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OR4X1 Gene

protein-coding   GIFtS: 47
GCID: GC11P048285

Olfactory Receptor, Family 4, Subfamily X, Member 1 (Gene/Pseudogene)

(Previous names: olfactory receptor, family 4, subfamily X, member 1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 4, Subfamily X, Member 1
(Gene/Pseudogene)1
Olfactory Receptor, Family 4, Subfamily X, Member 11 2
Olfactory Receptor OR11-1042 3
OR11-1042
Olfactory Receptor 4X12

External Ids:    HGNC: 148541   Entrez Gene: 3901132   Ensembl: ENSG000001765677   UniProtKB: Q8NH493   

Export aliases for OR4X1 gene to outside databases

Previous GC identifers: GC11U990332 GC11P048250 GC11P048241


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR4X1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR4X1 Gene:
OR4X1 (olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4C5.

UniProtKB/Swiss-Prot: OR4X1_HUMAN, Q8NH49
Function: Odorant receptor (Potential)

Gene Wiki entry for OR4X1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR4X1 gene promoter:
         Nkx3-1   Nkx3-1 v4   AML1a   Nkx3-1 v1   NF-kappaB   Nkx3-1 v2   Nkx3-1 v3   Pax-4a   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for OR4X1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR4X1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

OR4X1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR4X1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P048285:  view genomic region     (about GC identifiers)

Start:
48,285,413 bp from pter      End:
48,286,327 bp from pter
Size:
915 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR4X1_HUMAN, Q8NH49 (See protein sequence)
Recommended Name: Olfactory receptor 4X1  
Size: 305 amino acids; 34222 Da
Secondary accessions: Q6IF74

Explore the universe of human proteins at neXtProt for OR4X1: NX_Q8NH49

Explore proteomics data for OR4X1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn6, Asn18
  • HORDE protein sequence for OR4X1

    See OR4X1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004726.1  
    ENSEMBL proteins: 
     ENSP00000321506  
    Reactome Protein details: Q8NH49

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR4: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NH49

    ProtoNet protein and cluster: Q8NH49

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR4X1_HUMAN, Q8NH49
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR4X1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR4X1_HUMAN, Q8NH49
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR4X1           About GenesLikeMe


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR4X1_HUMAN, Q8NH49: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR4X1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR4X1 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR4X1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR4X1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR4X1):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR4X1
    Interactions:

        Search GeneGlobe Interaction Network for OR4X1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR4X1 (ENSP000003215064) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR2A14ENSP000003861374STRING: ENSP00000386137
    GNALENSP000003340514STRING: ENSP00000334051
    GNGT1ENSP000002485724STRING: ENSP00000248572
    OR10A3ENSP000003539884STRING: ENSP00000353988
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR4X1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR4X1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR4X1 gene: 
    NM_001004726.1  

    Unigene Cluster for OR4X1:

    Olfactory receptor, family 4, subfamily X, member 1
    Hs.553742
    Unigene Representative Sequence: NM_001004726
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000320048(uc010rht.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat OR4X1

    1 AceView cDNA sequence:

    NM_001004726 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR4X1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAGATTTA
    OR4X1 Expression
    About this image

    OR4X1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR4X1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553742
        Custom PCR Arrays for OR4X1
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    ENSEMBL Gene Tree for OR4X1 (if available)
    TreeFam Gene Tree for OR4X1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR4X1 gene
    OR4C52  OR4S12  OR4A472  OR4X22  OR4A162  OR4C152  OR4C132  OR4C62  
    OR4C462  OR4C162  OR4C32  OR4S22  OR4A152  OR4C112  OR4A52  OR4C122  
    OR4B12  OR4A8P2  
    Selected SIMAP similar genes for OR4X1 using alignment to 1 protein entry:     OR4X1_HUMAN(see all similar genes):
    OR4C15    OR4B1    OR4C13    OR4C46    OR4A15    OR4C11
    OR4C3    OR4X2    OR4A47    OR4A5    OR4C6    OR4Q3
    OR4S1    OR4S2    OR4A4P    OR4C12    OR4C5    OR4A16

    Find genes that share paralogs with OR4X1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR4X1 (see all 156)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs770644431,2
    F--48283470(+) TGTGTG/ACATCC 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1386614591,2
    --48283556(+) GTTTCA/GGGTTC 1 -- us2k10--------
    rs13937971,2
    C,F,H--48283763(-) AGCTAA/CAAATT 1 -- us2k115Minor allele frequency- C:0.04NS EA NA WA CSA 675
    rs1919969701,2
    --48283802(+) AAATAC/TATCTT 1 -- us2k10--------
    rs342901791,2
    C,F--48283811(+) TTGTTC/ATGTTA 1 -- us2k16Minor allele frequency- A:0.08NA WA EA 364
    rs128071251,2
    C,F,H--48283979(+) ACTCAC/ACTAGT 1 -- us2k111Minor allele frequency- A:0.09NS EA NA WA 784
    rs1419050881,2
    C--48283980(+) CTCACA/CTAGTG 1 -- us2k10--------
    rs11099051,2
    C,F,O--48284000(-) CACGGG/AAACAA 1 -- us2k113Minor allele frequency- A:0.37NA WA CSA EA 514
    rs1455665881,2
    --48284009(+) TGAGGA/GTGAAA 1 -- us2k10--------
    rs1838741591,2
    --48284020(+) CCTCCC/TCATGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR4X1 ( 48285413 - 48286327 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for OR4X1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv469953CNV Loss18288195
    nsv428253CNV Loss18775914
    nsv508628CNV Loss20534489
    nsv467873CNV Loss19166990
    nsv897329CNV Gain21882294
    dgv1091n71CNV Gain21882294
    nsv467871CNV Gain19166990

    Human Gene Mutation Database (HGMD): OR4X1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OR4X1
    DNA2.0 Custom Variant and Variant Library Synthesis for OR4X1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with OR4X1           About GenesLikeMe

    Genetic Association Database (GAD): OR4X1
    Human Genome Epidemiology (HuGE) Navigator: OR4X1 (1 document)

    Export disorders for OR4X1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR4X1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR4X1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A nonfunctioning single nucleotide polymorphism in olfactory receptor gene family is associated with the forced expiratory volume in the first second/the forced vital capacity values of pulmonary function test in a Japanese population. (PubMed id 17964544)1, 4 Takabatake N....Kubota I. (Biochem. Biophys. Res. Commun. 2007)
    2. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 390113 HGNC: 14854 AceView: OR4X1 Ensembl:ENSG00000176567 euGenes: HUgn390113
    ECgene: OR4X1 Kegg: 390113 H-InvDB: OR4X1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR4X1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR4X1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR4X1 gene:
    Search GeneIP for patents involving OR4X1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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