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OR51B4 Gene

protein-coding   GIFtS: 48
GCID: GC11M005325

Olfactory Receptor, Family 51, Subfamily B, Member 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 51, Subfamily B, Member 41 2
Odorant Receptor HOR5'Beta12 3
HOR5'Beta12
Olfactory Receptor 51B42
EC 1.3.3.18
EC 2.4.2.228

External Ids:    HGNC: 147081   Entrez Gene: 793392   Ensembl: ENSG000001832517   UniProtKB: Q9Y5P03   

Export aliases for OR51B4 gene to outside databases

Previous GC identifers: GC11M006070 GC11M005624 GC11M005281 GC11M005286 GC11M005279


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR51B4 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR51B4 Gene:
OR51B4 (olfactory receptor, family 51, subfamily B, member 4) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51M1.

UniProtKB/Swiss-Prot: O51B4_HUMAN, Q9Y5P0
Function: Odorant receptor (Potential)

Gene Wiki entry for OR51B4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the OR51B4 gene promoter:
         TBP   AML1a   HNF-3beta   GATA-1   FOXL1   RORalpha1   AREB6   Ik-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR51B4 promoter sequence
   Search Chromatin IP Primers for OR51B4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR51B4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

OR51B4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR51B4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M005325:  view genomic region     (about GC identifiers)

Start:
5,322,247 bp from pter      End:
5,323,176 bp from pter
Size:
930 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: O51B4_HUMAN, Q9Y5P0 (See protein sequence)
Recommended Name: Olfactory receptor 51B4  
Size: 310 amino acids; 34912 Da
Secondary accessions: A7MAV5 Q6NTD7

Explore the universe of human proteins at neXtProt for OR51B4: NX_Q9Y5P0

Explore proteomics data for OR51B4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn4
  • HORDE protein sequence for OR51B4
    2 DME Specific Peptides for OR51B4 (Q9Y5P0)
     SLAIVES  TVMGLSF 


    See OR51B4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_149419.2  
    ENSEMBL proteins: 
     ENSP00000369573  
    Reactome Protein details: Q9Y5P0

    OR51B4 Human Recombinant Protein Products:

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    antibodies-online proteins for OR51B4 (3 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR51: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9Y5P0

    ProtoNet protein and cluster: Q9Y5P0

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O51B4_HUMAN, Q9Y5P0
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR51B4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O51B4_HUMAN, Q9Y5P0
    Function: Odorant receptor (Potential)

         Enzyme Numbers (IUBMB): EC 1.3.3.12 EC 2.4.2.222

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity NAS11121057
         
    Find genes that share ontologies with OR51B4           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for OR51B4:
     Decreased viability  Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Olfr66):
     nervous system 

    Find genes that share phenotypes with OR51B4           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OR51B4

    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O51B4_HUMAN, Q9Y5P0: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane NAS11121057

    Find genes that share ontologies with OR51B4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR51B4 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR51B4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR51B4
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR51B4):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR51B4
    Interactions:

        Search GeneGlobe Interaction Network for OR51B4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR51B4 (ENSP000003695734) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR51B5ENSP000003007734STRING: ENSP00000300773
    GNALENSP000003340514STRING: ENSP00000334051
    GNGT1ENSP000002485724STRING: ENSP00000248572
    OR10A3ENSP000003539884STRING: ENSP00000353988
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007608sensory perception of smell NAS11121057
    GO:0050911detection of chemical stimulus involved in sensory perception of smell NAS11121057

    Find genes that share ontologies with OR51B4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR51B4 (O51B4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR51B4 gene: 
    NM_033179.2  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000380224(uc010qza.2)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat OR51B4
      QuantiFast Probe-based Assays in human, mouse, rat OR51B4

    4 AceView cDNA sequences:

    BC069094 BG527618 NM_033179 BG492876 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR51B4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCTATGTCC
    OR51B4 Expression
    About this image

    OR51B4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR51B4 Protein Expression
        Custom PCR Arrays for OR51B4
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OR51B4 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr661 , 5 olfactory receptor 661, 5 78.92(n)1
    75.16(a)1
      7 (54.85 cM)5
    183671  NM_013618.31  NP_038646.21 
     1038813065 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    41(a)
    1 → many
    1(193679670-193680620) ENSGALG00000026571


    ENSEMBL Gene Tree for OR51B4 (if available)
    TreeFam Gene Tree for OR51B4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR51B4 gene
    OR51M12  OR51D12  OR51V12  OR51B62  OR51B52  OR51J12  OR51Q12  OR51E22  
    OR51B22  OR51E12  
    Selected SIMAP similar genes for OR51B4 using alignment to 2 protein entries:     O51B4_HUMAN (see all proteins) (see all similar genes):
    OR51B2    OR51B6    OR51B5    OR51G1    OR51M1    OR51A4
    OR51I1    OR51V1    OR51A2    OR51A7    OR51F1    OR51F2
    OR52K3P    OR51G2    OR51H1P    OR51L1    OR51I2    OR51Q1

    Find genes that share paralogs with OR51B4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for OR51B4
    PGOHUM00000242144


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR51B4 (see all 130)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1504475351,2
    Cuntested15322912(+) AATCTC/TCCTCT 2 K E mis10--------
    rs2002812791,2
    --5321968(+) CTCTT-/CTTTTG 1 -- ds50010--------
    rs1467541571,2
    C--5321984(+) TTATAC/TCTCCT 1 -- ds50010--------
    rs1394448961,2
    --5322015(+) CTTCAC/GCATCA 1 -- ds50010--------
    rs714680231,2
    C--5322045(+) AGGTGAT/-ATATA 1 -- ds50011Minor allele frequency- -:0.50NA 2
    rs127929281,2
    F,A--5322066(+) ATATAC/TACACA 1 -- ds50014Minor allele frequency- T:0.25NA CSA 8
    rs672917001,2
    C--5322066(+) ATATA-/ACA   
      CAC
    /TA
    CACAC
    2 -- ds5001 cds10--------
    rs122702791,2
    C,A--5322101(+) TTTCTC/TGCTCA 1 -- ds50014Minor allele frequency- T:0.16CSA WA NA EA 360
    rs1848077811,2
    --5322157(+) GAAAAA/TAAAGT 1 -- ds50010--------
    rs1145440231,2
    C,F--5322249(+) TCAAGC/GCCTAC 2 P A mis13Minor allele frequency- G:0.02EA NA 640

    HapMap Linkage Disequilibrium report for OR51B4 ( 5322247 - 5323176 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for OR51B4: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OR51B4
    DNA2.0 Custom Variant and Variant Library Synthesis for OR51B4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with OR51B4           About GenesLikeMe

    Genetic Association Database (GAD): OR51B4

    Export disorders for OR51B4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR51B4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR51B4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PubMed id 11121057)1, 2 Bulger M.... Hardison R. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    3. Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. (PubMed id 10220430)1, 2 Bulger M.... Groudine M. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79339 HGNC: 14708 AceView: OR51B4 Ensembl:ENSG00000183251 euGenes: HUgn79339
    ECgene: OR51B4 Kegg: 79339 H-InvDB: OR51B4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR51B4 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR51B4 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR51B4 gene:
    Search GeneIP for patents involving OR51B4

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for OR51B4  
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     Block miRNA regulation of human, mouse, rat OR51B4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OR51B4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR51B4 Predesigned siRNA for gene silencing in human, mouse, rat OR51B4
     QuantiFast Probe-based Assays in human, mouse, rat OR51B4 QuantiTect SYBR Green Assays in human, mouse, rat OR51B4
     Custom PCR Arrays for OR51B4 Search Chromatin IP Primers for OR51B4
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     Search Tocris compounds for OR51B4 (O51B4)
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     Browse ESI BIO Cell Lines and PureStem Progenitors for OR51B4
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     Browse compounds at ApexBio
     Search Addgene for plasmids for OR51B4
      Search eBioscience for proteins for OR51B4
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      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for OR51B4
      Search antibodies-online for antibodies for OR51B4
     antibodies-online kits for OR51B4
      Search antibodies-online for peptides for OR51B4
     antibodies-online proteins for OR51B4 (3 products)
           
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