Aliases for OR51A4 Gene
Aliases for OR51A4 Gene
External Ids for OR51A4 Gene
- HGNC: 14795
- Entrez Gene: 401666
- Ensembl: ENSG00000205497
- UniProtKB: Q8NGJ6
- HORDE: OR51A4
Previous GeneCards Identifiers for OR51A4 Gene
- GC11U990371
- GC11M004932
- GC11M004923
Summaries for OR51A4 Gene
-
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
GeneCards Summary for OR51A4 Gene
OR51A4 (Olfactory Receptor Family 51 Subfamily A Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51A7.
UniProtKB/Swiss-Prot for OR51A4 Gene
-
Odorant receptor.
No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR51A4 Gene
Genomics for OR51A4 Gene
Regulatory Elements for OR51A4 Gene
Enhancers for OR51A4 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around OR51A4 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for OR51A4 Gene
- Chromosome:
- 11
- Start:
- 4,946,159 bp from pter
- End:
- 4,947,100 bp from pter
- Size:
- 942 bases
- Orientation:
- Minus strand
Genomic View for OR51A4 Gene
Genes around OR51A4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p15.4 by Ensembl
- 11p15.4 by Entrez Gene
- 11p15.4 by HGNC
OR51A4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for OR51A4 Gene
Proteins for OR51A4 Gene
-
Protein details for OR51A4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NGJ6-O51A4_HUMAN
- Recommended name:
- Olfactory receptor 51A4
- Protein Accession:
- Q8NGJ6
Protein attributes for OR51A4 Gene
- Size:
- 313 amino acids
- Molecular mass:
- 35256 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for OR51A4 Gene
Other Protein References for OR51A4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
- HORDE protein sequence:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for OR51A4
- Abcam antibodies for OR51A4
- Invitrogen Antibodies for OR51A4
- antibodies-online Antibodies for OR51A4: See all 13
- GeneTex OR51A4 antibody for OR51A4
-
Santa Cruz Biotechnology (SCBT) Antibodies for OR51A4
Protein Products
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Assay Products
- antibodies-online Kits for OR51A4: See all 19
No data available for DME Specific Peptides for OR51A4 Gene
Domains & Families for OR51A4 Gene
Gene Families for OR51A4 Gene
Protein Domains for OR51A4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for OR51A4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8NGJ6- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for OR51A4 Gene
Molecular function for OR51A4 Gene
- UniProtKB/Swiss-Prot Function:
- Odorant receptor.
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-
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CRISPR Products
-
OriGene CRISPR knockouts for OR51A4
-
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Inhibitory RNA Products
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51A4 Gene
Localization for OR51A4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for OR51A4 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for OR51A4 Gene
More details on SuperPathways for OR51A4| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by GPCR | ||
| 2 | Olfactory Signaling Pathway |
Pathways by source for OR51A4 Gene
4 Reactome pathways for OR51A4 Gene
1 KEGG pathway for OR51A4 Gene
Interacting Proteins for OR51A4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | -- |
| GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
No data available for SIGNOR curated interactions for OR51A4 Gene
Transcripts for OR51A4 Gene
mRNA/cDNA for OR51A4 Gene
- (1) REFSEQ mRNAs :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for OR51A4
-
Santa Cruz Biotechnology (SCBT) CRISPR for OR51A4
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miRNA Products
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Inhibitory RNA Products
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-
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Expression for OR51A4 Gene
SOURCE GeneReport for Unigene cluster for OR51A4 Gene Hs.555481
Primer Products
-
OriGene qPCR primer pairs for OR51A4
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR51A4 Gene
Orthologs for OR51A4 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | LOC508792 35 |
|
||
| -- 36 |
|
ManyToMany | |||
| -- 36 |
|
ManyToMany | |||
| dog (Canis familiaris) |
Mammalia | cOR51A16 35 |
|
||
| -- 36 |
|
OneToMany | |||
| chimpanzee (Pan troglodytes) |
Mammalia | LOC100615983 35 |
|
||
| -- 36 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 36 |
|
ManyToMany | |
| mouse (Mus musculus) |
Mammalia | Olfr575 36 |
|
ManyToMany |
- Species with no ortholog for OR51A4:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for OR51A4 Gene
(414) SIMAP similar genes for OR51A4 Gene using alignment to 2 proteins:
- OR51A2
- OR51A7
- OR51L1
- OR51E2
- OR51H1P
- OR51Q1
- OR51G1
- OR51M1
- OR51V1
- OR51I2
- OR51E1
- OR51B5
- OR51G2
- OR52M1
- OR52K3P
- OR51I1
- OR51F2
- OR51B6
- OR52D1
- OR52J3
- OR51F1
- OR51D1
- OR51B2
- OR51B4
- OR52P1P
- OR52N5
- OR52K2
- OR52K1
- OR51A1P
- OR52N1
- OR52E2
- OR51T1
- OR52L2P
- OR52R1
- OR52L1
- OR52E8
- OR52E1
- OR52N4
- OR52N2
- OR52E4
- OR52A5
- OR52E5
- OR52B6
- OR52A1
- OR52Z1
- OR52H1
- OR52B2
- OR52W1
- OR52E6
- OR51S1
- OR52I2
- OR52B4
- LOC441453
- OR52B1P
- OR56B2P
- OR56A1
- OR52I1
- OR56A4
- OR56B4
- OR56A5
- OR10R3P
- OR56B3P
- OR56A3
- OR56B1
- OR51J1
- OR6K6
- FKSG35
- OR6N2
- OR52A4
- OR17-16
- OR8U1
- OR6N1
- OR8U9
- OR6C4
- OR5B2
- OR2AT4
- OR10J3
- OR17-137
- OR10H2
- OR9Q1
- OR9A1P
- OR8U8
- OR7C2
- OR6K3
- OR5B3
- OR2AP1
- OR1A1
- OR1A2
- OR7D4
- OR8H3
- OR8H1
- OR7C1
- OR7A5
- OR8I2
- OR7E24
- OR6Y1
- OR6F1
- OR4K15
- OR4F5
- OR4F4
- OR4F17
- OR2T6
- OR2F1
- OR2A25
- OR1S2
- OR1S1
- OR1N2
- OR1F12
- OR1D4
- OR10Z1
- OR10R2
- OR10H5
- OR10A2
- OR4D5
- OR17-15
- OR6V1
- OR5F1
- OR5E1P
- OR7A2P
- OR6C1
- OR1D2
- OR10G7
- OR2D2
- OR10J5
- OR10H4
- OR1D5
- OR2A1
- OR9A4
- OR8H2
- OR7G3
- OR7G2
- OR7G1
- OR6P1
- OR6C75
- OR6C74
- OR6C70
- OR6C65
- OR6C6
- OR6C2
- OR5M3
- OR5AS1
- OR4N4
- OR4N2
- OR4E2
- OR3A3
- OR2T11
- OR2M5
- OR2M2
- OR2K2
- OR2A42
- OR2A12
- OR1E3
- OR1E1
- OR13H1
- OR11L1
- OR11H4
- OR11H2
- OR11G2
- OR10V1
- OR10J1
- OR10G9
- OR10A5
- OR4M1
- OR2B3
- OR2A2
- OR1M1
- OR16-90
- OR16-88
- OR16-37
- OR16-36
- OR13C9
- OR12D2
- OR10H3
- OR10H1
- OR10G4
- OR10A3
- JCG4
- HSA12
- OR6Q1
- OR8K5
- OR8K1
- OR5M9
- OR5D13
- OR5AN1
- OR4Q3
- OR4K3
- OR4A47
- OR3A2
- OR2M4
- OR2A14
- OR1Q1
- OR10Q1
- PJCG1
- OR7A17
- OR7-139
- OR6A2
- OR8J2
- OR8D4
- OR6S1
- OR6C68
- OR5M10
- OR5D18
- OR5B21
- OR5B17
- OR5B12
- OR5AU1
- OR5AK2
- OR4N5
- OR4M2
- OR4K17
- OR4K1
- OR4A5
- OR2Z1
- OR2M3
- OR2B11
- OR2A7
- OR2A5
- OR1L8
- OR1L3
- OR1K1
- OR1F1
- OR1C1
- OR1B1
- OR13C8
- OR11H1
- OR10X1
- OR10T2
- OR10J6P
- OR10G8
- OR10G6
- OR10G3
- OR10D4P
- OR10A4
- OR4S1
- OR4D2
- OR4D1
- OR2A4
- OR1G1
- OR1E3P
- OR16-89
- OR13C2
- OR12D3
- OR10A6
- OR5AR1
- OR5AP2
- OR8B8
- OR9G9
- OR6M1
- OR5T3
- OR5T1
- OR5P2
- OR5D14
- OR5AC1
- OR4K14
- OR4F21
- OR4D9
- OR4D10
- OR1N1
- OR14A2
- OR11H12
- OLFR 42A
- OR13F1
- OR4F3
- OR8J3
- OR8B12
- OR7E85P
- OR7E5P
- OR7A10
- OR7-140
- OR6T1
- OR5M1
- OR5J2
- OR9I1
- OR9G4
- OR9G1
- OR8J1
- OR8D1
- OR7D2
- OR6X1
- OR6K2
- OR6C3
- OR6B3
- OR5T2
- OR5M11
- OR5H6
- OR5D16
- OR5AC2
- OR5A2
- OR5A1
- OR4K5
- OR4K2
- OR4D6
- OR4D11
- OR4C6
- OR4C46
- OR4C3
- OR4C15
- OR4B1
- OR4A4P
- OR2T35
- OR2T2
- OR2T12
- OR2T1
- OR2M7
- OR2L13
- OR2H2
- OR2D3
- OR1J1
- OR13J1
- OR13C5
- OR11H6
- OR10P1
- OR10J4
- OR10G2
- OR10D3
- OR4F29
- OR4F16
- OR2F2
- OR1J2
- OR1E2
- OR11A1
- OR10C1
- OLFR 42B
- OR6B2
- OR8D2
- OR6C76
- OR5M8
- OR5AK3P
- OR4K13
- OR4F15
- OR2W3
- OR2C1
- OR1F2P
- OR11H7
- OR10AG1
- OR2S2
- OR2G3
- OR5V1
- OR5P3
- OR5I1
- OR5D3
- OR9Q2
- OR8A1
- OR6J1
- OR5L1
- OR5K4
- OR5K2
- OR5K1
- OR5H2
- OR5H1
- OR4X1
- OR4E1
- OR4C5
- OR4C16
- OR4C12
- OR2W6P
- OR2V1
- OR2T8
- OR2T33
- OR2T29
- OR2C3
- OR1J4
- OR14L1P
- OR14A16
- OR13G1
- OR13D1
- OR13A1
- OR10A7
- OR2W1
- OR2J4P
- OR2J3
- OR2J2
- OR2H5P
- OR14J1
- OR13C4
- OR6B1
- OR9K2
- OR8K3
- OR5G3
- OR5AL1
- OR3A1
- OR2L5
- OR2AG2
- OR1L1
- OR4L1
- OR2B6
- OR2AG1
- OR8G1
- OR8G5
- OR8B3
- OR5W2
- OR5R1
- OR5L2
- OR5H14
- OR4X2
- OR4Q2
- OR4P4
- OR4C11
- OR4A15
- OR2V2
- OR2T5
- OR2T4
- OR2T34
- OR2T3
- OR2L2
- OR2J1
- OR2G6
- OR2B8P
- OR2AK2
- OR1P1
- OR1L4
- OR14C36
- OR13C3
- OR10S1
Variants for OR51A4 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs2595988 | - | 4,946,302(-) | TTGCC(C/G/T)GGCAT | reference, missense | |
| VAR_034314 | - | ||||
| rs2412467 | - | 4,946,887(-) | TGTCA(A/C/G)ACTTG | reference, missense | |
| rs3845246 | - | 4,946,968(-) | GAAAT(G/T)GCACC | reference, missense | |
| rs2436782 | - | 4,946,170(-) | GTCAA(C/T)GGAAG | reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv340e1 | CNV | Complex | 17122850 |
| nsv7652 | CNV | Loss | 18451855 |
| nsv526998 | CNV | Loss | 19592680 |
| nsv64 | CNV | Loss | 15895083 |
| nsv896918 | CNV | Gain | 21882294 |
| essv16563 | CNV | CNV | 17122850 |
| nsv508614 | CNV | Loss | 20534489 |
| nsv510996 | CNV | Complex | 20534489 |
| dgv35n16 | CNV | Deletion | 17901297 |
| esv22784 | CNV | Gain+Loss | 19812545 |
| esv2568479 | CNV | Deletion | 19546169 |
| nsv8782 | CNV | Gain+Loss | 18304495 |
| nsv471358 | CNV | Duplication | 19718026 |
| dgv187e199 | CNV | Deletion | 23128226 |
| nsv7653 | CNV | Insertion | 18451855 |
| nsv820116 | CNV | Loss | 19587683 |
| nsv442596 | CNV | CNV | 18776908 |
| esv2744056 | CNV | Deletion | 23290073 |
| dgv191n67 | CNV | Gain+Loss | 20364138 |
| dgv11n47 | CNV | Loss | 21111241 |
| nsv443000 | CNV | Loss | 18674749 |
| dgv10n50 | CNV | Loss | 21212237 |
Residual Variation Intolerance Score:
92.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.76;
66.59% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR51A4 Gene
Disorders for OR51A4 Gene
Relevant External Links for OR51A4
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- OR51A4
No disorders were found for OR51A4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR51A4 Gene
Publications for OR51A4 Gene
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 67
Products for OR51A4 Gene
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- GeneTex OR51A4 antibody for OR51A4
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- ViGene Biosciences lentiviral particle packaged cDNA for OR51A4 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for OR51A4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for OR51A4 gene
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Sources for OR51A4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
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- (13) InterPro
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- (15) Blocks
- (16) MGI
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- (21) I2D
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- (48) GAD
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- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
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- (57) HORDE
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- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
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- (84) Proteopedia
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- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
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- (103) MaxQB
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- (105) BioGPS
- (106) Illumina
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- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
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- (118) PathCards
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- (149) ENCODE
- (150) ProSci
- (151) Horizon