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OR4N4 Gene

protein-coding   GIFtS: 48
GCID: GC15P022382

Olfactory Receptor, Family 4, Subfamily N, Member 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 4, Subfamily N, Member 41 2
Olfactory Receptor OR15-12 3
Olfactory Receptor OR15-52 3
OR15-12
OR15-52
Olfactory Receptor 4N42

External Ids:    HGNC: 153751   Entrez Gene: 2836942   Ensembl: ENSG000001837067   UniProtKB: Q8N0Y33   

Export aliases for OR4N4 gene to outside databases

Previous GC identifers: GC15U990129 GC15P019779 GC15P019883 GC15P019804


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR4N4 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR4N4 Gene:
OR4N4 (olfactory receptor, family 4, subfamily N, member 4) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4D11.

UniProtKB/Swiss-Prot: OR4N4_HUMAN, Q8N0Y3
Function: Odorant receptor (Potential)

Gene Wiki entry for OR4N4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_037852.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR4N4 gene promoter:
         AML1a   Bach2   SREBP-1c   c-Ets-1   C/EBPalpha   SREBP-1b   Meis-1b   SREBP-1a   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR4N4 promoter sequence
   Search Chromatin IP Primers for OR4N4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR4N4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q11.2   Ensembl cytogenetic band:  15q11.2   HGNC cytogenetic band: 15q11.2

OR4N4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR4N4 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P022382:  view genomic region     (about GC identifiers)

Start:
22,382,473 bp from pter      End:
22,383,420 bp from pter
Size:
948 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OR4N4_HUMAN, Q8N0Y3 (See protein sequence)
Recommended Name: Olfactory receptor 4N4  
Size: 316 amino acids; 35724 Da
Secondary accessions: Q6IEY3 Q6IF56

Explore the universe of human proteins at neXtProt for OR4N4: NX_Q8N0Y3

Explore proteomics data for OR4N4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • Modification sites at PhosphoSitePlus
  • HORDE protein sequence for OR4N4

    See OR4N4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001005241.2  
    ENSEMBL proteins: 
     ENSP00000332500  
    Reactome Protein details: Q8N0Y3

    OR4N4 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR4: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8N0Y3

    ProtoNet protein and cluster: Q8N0Y3

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR4N4_HUMAN, Q8N0Y3
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR4N4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR4N4_HUMAN, Q8N0Y3
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR4N4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for OR4N4:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR4N4
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    1 qRT-PCR Assays for microRNA that regulate OR4N4:
    hsa-miR-3145-3p
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR4N4_HUMAN, Q8N0Y3: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR4N4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR4N4 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR4N4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR4N4
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR4N4):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR4N4
    Interactions:

        Search GeneGlobe Interaction Network for OR4N4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR4N4 (ENSP000003325004) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10AG1ENSP000003114774STRING: ENSP00000311477
    OR10J1ENSP000003990784STRING: ENSP00000399078
    OR10R2ENSP000003571344STRING: ENSP00000357134
    OR1C1ENSP000003861384STRING: ENSP00000386138
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    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR4N4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR4N4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR4N4 gene: 
    NM_001005241.2  

    Unigene Cluster for OR4N4:

    Olfactory receptor, family 4, subfamily N, member 4
    Hs.525666  [show with all ESTs]
    Unigene Representative Sequence: AK097598
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000328795(uc010tzv.2)
    miRNA
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    hsa-miR-3145-3p
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    Inhib. RNA
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      Search QuantiTect SYBR Green Assays in human, mouse, rat OR4N4
      QuantiFast Probe-based Assays in human, mouse, rat OR4N4

    Additional mRNA sequence: 

    AK058056.1 AK097598.1 BC062994.1 BC107747.1 BC136597.1 BC136598.1 NR_015416.1 

    7 DOTS entries:

    DT.40128739  DT.40242990  DT.95122087  DT.103140  DT.121063837  DT.95367830  DT.100008927 

    Selected AceView cDNA sequences (see all 30):

    BX103267 AA973308 AI215971 BU854629 BX117400 NM_001005241 BI560827 AA972933 
    BC062994 AA968594 BI825296 BX109639 AI018459 AK097598 AA885313 AI350427 
    AK058056 NM_001004719 BI459838 BI825298 BE503460 AI220583 BI829521 AA994716 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR4N4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OR4N4 Expression
    About this image

    OR4N4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR4N4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525666
        Custom PCR Arrays for OR4N4
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OR4N4 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr7321 , 5 olfactory receptor 7321, 5 82.25(n)1
    85.06(a)1
      14 (26.03 cM)5
    2586591  NM_146665.21  NP_666876.11 
     502812285 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    50(a)
    1 → many
    27(6459-7394)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    56(a)
    1 → many
    GL343220.1(922414-923334)


    ENSEMBL Gene Tree for OR4N4 (if available)
    TreeFam Gene Tree for OR4N4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR4N4 gene
    LOC102723532  OR4D112  OR4D22  OR4D52  OR4N22  OR4N52  OR4D62  OR4M12  
    OR4Q22  OR4D102  OR4M22  OR4D12  OR4D92  OR4Q32  OR4E22  
    Selected SIMAP similar genes for OR4N4 using alignment to 1 protein entry:     OR4N4_HUMAN(see all similar genes):
    OR4N5    OR4N2    OR4M1    OR4F4    OR4K2    OR4M2
    OR4F17    OR4F5    OR4Q2    OR4Q3    OR4B1    OR4C3
    OR4D5    OR4E2    OR4K13    OR4K14    OR4K17    OR4K3

    Find genes that share paralogs with OR4N4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for OR4N4
    PGOHUM00000248033


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR4N4 (see all 212)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1847111641,2
    --22380549(+) TAACAA/GGGAAT 1 -- us2k10--------
    rs1174782341,2
    C,F--22380589(+) AACTCC/TCAATC 1 -- us2k12Minor allele frequency- T:0.08NA EA 240
    rs4742041,2
    C,F,O,H--22380617(-) CATAGA/GAGAAA 1 -- us2k110Minor allele frequency- G:0.47NA CSA WA EA 374
    rs1144471161,2
    F--22380688(+) AAGATG/ATACAC 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs558023321,2
    C--22380796(+) GTGCC-/AAAAAA 1 -- us2k10--------
    rs575907261,2
    C--22380811(+) AAAAA-/GAAAAG 1 -- us2k10--------
    rs575701831,2
    C--22380816(+) GAAAAG/-AAGAA 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs4974921,2
    C,F,A,H--22380828(+) GGTATG/CATATG 1 -- us2k111Minor allele frequency- C:0.22NA WA CSA EA 378
    rs791012761,2
    C,F--22380866(+) GGATAC/TGTGTG 1 -- us2k13Minor allele frequency- T:0.03WA 122
    rs1417420971,2
    --22380876(+) GTTTGC/TGTGTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR4N4 ( 22382473 - 22383420 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for OR4N4 (see all 88):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749374CNV Deletion23290073
    nsv435657CNV Deletion17901297
    esv2659516CNV Deletion23128226
    dgv7n31CNV Duplication19718026
    dgv44n16CNV Insertion17901297
    nsv821678CNV Loss15273396
    esv34233CNV Loss17911159
    dgv2188n71CNV Loss21882294
    nsv903377CNV Loss21882294
    dgv2194n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR4N4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR4N4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 283694 HGNC: 15375 AceView: OR4Q1P Ensembl:ENSG00000183706 euGenes: HUgn283694
    ECgene: OR4N4 Kegg: 283694 H-InvDB: OR4N4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR4N4 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR4N4 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR4N4 gene:
    Search GeneIP for patents involving OR4N4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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