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Aliases for OR51A4 Gene

Aliases for OR51A4 Gene

  • Olfactory Receptor Family 51 Subfamily A Member 4 2 3 5
  • Olfactory Receptor, Family 51, Subfamily A, Member 4 2

External Ids for OR51A4 Gene

Previous GeneCards Identifiers for OR51A4 Gene

  • GC11U990371
  • GC11M004932
  • GC11M004923

Summaries for OR51A4 Gene

Entrez Gene Summary for OR51A4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51A4 Gene

OR51A4 (Olfactory Receptor Family 51 Subfamily A Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51A7.

UniProtKB/Swiss-Prot for OR51A4 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR51A4 Gene

Genomics for OR51A4 Gene

Regulatory Elements for OR51A4 Gene

Enhancers for OR51A4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR51A4 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR51A4 Gene

4,946,159 bp from pter
4,947,100 bp from pter
942 bases
Minus strand

Genomic View for OR51A4 Gene

Genes around OR51A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51A4 Gene

Proteins for OR51A4 Gene

  • Protein details for OR51A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 51A4
    Protein Accession:

    Protein attributes for OR51A4 Gene

    313 amino acids
    Molecular mass:
    35256 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51A4 Gene

Proteomics data for OR51A4 Gene at MOPED

Post-translational modifications for OR51A4 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR51A4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51A4 Gene

Domains & Families for OR51A4 Gene

Gene Families for OR51A4 Gene

Protein Domains for OR51A4 Gene

Suggested Antigen Peptide Sequences for OR51A4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51A4: view

Function for OR51A4 Gene

Molecular function for OR51A4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51A4 Gene

Localization for OR51A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51A4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR51A4 Gene COMPARTMENTS Subcellular localization image for OR51A4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR51A4: view

Pathways & Interactions for OR51A4 Gene

genes like me logo Genes that share pathways with OR51A4: view

Pathways by source for OR51A4 Gene

Interacting Proteins for OR51A4 Gene

Gene Ontology (GO) - Biological Process for OR51A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR51A4: view

No data available for SIGNOR curated interactions for OR51A4 Gene

Drugs & Compounds for OR51A4 Gene

No Compound Related Data Available

Transcripts for OR51A4 Gene

mRNA/cDNA for OR51A4 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR51A4 Gene

No ASD Table

Relevant External Links for OR51A4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR51A4 Gene

mRNA expression in normal human tissues for OR51A4 Gene

SOURCE GeneReport for Unigene cluster for OR51A4 Gene Hs.555481

genes like me logo Genes that share expression patterns with OR51A4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR51A4 Gene

Orthologs for OR51A4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR51A4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC508792 35
  • 85.73 (n)
  • 85.62 (a)
-- 36
  • 84 (a)
-- 36
  • 82 (a)
(Canis familiaris)
Mammalia cOR51A16 35
  • 87.22 (n)
  • 87.86 (a)
-- 36
  • 88 (a)
(Pan troglodytes)
Mammalia LOC100615983 35
  • 98.62 (n)
  • 97.76 (a)
-- 36
  • 98 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
(Mus musculus)
Mammalia Olfr575 36
  • 72 (a)
Species with no ortholog for OR51A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR51A4 Gene

Gene Tree for OR51A4 (if available)
Gene Tree for OR51A4 (if available)

Paralogs for OR51A4 Gene

Paralogs for OR51A4 Gene

(414) SIMAP similar genes for OR51A4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR51A4: view

Variants for OR51A4 Gene

Sequence variations from dbSNP and Humsavar for OR51A4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2595988 - 4,946,302(-) TTGCC(C/G/T)GGCAT reference, missense
VAR_034314 -
rs2412467 - 4,946,887(-) TGTCA(A/C/G)ACTTG reference, missense
rs3845246 - 4,946,968(-) GAAAT(G/T)GCACC reference, missense
rs2436782 - 4,946,170(-) GTCAA(C/T)GGAAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR51A4 Gene

Variant ID Type Subtype PubMed ID
dgv340e1 CNV Complex 17122850
nsv7652 CNV Loss 18451855
nsv526998 CNV Loss 19592680
nsv64 CNV Loss 15895083
nsv896918 CNV Gain 21882294
essv16563 CNV CNV 17122850
nsv508614 CNV Loss 20534489
nsv510996 CNV Complex 20534489
dgv35n16 CNV Deletion 17901297
esv22784 CNV Gain+Loss 19812545
esv2568479 CNV Deletion 19546169
nsv8782 CNV Gain+Loss 18304495
nsv471358 CNV Duplication 19718026
dgv187e199 CNV Deletion 23128226
nsv7653 CNV Insertion 18451855
nsv820116 CNV Loss 19587683
nsv442596 CNV CNV 18776908
esv2744056 CNV Deletion 23290073
dgv191n67 CNV Gain+Loss 20364138
dgv11n47 CNV Loss 21111241
nsv443000 CNV Loss 18674749
dgv10n50 CNV Loss 21212237

Variation tolerance for OR51A4 Gene

Residual Variation Intolerance Score: 92.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.76; 66.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR51A4 Gene

Disorders for OR51A4 Gene

Relevant External Links for OR51A4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR51A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR51A4 Gene

Publications for OR51A4 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 67

Products for OR51A4 Gene

Sources for OR51A4 Gene