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Aliases for OR4N4 Gene

Aliases for OR4N4 Gene

  • Olfactory Receptor, Family 4, Subfamily N, Member 4 2 3
  • Olfactory Receptor OR15-1 3 4
  • Olfactory Receptor OR15-5 3 4
  • Olfactory Receptor 4N4 3
  • OR15-1 3
  • OR15-5 3

External Ids for OR4N4 Gene

Previous GeneCards Identifiers for OR4N4 Gene

  • GC15U990129
  • GC15P019779
  • GC15P019883
  • GC15P019804
  • GC15P022382

Summaries for OR4N4 Gene

Entrez Gene Summary for OR4N4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4N4 Gene

OR4N4 (Olfactory Receptor, Family 4, Subfamily N, Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4D9.

UniProtKB/Swiss-Prot for OR4N4 Gene

  • Odorant receptor.

Gene Wiki entry for OR4N4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4N4 Gene

Genomics for OR4N4 Gene

Regulatory Elements for OR4N4 Gene

Genomic Location for OR4N4 Gene

Start:
22,094,431 bp from pter
End:
22,095,864 bp from pter
Size:
1,434 bases
Orientation:
Plus strand

Genomic View for OR4N4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR4N4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4N4 Gene

Proteins for OR4N4 Gene

  • Protein details for OR4N4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0Y3-OR4N4_HUMAN
    Recommended name:
    Olfactory receptor 4N4
    Protein Accession:
    Q8N0Y3
    Secondary Accessions:
    • Q6IEY3
    • Q6IF56

    Protein attributes for OR4N4 Gene

    Size:
    316 amino acids
    Molecular mass:
    35724 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4N4 Gene

Proteomics data for OR4N4 Gene at MOPED

Post-translational modifications for OR4N4 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4N4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4N4 Gene

Domains for OR4N4 Gene

Gene Families for OR4N4 Gene

HGNC:
  • OR4 :GPCR / Class A : Olfactory receptors

Protein Domains for OR4N4 Gene

Suggested Antigen Peptide Sequences for OR4N4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N0Y3

UniProtKB/Swiss-Prot:

OR4N4_HUMAN :
  • Q8N0Y3
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4N4: view

Function for OR4N4 Gene

Molecular function for OR4N4 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4N4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4N4: view

Phenotypes for OR4N4 Gene

GenomeRNAi human phenotypes for OR4N4:
genes like me logo Genes that share phenotypes with OR4N4: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR4N4 Gene

Localization for OR4N4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4N4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4N4 Gene COMPARTMENTS Subcellular localization image for OR4N4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4N4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4N4: view

Pathways for OR4N4 Gene

genes like me logo Genes that share pathways with OR4N4: view

Pathways by source for OR4N4 Gene

Interacting Proteins for OR4N4 Gene

Gene Ontology (GO) - Biological Process for OR4N4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4N4: view

Transcripts for OR4N4 Gene

mRNA/cDNA for OR4N4 Gene

Unigene Clusters for OR4N4 Gene

Olfactory receptor, family 4, subfamily N, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OR4N4 Gene

No ASD Table

Relevant External Links for OR4N4 Gene

GeneLoc Exon Structure for
OR4N4
ECgene alternative splicing isoforms for
OR4N4

Expression for OR4N4 Gene

mRNA expression in normal human tissues for OR4N4 Gene

mRNA differential expression in normal tissues according to GTEx for OR4N4 Gene

This gene is overexpressed in Testis (50.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR4N4 Gene

SOURCE GeneReport for Unigene cluster for OR4N4 Gene Hs.525666

genes like me logo Genes that share expressions with OR4N4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OR4N4 Gene

Orthologs for OR4N4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4N4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 88 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
OR4N4 35
  • 88.13 (n)
  • 88.56 (a)
dog
(Canis familiaris)
Mammalia LOC482537 35
  • 88.1 (n)
  • 87.99 (a)
OR4N4 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr732 35
  • 82.25 (n)
  • 85.06 (a)
Olfr732 16
Olfr732 36
  • 85 (a)
OneToMany
Olfr733 36
  • 82 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 77 (a)
ManyToMany
-- 36
  • 78 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr1610 35
  • 81.6 (n)
  • 82.14 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 50 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 56 (a)
OneToMany
Species with no ortholog for OR4N4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4N4 Gene

ENSEMBL:
Gene Tree for OR4N4 (if available)
TreeFam:
Gene Tree for OR4N4 (if available)

Paralogs for OR4N4 Gene

Selected SIMAP similar genes for OR4N4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR4N4 Gene

genes like me logo Genes that share paralogs with OR4N4: view

Variants for OR4N4 Gene

Sequence variations from dbSNP and Humsavar for OR4N4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
VAR_048034 -
VAR_048035 -
VAR_048036 -
VAR_048037 -

Structural Variations from Database of Genomic Variants (DGV) for OR4N4 Gene

Variant ID Type Subtype PubMed ID
dgv668e1 CNV Complex 17122850
dgv669e1 CNV Complex 17122850
nsv428296 CNV Gain+Loss 18775914
dgv92e55 CNV Gain 17911159
dgv93e55 CNV Gain 17911159
dgv96e55 CNV Loss 17911159
nsv9179 CNV Gain+Loss 18304495
dgv2081n71 CNV Gain 21882294
nsv7260 OTHER Inversion 18451855
nsv821678 CNV Loss 15273396
dgv678e1 CNV Complex 17122850
dgv679e1 CNV Complex 17122850
esv33051 CNV Gain+Loss 17666407
dgv1n1 OTHER Inversion 15895083
esv1004259 OTHER Inversion 20482838
dgv44n16 CNV Insertion 17901297
dgv2108n71 CNV Gain 21882294
dgv2109n71 CNV Gain+Loss 21882294
dgv2110n71 CNV Gain 21882294
dgv684e1 CNV Complex 17122850
esv2751489 CNV Gain 17911159
dgv686e1 CNV Complex 17122850
dgv97e55 CNV Loss 17911159
dgv98e55 CNV Gain 17911159
esv34233 CNV Loss 17911159
dgv2148n71 CNV Gain 21882294
dgv2158n71 CNV Gain 21882294
nsv817667 CNV Gain 17921354
dgv691e1 CNV Complex 17122850
essv13315 CNV CNV 17122850
esv2751492 CNV Gain 17911159
dgv2175n71 CNV Gain 21882294
dgv2183n71 CNV Gain 21882294
esv29701 CNV Gain+Loss 19812545
dgv7n31 CNV Duplication 19718026
dgv422n67 CNV Gain 20364138
dgv2188n71 CNV Loss 21882294
dgv9n14 CNV Loss 18776910
dgv2189n71 CNV Gain 21882294
dgv10n14 CNV Loss 18776910
dgv11n14 CNV Gain 18776910
dgv2190n71 CNV Gain 21882294
dgv2192n71 CNV Gain 21882294
dgv2193n71 CNV Gain+Loss 21882294
dgv2194n71 CNV Loss 21882294
dgv2195n71 CNV Gain+Loss 21882294
dgv2196n71 CNV Loss 21882294
dgv2197n71 CNV Gain 21882294
dgv2198n71 CNV Gain+Loss 21882294
dgv2199n71 CNV Gain+Loss 21882294
dgv2200n71 CNV Gain 21882294
nsv510653 CNV Loss 20534489
nsv511041 OTHER Inversion 20534489
nsv819100 CNV Gain 19587683
dgv692e1 CNV Complex 17122850
dgv2202n71 CNV Loss 21882294
dgv693e1 CNV Complex 17122850
nsv903327 CNV Gain+Loss 21882294
essv10128 CNV CNV 17122850
dgv2204n71 CNV Gain 21882294
nsv442688 CNV CNV 18776908
nsv514767 CNV Complex 21397061
dgv2206n71 CNV Gain 21882294
dgv2207n71 CNV Gain 21882294
nsv469630 CNV Gain 16826518
dgv2209n71 CNV Gain 21882294
dgv99e55 CNV Gain 17911159
dgv100e55 CNV Loss 17911159
dgv101e55 CNV Loss 17911159
dgv2210n71 CNV Loss 21882294
nsv903377 CNV Loss 21882294
dgv2211n71 CNV Gain 21882294
dgv2212n71 CNV Loss 21882294
dgv2213n71 CNV Loss 21882294
nsv832918 CNV Gain+Loss 17160897
nsv817668 CNV Gain+Loss 17921354
dgv2214n71 CNV Gain 21882294
dgv2215n71 CNV Gain+Loss 21882294
dgv2216n71 CNV Gain 21882294
dgv2217n71 CNV Gain 21882294
nsv435657 CNV Deletion 17901297
esv2749374 CNV Deletion 23290073
esv2659516 CNV Deletion 23128226
dgv2218n71 CNV Loss 21882294
dgv2219n71 CNV Gain+Loss 21882294
nsv903429 CNV Gain+Loss 21882294
nsv903434 CNV Gain 21882294
dgv2222n71 CNV Loss 21882294

Relevant External Links for OR4N4 Gene

HapMap Linkage Disequilibrium report
OR4N4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4N4 Gene

Disorders for OR4N4 Gene

No disorders were found for OR4N4 Gene.

No data available for UniProtKB/Swiss-Prot for OR4N4 Gene

Publications for OR4N4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for OR4N4 Gene

Sources for OR4N4 Gene

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