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Aliases for OR4S2 Gene

Aliases for OR4S2 Gene

  • Olfactory Receptor, Family 4, Subfamily S, Member 2 2 3
  • Olfactory Receptor, Family 4, Subfamily S, Member 2 Pseudogene 2 3
  • Olfactory Receptor OR11-137 3 4
  • OR4S2P 3 4
  • Olfactory Receptor 4S2 3
  • OR11-137 3
  • OST725 3

External Ids for OR4S2 Gene

Previous HGNC Symbols for OR4S2 Gene

  • OR4S2P

Previous GeneCards Identifiers for OR4S2 Gene

  • GC11U900030
  • GC11P055163
  • GC11P055164
  • GC11P055418

Summaries for OR4S2 Gene

Entrez Gene Summary for OR4S2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4S2 Gene

OR4S2 (Olfactory Receptor, Family 4, Subfamily S, Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4A5.

UniProtKB/Swiss-Prot for OR4S2 Gene

  • Odorant receptor.

Gene Wiki entry for OR4S2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4S2 Gene

Genomics for OR4S2 Gene

Regulatory Elements for OR4S2 Gene

Genomic Location for OR4S2 Gene

Start:
55,650,904 bp from pter
End:
55,651,839 bp from pter
Size:
936 bases
Orientation:
Plus strand

Genomic View for OR4S2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR4S2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4S2 Gene

Proteins for OR4S2 Gene

  • Protein details for OR4S2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH73-OR4S2_HUMAN
    Recommended name:
    Olfactory receptor 4S2
    Protein Accession:
    Q8NH73
    Secondary Accessions:
    • Q6IF72

    Protein attributes for OR4S2 Gene

    Size:
    311 amino acids
    Molecular mass:
    35172 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4S2 Gene

Proteomics data for OR4S2 Gene at MOPED

Post-translational modifications for OR4S2 Gene

  • Glycosylation at Asn6
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4S2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4S2 Gene

Domains for OR4S2 Gene

Gene Families for OR4S2 Gene

HGNC:
  • OR4 :GPCR / Class A : Olfactory receptors

Protein Domains for OR4S2 Gene

Suggested Antigen Peptide Sequences for OR4S2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH73

UniProtKB/Swiss-Prot:

OR4S2_HUMAN :
  • Q8NH73
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4S2: view

Function for OR4S2 Gene

Molecular function for OR4S2 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4S2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4S2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR4S2 Gene

Localization for OR4S2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4S2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4S2 Gene COMPARTMENTS Subcellular localization image for OR4S2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4S2: view

Pathways for OR4S2 Gene

genes like me logo Genes that share pathways with OR4S2: view

Pathways by source for OR4S2 Gene

Interacting Proteins for OR4S2 Gene

Gene Ontology (GO) - Biological Process for OR4S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4S2: view

Transcripts for OR4S2 Gene

mRNA/cDNA for OR4S2 Gene

(1) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4S2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR4S2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4S2 Gene

No ASD Table

Relevant External Links for OR4S2 Gene

GeneLoc Exon Structure for
OR4S2
ECgene alternative splicing isoforms for
OR4S2

Expression for OR4S2 Gene

mRNA expression in normal human tissues for OR4S2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR4S2 Gene

SOURCE GeneReport for Unigene cluster for OR4S2 Gene Hs.553621

genes like me logo Genes that share expressions with OR4S2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR4S2 Gene

Orthologs for OR4S2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4S2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466536 35
  • 99.04 (n)
  • 99.04 (a)
OR4S2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR4S2 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100682721 35
  • 88.96 (n)
  • 88.75 (a)
OR4S2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr1193 35
  • 84.03 (n)
  • 88.1 (a)
Olfr1193 16
Olfr1193 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OR4S2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OR4S2 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr649 35
  • 84.35 (n)
  • 89.39 (a)
chicken
(Gallus gallus)
Aves LOC100859598 35
  • 67.76 (n)
  • 66.99 (a)
Species with no ortholog for OR4S2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4S2 Gene

ENSEMBL:
Gene Tree for OR4S2 (if available)
TreeFam:
Gene Tree for OR4S2 (if available)

Paralogs for OR4S2 Gene

Selected SIMAP similar genes for OR4S2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4S2: view

Variants for OR4S2 Gene

Sequence variations from dbSNP and Humsavar for OR4S2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs6591569 -- 55,651,201(+) AACTG(C/T)TTGGA missense, reference
rs7483877 -- 55,649,195(+) TTTTT(C/T)TTTTA upstream-variant-2KB
rs7949664 - 55,651,487(+) TGGTG(G/T)TGTTG missense, reference
rs11230541 -- 55,651,217(+) TTTCT(C/T)TGGTT missense, reference
rs11230552 -- 55,652,183(+) TCACC(A/G)TATGT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR4S2 Gene

Variant ID Type Subtype PubMed ID
esv2751030 CNV Gain 17911159
nsv524091 CNV Gain 19592680
nsv821668 CNV Loss 15273396
dgv376e1 CNV Complex 17122850
esv782 CNV CNV 17122850
dgv12n68 CNV Loss 17160897
dgv377e1 CNV Complex 17122850
nsv428256 CNV Loss 18775914
dgv4e49 CNV Loss 18971310
dgv378e1 CNV Complex 17122850
dgv379e1 CNV Complex 17122850
dgv143n27 CNV Loss 19166990
nsv517440 CNV Gain+Loss 19592680
nsv323 CNV Loss 18451855
nsv71 CNV Loss 15895083
nsv437717 CNV Loss 16327808
nsv469957 CNV Gain 18288195
nsv818824 CNV Gain 17921354
dgv144n27 CNV Gain 19166990
dgv145n27 CNV Loss 19166990
dgv146n27 CNV Gain 19166990
nsv508632 CNV Loss 20534489
nsv511485 CNV Gain 21212237
nsv435950 OTHER Inversion 17901297
dgv211e199 CNV Deletion 23128226
nsv443003 CNV Complex 18674749
dgv12n47 CNV Loss 21111241
esv22842 CNV Gain+Loss 19812545
esv2663268 CNV Deletion 23128226
nsv825892 CNV Loss 20364138
dgv217n67 CNV Loss 20364138
nsv8827 CNV Gain+Loss 18304495
esv33874 CNV Gain 17666407
dgv6n14 CNV Loss 18776910
esv2421634 CNV Deletion 20811451
esv29944 CNV Loss 18421352
nsv469958 CNV Loss 18288195
nsv818827 CNV Gain 17921354
dgv10n64 CNV Loss 17921354
dgv11n64 CNV Gain+Loss 17921354
dgv380e1 CNV Complex 17122850
dgv381e1 CNV Complex 17122850
dgv382e1 CNV Complex 17122850
nsv442617 CNV CNV 18776908
dgv50e55 CNV Loss 17911159
dgv5e49 CNV Loss 18971310
dgv13n68 CNV Loss 17160897
dgv148n27 CNV Loss 19166990
nsv825896 CNV Loss 20364138
nsv514622 CNV Loss 21397061
dgv149n27 CNV Loss 19166990
nsv468563 CNV Loss 19166990
nsv471364 CNV Complex 19718026

Relevant External Links for OR4S2 Gene

HapMap Linkage Disequilibrium report
OR4S2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4S2 Gene

Disorders for OR4S2 Gene

No disorders were found for OR4S2 Gene.

No data available for UniProtKB/Swiss-Prot for OR4S2 Gene

Publications for OR4S2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3
  5. Population differences in the human functional olfactory repertoire. (PMID: 12644552) Gilad Y. … Lancet D. (Mol. Biol. Evol. 2003) 3

Products for OR4S2 Gene

Sources for OR4S2 Gene

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