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Aliases for OR4Q3 Gene

Aliases for OR4Q3 Gene

  • Olfactory Receptor Family 4 Subfamily Q Member 3 2 3 5
  • Olfactory Receptor OR14-3 3 4
  • Olfactory Receptor 4Q4 3 4
  • C14orf13 3 4
  • OR4Q4 3 4
  • Olfactory Receptor, Family 4, Subfamily Q, Member 3 2
  • Olfactory Receptor, Family 4, Subfamily Q, Member 4 3
  • Olfactory Receptor 4Q3 3
  • C14_5008 3
  • OR14-3 3
  • HSA6 3

External Ids for OR4Q3 Gene

Previous HGNC Symbols for OR4Q3 Gene

  • OR4Q4

Previous GeneCards Identifiers for OR4Q3 Gene

  • GC00U990949
  • GC14U900436
  • GC14P019285
  • GC14P020215

Summaries for OR4Q3 Gene

Entrez Gene Summary for OR4Q3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4Q3 Gene

OR4Q3 (Olfactory Receptor Family 4 Subfamily Q Member 3) is a Protein Coding gene. Diseases associated with OR4Q3 include Cataract 37 and Cataract 3, Multiple Types. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4Q2.

UniProtKB/Swiss-Prot for OR4Q3 Gene

  • Odorant receptor.

Gene Wiki entry for OR4Q3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4Q3 Gene

Genomics for OR4Q3 Gene

Regulatory Elements for OR4Q3 Gene

Enhancers for OR4Q3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G020071 0.3 FANTOM5 9.2 +324.3 324341 0.2 OR4K17 OR4K14 OR4L1 OR4Q3 OR11H4 OR11H6 OR4N5 OR4M1 OR4K5 OR4K1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR4Q3 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR4Q3 Gene

Chromosome:
14
Start:
19,747,428 bp from pter
End:
19,748,369 bp from pter
Size:
942 bases
Orientation:
Plus strand

Genomic View for OR4Q3 Gene

Genes around OR4Q3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4Q3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4Q3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4Q3 Gene

Proteins for OR4Q3 Gene

  • Protein details for OR4Q3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH05-OR4Q3_HUMAN
    Recommended name:
    Olfactory receptor 4Q3
    Protein Accession:
    Q8NH05
    Secondary Accessions:
    • Q6IEX4

    Protein attributes for OR4Q3 Gene

    Size:
    313 amino acids
    Molecular mass:
    35491 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4Q3 Gene

Post-translational modifications for OR4Q3 Gene

Other Protein References for OR4Q3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4Q3 Gene

Domains & Families for OR4Q3 Gene

Gene Families for OR4Q3 Gene

Protein Domains for OR4Q3 Gene

Suggested Antigen Peptide Sequences for OR4Q3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH05

UniProtKB/Swiss-Prot:

OR4Q3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4Q3: view

Function for OR4Q3 Gene

Molecular function for OR4Q3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4Q3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4Q3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4Q3 Gene

Localization for OR4Q3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4Q3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4Q3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4Q3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4Q3: view

Pathways & Interactions for OR4Q3 Gene

genes like me logo Genes that share pathways with OR4Q3: view

Pathways by source for OR4Q3 Gene

Interacting Proteins for OR4Q3 Gene

Gene Ontology (GO) - Biological Process for OR4Q3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4Q3: view

No data available for SIGNOR curated interactions for OR4Q3 Gene

Drugs & Compounds for OR4Q3 Gene

No Compound Related Data Available

Transcripts for OR4Q3 Gene

mRNA/cDNA for OR4Q3 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4Q3 Gene

No ASD Table

Relevant External Links for OR4Q3 Gene

GeneLoc Exon Structure for
OR4Q3
ECgene alternative splicing isoforms for
OR4Q3

Expression for OR4Q3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4Q3 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4Q3 Gene:

OR4Q3

SOURCE GeneReport for Unigene cluster for OR4Q3 Gene:

Hs.553828
genes like me logo Genes that share expression patterns with OR4Q3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4Q3 Gene

Orthologs for OR4Q3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4Q3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia OR16G03 34 35
  • 86.56 (n)
-- 35
  • 73 (a)
OneToMany
cow
(Bos Taurus)
Mammalia OR4Q3 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or4q3 55 Olfr735 34 16 35
  • 82.02 (n)
oppossum
(Monodelphis domestica)
Mammalia OR4Q3 35
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 57 (a)
OneToMany
-- 35
  • 48 (a)
OneToMany
Species where no ortholog for OR4Q3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4Q3 Gene

ENSEMBL:
Gene Tree for OR4Q3 (if available)
TreeFam:
Gene Tree for OR4Q3 (if available)

Paralogs for OR4Q3 Gene

(447) SIMAP similar genes for OR4Q3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR4Q3 Gene

genes like me logo Genes that share paralogs with OR4Q3: view

Variants for OR4Q3 Gene

Sequence variations from dbSNP and Humsavar for OR4Q3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000120449 -- 19,745,546(+) TCTAG(-/A)AAACC upstream-variant-2KB
rs1008348664 -- 19,748,534(+) GGTGG(C/G)ACTCT downstream-variant-500B
rs1008937226 -- 19,746,666(+) CTTCC(C/T)AATTT upstream-variant-2KB
rs1009297937 -- 19,746,297(+) AGAAA(C/T)GTATC upstream-variant-2KB
rs1011839852 -- 19,748,030(+) GTGAT(A/T)GCCAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for OR4Q3 Gene

Variant ID Type Subtype PubMed ID
dgv1050n106 CNV duplication 24896259
dgv14e213 CNV gain 24956385
dgv1753n100 CNV gain 25217958
dgv1757n100 CNV gain 25217958
dgv1759n100 CNV gain 25217958
dgv1761n100 CNV gain+loss 25217958
dgv1762n100 CNV loss 25217958
dgv1764n100 CNV loss 25217958
dgv1765n100 CNV gain+loss 25217958
dgv1766n100 CNV gain 25217958
dgv1767n100 CNV loss 25217958
dgv1768n100 CNV gain 25217958
dgv1769n100 CNV gain 25217958
dgv1770n100 CNV gain+loss 25217958
dgv1771n100 CNV loss 25217958
dgv1772n100 CNV gain 25217958
dgv1773n100 CNV gain+loss 25217958
dgv1774n100 CNV gain 25217958
dgv1775n100 CNV gain 25217958
dgv1776n100 CNV gain 25217958
dgv1777n100 CNV loss 25217958
dgv1778n100 CNV gain 25217958
dgv1779n100 CNV loss 25217958
dgv1780n100 CNV loss 25217958
dgv24n68 CNV gain 17160897
dgv33e203 CNV gain+loss 21179565
dgv3489n54 CNV gain 21841781
dgv3494n54 CNV loss 21841781
dgv3513n54 CNV loss 21841781
dgv3518n54 CNV gain 21841781
dgv3519n54 CNV gain 21841781
dgv3520n54 CNV gain 21841781
dgv3521n54 CNV loss 21841781
dgv3522n54 CNV loss 21841781
dgv3523n54 CNV gain 21841781
dgv3524n54 CNV gain+loss 21841781
dgv3525n54 CNV loss 21841781
dgv361n67 CNV gain 20364138
dgv45e180 CNV loss 20482838
dgv6n31 CNV gain 19718026
dgv79e55 CNV loss 17911159
dgv80e55 CNV gain 17911159
dgv81e55 CNV gain 17911159
dgv86n111 CNV duplication 26073780
dgv87n111 CNV duplication 26073780
esv1002355 CNV loss 20482838
esv23873 CNV gain+loss 19812545
esv2421752 OTHER complex 20811451
esv2751268 CNV gain 17911159
esv2759971 CNV gain+loss 17122850
esv3327694 CNV duplication 20981092
esv33527 CNV gain+loss 17666407
esv3447061 CNV duplication 20981092
esv3584743 CNV gain 24956385
esv3892451 CNV gain 25118596
esv3892461 CNV gain 25118596
esv3892464 CNV gain 25118596
esv3892466 CNV gain 25118596
nsv1038826 CNV gain 25217958
nsv1042164 CNV gain+loss 25217958
nsv1044659 CNV gain 25217958
nsv1047431 CNV loss 25217958
nsv1048393 CNV gain+loss 25217958
nsv1077784 CNV duplication 25765185
nsv1150747 CNV duplication 26484159
nsv1160152 CNV duplication 26073780
nsv428292 CNV gain+loss 18775914
nsv433273 CNV loss 18776910
nsv433422 CNV gain 18776910
nsv442679 CNV gain 18776908
nsv511546 CNV gain 21212237
nsv514728 CNV gain 21397061
nsv563705 CNV loss 21841781
nsv563739 CNV loss 21841781
nsv563742 CNV gain 21841781
nsv563751 CNV loss 21841781
nsv563752 CNV loss 21841781
nsv563766 CNV loss 21841781
nsv563769 CNV loss 21841781
nsv563780 CNV loss 21841781
nsv819711 CNV loss 19587683
nsv821676 CNV gain 15273396
nsv826860 CNV gain 20364138
nsv9117 CNV gain+loss 18304495
nsv952808 CNV duplication 24416366

Variation tolerance for OR4Q3 Gene

Residual Variation Intolerance Score: 96.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.81; 66.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR4Q3 Gene

Human Gene Mutation Database (HGMD)
OR4Q3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4Q3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4Q3 Gene

Disorders for OR4Q3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for OR4Q3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cataract 37
  • cca5
cataract 3, multiple types
  • cataract 3 multiple types
cataract 21, multiple types
  • cataract 21 multiple types
cataract 7
  • cca1
- elite association - COSMIC cancer census association via MalaCards
Search OR4Q3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for OR4Q3

Genetic Association Database (GAD)
OR4Q3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR4Q3
genes like me logo Genes that share disorders with OR4Q3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR4Q3 Gene

Publications for OR4Q3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PMID: 17903295) Lunetta K.L. … Murabito J.M. (BMC Med. Genet. 2007) 46 64
  3. The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. (PMID: 10706615) Rouquier S. … Giorgi D. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 64

Products for OR4Q3 Gene

Sources for OR4Q3 Gene

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