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Aliases for OR51B2 Gene

Aliases for OR51B2 Gene

  • Olfactory Receptor Family 51 Subfamily B Member 2 (Gene/Pseudogene) 2 3 5
  • Odorant Receptor HOR5beta3 3 4
  • Olfactory Receptor 51B1 3 4
  • OR51B1P 3 4
  • Olfactory Receptor, Family 51, Subfamily B, Member 2 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 51, Subfamily B, Member 2 3
  • Olfactory Receptor 51B2 3
  • HOR5Beta3 3

External Ids for OR51B2 Gene

Previous HGNC Symbols for OR51B2 Gene

  • OR51B1P

Previous GeneCards Identifiers for OR51B2 Gene

  • GC11M006092
  • GC11M005646
  • GC11M005303
  • GC11M005308
  • GC11M005301

Summaries for OR51B2 Gene

Entrez Gene Summary for OR51B2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR51B2 Gene

OR51B2 (Olfactory Receptor Family 51 Subfamily B Member 2 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51B6.

UniProtKB/Swiss-Prot for OR51B2 Gene

  • Odorant receptor.

Gene Wiki entry for OR51B2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR51B2 Gene

Genomics for OR51B2 Gene

Regulatory Elements for OR51B2 Gene

Enhancers for OR51B2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F005546 0.6 FANTOM5 5.2 -221.9 -221894 0.1 OR56A1 OR56A3 OR51Q1 OR52E8 OR52N1 OR56A4 OR52N4 OR52E2 OR52E4 OR52A1
GH11F005328 0.5 FANTOM5 3.4 -4.8 -4827 0.4 OR51G1 OR51T1 OR52N2 OR52N4 OR52D1 OR52J3 MMP26 OR51L1 OR51B2 OR51M1
GH11F005379 0.3 FANTOM5 2 -55.6 -55640 0.0 ZNF316 OR51V1 OR51T1 HBB OR51B5 OR51G1 OR56B1 OR52J3 OR51L1 OR52N4 OR52D1
GH11F005623 1.1 FANTOM5 ENCODE 1.8 -301.1 -301084 3.2 TBP HDAC1 PKNOX1 TBL1XR1 WRNIP1 SIN3A RAD21 RFX5 YY1 FOS TRIM5 TRIM34 TRIM22 OR51B2 OR56B4 OR56A1 OR56A3 OR52N4 OR51Q1 OR52E6
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR51B2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR51B2 Gene

Chromosome:
11
Start:
5,323,298 bp from pter
End:
5,324,352 bp from pter
Size:
1,055 bases
Orientation:
Minus strand

Genomic View for OR51B2 Gene

Genes around OR51B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51B2 Gene

Proteins for OR51B2 Gene

  • Protein details for OR51B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5P1-O51B2_HUMAN
    Recommended name:
    Olfactory receptor 51B2
    Protein Accession:
    Q9Y5P1
    Secondary Accessions:
    • Q96RD4

    Protein attributes for OR51B2 Gene

    Size:
    312 amino acids
    Molecular mass:
    35373 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51B2 Gene

Post-translational modifications for OR51B2 Gene

  • Glycosylation at Asn 4
  • Modification sites at PhosphoSitePlus

Other Protein References for OR51B2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51B2 Gene

Domains & Families for OR51B2 Gene

Gene Families for OR51B2 Gene

Protein Domains for OR51B2 Gene

Suggested Antigen Peptide Sequences for OR51B2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5P1

UniProtKB/Swiss-Prot:

O51B2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51B2: view

Function for OR51B2 Gene

Molecular function for OR51B2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR51B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR51B2: view
genes like me logo Genes that share phenotypes with OR51B2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51B2 Gene

Localization for OR51B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51B2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR51B2 Gene COMPARTMENTS Subcellular localization image for OR51B2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR51B2: view

Pathways & Interactions for OR51B2 Gene

genes like me logo Genes that share pathways with OR51B2: view

Pathways by source for OR51B2 Gene

Interacting Proteins for OR51B2 Gene

Gene Ontology (GO) - Biological Process for OR51B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR51B2: view

No data available for SIGNOR curated interactions for OR51B2 Gene

Transcripts for OR51B2 Gene

mRNA/cDNA for OR51B2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR51B2 Gene

No ASD Table

Relevant External Links for OR51B2 Gene

GeneLoc Exon Structure for
OR51B2
ECgene alternative splicing isoforms for
OR51B2

Expression for OR51B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR51B2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR51B2 Gene:

OR51B2

SOURCE GeneReport for Unigene cluster for OR51B2 Gene:

Hs.680163
genes like me logo Genes that share expression patterns with OR51B2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR51B2 Gene

Orthologs for OR51B2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR51B2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC745965 34
  • 99.04 (n)
dog
(Canis familiaris)
Mammalia LOC485258 34
  • 77.45 (n)
mouse
(Mus musculus)
Mammalia Or51b17 55 Olfr64 34 16
  • 75.6 (n)
rat
(Rattus norvegicus)
Mammalia Olr131 34
  • 74.97 (n)
Species where no ortholog for OR51B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR51B2 Gene

ENSEMBL:
Gene Tree for OR51B2 (if available)
TreeFam:
Gene Tree for OR51B2 (if available)

Paralogs for OR51B2 Gene

(417) SIMAP similar genes for OR51B2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR51B2: view

Variants for OR51B2 Gene

Sequence variations from dbSNP and Humsavar for OR51B2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10538219 -- 5,323,134(+) AAGAA(-/GAA)TTTAA downstream-variant-500B
rs10664726 -- 5,325,855(+) AAAAT(-/AAAAC)AAAAA upstream-variant-2KB
rs10712211 -- 5,322,978(+) TCAAC(-/T)TTTTT downstream-variant-500B
rs10742622 -- 5,323,542(+) ATCAC(C/T)GTAAC reference, synonymous-codon
rs10768793 -- 5,323,617(+) CCAGA(A/G)GCAAT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for OR51B2 Gene

Variant ID Type Subtype PubMed ID
nsv1046068 CNV gain 25217958
nsv1048608 CNV gain 25217958
nsv524400 CNV loss 19592680
nsv819271 CNV gain 19587683

Variation tolerance for OR51B2 Gene

Residual Variation Intolerance Score: 48.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.32; 96.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR51B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR51B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR51B2 Gene

Disorders for OR51B2 Gene

Relevant External Links for OR51B2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR51B2

No disorders were found for OR51B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR51B2 Gene

Publications for OR51B2 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  2. Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. (PMID: 10220430) Bulger M. … Groudine M. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 64
  3. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T. … Lancet D. (BMC Genomics 2012) 3 64
  4. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I. … Lancet D. (BMC Bioinformatics 2006) 3 64
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64

Products for OR51B2 Gene

Sources for OR51B2 Gene

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