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Aliases for OR4X1 Gene

Aliases for OR4X1 Gene

  • Olfactory Receptor, Family 4, Subfamily X, Member 1 (Gene/Pseudogene) 2 3
  • Olfactory Receptor OR11-104 3 4
  • Olfactory Receptor, Family 4, Subfamily X, Member 1 2
  • Olfactory Receptor 4X1 3
  • OR11-104 3

External Ids for OR4X1 Gene

Previous GeneCards Identifiers for OR4X1 Gene

  • GC11U990332
  • GC11P048250
  • GC11P048241

Summaries for OR4X1 Gene

Entrez Gene Summary for OR4X1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4X1 Gene

OR4X1 (Olfactory Receptor, Family 4, Subfamily X, Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4A5.

UniProtKB/Swiss-Prot for OR4X1 Gene

  • Odorant receptor.

Gene Wiki entry for OR4X1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4X1 Gene

Genomics for OR4X1 Gene

Regulatory Elements for OR4X1 Gene

Genomic Location for OR4X1 Gene

Start:
48,263,861 bp from pter
End:
48,264,778 bp from pter
Size:
918 bases
Orientation:
Plus strand

Genomic View for OR4X1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR4X1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4X1 Gene

Proteins for OR4X1 Gene

  • Protein details for OR4X1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH49-OR4X1_HUMAN
    Recommended name:
    Olfactory receptor 4X1
    Protein Accession:
    Q8NH49
    Secondary Accessions:
    • Q6IF74

    Protein attributes for OR4X1 Gene

    Size:
    305 amino acids
    Molecular mass:
    34222 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4X1 Gene

Proteomics data for OR4X1 Gene at MOPED

Post-translational modifications for OR4X1 Gene

Other Protein References for OR4X1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4X1 Gene

Domains for OR4X1 Gene

Gene Families for OR4X1 Gene

HGNC:
  • OR4 :GPCR / Class A : Olfactory receptors

Protein Domains for OR4X1 Gene

Suggested Antigen Peptide Sequences for OR4X1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH49

UniProtKB/Swiss-Prot:

OR4X1_HUMAN :
  • Q8NH49
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4X1: view

Function for OR4X1 Gene

Molecular function for OR4X1 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4X1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR4X1 Gene

Localization for OR4X1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4X1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4X1 Gene COMPARTMENTS Subcellular localization image for OR4X1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4X1: view

Pathways for OR4X1 Gene

genes like me logo Genes that share pathways with OR4X1: view

Pathways by source for OR4X1 Gene

Interacting Proteins for OR4X1 Gene

Gene Ontology (GO) - Biological Process for OR4X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4X1: view

Transcripts for OR4X1 Gene

mRNA/cDNA for OR4X1 Gene

(1) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4X1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR4X1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4X1 Gene

No ASD Table

Relevant External Links for OR4X1 Gene

GeneLoc Exon Structure for
OR4X1
ECgene alternative splicing isoforms for
OR4X1

Expression for OR4X1 Gene

mRNA expression in normal human tissues for OR4X1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR4X1 Gene

SOURCE GeneReport for Unigene cluster for OR4X1 Gene Hs.553742

genes like me logo Genes that share expressions with OR4X1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR4X1 Gene

Orthologs for OR4X1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4X1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR4X1 35
  • 84.71 (n)
  • 77.85 (a)
OR4X1 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC483609 35
  • 81.56 (n)
  • 72.95 (a)
OR4X1 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr1270 36
  • 59 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr735 35
  • 79.93 (n)
  • 78.29 (a)
Species with no ortholog for OR4X1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4X1 Gene

ENSEMBL:
Gene Tree for OR4X1 (if available)
TreeFam:
Gene Tree for OR4X1 (if available)

Paralogs for OR4X1 Gene

Selected SIMAP similar genes for OR4X1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4X1: view

Variants for OR4X1 Gene

Sequence variations from dbSNP and Humsavar for OR4X1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs713323 -- 48,263,872(-) TTGTT(C/T)GTAGC reference, synonymous-codon
rs713324 -- 48,263,512(-) CCCAA(A/G)GCCAC upstream-variant-2KB
rs713325 -- 48,263,749(-) CCTCT(C/T)GAGTT upstream-variant-2KB
rs871248 -- 48,262,706(+) ATGTA(A/C)ATGCT upstream-variant-2KB
rs871249 -- 48,262,925(+) TTCTT(A/G)GAGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR4X1 Gene

Variant ID Type Subtype PubMed ID
dgv1091n71 CNV Gain 21882294
nsv897329 CNV Gain 21882294
nsv467871 CNV Gain 19166990
nsv428253 CNV Loss 18775914
nsv467873 CNV Loss 19166990
nsv469953 CNV Loss 18288195
nsv508628 CNV Loss 20534489

Relevant External Links for OR4X1 Gene

HapMap Linkage Disequilibrium report
OR4X1
Human Gene Mutation Database (HGMD)
OR4X1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4X1 Gene

Disorders for OR4X1 Gene

Relevant External Links for OR4X1

Genetic Association Database (GAD)
OR4X1
Human Genome Epidemiology (HuGE) Navigator
OR4X1
genes like me logo Genes that share disorders with OR4X1: view

No data available for UniProtKB/Swiss-Prot for OR4X1 Gene

Publications for OR4X1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. A nonfunctioning single nucleotide polymorphism in olfactory receptor gene family is associated with the forced expiratory volume in the first second/the forced vital capacity values of pulmonary function test in a Japanese population. (PMID: 17964544) Takabatake N. … Kubota I. (Biochem. Biophys. Res. Commun. 2007) 3 48

Products for OR4X1 Gene

Sources for OR4X1 Gene

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