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Aliases for OR4P4 Gene

Aliases for OR4P4 Gene

  • Olfactory Receptor Family 4 Subfamily P Member 4 2 3 5
  • Olfactory Receptor 4P3 3 4
  • OR4P3P 3 4
  • Olfactory Receptor, Family 4, Subfamily P, Member 3 Pseudogene 3
  • Olfactory Receptor, Family 4, Subfamily P, Member 4 2
  • Olfactory Receptor 4P4 3

External Ids for OR4P4 Gene

Previous HGNC Symbols for OR4P4 Gene

  • OR4P3P

Previous GeneCards Identifiers for OR4P4 Gene

  • GC11U990533
  • GC11P055162
  • GC11P055405

Summaries for OR4P4 Gene

Entrez Gene Summary for OR4P4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4P4 Gene

OR4P4 (Olfactory Receptor Family 4 Subfamily P Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot for OR4P4 Gene

  • Odorant receptor.

Gene Wiki entry for OR4P4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4P4 Gene

Genomics for OR4P4 Gene

Regulatory Elements for OR4P4 Gene

Enhancers for OR4P4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F055430 0.4 FANTOM5 1.7 -208.0 -208006 0.0 OR5D14 OR5D18 OR4C15 OR5L2 OR4C16 OR5D16 OR4C6 OR4S2 OR4A16 OR4C11
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR4P4 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR4P4 Gene

Chromosome:
11
Start:
55,638,337 bp from pter
End:
55,639,296 bp from pter
Size:
960 bases
Orientation:
Plus strand

Genomic View for OR4P4 Gene

Genes around OR4P4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4P4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4P4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4P4 Gene

Proteins for OR4P4 Gene

  • Protein details for OR4P4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGL7-OR4P4_HUMAN
    Recommended name:
    Olfactory receptor 4P4
    Protein Accession:
    Q8NGL7

    Protein attributes for OR4P4 Gene

    Size:
    312 amino acids
    Molecular mass:
    35795 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4P4 Gene

Post-translational modifications for OR4P4 Gene

Other Protein References for OR4P4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4P4 Gene

Domains & Families for OR4P4 Gene

Gene Families for OR4P4 Gene

Protein Domains for OR4P4 Gene

Suggested Antigen Peptide Sequences for OR4P4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGL7

UniProtKB/Swiss-Prot:

OR4P4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4P4: view

Function for OR4P4 Gene

Molecular function for OR4P4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4P4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4P4: view
genes like me logo Genes that share phenotypes with OR4P4: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4P4 Gene

Localization for OR4P4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4P4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4P4 Gene COMPARTMENTS Subcellular localization image for OR4P4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4P4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4P4: view

Pathways & Interactions for OR4P4 Gene

genes like me logo Genes that share pathways with OR4P4: view

Pathways by source for OR4P4 Gene

Gene Ontology (GO) - Biological Process for OR4P4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4P4: view

No data available for SIGNOR curated interactions for OR4P4 Gene

Transcripts for OR4P4 Gene

mRNA/cDNA for OR4P4 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4P4 Gene

No ASD Table

Relevant External Links for OR4P4 Gene

GeneLoc Exon Structure for
OR4P4
ECgene alternative splicing isoforms for
OR4P4

Expression for OR4P4 Gene

mRNA expression in normal human tissues for OR4P4 Gene

Protein differential expression in normal tissues from HIPED for OR4P4 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR4P4 Gene



Protein tissue co-expression partners for OR4P4 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4P4 Gene:

OR4P4

SOURCE GeneReport for Unigene cluster for OR4P4 Gene:

Hs.626750
genes like me logo Genes that share expression patterns with OR4P4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR4P4 Gene

Orthologs for OR4P4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4P4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC747017 34
  • 99.14 (n)
dog
(Canis familiaris)
Mammalia OR4P4 34 35
  • 84.91 (n)
rat
(Rattus norvegicus)
Mammalia Olr648 34
  • 84.8 (n)
mouse
(Mus musculus)
Mammalia Or4p19 55 Olfr1180 35
  • 75 (a)
OneToOne
Or4a27 55 Olfr1197
  • chr2:88,728,656-88,729,618
Or4a66 55 Olfr1196
  • chr2:88,700,386-88,701,348
Or4a67 55 Olfr1200
  • chr2:88,767,306-88,768,334
Or4p18 55 Olfr1179
  • chr2:88,402,012-88,402,932
Or4p20 55 Olfr1181
  • chr2:88,423,091-88,424,023
Or4p21 55 Olfr1182
  • chr2:88,446,022-88,446,936
Or4p22 55 Olfr1184
  • chr2:88,486,734-88,487,666
Or4p23 55 Olfr1198
  • chr2:88,745,963-88,746,886
Or4p4 55 Olfr1192
  • chr2:88,652,154-88,653,080
Or4p4b-ps 55 Olfr475-ps1
  • chr2:88,623,305-88,624,230
Or4p7 55 Olfr1178
  • chr2:88,391,249-88,392,217
Or4p8 55 Olfr1208
  • chr2:88,896,672-88,897,595
oppossum
(Monodelphis domestica)
Mammalia OR4P4 35
  • 68 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR4P4 35
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 66 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
Species where no ortholog for OR4P4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4P4 Gene

ENSEMBL:
Gene Tree for OR4P4 (if available)
TreeFam:
Gene Tree for OR4P4 (if available)

Paralogs for OR4P4 Gene

(444) SIMAP similar genes for OR4P4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR4P4 Gene

genes like me logo Genes that share paralogs with OR4P4: view

No data available for Paralogs for OR4P4 Gene

Variants for OR4P4 Gene

Sequence variations from dbSNP and Humsavar for OR4P4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111838665 -- 55,639,307(-) GAAAA(A/G)CAGAA downstream-variant-500B
rs112073392 -- 55,639,260(+) TGGTG(G/T)TGTCA reference, missense
rs113342491 -- 55,639,107(+) TTTGC(A/T)CCTGC reference, synonymous-codon
rs113440596 -- 55,638,797(+) TTGTT(A/G)TACTG reference, missense
rs113739984 -- 55,638,337(+) CTTAT(A/G)TGTTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR4P4 Gene

Variant ID Type Subtype PubMed ID
dgv10e213 CNV loss 24956385
dgv10n64 CNV loss 17921354
dgv1172n100 CNV gain 25217958
dgv1173n100 CNV gain 25217958
dgv1175n100 CNV loss 25217958
dgv1176n100 CNV gain 25217958
dgv1177n100 CNV gain+loss 25217958
dgv1178n100 CNV gain+loss 25217958
dgv1179n100 CNV loss 25217958
dgv1182n100 CNV loss 25217958
dgv1183n100 CNV gain+loss 25217958
dgv1184n100 CNV loss 25217958
dgv1185n100 CNV gain+loss 25217958
dgv1186n100 CNV gain+loss 25217958
dgv1187n100 CNV gain 25217958
dgv1188n100 CNV gain+loss 25217958
dgv1189n100 CNV gain 25217958
dgv1190n100 CNV gain 25217958
dgv1191n100 CNV loss 25217958
dgv1192n100 CNV loss 25217958
dgv1193n100 CNV loss 25217958
dgv1194n100 CNV gain+loss 25217958
dgv1195n100 CNV loss 25217958
dgv1196n100 CNV gain 25217958
dgv1197n100 CNV gain+loss 25217958
dgv1198n100 CNV loss 25217958
dgv1199n100 CNV gain 25217958
dgv11n64 CNV gain+loss 17921354
dgv1200n100 CNV loss 25217958
dgv1201n100 CNV gain+loss 25217958
dgv12n47 CNV loss 21111241
dgv12n68 CNV loss 17160897
dgv13n68 CNV loss 17160897
dgv143n27 CNV loss 19166990
dgv144n27 CNV gain 19166990
dgv145n27 CNV loss 19166990
dgv146n27 CNV gain 19166990
dgv147n27 CNV loss 19166990
dgv148n27 CNV loss 19166990
dgv1905n54 CNV gain 21841781
dgv1906n54 CNV gain+loss 21841781
dgv1907n54 CNV loss 21841781
dgv1908n54 CNV gain 21841781
dgv1909n54 CNV loss 21841781
dgv1911n54 CNV loss 21841781
dgv1912n54 CNV gain+loss 21841781
dgv1913n54 CNV gain+loss 21841781
dgv1914n54 CNV loss 21841781
dgv1915n54 CNV gain+loss 21841781
dgv1916n54 CNV loss 21841781
dgv1920n54 CNV loss 21841781
dgv1922n54 CNV loss 21841781
dgv1923n54 CNV loss 21841781
dgv1926n54 CNV loss 21841781
dgv1927n54 CNV gain+loss 21841781
dgv1928n54 CNV loss 21841781
dgv1929n54 CNV loss 21841781
dgv1930n54 CNV loss 21841781
dgv1931n54 CNV loss 21841781
dgv1932n54 CNV loss 21841781
dgv1933n54 CNV loss 21841781
dgv1934n54 CNV loss 21841781
dgv211e199 CNV deletion 23128226
dgv217n67 CNV loss 20364138
dgv368e212 CNV loss 25503493
dgv369e212 CNV gain 25503493
dgv370e212 CNV loss 25503493
dgv371e212 CNV gain 25503493
dgv372e212 CNV gain 25503493
dgv373e212 CNV gain 25503493
dgv374e212 CNV loss 25503493
dgv375e212 CNV loss 25503493
dgv376e212 CNV gain 25503493
dgv377e212 CNV loss 25503493
dgv378e212 CNV loss 25503493
dgv379e212 CNV gain 25503493
dgv380e212 CNV gain 25503493
dgv381e212 CNV loss 25503493
dgv382e212 CNV gain 25503493
dgv48n111 CNV deletion 26073780
dgv4e49 CNV loss 18971310
dgv50e55 CNV loss 17911159
dgv5e49 CNV loss 18971310
dgv6n14 CNV loss 18776910
dgv9n64 CNV gain+loss 17921354
esv22842 CNV gain+loss 19812545
esv2421634 CNV deletion 20811451
esv2663268 CNV deletion 23128226
esv2751030 CNV gain 17911159
esv2759828 CNV gain+loss 17122850
esv2760216 CNV loss 21179565
esv2760311 CNV gain+loss 21179565
esv29944 CNV loss 18421352
esv3380977 OTHER inversion 20981092
esv33874 CNV gain 17666407
esv3579560 CNV gain 25503493
esv3579649 CNV gain 25503493
esv3579680 CNV loss 25503493
esv3579686 CNV loss 25503493
esv3579687 CNV loss 25503493
esv3579688 CNV loss 25503493
esv3626445 CNV loss 21293372
esv3626446 CNV gain 21293372
esv3892006 CNV gain+loss 25118596
esv3892007 CNV loss 25118596
esv3892009 CNV gain 25118596
nsv1036325 CNV gain 25217958
nsv1037763 CNV gain 25217958
nsv1039780 CNV gain 25217958
nsv1041927 CNV gain 25217958
nsv1050439 CNV loss 25217958
nsv1143540 CNV deletion 24896259
nsv323 CNV deletion 18451855
nsv428256 CNV loss 18775914
nsv435950 OTHER inversion 17901297
nsv437717 CNV loss 16327808
nsv442617 CNV loss 18776908
nsv443003 CNV deletion 18674749
nsv467886 CNV gain 19166990
nsv469957 CNV gain 18288195
nsv469958 CNV loss 18288195
nsv471363 CNV loss 19718026
nsv508632 CNV deletion 20534489
nsv511485 CNV gain 21212237
nsv514622 CNV loss 21397061
nsv517440 CNV gain+loss 19592680
nsv518225 CNV loss 19592680
nsv524091 CNV gain 19592680
nsv554799 CNV gain 21841781
nsv554801 CNV loss 21841781
nsv554803 CNV gain 21841781
nsv554805 CNV loss 21841781
nsv554809 CNV gain 21841781
nsv554915 CNV gain 21841781
nsv554920 CNV loss 21841781
nsv554971 CNV gain 21841781
nsv554994 CNV loss 21841781
nsv71 CNV deletion 15895083
nsv818824 CNV gain 17921354
nsv818827 CNV gain 17921354
nsv821668 CNV loss 15273396
nsv825892 CNV loss 20364138
nsv825896 CNV loss 20364138
nsv8827 CNV gain+loss 18304495
nsv952449 CNV deletion 24416366
nsv972950 CNV deletion 23825009

Variation tolerance for OR4P4 Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.28; 92.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR4P4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4P4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4P4 Gene

Disorders for OR4P4 Gene

Relevant External Links for OR4P4

Human Genome Epidemiology (HuGE) Navigator
OR4P4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR4P4

No disorders were found for OR4P4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4P4 Gene

Publications for OR4P4 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 64

Products for OR4P4 Gene

Sources for OR4P4 Gene

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