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OR51B2 Gene

protein-coding   GIFtS: 49
GCID: GC11M005344

Olfactory Receptor, Family 51, Subfamily B, Member 2


(Previous symbol: OR51B1P)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 51, Subfamily B, Member 21 2
OR51B1P1 2 3
Odorant Receptor HOR5'Beta32 3
Olfactory Receptor 51B12 3
HOR5'Beta32
Olfactory Receptor 51B22

External Ids:    HGNC: 147031   Entrez Gene: 793452   Ensembl: ENSG000001848817   UniProtKB: Q9Y5P13   

Export aliases for OR51B2 gene to outside databases

Previous GC identifers: GC11M006092 GC11M005646 GC11M005303 GC11M005308 GC11M005301


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR51B2 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR51B2 Gene:
OR51B2 (olfactory receptor, family 51, subfamily B, member 2) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51M1.

UniProtKB/Swiss-Prot: O51B2_HUMAN, Q9Y5P1
Function: Odorant receptor (Potential)

Gene Wiki entry for OR51B2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the OR51B2 gene promoter:
         Max1   AML1a   Brachyury   POU3F2   HNF-3beta   LCR-F1   Evi-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR51B2 promoter sequence
   Search Chromatin IP Primers for OR51B2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR51B2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

OR51B2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR51B2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M005344:  view genomic region     (about GC identifiers)

Start:
5,344,592 bp from pter      End:
5,345,527 bp from pter
Size:
936 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: O51B2_HUMAN, Q9Y5P1 (See protein sequence)
Recommended Name: Olfactory receptor 51B2  
Size: 312 amino acids; 35373 Da
Secondary accessions: Q96RD4

Explore the universe of human proteins at neXtProt for OR51B2: NX_Q9Y5P1

Explore proteomics data for OR51B2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn4
  • HORDE protein sequence for OR51B2

    See OR51B2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_149420.4  
    ENSEMBL proteins: 
     ENSP00000327540  
    Reactome Protein details: Q9Y5P1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR51: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9Y5P1

    ProtoNet protein and cluster: Q9Y5P1

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O51B2_HUMAN, Q9Y5P1
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR51B2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O51B2_HUMAN, Q9Y5P1
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR51B2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for OR51B2:
     Decreased circadian period len  Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OR51B2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O51B2_HUMAN, Q9Y5P1: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR51B2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR51B2 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR51B2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for OR51B2
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR51B2):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR51B2
    Interactions:

        Search GeneGlobe Interaction Network for OR51B2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR51B2 (ENSP000003275404) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10A3ENSP000003539884STRING: ENSP00000353988
    OR10A7ENSP000003267184STRING: ENSP00000326718
    OR14A16ENSP000003502484STRING: ENSP00000350248
    OR14A2ENSP000003554414STRING: ENSP00000355441
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007608sensory perception of smell ----
    GO:0050911detection of chemical stimulus involved in sensory perception of smell ----

    Find genes that share ontologies with OR51B2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for OR51B2 (O51B2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR51B2 gene: 
    NM_033180.4  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000328813(uc001mao.1)
    miRNA
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    1 AceView cDNA sequence:

    NM_033180 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR51B2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTACATCT
    OR51B2 Expression
    About this image

    OR51B2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR51B2 Protein Expression
        Custom PCR Arrays for OR51B2
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OR51B2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr641 , 5 olfactory receptor 641, 5 75.6(n)1
    76.47(a)1
      7 (54.85 cM)5
    183661  NM_013617.31  NP_038645.21 
     1038928105 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    43(a)
    1 → many
    1(193679670-193680620) ENSGALG00000026571


    ENSEMBL Gene Tree for OR51B2 (if available)
    TreeFam Gene Tree for OR51B2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR51B2 gene
    OR51M12  OR51D12  OR51V12  OR51B62  OR51B52  OR51J12  OR51Q12  OR51E22  
    OR51B42  OR51E12  
    Selected SIMAP similar genes for OR51B2 using alignment to 2 protein entries:     O51B2_HUMAN (see all proteins) (see all similar genes):
    OR51B5    OR51B6    OR51B4    OR51V1    OR51G1    OR51F1
    OR51F2    OR51G2    OR51I2    OR51L1    OR51A4    OR51E2
    OR51H1P    OR51I1    OR51M1    OR52K3P    OR51A2    OR51E1

    Find genes that share paralogs with OR51B2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for OR51B2
    PGOHUM00000242145


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR51B2 (see all 146)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1404959711,2
    Cuntested15344739(+) TTCTTC/G/TCCAAA 2 G syn10--------
    rs571303731,2
    --5344049(+) TGGCCC/GTAGAG 1 -- ds50010--------
    rs1900256911,2
    --5344071(+) TCAGGC/GTAGAG 1 -- ds50010--------
    rs1145092361,2
    F--5344139(+) TCTTAT/GCACTA 1 -- ds50011Minor allele frequency- G:0.02WA 118
    rs44335941,2
    C,F,A,H--5344159(+) TGAGAG/ATAATG 1 -- ds500126Minor allele frequency- A:0.27NS EA NA WA CSA 2488
    rs38862241,2
    C,F--5344164(+) ATAATG/AAAAAT 1 -- ds50011Minor allele frequency- A:0.17NA 120
    rs107122111,2
    C--5344208(+) TCAAC-/TTTTTT 1 -- ds50010--------
    rs1812487451,2
    --5344290(+) AGTTTC/TTCATA 1 -- ds50010--------
    rs1159858461,2
    F--5344348(+) TTTCAG/AGTGCA 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs673051671,2
    C--5344359(+) TTTGA-/AAGAAGAA 2 -- ds5001 cds11Minor allele frequency- AAG:0.17CSA 6

    HapMap Linkage Disequilibrium report for OR51B2 ( 5344592 - 5345527 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for OR51B2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv524400CNV Loss19592680
    nsv819271CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease from the University of Copenhagen DISEASES database for OR51B2:
    Sickle cell anemia

    Find genes that share disorders with OR51B2           About GenesLikeMe


    Export disorders for OR51B2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR51B2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR51B2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    2. Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. (PubMed id 10220430)1, 2 Bulger M.... Groudine M. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PubMed id 11121057)1 Bulger M.... Hardison R. (Proc. Natl. Acad. Sci. U.S.A. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79345 HGNC: 14703 AceView: OR51B2 Ensembl:ENSG00000184881 euGenes: HUgn79345
    ECgene: OR51B2 Kegg: 79345 H-InvDB: OR51B2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR51B2 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR51B2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR51B2 gene:
    Search GeneIP for patents involving OR51B2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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