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Aliases for OR4S1 Gene

Aliases for OR4S1 Gene

  • Olfactory Receptor Family 4 Subfamily S Member 1 2 3 5
  • Olfactory Receptor OR11-100 3 4
  • Olfactory Receptor, Family 4, Subfamily S, Member 1 2
  • Olfactory Receptor 4S1 3
  • OR11-100 3

External Ids for OR4S1 Gene

Previous GeneCards Identifiers for OR4S1 Gene

  • GC16U990203
  • GC11P048292
  • GC11P048283

Summaries for OR4S1 Gene

Entrez Gene Summary for OR4S1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4S1 Gene

OR4S1 (Olfactory Receptor Family 4 Subfamily S Member 1) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4S2.

UniProtKB/Swiss-Prot for OR4S1 Gene

  • Odorant receptor.

Gene Wiki entry for OR4S1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4S1 Gene

Genomics for OR4S1 Gene

Regulatory Elements for OR4S1 Gene

Enhancers for OR4S1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G048103 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.8 -199.0 -198999 7.3 HDGF PKNOX1 ARNT SIN3A FEZF1 BRCA1 ZNF2 YY1 ELK1 ZNF143 NUP160 OR4S1 PTPRJ-AS1 PTPRJ OR4B1 PACSIN3 ACP2 MADD C1QTNF4 OR4X2
GH11G048266 0.3 FANTOM5 30.1 -39.4 -39438 0.0 OR4B1 OR4S1 OR4X2 OR4C3 OR4X1
GH11G047869 1.2 FANTOM5 ENCODE dbSUPER 6.2 -436.4 -436419 1.0 TBP PKNOX1 STAT1 TAF1 JUN FEZF1 EP300 PRDM6 JUND NFE2 OR4C3 OR4B1 OR4S1 PTPRJ OR4X2 NUP160 GC11M054020
GH11G047850 0.9 FANTOM5 ENCODE 3.9 -455.2 -455163 2.0 FOSL1 POLR2A EED JUN IKZF1 HMBOX1 ETV6 IKZF2 SPI1 C1QTNF4 MTCH2 OR4S1 OR4B1 OR4X2 OR4C3 NUP160 GC11M054020
GH11G047912 2 FANTOM5 Ensembl ENCODE dbSUPER 1.3 -387.4 -387391 13.2 HDGF FOXA2 PKNOX1 CREB3L1 ARNT SIN3A ARID4B FEZF1 YY1 ZNF766 NUP160 FNBP4 ENSG00000270060 PTPRJ C1QTNF4 ENSG00000200090 DDB2 PTPRJ-AS1 MYBPC3 KBTBD4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR4S1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR4S1 Gene

Chromosome:
11
Start:
48,306,223 bp from pter
End:
48,307,152 bp from pter
Size:
930 bases
Orientation:
Plus strand

Genomic View for OR4S1 Gene

Genes around OR4S1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4S1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4S1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4S1 Gene

Proteins for OR4S1 Gene

  • Protein details for OR4S1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGB4-OR4S1_HUMAN
    Recommended name:
    Olfactory receptor 4S1
    Protein Accession:
    Q8NGB4
    Secondary Accessions:
    • Q6IFB4

    Protein attributes for OR4S1 Gene

    Size:
    309 amino acids
    Molecular mass:
    34800 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4S1 Gene

Post-translational modifications for OR4S1 Gene

Other Protein References for OR4S1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4S1 Gene

Domains & Families for OR4S1 Gene

Gene Families for OR4S1 Gene

Protein Domains for OR4S1 Gene

Suggested Antigen Peptide Sequences for OR4S1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGB4

UniProtKB/Swiss-Prot:

OR4S1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4S1: view

Function for OR4S1 Gene

Molecular function for OR4S1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4S1: view
genes like me logo Genes that share phenotypes with OR4S1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4S1 Gene

Localization for OR4S1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4S1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4S1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4S1: view

Pathways & Interactions for OR4S1 Gene

genes like me logo Genes that share pathways with OR4S1: view

Pathways by source for OR4S1 Gene

Interacting Proteins for OR4S1 Gene

Gene Ontology (GO) - Biological Process for OR4S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4S1: view

No data available for SIGNOR curated interactions for OR4S1 Gene

Drugs & Compounds for OR4S1 Gene

No Compound Related Data Available

Transcripts for OR4S1 Gene

mRNA/cDNA for OR4S1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4S1 Gene

No ASD Table

Relevant External Links for OR4S1 Gene

GeneLoc Exon Structure for
OR4S1
ECgene alternative splicing isoforms for
OR4S1

Expression for OR4S1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4S1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4S1 Gene:

OR4S1

SOURCE GeneReport for Unigene cluster for OR4S1 Gene:

Hs.553657
genes like me logo Genes that share expression patterns with OR4S1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4S1 Gene

Orthologs for OR4S1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4S1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466514 34
  • 98.6 (n)
OR4S1 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR4S1 35
  • 89 (a)
OneToOne
LOC483607 34
  • 87.38 (n)
oppossum
(Monodelphis domestica)
Mammalia OR4S1 35
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR4S1 34 35
  • 85.9 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 61 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr140 35
  • 55 (a)
ManyToMany
Species where no ortholog for OR4S1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4S1 Gene

ENSEMBL:
Gene Tree for OR4S1 (if available)
TreeFam:
Gene Tree for OR4S1 (if available)

Paralogs for OR4S1 Gene

Paralogs for OR4S1 Gene

(445) SIMAP similar genes for OR4S1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4S1: view

Variants for OR4S1 Gene

Sequence variations from dbSNP and Humsavar for OR4S1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000287037 -- 48,307,463(+) GGGAG(A/T)GTCTT downstream-variant-500B
rs1002731369 -- 48,305,444(+) CAAGG(C/G)GCAGC upstream-variant-2KB
rs1004112348 -- 48,306,911(+) TGAGG(A/G)CCGGC reference, missense
rs1005121219 -- 48,305,397(+) GGGTG(C/G)GTGCA upstream-variant-2KB
rs1006548277 -- 48,304,951(+) CTTAT(C/T)TAATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR4S1 Gene

Variant ID Type Subtype PubMed ID
dgv1111n100 CNV gain 25217958
dgv1112n100 CNV gain 25217958
dgv1779n54 CNV loss 21841781
dgv198e214 CNV gain 21293372
dgv213n67 CNV gain 20364138
dgv214n67 CNV gain 20364138
esv23698 CNV gain 19812545
esv2677985 CNV deletion 23128226
esv2759824 CNV gain+loss 17122850
esv2760610 CNV gain 21179565
esv33256 CNV loss 17666407
esv3578682 CNV gain 25503493
esv3579506 CNV loss 25503493
esv3891986 CNV gain 25118596
nsv1041394 CNV gain 25217958
nsv1127182 CNV deletion 24896259
nsv428253 CNV loss 18775914
nsv467871 CNV gain 19166990
nsv467873 CNV loss 19166990
nsv469953 CNV loss 18288195
nsv508628 CNV deletion 20534489
nsv554211 CNV gain 21841781
nsv554212 CNV loss 21841781
nsv554215 CNV loss 21841781
nsv554216 CNV loss 21841781
nsv820164 CNV gain 19587683
nsv8812 CNV gain 18304495

Variation tolerance for OR4S1 Gene

Residual Variation Intolerance Score: 87.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR4S1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4S1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4S1 Gene

Disorders for OR4S1 Gene

Relevant External Links for OR4S1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR4S1

No disorders were found for OR4S1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4S1 Gene

Publications for OR4S1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. (PMID: 22581228) Manning A.K. … Langenberg C. (Nat. Genet. 2012) 3 64

Products for OR4S1 Gene

Sources for OR4S1 Gene

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