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Aliases for OR51A2 Gene

Aliases for OR51A2 Gene

  • Olfactory Receptor, Family 51, Subfamily A, Member 2 2 3

External Ids for OR51A2 Gene

Previous GeneCards Identifiers for OR51A2 Gene

  • GC11U990311
  • GC11M004941
  • GC11M004933

Summaries for OR51A2 Gene

Entrez Gene Summary for OR51A2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51A2 Gene

OR51A2 (Olfactory Receptor, Family 51, Subfamily A, Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51I2.

UniProtKB/Swiss-Prot for OR51A2 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR51A2 Gene

Genomics for OR51A2 Gene

Regulatory Elements for OR51A2 Gene

Genomic Location for OR51A2 Gene

Chromosome:
11
Start:
4,954,772 bp from pter
End:
4,955,713 bp from pter
Size:
942 bases
Orientation:
Minus strand

Genomic View for OR51A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR51A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51A2 Gene

Proteins for OR51A2 Gene

  • Protein details for OR51A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGJ7-O51A2_HUMAN
    Recommended name:
    Olfactory receptor 51A2
    Protein Accession:
    Q8NGJ7

    Protein attributes for OR51A2 Gene

    Size:
    313 amino acids
    Molecular mass:
    35078 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51A2 Gene

Proteomics data for OR51A2 Gene at MOPED

Post-translational modifications for OR51A2 Gene

Other Protein References for OR51A2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51A2 Gene

Domains & Families for OR51A2 Gene

Gene Families for OR51A2 Gene

Protein Domains for OR51A2 Gene

Suggested Antigen Peptide Sequences for OR51A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGJ7

UniProtKB/Swiss-Prot:

O51A2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51A2: view

Function for OR51A2 Gene

Molecular function for OR51A2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR51A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR51A2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR51A2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51A2 Gene

Localization for OR51A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51A2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR51A2 Gene COMPARTMENTS Subcellular localization image for OR51A2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR51A2: view

Pathways & Interactions for OR51A2 Gene

genes like me logo Genes that share pathways with OR51A2: view

Pathways by source for OR51A2 Gene

Interacting Proteins for OR51A2 Gene

Gene Ontology (GO) - Biological Process for OR51A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IBA --
genes like me logo Genes that share ontologies with OR51A2: view

No data available for SIGNOR curated interactions for OR51A2 Gene

Drugs & Compounds for OR51A2 Gene

No Compound Related Data Available

Transcripts for OR51A2 Gene

mRNA/cDNA for OR51A2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR51A2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR51A2 Gene

No ASD Table

Relevant External Links for OR51A2 Gene

GeneLoc Exon Structure for
OR51A2
ECgene alternative splicing isoforms for
OR51A2

Expression for OR51A2 Gene

mRNA expression in normal human tissues for OR51A2 Gene

Protein differential expression in normal tissues from HIPED for OR51A2 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR51A2 Gene



SOURCE GeneReport for Unigene cluster for OR51A2 Gene Hs.553805

genes like me logo Genes that share expression patterns with OR51A2: view

Protein tissue co-expression partners for OR51A2 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR51A2 Gene

Orthologs for OR51A2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR51A2 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Olfr586 16
Olfr570 36
  • 71 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 82 (a)
ManyToMany
-- 36
  • 81 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 86 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 66 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
OneToMany
Species with no ortholog for OR51A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR51A2 Gene

ENSEMBL:
Gene Tree for OR51A2 (if available)
TreeFam:
Gene Tree for OR51A2 (if available)

Paralogs for OR51A2 Gene

(342) SIMAP similar genes for OR51A2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR51A2: view

Variants for OR51A2 Gene

Sequence variations from dbSNP and Humsavar for OR51A2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2412437 -- 4,954,557(-) AATAA(A/G)TGTCT downstream-variant-500B
rs2412438 -- 4,954,286(-) AGTGA(A/G)CATAG downstream-variant-500B
rs2442425 -- 4,955,034(-) TGTAC(C/T)GGGAA reference, missense
rs2442426 - 4,954,851(-) GCTGA(C/T)GAAAC missense, reference
rs11034892 -- 4,956,746(+) TCCAA(C/G)TTAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR51A2 Gene

Variant ID Type Subtype PubMed ID
dgv340e1 CNV Complex 17122850
nsv7652 CNV Loss 18451855
nsv526998 CNV Loss 19592680
nsv64 CNV Loss 15895083
nsv896918 CNV Gain 21882294
essv16563 CNV CNV 17122850
dgv35n16 CNV Deletion 17901297
esv22784 CNV Gain+Loss 19812545
esv2568479 CNV Deletion 19546169
nsv8782 CNV Gain+Loss 18304495
dgv187e199 CNV Deletion 23128226
nsv7653 CNV Insertion 18451855
nsv820116 CNV Loss 19587683
nsv442596 CNV CNV 18776908
esv2744056 CNV Deletion 23290073
dgv191n67 CNV Gain+Loss 20364138
dgv11n47 CNV Loss 21111241
nsv443000 CNV Loss 18674749
dgv10n50 CNV Loss 21212237
dgv192n67 CNV Loss 20364138
nsv471359 CNV Duplication 19718026
nsv438182 CNV Loss 16468122

Variation tolerance for OR51A2 Gene

Residual Variation Intolerance Score: 95.09% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.49; 91.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR51A2 Gene

HapMap Linkage Disequilibrium report
OR51A2
Human Gene Mutation Database (HGMD)
OR51A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR51A2 Gene

Disorders for OR51A2 Gene

Relevant External Links for OR51A2

Genetic Association Database (GAD)
OR51A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR51A2
genes like me logo Genes that share disorders with OR51A2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR51A2 Gene

Publications for OR51A2 Gene

No publications were found for OR51A2 Gene.

Products for OR51A2 Gene

Sources for OR51A2 Gene

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