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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

OR51A4 Gene

protein-coding GIFtS: 42
GCID: GC11M004967

Olfactory Receptor, Family 51, Subfamily A, Member 4

1 related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 51, Subfamily A, Member 4¹ ²
Olfactory Receptor 51A4²

External Ids:	HGNC: 14795¹	Entrez Gene: 401666²	Ensembl: ENSG00000205497⁷	UniProtKB: Q8NGJ6³

Export aliases for OR51A4 gene to outside databases

Previous GC identifers: GC11U990371 GC11M004932 GC11M004923

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR51A4 Gene:

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the

perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors

(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many

neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of

odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the

olfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul

2008)

GeneCards Summary for OR51A4 Gene:

OR51A4 (olfactory receptor, family 51, subfamily A, member 4) is a protein-coding gene. Diseases associated with OR51A4 include neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51M1.

UniProtKB/Swiss-Prot: O51A4_HUMAN, Q8NGJ6

Function: Odorant receptor (Potential)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.2 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the OR51A4 gene promoter:
HOXA9 HOXA9B AML1a E47 HNF-1A Meis-1b SRY HNF-1 Sox9 Meis-1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR51A4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.4

OR51A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR51A4 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M004967: view genomic region (about GC identifiers)

Start:	4,967,392 bp from pter	End:	4,968,330 bp from pter
Size:	939 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: O51A4_HUMAN, Q8NGJ6 (See protein sequence)

Recommended Name: Olfactory receptor 51A4

Size: 313 amino acids; 35256 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for OR51A4: NX_Q8NGJ6

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q8NGJ6

HORDE protein sequence for OR51A4
OR51A4 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : --

REFSEQ proteins: NP_001005329.1

ENSEMBL proteins:

ENSP00000369731

Reactome Protein details: Q8NGJ6
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Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	IEA	--
GO:0016021	integral to membrane	--	--

OR51A4 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

OR51: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:

IPR017452 GPCR_Rhodpsn_7TM

IPR000725 Olfact_rcpt

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8NGJ6

ProtoNet protein and cluster: Q8NGJ6

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: O51A4_HUMAN, Q8NGJ6

Similarity: Belongs to the G-protein coupled receptor 1 family

OR51A4 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: O51A4_HUMAN, Q8NGJ6

Function: Odorant receptor (Potential)

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004930	G-protein coupled receptor activity	--	--
GO:0004984	olfactory receptor activity	IEA	--
GO:0004993	serotonin receptor activity	IEA	--

OR51A4 for ontologies About GeneDecksing

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for OR51A4 About

See pathways by source

SuperPath

Contained pathways About

Olfactory transduction

Olfactory Signaling Pathway

0.81

Olfactory transduction

0.81

Signaling by GPCR

	Signaling by GPCR	0.90			Signal Transduction	0.55
	GPCR downstream signaling	0.90

Pathways by source See SuperPaths
Show all pathways

4 Reactome Pathways for OR51A4

	GPCR downstream signaling
	Olfactory Signaling Pathway
	Signal Transduction
	Signaling by GPCR

1 Kegg Pathway (Kegg details for OR51A4):

Olfactory transduction

OR51A4 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for OR51A4

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for OR51A4 (ENSP00000369731⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADRBK2	ENSP00000317578⁴	STRING: ENSP00000317578
ARRB2	ENSP00000269260⁴	STRING: ENSP00000269260
GNAL	ENSP00000334051⁴	STRING: ENSP00000334051

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007186	G-protein coupled receptor signaling pathway	--	--

OR51A4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for OR51A4 (O51A4)

Search CenterWatch for drugs/clinical trials and news about OR51A4 / O51A4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for OR51A4 gene:

NM_001005329.1

Unigene Cluster for OR51A4:

Olfactory receptor, family 51, subfamily A, member 4

Hs.555481

Unigene Representative Sequence: BC140757

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000380373(uc010qys.2)

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Additional mRNA sequence: BC140757.1

1 DOTS entry:

DT.120758762

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OR51A4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

SOURCE GeneReport for Unigene cluster: Hs.555481

SABiosciences Custom PCR Arrays for OR51A4

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of mammals.

Orthologs for OR51A4 gene from 1/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
dog (Canis familiaris)	Mammalia	--	--	88(a)	1 → many	21(27381999-27382940)

ENSEMBL Gene Tree for OR51A4 (if available)
TreeFam Gene Tree for OR51A4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for OR51A4 gene

OR51M1² OR51L1² OR51T1² OR51C1P² OR51F2² OR51G2² OR51I1² OR51A7²

OR51G1² OR51H1P² OR51A2² OR51I2² OR51F1²

18/414 SIMAP similar genes for OR51A4 using alignment to 2 protein entries: O51A4_HUMAN (see all proteins) (see all similar genes):

OR51A2 OR51A7 OR51L1 OR51E2 OR51G1 OR51H1P

OR51Q1 OR51M1 OR51B5 OR51E1 OR51I2 OR51V1

OR51G2 OR52M1 OR51B6 OR51F2 OR51I1 OR52K3P

OR51A4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_034314⁴		--	--	see VAR_034314	2	T M	mis⁴		0	--	--	--	--
rs7942178^1,2	C	--	4892829(+)	`AATTAA/GGATAC`	1	--	us2k¹		0	--	--	--	--
rs7942281^1,2	C,F,A	--	4892837(+)	`TACACA/GCATTT`	1	--	us2k¹		11		NA WA CSA EA	373
rs78781466^1,2	F	--	4892914(+)	`TTTACA/GTCATT`	1	--	us2k¹		1		WA	118
rs7945456^1,2	C,F,A,H	--	4892984(+)	`ATCTAT/CATCTT`	1	--	us2k¹		12		NS EA NA WA CSA	781
rs7942442^1,2	C,F,H	--	4893032(+)	`CTACAA/GAGGGC`	1	--	us2k¹		5		NS EA CSA	418
rs187024284^1,2		--	4893047(+)	`AGGTCA/GATTGC`	1	--	us2k¹		0	--	--	--	--
rs188513235^1,2		--	4893051(+)	`CAATTA/GCTCAT`	1	--	us2k¹		0	--	--	--	--
rs181285798^1,2		--	4893193(+)	`CTCTTA/GTCTTG`	1	--	us2k¹		0	--	--	--	--
rs75354296^1,2		--	4893311(+)	`ACACAC/TTTCTG`	1	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for OR51A4 ( 4967392 - 4968330 bp)

Structural Variations
Database of Genomic Variants (DGV) 10/22 variations for OR51A4 (see all 22): About this table

Variant ID	Type	Subtype	PubMed ID
dgv187e199	CNV	Deletion	23128226
dgv35n16	CNV	Deletion	17901297
esv2744056	CNV	Deletion	23290073
esv2568479	CNV	Deletion	19546169
nsv471358	CNV	Duplication	19718026
nsv7653	CNV	Insertion	18451855
nsv443000	CNV	Loss	18674749
dgv10n50	CNV	Loss	21212237
nsv64	CNV	Loss	15895083
nsv7652	CNV	Loss	18451855

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OR51A4 for disorders About GeneDecksing

2 diseases for OR51A4: About MalaCards

neuronitis

Export disorders for OR51A4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed article for OR51A4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR51A4)

Utopia: connect your pdf to the dynamic
world of online information

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 401666	HGNC: 14795	Ensembl:ENSG00000205497	euGenes: HUgn401666	ECgene: OR51A4	Kegg: 401666
H-InvDB: OR51A4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for OR51A4	Pharmacogenomics, SNPs, Pathways
HORDE entry for OR51A4	The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

Intellectual Property for OR51A4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for OR51A4 gene:
Search GeneIP for patents involving OR51A4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
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OR51A4 Gene

Olfactory Receptor, Family 51, Subfamily A, Member 4

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OR51A4 Gene

Olfactory Receptor, Family 51, Subfamily A, Member 4

Aliasesfor OR51A4 gene

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Genomic Viewsfor OR51A4 gene

Proteinsfor OR51A4 gene

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for OR51A4 gene

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for OR51A4 gene

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for OR51A4 gene

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