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Aliases for OR51B5 Gene

Aliases for OR51B5 Gene

  • Olfactory Receptor Family 51 Subfamily B Member 5 2 3 5
  • Olfactory Receptor, Family 51, Subfamily B, Member 5 2 3
  • Odorant Receptor HOR5beta5 3 4
  • Olfactory Receptor OR11-37 3 4
  • HOR5Beta5 3
  • OR11-37 3

External Ids for OR51B5 Gene

Previous GeneCards Identifiers for OR51B5 Gene

  • GC00U903062
  • GC11U900610
  • GC11M005321
  • GC11M005323

Summaries for OR51B5 Gene

Entrez Gene Summary for OR51B5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51B5 Gene

OR51B5 (Olfactory Receptor Family 51 Subfamily B Member 5) is a Protein Coding gene. Diseases associated with OR51B5 include sickle cell anemia. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51E1.

UniProtKB/Swiss-Prot for OR51B5 Gene

  • Odorant receptor.

Gene Wiki entry for OR51B5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR51B5 Gene

Genomics for OR51B5 Gene

Regulatory Elements for OR51B5 Gene

Promoters for OR51B5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OR51B5 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR51B5 Gene

Chromosome:
11
Start:
5,340,479 bp from pter
End:
5,505,652 bp from pter
Size:
165,174 bases
Orientation:
Minus strand

Genomic View for OR51B5 Gene

Genes around OR51B5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51B5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51B5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51B5 Gene

Proteins for OR51B5 Gene

  • Protein details for OR51B5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H339-O51B5_HUMAN
    Recommended name:
    Olfactory receptor 51B5
    Protein Accession:
    Q9H339
    Secondary Accessions:
    • B2RN59

    Protein attributes for OR51B5 Gene

    Size:
    312 amino acids
    Molecular mass:
    35241 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51B5 Gene

Proteomics data for OR51B5 Gene at MOPED

Post-translational modifications for OR51B5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR51B5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51B5 Gene

Domains & Families for OR51B5 Gene

Gene Families for OR51B5 Gene

Protein Domains for OR51B5 Gene

Suggested Antigen Peptide Sequences for OR51B5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H339

UniProtKB/Swiss-Prot:

O51B5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51B5: view

Function for OR51B5 Gene

Molecular function for OR51B5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes for OR51B5 Gene

genes like me logo Genes that share phenotypes with OR51B5: view

Animal Model Products

CRISPR Products

miRNA for OR51B5 Gene

miRTarBase miRNAs that target OR51B5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR51B5 Gene

Localization for OR51B5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51B5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR51B5 Gene COMPARTMENTS Subcellular localization image for OR51B5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51B5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,NAS 11121057
genes like me logo Genes that share ontologies with OR51B5: view

Pathways & Interactions for OR51B5 Gene

genes like me logo Genes that share pathways with OR51B5: view

Pathways by source for OR51B5 Gene

Interacting Proteins for OR51B5 Gene

Gene Ontology (GO) - Biological Process for OR51B5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 11121057
GO:0050911 detection of chemical stimulus involved in sensory perception of smell NAS 11121057
genes like me logo Genes that share ontologies with OR51B5: view

No data available for SIGNOR curated interactions for OR51B5 Gene

Drugs & Compounds for OR51B5 Gene

No Compound Related Data Available

Transcripts for OR51B5 Gene

mRNA/cDNA for OR51B5 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR51B5 Gene

Olfactory receptor, family 51, subfamily B, member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OR51B5 Gene

No ASD Table

Relevant External Links for OR51B5 Gene

GeneLoc Exon Structure for
OR51B5
ECgene alternative splicing isoforms for
OR51B5

Expression for OR51B5 Gene

mRNA expression in normal human tissues for OR51B5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OR51B5 Gene

This gene is overexpressed in Ovary (x4.8) and Testis (x4.5).

SOURCE GeneReport for Unigene cluster for OR51B5 Gene Hs.690458

genes like me logo Genes that share expression patterns with OR51B5: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR51B5 Gene

Orthologs for OR51B5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR51B5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OR51B5 36
  • 96 (a)
OneToOne
LOC450980 35
  • 98.61 (n)
  • 96.47 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 50 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia OR51B5 36
  • 84 (a)
OneToOne
LOC100684132 35
  • 72.02 (n)
  • 73.44 (a)
mouse
(Mus musculus)
Mammalia Olfr606 36
  • 49 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 72 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 46 (a)
OneToMany
Species with no ortholog for OR51B5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR51B5 Gene

ENSEMBL:
Gene Tree for OR51B5 (if available)
TreeFam:
Gene Tree for OR51B5 (if available)

Paralogs for OR51B5 Gene

(430) SIMAP similar genes for OR51B5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR51B5: view

Variants for OR51B5 Gene

Sequence variations from dbSNP and Humsavar for OR51B5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11036913 - 5,343,512(+) GCTGC(C/T)GCTGG intron-variant, reference, missense
rs11036912 - 5,343,220(+) AGTGT(A/G)TAAAG intron-variant, reference, missense
rs12273630 - 5,343,065(+) AACAA(C/T)GGATA intron-variant, reference, missense
rs4910551 - 5,343,046(+) AGAGG(A/G)GCCTG intron-variant, reference, missense
rs7120319 - 5,342,867(+) CTTGA(A/G)TATCA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR51B5 Gene

Variant ID Type Subtype PubMed ID
nsv524400 CNV Loss 19592680
nsv896931 CNV Loss 21882294
esv268103 CNV Insertion 20981092
esv26010 CNV Gain 19812545
dgv56n21 CNV Loss 19592680
nsv832057 CNV Loss 17160897
esv997323 CNV Gain 20482838
nsv896932 CNV Gain 21882294
nsv896933 CNV Gain 21882294
esv22160 CNV Loss 19812545
essv3627 CNV CNV 17122850
nsv896934 CNV Loss 21882294
dgv1025n71 CNV Loss 21882294
esv2664205 CNV Deletion 23128226
esv34391 CNV Loss 17911159
esv2744060 CNV Deletion 23290073
esv9420 CNV Loss 19470904
nsv521722 CNV Gain 19592680
nsv896938 CNV Gain 21882294
nsv467669 CNV Gain 19166990
nsv896939 CNV Loss 21882294
esv2660728 CNV Deletion 23128226
esv2744061 CNV Deletion 23290073
dgv195n67 CNV Loss 20364138
esv4563 CNV Deletion 18987735
esv2744062 CNV Deletion 23290073
esv2676206 CNV Deletion 23128226
nsv471745 CNV Loss 16327809
esv21699 CNV Loss 19812545
nsv442597 CNV CNV 18776908
nsv514621 CNV Loss 21397061
nsv510997 CNV Complex 20534489

Variation tolerance for OR51B5 Gene

Residual Variation Intolerance Score: 97.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.00; 98.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR51B5 Gene

HapMap Linkage Disequilibrium report
OR51B5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR51B5 Gene

Disorders for OR51B5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR51B5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
sickle cell anemia
  • drepanocytosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for OR51B5

Genetic Association Database (GAD)
OR51B5
Human Genome Epidemiology (HuGE) Navigator
OR51B5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR51B5
genes like me logo Genes that share disorders with OR51B5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR51B5 Gene

Publications for OR51B5 Gene

  1. Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster. (PMID: 20018918) Solovieff N. … Steinberg M.H. (Blood 2010) 3 48 67
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PMID: 11121057) Bulger M. … Hardison R. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3
  5. Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. (PMID: 10220430) Bulger M. … Groudine M. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3

Products for OR51B5 Gene

Sources for OR51B5 Gene

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