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Aliases for OR4X2 Gene

Aliases for OR4X2 Gene

  • Olfactory Receptor, Family 4, Subfamily X, Member 2 (Gene/Pseudogene) 2 3
  • Olfactory Receptor OR11-105 3 4
  • Olfactory Receptor 4X2 3
  • OR11-105 3

External Ids for OR4X2 Gene

Summaries for OR4X2 Gene

Entrez Gene Summary for OR4X2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4X2 Gene

OR4X2 (Olfactory Receptor, Family 4, Subfamily X, Member 2 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot for OR4X2 Gene

  • Odorant receptor.

Gene Wiki entry for OR4X2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4X2 Gene

Genomics for OR4X2 Gene

Genomic Location for OR4X2 Gene

Start:
48,245,104 bp from pter
End:
48,246,015 bp from pter
Size:
912 bases
Orientation:
Plus strand

Genomic View for OR4X2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR4X2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4X2 Gene

Regulatory Elements for OR4X2 Gene

Proteins for OR4X2 Gene

  • Protein details for OR4X2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGF9-OR4X2_HUMAN
    Recommended name:
    Olfactory receptor 4X2
    Protein Accession:
    Q8NGF9
    Secondary Accessions:
    • B2RNK3
    • Q6IF73
    • Q96R63

    Protein attributes for OR4X2 Gene

    Size:
    303 amino acids
    Molecular mass:
    34289 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4X2 Gene

Proteomics data for OR4X2 Gene at MOPED

Post-translational modifications for OR4X2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR4X2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR4X2 Gene

Domains for OR4X2 Gene

Gene Families for OR4X2 Gene

HGNC:
  • OR4 :GPCR / Class A : Olfactory receptors

Protein Domains for OR4X2 Gene

Suggested Antigen Peptide Sequences for OR4X2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGF9

UniProtKB/Swiss-Prot:

OR4X2_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q8NGF9
genes like me logo Genes that share domains with OR4X2: view

Function for OR4X2 Gene

Molecular function for OR4X2 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4X2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4X2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR4X2 Gene

Localization for OR4X2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4X2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4X2 Gene COMPARTMENTS Subcellular localization image for OR4X2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4X2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4X2: view

Pathways for OR4X2 Gene

genes like me logo Genes that share pathways with OR4X2: view

Pathways by source for OR4X2 Gene

Interacting Proteins for OR4X2 Gene

Gene Ontology (GO) - Biological Process for OR4X2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4X2: view

Transcripts for OR4X2 Gene

mRNA/cDNA for OR4X2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR4X2 Gene

No ASD Table

Relevant External Links for OR4X2 Gene

GeneLoc Exon Structure for
OR4X2
ECgene alternative splicing isoforms for
OR4X2

Expression for OR4X2 Gene

mRNA expression in normal human tissues for OR4X2 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for OR4X2 Gene

SOURCE GeneReport for Unigene cluster for OR4X2 Gene Hs.553565

genes like me logo Genes that share expressions with OR4X2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR4X2 Gene

Orthologs for OR4X2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4X2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466512 35
  • 99.12 (n)
  • 98.68 (a)
cow
(Bos Taurus)
Mammalia LOC510901 35
  • 86.14 (n)
  • 80.53 (a)
dog
(Canis familiaris)
Mammalia OR4X2 35
  • 85.92 (n)
  • 81.19 (a)
mouse
(Mus musculus)
Mammalia Olfr1274-ps 16
rat
(Rattus norvegicus)
Mammalia Olr733 35
  • 82.62 (n)
  • 77.89 (a)
Species with no ortholog for OR4X2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4X2 Gene

ENSEMBL:
Gene Tree for OR4X2 (if available)
TreeFam:
Gene Tree for OR4X2 (if available)

Paralogs for OR4X2 Gene

Selected SIMAP similar genes for OR4X2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4X2: view

No data available for Paralogs for OR4X2 Gene

Variants for OR4X2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR4X2 Gene

Q8NGF9-OR4X2_HUMAN
A stop codon in the gene coding for this protein at position Tyr-27 is responsible for functional diversity thus producing a pseudogene

Sequence variations from dbSNP and Humsavar for OR4X2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1393790 -- 48,243,549(-) AAACA(A/G)AGAAA upstream-variant-2KB
rs1503178 -- 48,246,445(-) gtgtc(C/T)taagg downstream-variant-500B
rs1503179 -- 48,246,274(-) TAAGC(C/T)TAAAA downstream-variant-500B
rs1503180 -- 48,246,037(-) CCAAG(C/T)ATCAA downstream-variant-500B
rs1503181 -- 48,243,827(-) CACAG(C/G)CCAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR4X2 Gene

Variant ID Type Subtype PubMed ID
dgv1091n71 CNV Gain 21882294
nsv897329 CNV Gain 21882294
nsv467871 CNV Gain 19166990
nsv428253 CNV Loss 18775914
nsv467873 CNV Loss 19166990
nsv469953 CNV Loss 18288195

Relevant External Links for OR4X2 Gene

HapMap Linkage Disequilibrium report
OR4X2

Disorders for OR4X2 Gene

Relevant External Links for OR4X2

Genetic Association Database (GAD)
OR4X2
genes like me logo Genes that share disorders with OR4X2: view

No data available for UniProtKB/Swiss-Prot for OR4X2 Gene

Publications for OR4X2 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Genetic elucidation of human hyperosmia to isovaleric acid. (PMID: 17973576) Menashe I. … Lancet D. (PLoS Biol. 2007) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR4X2 Gene

Sources for OR4X2 Gene

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