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Aliases for OR51B4 Gene

Aliases for OR51B4 Gene

  • Olfactory Receptor Family 51 Subfamily B Member 4 2 3 5
  • Odorant Receptor HOR5beta1 3 4
  • Olfactory Receptor, Family 51, Subfamily B, Member 4 2
  • Olfactory Receptor 51B4 3
  • EC 2.4.2.22 61
  • EC 1.3.3.1 61
  • HOR5Beta1 3

External Ids for OR51B4 Gene

Previous GeneCards Identifiers for OR51B4 Gene

  • GC11M006070
  • GC11M005624
  • GC11M005281
  • GC11M005286
  • GC11M005279
  • GC11M005325

Summaries for OR51B4 Gene

Entrez Gene Summary for OR51B4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51B4 Gene

OR51B4 (Olfactory Receptor Family 51 Subfamily B Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51B6.

UniProtKB/Swiss-Prot for OR51B4 Gene

  • Odorant receptor.

Gene Wiki entry for OR51B4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR51B4 Gene

Genomics for OR51B4 Gene

Regulatory Elements for OR51B4 Gene

Enhancers for OR51B4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F005279 1.6 FANTOM5 Ensembl ENCODE 10.8 +21.0 20971 2.6 PKNOX1 ATF1 ARNT CREB3L1 ELK1 GATA2 FOS DEK JUNB NCOA1 HBG2 HBD HBB TRIM68 ENSG00000221031 OR51B4 HBG1 GC11M005280 GC11M005283
GH11F005274 1.2 FANTOM5 ENCODE 10.1 +26.5 26455 2.2 TBP HDAC1 CBX3 ATF1 ARNT TBL1XR1 CHAMP1 GATA2 CREM ZBTB2 HBD HBG2 HBB HBG1 HBBP1 ENSG00000221031 OR51V1 OR51B4 GC11M005280 ENSG00000279346
GH11F005361 1.1 Ensembl ENCODE 10.4 -63.5 -63538 7.4 CTCF HINFP DDX20 JUN PTRF CHAMP1 IRF9 ZNF316 NFE2 MAFK ENSG00000224091 OR51B5 OR51M1 OR51B4 OR51J1 OR51V1 OR52A4P HBB ENSG00000221031 OR51I2
GH11F005278 0.4 FANTOM5 10.2 +23.1 23082 0.2 NFYB HBD HBG2 HBG1 HBB ENSG00000221031 HBBP1 OR51B4 GC11M005280 ENSG00000279346
GH11F004429 0.4 ENCODE 6.1 +871.5 871531 2.4 ZNF316 MAFK OR51B4 OR52K3P OR52P2P OR51R1P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR51B4 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR51B4 Gene

Chromosome:
11
Start:
5,301,014 bp from pter
End:
5,301,996 bp from pter
Size:
983 bases
Orientation:
Minus strand

Genomic View for OR51B4 Gene

Genes around OR51B4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51B4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51B4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51B4 Gene

Proteins for OR51B4 Gene

  • Protein details for OR51B4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5P0-O51B4_HUMAN
    Recommended name:
    Olfactory receptor 51B4
    Protein Accession:
    Q9Y5P0
    Secondary Accessions:
    • A7MAV5
    • Q6NTD7

    Protein attributes for OR51B4 Gene

    Size:
    310 amino acids
    Molecular mass:
    34912 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51B4 Gene

Selected DME Specific Peptides for OR51B4 Gene

Q9Y5P0:
  • SLAIVES
  • TVMGLSF

Post-translational modifications for OR51B4 Gene

  • Glycosylation at Asn 4
  • Modification sites at PhosphoSitePlus

Other Protein References for OR51B4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

Domains & Families for OR51B4 Gene

Gene Families for OR51B4 Gene

Protein Domains for OR51B4 Gene

Suggested Antigen Peptide Sequences for OR51B4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5P0

UniProtKB/Swiss-Prot:

O51B4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51B4: view

Function for OR51B4 Gene

Molecular function for OR51B4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Enzyme Numbers (IUBMB) for OR51B4 Gene

Gene Ontology (GO) - Molecular Function for OR51B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 11121057
genes like me logo Genes that share ontologies with OR51B4: view
genes like me logo Genes that share phenotypes with OR51B4: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51B4 Gene

Localization for OR51B4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51B4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR51B4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 11121057
genes like me logo Genes that share ontologies with OR51B4: view

Pathways & Interactions for OR51B4 Gene

genes like me logo Genes that share pathways with OR51B4: view

Pathways by source for OR51B4 Gene

Gene Ontology (GO) - Biological Process for OR51B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA,IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 11121057
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR51B4: view

No data available for SIGNOR curated interactions for OR51B4 Gene

Transcripts for OR51B4 Gene

mRNA/cDNA for OR51B4 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR51B4 Gene

Olfactory receptor, family 51, subfamily B, member 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR51B4 Gene

No ASD Table

Relevant External Links for OR51B4 Gene

GeneLoc Exon Structure for
OR51B4
ECgene alternative splicing isoforms for
OR51B4

Expression for OR51B4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR51B4 Gene

Protein differential expression in normal tissues from HIPED for OR51B4 Gene

This gene is overexpressed in Liver (64.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR51B4 Gene



Protein tissue co-expression partners for OR51B4 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR51B4 Gene:

OR51B4

SOURCE GeneReport for Unigene cluster for OR51B4 Gene:

Hs.679499
genes like me logo Genes that share expression patterns with OR51B4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR51B4 Gene

Orthologs for OR51B4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR51B4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC745918 34
  • 98.82 (n)
OR51B4 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100684060 34
  • 82.26 (n)
OR51B4 35
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr130 34
  • 79.1 (n)
mouse
(Mus musculus)
Mammalia Or51b4 55 Olfr66 34 16 35
  • 78.92 (n)
Olfr64 35
  • 73 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 70 (a)
ManyToMany
-- 35
  • 70 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 41 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 41 (a)
OneToMany
Species where no ortholog for OR51B4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR51B4 Gene

ENSEMBL:
Gene Tree for OR51B4 (if available)
TreeFam:
Gene Tree for OR51B4 (if available)

Paralogs for OR51B4 Gene

(379) SIMAP similar genes for OR51B4 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for OR51B4 Gene

genes like me logo Genes that share paralogs with OR51B4: view

Variants for OR51B4 Gene

Sequence variations from dbSNP and Humsavar for OR51B4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10742615 -- 5,303,747(+) CTACC(G/T)CCACA upstream-variant-2KB
rs10837771 -- 5,301,507(+) CTCTC(A/G)TCAGT reference, missense
rs10837774 -- 5,302,158(+) ATCAT(A/G)GTCAG upstream-variant-2KB
rs10837776 -- 5,303,257(+) GTTGT(C/T)GTGAT upstream-variant-2KB
rs11036683 -- 5,303,775(+) ATTAT(A/C)AGTTC upstream-variant-2KB

Variation tolerance for OR51B4 Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.02; 84.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR51B4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR51B4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR51B4 Gene

Disorders for OR51B4 Gene

Relevant External Links for OR51B4

Genetic Association Database (GAD)
OR51B4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR51B4

No disorders were found for OR51B4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR51B4 Gene

Publications for OR51B4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PMID: 11121057) Bulger M. … Hardison R. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 64
  3. Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. (PMID: 10220430) Bulger M. … Groudine M. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 64
  4. Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis. (PMID: 24657165) Kim H. … D'Andrea A.D. (Mol. Cell 2014) 3 64
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64

Products for OR51B4 Gene

Sources for OR51B4 Gene

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