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Aliases for OR4N5 Gene

Aliases for OR4N5 Gene

  • Olfactory Receptor Family 4 Subfamily N Member 5 2 3 5
  • Olfactory Receptor, Family 4, Subfamily N, Member 5 2
  • Olfactory Receptor OR14-33 4

External Ids for OR4N5 Gene

Previous GeneCards Identifiers for OR4N5 Gene

  • GC14U990435
  • GC14P018604
  • GC14P019682
  • GC14P020611

Summaries for OR4N5 Gene

Entrez Gene Summary for OR4N5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4N5 Gene

OR4N5 (Olfactory Receptor Family 4 Subfamily N Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4N2.

UniProtKB/Swiss-Prot for OR4N5 Gene

  • Odorant receptor.

Gene Wiki entry for OR4N5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4N5 Gene

Genomics for OR4N5 Gene

Regulatory Elements for OR4N5 Gene

Enhancers for OR4N5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F020591 0.4 FANTOM5 14.5 +448.1 448136 0.1 ZFHX2 IKZF1 EGR2 OR4K17 OR6S1 RNASE12 OR11H6 OR4N5 OR11H4 RNASE8 EDDM3B RNASE9 RNASE13
GH14F020071 0.3 FANTOM5 5 -72.0 -71968 0.2 OR4K17 OR4K14 OR4L1 OR4Q3 OR11H4 OR11H6 OR4N5 OR4M1 OR4K5 OR4K1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR4N5 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR4N5 Gene

Chromosome:
14
Start:
20,143,736 bp from pter
End:
20,144,662 bp from pter
Size:
927 bases
Orientation:
Plus strand

Genomic View for OR4N5 Gene

Genes around OR4N5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4N5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4N5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4N5 Gene

Proteins for OR4N5 Gene

  • Protein details for OR4N5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXE1-OR4N5_HUMAN
    Recommended name:
    Olfactory receptor 4N5
    Protein Accession:
    Q8IXE1
    Secondary Accessions:
    • Q6IF11

    Protein attributes for OR4N5 Gene

    Size:
    308 amino acids
    Molecular mass:
    34696 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4N5 Gene

Post-translational modifications for OR4N5 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4N5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4N5 Gene

Domains & Families for OR4N5 Gene

Gene Families for OR4N5 Gene

Protein Domains for OR4N5 Gene

Suggested Antigen Peptide Sequences for OR4N5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IXE1

UniProtKB/Swiss-Prot:

OR4N5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4N5: view

Function for OR4N5 Gene

Molecular function for OR4N5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4N5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4N5: view

Phenotypes for OR4N5 Gene

GenomeRNAi human phenotypes for OR4N5:
genes like me logo Genes that share phenotypes with OR4N5: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4N5 Gene

Localization for OR4N5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4N5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4N5 Gene COMPARTMENTS Subcellular localization image for OR4N5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4N5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4N5: view

Pathways & Interactions for OR4N5 Gene

genes like me logo Genes that share pathways with OR4N5: view

Pathways by source for OR4N5 Gene

Gene Ontology (GO) - Biological Process for OR4N5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4N5: view

No data available for SIGNOR curated interactions for OR4N5 Gene

Transcripts for OR4N5 Gene

mRNA/cDNA for OR4N5 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4N5 Gene

No ASD Table

Relevant External Links for OR4N5 Gene

GeneLoc Exon Structure for
OR4N5
ECgene alternative splicing isoforms for
OR4N5

Expression for OR4N5 Gene

mRNA expression in normal human tissues for OR4N5 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4N5 Gene:

OR4N5

SOURCE GeneReport for Unigene cluster for OR4N5 Gene:

Hs.553766
genes like me logo Genes that share expression patterns with OR4N5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR4N5 Gene

Orthologs for OR4N5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4N5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100614621 34
  • 99.13 (n)
OR4N5 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR4N5 35
  • 89 (a)
OneToOne
LOC487467 34
  • 86.36 (n)
cow
(Bos Taurus)
Mammalia OR4N5 34 35
  • 86.8 (n)
mouse
(Mus musculus)
Mammalia Or4n5 55 Olfr722 34 16 35
  • 82.58 (n)
rat
(Rattus norvegicus)
Mammalia Olr1624 34
  • 81.6 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 80 (a)
ManyToMany
-- 35
  • 79 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 54 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 56 (a)
OneToMany
Species where no ortholog for OR4N5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4N5 Gene

ENSEMBL:
Gene Tree for OR4N5 (if available)
TreeFam:
Gene Tree for OR4N5 (if available)

Paralogs for OR4N5 Gene

(448) SIMAP similar genes for OR4N5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4N5: view

Variants for OR4N5 Gene

Sequence variations from dbSNP and Humsavar for OR4N5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10131326 -- 20,144,306(+) GCACC(A/G)ATACC reference, missense
rs10134272 -- 20,144,960(+) agcag(A/G)aagtg downstream-variant-500B
rs10134379 -- 20,144,446(+) GCTAT(C/T)TCCAC reference, synonymous-codon
rs10134472 -- 20,144,513(+) ACACT(C/T)GCCCC reference, missense
rs10136968 -- 20,144,776(+) TTAAG(C/T)ACTTC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR4N5 Gene

Variant ID Type Subtype PubMed ID
dgv3532n54 CNV loss 21841781
dgv81e55 CNV gain 17911159
esv2751268 CNV gain 17911159
esv2761819 CNV loss 21179565
esv3580929 CNV loss 25503493
nsv1037890 CNV gain 25217958
nsv521393 CNV loss 19592680
nsv832738 CNV loss 17160897
nsv832739 CNV gain 17160897

Variation tolerance for OR4N5 Gene

Residual Variation Intolerance Score: 89.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.14; 69.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR4N5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4N5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4N5 Gene

Disorders for OR4N5 Gene

Relevant External Links for OR4N5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR4N5

No disorders were found for OR4N5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4N5 Gene

Publications for OR4N5 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64

Products for OR4N5 Gene

Sources for OR4N5 Gene

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