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OR4Q3 Gene

protein-coding   GIFtS: 46
GCID: GC14P020215

Olfactory Receptor, Family 4, Subfamily Q, Member 3


(Previous symbol: OR4Q4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 4, Subfamily Q, Member 31 2     HSA62
OR4Q41 2 3     OR14-32
Olfactory Receptor 4Q42 3     c14_50082
Olfactory Receptor OR14-32 3     Olfactory Receptor 4Q32
C14orf132 3     Olfactory Receptor, Family 4, Subfamily Q, Member 42

External Ids:    HGNC: 154261   Entrez Gene: 4416692   Ensembl: ENSG000001826527   UniProtKB: Q8NH053   

Export aliases for OR4Q3 gene to outside databases

Previous GC identifers: GC00U990949 GC14U900436 GC14P019285


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR4Q3 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR4Q3 Gene:
OR4Q3 (olfactory receptor, family 4, subfamily Q, member 3) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4D11.

UniProtKB/Swiss-Prot: OR4Q3_HUMAN, Q8NH05
Function: Odorant receptor (Potential)

Gene Wiki entry for OR4Q3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR4Q3 gene promoter:
         Elk-1   RelA   CUTL1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   NF-kappaB   POU3F2   Evi-1   AREB6   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR4Q3 promoter sequence
   Search Chromatin IP Primers for OR4Q3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR4Q3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14p13

OR4Q3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR4Q3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P020215:  view genomic region     (about GC identifiers)

Start:
20,215,587 bp from pter      End:
20,216,525 bp from pter
Size:
939 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OR4Q3_HUMAN, Q8NH05 (See protein sequence)
Recommended Name: Olfactory receptor 4Q3  
Size: 313 amino acids; 35491 Da
Secondary accessions: Q6IEX4

Explore the universe of human proteins at neXtProt for OR4Q3: NX_Q8NH05

Explore proteomics data for OR4Q3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn8
  • HORDE protein sequence for OR4Q3

    See OR4Q3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_751944.1  
    ENSEMBL proteins: 
     ENSP00000330049  
    Reactome Protein details: Q8NH05

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR4: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NH05

    ProtoNet protein and cluster: Q8NH05

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR4Q3_HUMAN, Q8NH05
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR4Q3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR4Q3_HUMAN, Q8NH05
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR4Q3           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR4Q3_HUMAN, Q8NH05: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR4Q3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR4Q3 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR4Q3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR4Q3
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR4Q3):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR4Q3
    Interactions:

        Search GeneGlobe Interaction Network for OR4Q3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR4Q3 (ENSP000003300494) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10H3ENSP000003071304STRING: ENSP00000307130
    OR1J2ENSP000003355754STRING: ENSP00000335575
    OR2Z1ENSP000003162844STRING: ENSP00000316284
    OR52J3ENSP000003697284STRING: ENSP00000369728
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR4Q3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR4Q3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR4Q3 gene: 
    NM_172194.1  

    Unigene Cluster for OR4Q3:

    Olfactory receptor, family 4, subfamily Q, member 3
    Hs.553828
    Unigene Representative Sequence: NM_172194
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000331723(uc010tkt.2)
    miRNA
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR4Q3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCATTCCA
    OR4Q3 Expression
    About this image

    OR4Q3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR4Q3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553828
        Custom PCR Arrays for OR4Q3
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OR4Q3 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr7351 , 5 olfactory receptor 7351, 5 82.02(n)1
    81.58(a)1
      14 (26.06 cM)5
    2579091  NM_001011754.21  NP_001011754.11 
     503453765 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    57(a)
    48(a)
    1 ↔ many
    1 ↔ many
    GL343220.1(953788-954738)
    GL343220.1(946844-947812)


    ENSEMBL Gene Tree for OR4Q3 (if available)
    TreeFam Gene Tree for OR4Q3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR4Q3 gene
    OR4D112  OR4D22  OR4D52  OR4N22  OR4N52  OR4D62  OR4M12  OR4Q22  
    OR4N42  OR4D102  OR4M22  OR4D12  OR4D92  OR4E22  
    Selected SIMAP similar genes for OR4Q3 using alignment to 1 protein entry:     OR4Q3_HUMAN(see all similar genes):
    OR4K2    OR4K3    OR4D11    OR4D2    OR4F17    OR4F4
    OR4F5    OR4K13    OR4K14    OR4K15    OR4K17    OR4S2
    OR4D1    OR4D9    OR4E1    OR4E2    OR4P4    OR4Q2

    Find genes that share paralogs with OR4Q3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for OR4Q3
    PGOHUM00000246984


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR4Q3 (see all 156)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1408428271,2
    C,Funtested120216261(+) ATCACC/TCTGAG 2 T syn11Minor allele frequency- T:0.00NA 4550
    rs357688771,2
    C,F--20213590(+) ACACCT/CTTGGT 1 -- us2k13Minor allele frequency- C:0.12NA 124
    rs348614991,2
    C,F--20213665(+) TAACAG/TTGTGT 1 -- us2k13Minor allele frequency- T:0.50NA 6
    rs1879333971,2
    --20213675(+) TAGGAC/TTATGT 1 -- us2k10--------
    rs352018791,2
    C,F--20213791(+) AGATCC/AATAAT 1 -- us2k13Minor allele frequency- A:0.50NA 6
    rs1908461241,2
    --20213870(+) TCTTAC/TGGAAA 1 -- us2k10--------
    rs1829828071,2
    --20213924(+) ATATAA/GCAGAG 1 -- us2k10--------
    rs171142961,2
    C,F,H--20213937(+) CAAGTG/AAGGCT 1 -- us2k1 tfbs318Minor allele frequency- A:0.09NA NS EA 2004
    rs353440271,2
    C,F--20213949(+) TACATG/ATAACA 1 -- us2k14Minor allele frequency- A:0.14NA 126
    rs1169887381,2
    C,F--20213962(+) AAATCG/ATTCCC 1 -- us2k11Minor allele frequency- A:0.03NA 120

    HapMap Linkage Disequilibrium report for OR4Q3 ( 20215587 - 20216525 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for OR4Q3 (see all 58):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv6n31CNV Duplication19718026
    nsv819711CNV Loss19587683
    nsv901198CNV Loss21882294
    dgv45e180CNV Loss20482838
    nsv901192CNV Loss21882294
    nsv901268CNV Loss21882294
    nsv433273CNV Loss18776910
    esv1002355CNV Loss20482838
    dgv1833n71CNV Loss21882294
    dgv79e55CNV Loss17911159

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with OR4Q3           About GenesLikeMe

    Genetic Association Database (GAD): OR4Q3

    Export disorders for OR4Q3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR4Q3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR4Q3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PubMed id 17903295)4 Lunetta K.L....Murabito J.M. (BMC Med. Genet. 2007)
    3. The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. (PubMed id 10706615)1 Rouquier S.... Giorgi D. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    4. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 441669 HGNC: 15426 Ensembl:ENSG00000182652 euGenes: HUgn441669 ECgene: OR4Q3 Kegg: 441669
    H-InvDB: OR4Q3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR4Q3 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR4Q3 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR4Q3 gene:
    Search GeneIP for patents involving OR4Q3

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     OriGene Antibodies for OR4Q3   OriGene RNAi products in human, mouse, rat for OR4Q3  
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     Block miRNA regulation of human, mouse, rat OR4Q3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OR4Q3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR4Q3 Predesigned siRNA for gene silencing in human, mouse, rat OR4Q3
     QuantiFast Probe-based Assays in human, mouse, rat OR4Q3 QuantiTect SYBR Green Assays in human, mouse, rat OR4Q3
     Custom PCR Arrays for OR4Q3 Search Chromatin IP Primers for OR4Q3
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     Search Tocris compounds for OR4Q3
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     Novus Tissue Slides
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     Browse ESI BIO Cell Lines and PureStem Progenitors for OR4Q3
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     Search ThermoFisher Antibodies for OR4Q3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR4Q3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR4Q3
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     Search Addgene for plasmids for OR4Q3
      Search eBioscience for proteins for OR4Q3
      Search eBioscience for elisas for OR4Q3
      eBioscience FlowRNA Probe Sets
           
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