OR4N4 Gene
protein-coding GIFtS: 47
GCID: GC15P022382
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olfactory receptor, family 4, subfamily N, member 4
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Aliases
for OR4N4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Olfactory Receptor, Family 4, Subfamily N, Member 41 2 | | Olfactory Receptor OR15-12 3 | | Olfactory Receptor OR15-52 3 | | OR15-12 | | OR15-52 | | Olfactory Receptor 4N42 |
Export aliases for OR4N4 gene to outside databasesPrevious GC identifers: GC15U990129 GC15P019779 GC15P019883 GC15P019804 |
Summaries
for OR4N4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OR4N4:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: OR4N4_HUMAN, Q8N0Y3Function: Odorant receptor (Potential)
Gene Wiki entry for OR4N4
|
Genomic Views
for OR4N4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_077631.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OR4N4 gene promoter:
AML1a Bach2 SREBP-1c c-Ets-1 C/EBPalpha SREBP-1b Meis-1b SREBP-1a Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for OR4N4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR4N4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q11.2 Ensembl cytogenetic band: 15q11.2 HGNC cytogenetic band: 15q11.2OR4N4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P022382: view genomic region
(about GC identifiers)
Start:
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22,382,473 bp from pter |
End:
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22,383,420 bp from pter |
Size:
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948 bases |
Orientation:
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plus strand |
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Proteins
for OR4N4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OR4N4_HUMAN, Q8N0Y3 (See
protein sequence)Recommended Name: Olfactory receptor 4N4 Size: 316 amino acids; 35724 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q6IEY3 Q6IF56Explore the universe of human proteins at neXtProt for OR4N4: NX_Q8N0Y3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N0Y3
HORDE protein sequence for OR4N4
OR4N4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001005241.2
ENSEMBL proteins: ENSP00000332500 Reactome Protein details: Q8N0Y3
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
OR4N4 for ontologies About GeneDecksing
OR4N4 Antibody Products:
Assay Products for OR4N4: |
Protein
Domains /
Families
for OR4N4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR4N4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N0Y3ProtoNet protein and cluster: Q8N0Y3 1 Blocks protein family: IPB000725 Olfactory receptor signature
UniProtKB/Swiss-Prot: OR4N4_HUMAN, Q8N0Y3Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for OR4N4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: OR4N4_HUMAN, Q8N0Y3Function: Odorant receptor (Potential)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR4N4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR4N4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OR4N4 (NM_001005241) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR4N4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR4N4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR4N4 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0004984 | olfactory receptor activity |
IEA | -- |
OR4N4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for OR4N4:
|
Pathways & Interactions
for OR4N4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | Olfactory transduction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for OR4N4
1 
Kegg Pathway (Kegg details for OR4N4):
OR4N4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR4N4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/273 Interacting proteins for OR4N4 (ENSP000003325004) via UniProtKB, MINT, STRING, and/or I2D (see all 273)About this table
|
Drugs & Compounds
for OR4N4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OR4N4
Search CenterWatch for drugs/clinical trials and news about OR4N4
|
Transcripts
for OR4N4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OR4N4 gene: NM_001005241.2 Unigene Cluster for OR4N4: Olfactory receptor, family 4, subfamily N, member 4 Hs.525666 [show with all ESTs]Unigene Representative Sequence: AK0975981 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000328795(uc010tzv.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR4N4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR4N4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OR4N4 (NM_001005241) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR4N4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR4N4 |
Additional cDNA sequence: AK058056.1 AK097598.1 BC062994.1 BC107747.1 BC136597.1 BC136598.1 NR_015416.1 7 DOTS entries: DT.40128739 DT.40242990 DT.95122087 DT.103140 DT.121063837 DT.95367830 DT.100008927 24/30 AceView cDNA sequences (see all 30): AA973308 BX103267 AI215971 BC062994 BX117400 BI560827 BI825296 BU854629 AK058056 AA968594 AA885313 AI350427 AK097598 NM_001004719 AA972933 AI018459 NM_001005241 BX109639 BI829521 AA994716 AI220583 BI459838 BE503460 BI825298
GeneLoc Exon Structure
|
Expression
for OR4N4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR4N4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See OR4N4 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.525666
SABiosciences Custom PCR Arrays for OR4N4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR4N4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OR4N4 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR4N4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR4N4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR4N4 |
Orthologs
for OR4N4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for OR4N4 (if available)
TreeFam Gene Tree for OR4N4 (if available) |
Paralogs
for OR4N4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OR4N4 gene
- OR4D112 OR4D22 OR4D52 OR4N22 OR4N52 OR4D62 OR4M12 OR4D102
- OR4D12 OR4M22 OR4Q32 OR4D92
18/451 SIMAP similar genes for OR4N4 using alignment to 1 protein entry: OR4N4_HUMAN(see all similar genes):OR4N5 OR4N2 OR4M1 OR4F4 OR4K2 OR4M2
OR4F17 OR4F5 OR4Q2 OR4Q3 OR4B1 OR4C3
OR4D5 OR4E2 OR4K13 OR4K14 OR4K17 OR4K3
OR4N4 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for OR4N4
PGOHUM00000248033
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Genomic Variants
for OR4N4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OR4N4 ( 22382473 - 22383420 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 54 variations for OR4N4
15/52 CNVs (see all 52): 8782 4873 8779 23197 87468 34643 9256 9254 34557 7046 10464 9252 9249 0318 34665
2 Inversions: 0444 0443 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR4N4 |
|
Disorders
/ Diseases
for OR4N4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OR4N4 for disorders About GeneDecksing
2  diseases for OR4N4: About MalaCardsprader-willi syndrome neuronitis
Export disorders for OR4N4 gene to outside databases
|
Publications
for OR4N4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OR4N4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR4N4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for OR4N4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OR4N4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR4N4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR4N4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OR4N4 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR4N4 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
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| | |
About This Section
| Patent Information for OR4N4 gene:
Search GeneIP for patents involving OR4N4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OR4N4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OR4N4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OR4N4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR4N4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OR4N4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR4N4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR4N4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OR4N4 | | OriGene Custom Protein Services for OR4N4 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OR4N4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR4N4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR4N4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OR4N4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR4N4 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR4N4 |
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 |  |  |  | |
| | | | Search Tocris compounds for OR4N4 |
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 | | | OR4N4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR4N4 |
|  |  |  | | | | Search ThermoFisher Antibodies for OR4N4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR4N4 |
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