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Aliases for OR51A4 Gene

Aliases for OR51A4 Gene

  • Olfactory Receptor Family 51 Subfamily A Member 4 2 3 5
  • Olfactory Receptor, Family 51, Subfamily A, Member 4 2

External Ids for OR51A4 Gene

Previous GeneCards Identifiers for OR51A4 Gene

  • GC11U990371
  • GC11M004932
  • GC11M004923

Summaries for OR51A4 Gene

Entrez Gene Summary for OR51A4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51A4 Gene

OR51A4 (Olfactory Receptor Family 51 Subfamily A Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51A2.

UniProtKB/Swiss-Prot for OR51A4 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR51A4 Gene

Genomics for OR51A4 Gene

Regulatory Elements for OR51A4 Gene

Enhancers for OR51A4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around OR51A4 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR51A4 Gene

Chromosome:
11
Start:
4,946,159 bp from pter
End:
4,947,100 bp from pter
Size:
942 bases
Orientation:
Minus strand

Genomic View for OR51A4 Gene

Genes around OR51A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51A4 Gene

Proteins for OR51A4 Gene

  • Protein details for OR51A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGJ6-O51A4_HUMAN
    Recommended name:
    Olfactory receptor 51A4
    Protein Accession:
    Q8NGJ6

    Protein attributes for OR51A4 Gene

    Size:
    313 amino acids
    Molecular mass:
    35256 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51A4 Gene

Post-translational modifications for OR51A4 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR51A4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51A4 Gene

Domains & Families for OR51A4 Gene

Gene Families for OR51A4 Gene

Protein Domains for OR51A4 Gene

Suggested Antigen Peptide Sequences for OR51A4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NGJ6

UniProtKB/Swiss-Prot:

O51A4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51A4: view

Function for OR51A4 Gene

Molecular function for OR51A4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR51A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR51A4: view

Phenotypes for OR51A4 Gene

GenomeRNAi human phenotypes for OR51A4:
genes like me logo Genes that share phenotypes with OR51A4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51A4 Gene

Localization for OR51A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51A4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR51A4 Gene COMPARTMENTS Subcellular localization image for OR51A4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR51A4: view

Pathways & Interactions for OR51A4 Gene

genes like me logo Genes that share pathways with OR51A4: view

Pathways by source for OR51A4 Gene

Gene Ontology (GO) - Biological Process for OR51A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR51A4: view

No data available for SIGNOR curated interactions for OR51A4 Gene

Drugs & Compounds for OR51A4 Gene

No Compound Related Data Available

Transcripts for OR51A4 Gene

mRNA/cDNA for OR51A4 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR51A4 Gene

No ASD Table

Relevant External Links for OR51A4 Gene

GeneLoc Exon Structure for
OR51A4
ECgene alternative splicing isoforms for
OR51A4

Expression for OR51A4 Gene

mRNA expression in normal human tissues for OR51A4 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR51A4 Gene:

OR51A4

SOURCE GeneReport for Unigene cluster for OR51A4 Gene:

Hs.555481
genes like me logo Genes that share expression patterns with OR51A4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR51A4 Gene

Orthologs for OR51A4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR51A4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC508792 34
  • 85.73 (n)
  • 85.62 (a)
-- 35
  • 84 (a)
ManyToMany
-- 35
  • 82 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia cOR51A16 34
  • 87.22 (n)
  • 87.86 (a)
-- 35
  • 88 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC100615983 34
  • 98.62 (n)
  • 97.76 (a)
-- 35
  • 98 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 74 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr575 35
  • 72 (a)
ManyToMany
Species where no ortholog for OR51A4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR51A4 Gene

ENSEMBL:
Gene Tree for OR51A4 (if available)
TreeFam:
Gene Tree for OR51A4 (if available)

Paralogs for OR51A4 Gene

Paralogs for OR51A4 Gene

(414) SIMAP similar genes for OR51A4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR51A4: view

Variants for OR51A4 Gene

Sequence variations from dbSNP and Humsavar for OR51A4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2595988 - 4,946,302(-) TTGCC(C/G/T)GGCAT reference, missense
VAR_034314 -
rs2412467 - 4,946,887(-) TGTCA(A/C/G)ACTTG reference, missense
rs3845246 - 4,946,968(-) GAAAT(G/T)GCACC reference, missense
rs2436782 - 4,946,170(-) GTCAA(C/T)GGAAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR51A4 Gene

Variant ID Type Subtype PubMed ID
dgv1027n100 CNV gain 25217958
dgv1028n100 CNV gain 25217958
dgv1029n100 CNV gain 25217958
dgv1030n100 CNV gain 25217958
dgv1031n100 CNV gain 25217958
dgv1032n100 CNV gain+loss 25217958
dgv1033n100 CNV loss 25217958
dgv1034n100 CNV gain 25217958
dgv1035n100 CNV gain+loss 25217958
dgv1036n100 CNV gain 25217958
dgv1037n100 CNV loss 25217958
dgv10n50 CNV loss 21212237
dgv11n47 CNV loss 21111241
dgv1589n54 CNV gain+loss 21841781
dgv1590n54 CNV gain 21841781
dgv1591n54 CNV gain 21841781
dgv187e199 CNV deletion 23128226
dgv191n67 CNV gain+loss 20364138
dgv307e212 CNV loss 25503493
dgv308e212 CNV loss 25503493
dgv309e212 CNV gain 25503493
dgv35n16 CNV deletion 17901297
dgv570e59 CNV duplication 20981092
esv22784 CNV gain+loss 19812545
esv2568479 CNV deletion 19546169
esv2744056 CNV deletion 23290073
esv2759799 CNV loss 17122850
esv2760169 CNV gain+loss 21179565
esv2760399 CNV loss 21179565
esv3410682 CNV duplication 20981092
esv3584628 CNV loss 24956385
esv3891914 CNV gain 25118596
nsv1040062 CNV gain+loss 25217958
nsv1043954 CNV gain+loss 25217958
nsv1047364 CNV loss 25217958
nsv1054847 CNV gain 25217958
nsv1070430 CNV deletion 25765185
nsv1143674 CNV deletion 24896259
nsv1159807 CNV deletion 26073780
nsv1159808 CNV deletion 26073780
nsv1159813 OTHER complex 26073780
nsv442596 CNV gain+loss 18776908
nsv443000 CNV deletion 18674749
nsv471358 CNV gain 19718026
nsv508614 CNV deletion 20534489
nsv510996 OTHER complex 20534489
nsv526998 CNV loss 19592680
nsv553189 CNV gain 21841781
nsv553190 CNV loss 21841781
nsv553202 CNV gain 21841781
nsv64 CNV deletion 15895083
nsv7652 CNV deletion 18451855
nsv7653 CNV insertion 18451855
nsv820116 CNV loss 19587683
nsv8782 CNV gain+loss 18304495
nsv951300 CNV deletion 24416366
nsv983202 CNV duplication 23825009

Variation tolerance for OR51A4 Gene

Residual Variation Intolerance Score: 92.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.76; 66.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR51A4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR51A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR51A4 Gene

Disorders for OR51A4 Gene

Relevant External Links for OR51A4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR51A4

No disorders were found for OR51A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR51A4 Gene

Publications for OR51A4 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65

Products for OR51A4 Gene

Sources for OR51A4 Gene

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