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OR4P4 Gene

protein-coding   GIFtS: 42
GCID: GC11P055405

Olfactory Receptor, Family 4, Subfamily P, Member 4


(Previous symbol: OR4P3P)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 4, Subfamily P, Member 41 2
OR4P3P1 2 3
Olfactory Receptor 4P32 3
Olfactory Receptor 4P42
Olfactory Receptor, Family 4, Subfamily P, Member 3 Pseudogene2

External Ids:    HGNC: 151801   Entrez Gene: 813002   Ensembl: ENSG000001819277   UniProtKB: Q8NGL73   

Export aliases for OR4P4 gene to outside databases

Previous GC identifers: GC11U990533 GC11P055162


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR4P4 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR4P4 Gene:
OR4P4 (olfactory receptor, family 4, subfamily P, member 4) is a protein-coding gene. Diseases associated with OR4P4 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot: OR4P4_HUMAN, Q8NGL7
Function: Odorant receptor (Potential)

Gene Wiki entry for OR4P4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR4P4 gene promoter:
         HOXA9   HOXA9B   HNF-4alpha1   Meis-1b   PPAR-alpha   NF-kappaB2   FOXJ2 (long isoform)   FOXJ2   NF-kappaB1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR4P4 promoter sequence
   Search Chromatin IP Primers for OR4P4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR4P4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q11   HGNC cytogenetic band: 11q11

OR4P4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR4P4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P055405:  view genomic region     (about GC identifiers)

Start:
55,405,813 bp from pter      End:
55,406,769 bp from pter
Size:
957 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR4P4_HUMAN, Q8NGL7 (See protein sequence)
Recommended Name: Olfactory receptor 4P4  
Size: 312 amino acids; 35795 Da

Explore the universe of human proteins at neXtProt for OR4P4: NX_Q8NGL7

Explore proteomics data for OR4P4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5, Asn6
  • HORDE protein sequence for OR4P4

    See OR4P4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004124.1  
    ENSEMBL proteins: 
     ENSP00000324831  
    Reactome Protein details: Q8NGL7

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR4: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGL7

    ProtoNet protein and cluster: Q8NGL7

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR4P4_HUMAN, Q8NGL7
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR4P4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR4P4_HUMAN, Q8NGL7
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR4P4 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR4P4_HUMAN, Q8NGL7: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR4P4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR4P4 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR4P4
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR4P4):
        Olfactory transduction


    OR4P4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR4P4
    Interactions:

        Search GeneGlobe Interaction Network for OR4P4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR4P4 (ENSP000003248314) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR1N1ENSP000003069744STRING: ENSP00000306974
    OR4C11ENSP000003066514STRING: ENSP00000306651
    OR4C6ENSP000003247694STRING: ENSP00000324769
    OR4S2ENSP000003103374STRING: ENSP00000310337
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR4P4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR4P4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR4P4 gene: 
    NM_001004124.1  

    Unigene Cluster for OR4P4:

    Olfactory receptor, family 4, subfamily P, member 4
    Hs.626750
    Unigene Representative Sequence: NM_001004124
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000314612(uc010rij.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat OR4P4

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR4P4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OR4P4 Expression
    About this image

    OR4P4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR4P4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.626750
        Custom PCR Arrays for OR4P4
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for OR4P4 (if available)
    TreeFam Gene Tree for OR4P4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR4P4 gene
    Selected SIMAP similar genes for OR4P4 using alignment to 1 protein entry:     OR4P4_HUMAN(see all similar genes):
    OR4C15    OR4Q3    OR4S1    OR4S2    OR4C11    OR4C3
    OR4Q2    OR4X2    OR4B1    OR4C12    OR4C6    OR4X1
    OR4A5    OR4C16    OR4D10    OR4F17    OR4F4    OR4F5

    OR4P4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OR4P4
    PGOHUM00000257883


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR4P4 (see all 94)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1443421721,2
    C--55403943(+) AGTGTC/TCTACT 1 -- us2k10--------
    rs171468421,2
    C,F--55404136(+) TTACTA/GTGTAC 1 -- us2k14Minor allele frequency- G:0.01NA CSA 136
    rs1151868941,2
    F--55404159(+) CTCTAG/AAATCC 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs803009051,2
    --55404178(+) TTTTCA/GTGTGT 1 -- us2k10--------
    rs171468461,2
    C,F--55404214(+) CACAAC/TGATAT 1 -- us2k15Minor allele frequency- T:0.02NA WA CSA 136
    rs1141327021,2
    C,F--55404221(+) ATATCA/GTCCCT 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1450470851,2
    --55404236(+) CACTAC/TTTTAT 1 -- us2k10--------
    rs1491121461,2
    --55404254(+) AATGTA/CCTTTA 1 -- us2k10--------
    rs1907887141,2
    --55404379(+) AAGATC/TACATT 1 -- us2k10--------
    rs1449560361,2
    --55404432(+) CCAAAA/TTATAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR4P4 ( 55405813 - 55406769 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for OR4P4 (see all 55):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv471363CNV Deletion19718026
    esv2421634CNV Deletion20811451
    dgv211e199CNV Deletion23128226
    esv2663268CNV Deletion23128226
    dgv5e49CNV Loss18971310
    nsv518225CNV Loss19592680
    dgv217n67CNV Loss20364138
    nsv508632CNV Loss20534489
    dgv13n68CNV Loss17160897
    dgv12n68CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for OR4P4:    
    About MalaCards
    neuronitis


    OR4P4 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: OR4P4 (1 document)

    Export disorders for OR4P4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed article for OR4P4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR4P4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1 Fuchs T.... Shamir R. (Genomics 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81300 HGNC: 15180 Ensembl:ENSG00000181927 euGenes: HUgn81300 ECgene: OR4P4 Kegg: 81300
    H-InvDB: OR4P4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR4P4 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR4P4 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR4P4 gene:
    Search GeneIP for patents involving OR4P4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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