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Aliases for OR4X2 Gene

Aliases for OR4X2 Gene

  • Olfactory Receptor Family 4 Subfamily X Member 2 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor OR11-105 3 4
  • Olfactory Receptor, Family 4, Subfamily X, Member 2 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 4, Subfamily X, Member 2 3
  • Olfactory Receptor 4X2 3
  • OR11-105 3

External Ids for OR4X2 Gene

Previous GeneCards Identifiers for OR4X2 Gene

  • GC11U990529
  • GC11P048230
  • GC11P048223

Summaries for OR4X2 Gene

Entrez Gene Summary for OR4X2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR4X2 Gene

OR4X2 (Olfactory Receptor Family 4 Subfamily X Member 2 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4B1.

UniProtKB/Swiss-Prot for OR4X2 Gene

  • Odorant receptor.

Gene Wiki entry for OR4X2 Gene

Additional gene information for OR4X2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4X2 Gene

Genomics for OR4X2 Gene

Regulatory Elements for OR4X2 Gene

Enhancers for OR4X2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H048266 0.3 FANTOM5 17.7 +21.7 21730 0 OR4B1 OR4S1 OR4X2 OR4C3 OR4X1
GH11H047869 1.2 FANTOM5 ENCODE dbSUPER 3.7 -375.3 -375252 1 TBP PKNOX1 STAT1 JUN FEZF1 EP300 PRDM6 JUND POLR2A NR2C2 OR4C3 OR4B1 OR4S1 PTPRJ OR4X2 NUP160 GC11M054682
GH11H047850 0.9 FANTOM5 ENCODE 2.8 -394.0 -393996 2 JUN ELF1 FOSL1 POLR2A IKZF1 EED ETV6 IKZF2 RUNX3 SPI1 C1QTNF4 MTCH2 OR4S1 OR4B1 OR4X2 OR4C3 NUP160 GC11M054682
GH11H048173 0.3 FANTOM5 6 -73.0 -72963 0 OR4S1 OR4C3 OR4X2 OR4B1 OR4X1 PIR60737
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR4X2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for OR4X2 Gene

Genomic Locations for OR4X2 Gene
1,025 bases
Plus strand

Genomic View for OR4X2 Gene

Genes around OR4X2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4X2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4X2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4X2 Gene

Proteins for OR4X2 Gene

  • Protein details for OR4X2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4X2
    Protein Accession:
    Secondary Accessions:
    • B2RNK3
    • Q6IF73
    • Q96R63

    Protein attributes for OR4X2 Gene

    303 amino acids
    Molecular mass:
    34289 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4X2 Gene

Post-translational modifications for OR4X2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR4X2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4X2 Gene

Domains & Families for OR4X2 Gene

Gene Families for OR4X2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4X2 Gene

Suggested Antigen Peptide Sequences for OR4X2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4X2: view

Function for OR4X2 Gene

Molecular function for OR4X2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4X2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4X2: view
genes like me logo Genes that share phenotypes with OR4X2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4X2 Gene

Localization for OR4X2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4X2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4X2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4X2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4X2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4X2 Gene

Pathways & Interactions for OR4X2 Gene

genes like me logo Genes that share pathways with OR4X2: view

Pathways by source for OR4X2 Gene

Interacting Proteins for OR4X2 Gene

Gene Ontology (GO) - Biological Process for OR4X2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4X2: view

No data available for SIGNOR curated interactions for OR4X2 Gene

Drugs & Compounds for OR4X2 Gene

No Compound Related Data Available

Transcripts for OR4X2 Gene

mRNA/cDNA for OR4X2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4X2 Gene

No ASD Table

Relevant External Links for OR4X2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR4X2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4X2 Gene

Protein differential expression in normal tissues from HIPED for OR4X2 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR4X2 Gene

Protein tissue co-expression partners for OR4X2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4X2 Gene:


SOURCE GeneReport for Unigene cluster for OR4X2 Gene:

genes like me logo Genes that share expression patterns with OR4X2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4X2 Gene

Orthologs for OR4X2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4X2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466512 33
  • 99.12 (n)
OR4X2 34
  • 99 (a)
(Bos Taurus)
Mammalia LOC510901 33
  • 86.14 (n)
-- 34
  • 79 (a)
-- 34
  • 77 (a)
(Canis familiaris)
Mammalia OR4X2 33 34
  • 85.92 (n)
(Rattus norvegicus)
Mammalia Olr733 33
  • 82.62 (n)
(Mus musculus)
Mammalia Or4x6 52 Olfr1269 34
  • 78 (a)
Or4x11 52 Olfr1265 34
  • 77 (a)
Gm13769 34
  • 73 (a)
Or4x14 52 Olfr1506 34
  • 73 (a)
Or4x12-ps 52 Olfr1267-ps1
  • chr2:90,085,533-90,086,459
Or4x13 52 Olfr1274
  • chr2:90,400,582-90,401,589
Or4x15 52 Olfr1506a
  • chr2:90,324,116-90,325,123
(Monodelphis domestica)
Mammalia -- 34
  • 72 (a)
-- 34
  • 68 (a)
-- 34
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 66 (a)
Species where no ortholog for OR4X2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4X2 Gene

Gene Tree for OR4X2 (if available)
Gene Tree for OR4X2 (if available)

Paralogs for OR4X2 Gene

Paralogs for OR4X2 Gene

(448) SIMAP similar genes for OR4X2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4X2: view

Variants for OR4X2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR4X2 Gene

A stop codon in the gene coding for this protein at position Tyr-27 is responsible for functional diversity thus producing a pseudogene.

Sequence variations from dbSNP and Humsavar for OR4X2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000870843 -- 48,243,756(+) GTTCA(C/G)CATGG upstream-variant-2KB
rs1000921729 -- 48,243,951(+) ATGTG(A/G)CTGGA upstream-variant-2KB
rs1001538798 -- 48,245,618(+) CTGTG(A/G)CCTAG reference, missense
rs1002671628 -- 48,243,407(+) GAACT(C/T)TCTAG upstream-variant-2KB
rs1004027926 -- 48,246,493(+) ATAGC(C/G)CTTCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR4X2 Gene

Variant ID Type Subtype PubMed ID
nsv554212 CNV loss 21841781
nsv554211 CNV gain 21841781
nsv469953 CNV loss 18288195
nsv467873 CNV loss 19166990
nsv467871 CNV gain 19166990
nsv428253 CNV loss 18775914
nsv1041394 CNV gain 25217958
esv3891986 CNV gain 25118596
dgv198e214 CNV gain 21293372
dgv1112n100 CNV gain 25217958
dgv1111n100 CNV gain 25217958

Variation tolerance for OR4X2 Gene

Residual Variation Intolerance Score: 72.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR4X2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

Disorders for OR4X2 Gene

Relevant External Links for OR4X2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR4X2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4X2 Gene

Publications for OR4X2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 60
  3. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3 60
  4. Genetic elucidation of human hyperosmia to isovaleric acid. (PMID: 17973576) Menashe I … Lancet D (PLoS biology 2007) 4 60
  5. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I … Lancet D (BMC bioinformatics 2006) 3 60

Products for OR4X2 Gene

Sources for OR4X2 Gene

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