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Aliases for OR51B5 Gene

Aliases for OR51B5 Gene

  • Olfactory Receptor Family 51 Subfamily B Member 5 2 3 5
  • Odorant Receptor HOR5beta5 3 4
  • Olfactory Receptor OR11-37 3 4
  • Olfactory Receptor, Family 51, Subfamily B, Member 5 2
  • Olfactory Receptor 51B5 3
  • HOR5Beta5 3
  • OR11-37 3

External Ids for OR51B5 Gene

Previous GeneCards Identifiers for OR51B5 Gene

  • GC00U903062
  • GC11U900610
  • GC11M005321
  • GC11M005323

Summaries for OR51B5 Gene

Entrez Gene Summary for OR51B5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51B5 Gene

OR51B5 (Olfactory Receptor Family 51 Subfamily B Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51B6.

UniProtKB/Swiss-Prot for OR51B5 Gene

  • Odorant receptor.

Gene Wiki entry for OR51B5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR51B5 Gene

Genomics for OR51B5 Gene

Regulatory Elements for OR51B5 Gene

Enhancers for OR51B5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F005361 1.1 Ensembl ENCODE 11 +140.1 140119 7.4 CTCF HINFP DDX20 JUN PTRF CHAMP1 IRF9 ZNF316 NFE2 MAFK ENSG00000224091 OR51B5 OR51M1 OR51B4 OR51J1 OR51V1 OR52A4P HBB ENSG00000221031 OR51I2
GH11F005284 0.7 ENCODE 9.7 +219.8 219795 1.8 TAL1 RELA ZKSCAN1 ZNF316 NCOR1 POLR2A NR2F6 STAT1 ZBTB11 NCOA1 ENSG00000224091 HBB ENSG00000221031 HBBP1 HBD OR51V1 HBG1 OR51B5 GC11M005283 LCRB
GH11F005379 0.3 FANTOM5 9.6 +125.7 125661 0.0 ZNF316 OR51V1 OR51T1 HBB OR51B5 OR51G1 OR56B1 OR52J3 OR51L1 OR52N4 OR52D1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR51B5 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR51B5 Gene

Chromosome:
11
Start:
5,340,479 bp from pter
End:
5,505,652 bp from pter
Size:
165,174 bases
Orientation:
Minus strand

Genomic View for OR51B5 Gene

Genes around OR51B5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51B5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51B5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51B5 Gene

Proteins for OR51B5 Gene

  • Protein details for OR51B5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H339-O51B5_HUMAN
    Recommended name:
    Olfactory receptor 51B5
    Protein Accession:
    Q9H339
    Secondary Accessions:
    • B2RN59

    Protein attributes for OR51B5 Gene

    Size:
    312 amino acids
    Molecular mass:
    35241 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51B5 Gene

Post-translational modifications for OR51B5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR51B5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51B5 Gene

Domains & Families for OR51B5 Gene

Gene Families for OR51B5 Gene

Protein Domains for OR51B5 Gene

Suggested Antigen Peptide Sequences for OR51B5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H339

UniProtKB/Swiss-Prot:

O51B5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51B5: view

Function for OR51B5 Gene

Molecular function for OR51B5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR51B5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 11121057
genes like me logo Genes that share ontologies with OR51B5: view

Phenotypes for OR51B5 Gene

genes like me logo Genes that share phenotypes with OR51B5: view

Animal Model Products

miRNA for OR51B5 Gene

miRTarBase miRNAs that target OR51B5

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR51B5 Gene

Localization for OR51B5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51B5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR51B5 Gene COMPARTMENTS Subcellular localization image for OR51B5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51B5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 11121057
genes like me logo Genes that share ontologies with OR51B5: view

Pathways & Interactions for OR51B5 Gene

genes like me logo Genes that share pathways with OR51B5: view

Pathways by source for OR51B5 Gene

Gene Ontology (GO) - Biological Process for OR51B5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA,IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 11121057
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR51B5: view

No data available for SIGNOR curated interactions for OR51B5 Gene

Transcripts for OR51B5 Gene

mRNA/cDNA for OR51B5 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR51B5 Gene

Olfactory receptor, family 51, subfamily B, member 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR51B5 Gene

No ASD Table

Relevant External Links for OR51B5 Gene

GeneLoc Exon Structure for
OR51B5
ECgene alternative splicing isoforms for
OR51B5

Expression for OR51B5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR51B5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OR51B5 Gene

This gene is overexpressed in Ovary (x4.8) and Testis (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of OR51B5 Gene:

OR51B5

SOURCE GeneReport for Unigene cluster for OR51B5 Gene:

Hs.690458
genes like me logo Genes that share expression patterns with OR51B5: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR51B5 Gene

Orthologs for OR51B5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR51B5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC450980 34
  • 98.61 (n)
OR51B5 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR51B5 35
  • 84 (a)
OneToOne
LOC100684132 34
  • 72.02 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 72 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 50 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr606 35
  • 49 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 46 (a)
OneToMany
Species where no ortholog for OR51B5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR51B5 Gene

ENSEMBL:
Gene Tree for OR51B5 (if available)
TreeFam:
Gene Tree for OR51B5 (if available)

Paralogs for OR51B5 Gene

(430) SIMAP similar genes for OR51B5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR51B5: view

Variants for OR51B5 Gene

Sequence variations from dbSNP and Humsavar for OR51B5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1009517 -- 5,391,768(+) ATGCT(A/G)TAATC intron-variant
rs10160740 -- 5,495,384(+) tttta(A/C)aaata intron-variant
rs1039215 -- 5,464,062(-) GTTTT(C/T)CATCA intron-variant
rs1039216 -- 5,463,284(-) TTTAC(A/G)CTTGA intron-variant
rs10450568 -- 5,455,219(+) CATAG(A/G)ATTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OR51B5 Gene

Variant ID Type Subtype PubMed ID
dgv1042n100 CNV gain 25217958
dgv1043n100 CNV loss 25217958
dgv1598n54 CNV loss 21841781
dgv1599n54 CNV loss 21841781
dgv1600n54 CNV loss 21841781
dgv1601n54 CNV loss 21841781
dgv1602n54 CNV loss 21841781
dgv1603n54 CNV loss 21841781
dgv195n67 CNV loss 20364138
dgv310e212 CNV loss 25503493
dgv311e212 CNV loss 25503493
dgv56n21 CNV loss 19592680
esv21699 CNV loss 19812545
esv22160 CNV loss 19812545
esv26010 CNV gain 19812545
esv2660728 CNV deletion 23128226
esv2664205 CNV deletion 23128226
esv2676206 CNV deletion 23128226
esv2744060 CNV deletion 23290073
esv2744061 CNV deletion 23290073
esv2744062 CNV deletion 23290073
esv2759800 CNV loss 17122850
esv2761646 CNV loss 21179565
esv2761647 CNV loss 21179565
esv2761648 CNV loss 21179565
esv2762893 CNV loss 21179565
esv3258941 CNV deletion 24192839
esv3337098 CNV duplication 20981092
esv3428467 CNV insertion 20981092
esv3431009 CNV duplication 20981092
esv34391 CNV loss 17911159
esv3547253 CNV deletion 23714750
esv3625225 CNV loss 21293372
esv3625226 CNV loss 21293372
esv3625227 CNV loss 21293372
esv3625228 CNV loss 21293372
esv3625229 CNV gain 21293372
esv3625230 CNV loss 21293372
esv3625231 CNV loss 21293372
esv3625232 CNV loss 21293372
esv3625234 CNV loss 21293372
esv4563 CNV loss 18987735
esv9420 CNV loss 19470904
esv997323 CNV gain 20482838
nsv1039047 CNV gain 25217958
nsv1043028 CNV gain 25217958
nsv1044243 CNV loss 25217958
nsv1046068 CNV gain 25217958
nsv1047754 CNV gain 25217958
nsv1048608 CNV gain 25217958
nsv1113355 CNV deletion 24896259
nsv442597 CNV loss 18776908
nsv467669 CNV gain 19166990
nsv471745 CNV loss 16327809
nsv510997 OTHER complex 20534489
nsv514621 CNV loss 21397061
nsv521722 CNV gain 19592680
nsv524400 CNV loss 19592680
nsv553235 CNV loss 21841781
nsv553239 CNV gain 21841781
nsv553240 CNV loss 21841781
nsv553241 CNV gain 21841781
nsv553243 CNV loss 21841781
nsv553253 CNV loss 21841781
nsv832057 CNV loss 17160897

Variation tolerance for OR51B5 Gene

Residual Variation Intolerance Score: 97.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.00; 98.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR51B5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR51B5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR51B5 Gene

Disorders for OR51B5 Gene

Relevant External Links for OR51B5

Genetic Association Database (GAD)
OR51B5
Human Genome Epidemiology (HuGE) Navigator
OR51B5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR51B5

No disorders were found for OR51B5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR51B5 Gene

Publications for OR51B5 Gene

  1. Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster. (PMID: 20018918) Solovieff N. … Steinberg M.H. (Blood 2010) 3 46 64
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  3. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PMID: 11121057) Bulger M. … Hardison R. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 64
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for OR51B5 Gene

Sources for OR51B5 Gene

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