OR51B5 gene: 
NM_001005567.2  

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000300773(uc001map.1)
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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OR51B5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTCTTTCACA
OR51B5 Expression
About this image

OR51B5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

OR51B5 Protein Expression
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for OR51B5 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Olfr6235 olfactory receptor 623   --   7 (54.85 cM) 103660295 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
46(a)
1 → many
1(193679670-193680620) ENSGALG00000026571


ENSEMBL Gene Tree for OR51B5 (if available)
TreeFam Gene Tree for OR51B5 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for OR51B5 gene
OR51M12  OR51D12  OR51V12  OR51B62  OR51J12  OR51Q12  OR51E22  OR51B22  
OR51B42  OR51E12  
Selected SIMAP similar genes for OR51B5 using alignment to 1 protein entry:     O51B5_HUMAN(see all similar genes):
OR51B2    OR51B6    OR51B4    OR51A2    OR51L1    OR51V1
OR51A4    OR51F2    OR51G1    OR51G2    OR51I1    OR52K3P
OR51M1    OR51A7    OR51E2    OR51Q1    OR52K2    OR51E1

OR51B5 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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7 SNPs for OR51B5    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs110369131,2,4
----see VAR_0533072 mis40--------
rs572737811,2,4
----see VAR_0620782 mis40--------
rs122736301,2,4
----see VAR_0533092 mis40--------
rs579001411,2,4
----see VAR_0620792 mis40--------
rs110369121,2,4
----see VAR_0533082 mis40--------
rs71203191,2,4
----see VAR_0533112 mis40--------
rs49105511,2,4
----see VAR_0533102 mis40--------

HapMap Linkage Disequilibrium report for OR51B5 ( 5363819 - 5364754 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for OR51B5 (see all 32):    About this table    
Variant IDTypeSubtypePubMed ID
esv2660728CNV Deletion23128226
esv2744061CNV Deletion23290073
esv2744062CNV Deletion23290073
esv4563CNV Deletion18987735
esv2676206CNV Deletion23128226
esv2744060CNV Deletion23290073
esv2664205CNV Deletion23128226
esv268103CNV Insertion20981092
nsv896939CNV Loss21882294
nsv524400CNV Loss19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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4 diseases for OR51B5:    
About MalaCards
sickle cell anemia    beta thalassemia    thalassemia    neuronitis

1 disease from the University of Copenhagen DISEASES database for OR51B5:
Sickle cell anemia

OR51B5 for disorders           About GeneDecksing

Genetic Association Database (GAD): OR51B5
Human Genome Epidemiology (HuGE) Navigator: OR51B5 (1 document)

Export disorders for OR51B5 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for OR51B5 gene integrated from 10 sources:
(articles sorted by number of sources associating them with OR51B5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster. (PubMed id 20018918)1, 4 Solovieff N....Steinberg M.H. (Blood 2010)
  2. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
  3. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PubMed id 11121057)1, 2 Bulger M.... Hardison R. (Proc. Natl. Acad. Sci. U.S.A. 2000)
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  7. Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. (PubMed id 10220430)1 Bulger M.... Groudine M. (Proc. Natl. Acad. Sci. U.S.A. 1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 282763 HGNC: 19599 Ensembl:ENSG00000242180 euGenes: HUgn282763 ECgene: OR51B5 Kegg: 282763
H-InvDB: OR51B5

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for OR51B5 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR51B5 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for OR51B5 gene:
Search GeneIP for patents involving OR51B5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR51B5
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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