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OR4N2 Gene

protein-coding   GIFtS: 48
GCID: GC14P020187

Olfactory Receptor, Family 4, Subfamily N, Member 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 4, Subfamily N, Member 21 2
Olfactory Receptor OR14-132 3
Olfactory Receptor OR14-82 3
OR14-132
OR14-82
Olfactory Receptor 4N22

External Ids:    HGNC: 147421   Entrez Gene: 3904292   Ensembl: ENSG000001762947   UniProtKB: Q8NGD13   

Export aliases for OR4N2 gene to outside databases

Previous GC identifers: GC14U990418 GC14P018286 GC14P019341 GC14P020295


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR4N2 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a seven-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Mar 2014)

GeneCards Summary for OR4N2 Gene:
OR4N2 (olfactory receptor, family 4, subfamily N, member 2) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4D11.

UniProtKB/Swiss-Prot: OR4N2_HUMAN, Q8NGD1
Function: Odorant receptor (Potential)

Gene Wiki entry for OR4N2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR4N2 gene promoter:
         TBP   C/EBPbeta   Tal-1   Tal-1beta   LCR-F1   E47   HOXA5   FOXO1a   ITF-2   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR4N2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

OR4N2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR4N2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P020187:  view genomic region     (about GC identifiers)

Start:
20,295,608 bp from pter      End:
20,296,528 bp from pter
Size:
921 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OR4N2_HUMAN, Q8NGD1 (See protein sequence)
Recommended Name: Olfactory receptor 4N2  
Size: 307 amino acids; 34721 Da
Secondary accessions: Q6IEY9 Q6IFA2

Explore the universe of human proteins at neXtProt for OR4N2: NX_Q8NGD1

Explore proteomics data for OR4N2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • Modification sites at PhosphoSitePlus
  • HORDE protein sequence for OR4N2

    See OR4N2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004723.1  
    ENSEMBL proteins: 
     ENSP00000451462   ENSP00000452022   ENSP00000457130   ENSP00000319601  
    Reactome Protein details: Q8NGD1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR4: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGD1

    ProtoNet protein and cluster: Q8NGD1

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR4N2_HUMAN, Q8NGD1
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR4N2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR4N2_HUMAN, Q8NGD1
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR4N2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for OR4N2:
     High actin ratio cells 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OR4N2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR4N2_HUMAN, Q8NGD1: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR4N2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR4N2 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR4N2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR4N2
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR4N2):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR4N2
    Interactions:

        Search GeneGlobe Interaction Network for OR4N2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR4N2 (ENSP000003196014) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10J1ENSP000003990784STRING: ENSP00000399078
    OR1I1ENSP000002095404STRING: ENSP00000209540
    OR1M1ENSP000004019664STRING: ENSP00000401966
    OR2T10ENSP000003292104STRING: ENSP00000329210
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR4N2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for OR4N2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR4N2 gene: 
    NM_001004723.2  

    Unigene Cluster for OR4N2:

    Olfactory receptor, family 4, subfamily N, member 2
    Hs.512490
    Unigene Representative Sequence: NM_001004723
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000557414 ENST00000557677 ENST00000568211 ENST00000315947(uc010tkv.2)

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    1 DOTS entry:

    DT.120771643 

    7 AceView cDNA sequences:

    NM_001004723 BM696516 AI939631 BM667886 AI536941 AI199625 AW891589 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR4N2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAAGGTGT
    OR4N2 Expression
    About this image

    OR4N2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR4N2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.512490
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OR4N2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr7331 olfactory receptor 733 79.85(n)
    81.05(a)
      258657  NM_146663.2  NP_666874.2 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    53(a)
    1 → many
    27(6459-7394)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    56(a)
    1 → many
    GL343220.1(922414-923334)


    ENSEMBL Gene Tree for OR4N2 (if available)
    TreeFam Gene Tree for OR4N2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR4N2 gene
    OR4D112  OR4D22  OR4D52  OR4N52  OR4D62  OR4M12  OR4Q22  OR4N42  
    OR4D102  OR4M22  OR4D12  OR4D92  OR4Q32  OR4E22  
    Selected SIMAP similar genes for OR4N2 using alignment to 4 protein entries:     OR4N2_HUMAN (see all proteins) (see all similar genes):
    OR4N4    OR4N5    OR4M1    OR4F4    OR4F5    OR4F17
    OR4M2    OR4K17    OR4Q2    OR4Q3    OR4F15    OR4K2
    OR4A15    OR4F16    OR4F21    OR4F29    OR4F3    OR4C15

    Find genes that share paralogs with OR4N2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for OR4N2
    PGOHUM00000246986


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR4N2 (see all 172)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1884047411,2
    --20293629(+) CAGTAA/GCATTT 1 -- us2k10--------
    rs2022144431,2
    C--20293645(+) CAAAG-/AAAT  
            
    ATTTT
    1 -- us2k10--------
    rs16865781,2
    C,H--20293648(+) AGAAAG/TATTTT 1 -- us2k113Minor allele frequency- T:0.00NS EA NA WA CSA 651
    rs1926407211,2
    --20293665(+) CTTCCA/GCACCC 1 -- us2k10--------
    rs286891471,2
    C--20293685(+) GAGCAC/TTTATT 1 -- us2k1 tfbs30--------
    rs1419524791,2
    C--20293746(+) GTCTCA/GCTCTG 1 -- us2k10--------
    rs1831276281,2
    --20293778(+) GGCGCA/GATCTC 1 -- us2k10--------
    rs124365991,2
    C,H--20293831(+) tgcctC/Gagcct 1 -- us2k10--------
    rs101489791,2
    C--20293855(+) gactaC/Taggca 1 -- us2k10--------
    rs101357261,2
    C,A,H--20293883(+) CTAATT/ATTTTT 1 -- us2k11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for OR4N2 ( 20295608 - 20296528 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for OR4N2 (see all 60):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv6n31CNV Duplication19718026
    esv34243CNV Loss17911159
    nsv819711CNV Loss19587683
    dgv45e180CNV Loss20482838
    nsv901192CNV Loss21882294
    nsv901404CNV Loss21882294
    dgv1841n71CNV Loss21882294
    nsv901268CNV Loss21882294
    dgv1840n71CNV Loss21882294
    nsv433273CNV Loss18776910

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR4N2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR4N2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)
    3. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 390429 HGNC: 14742 AceView: OR4N2 Ensembl:ENSG00000176294 euGenes: HUgn390429
    ECgene: OR4N2 Kegg: 390429 H-InvDB: OR4N2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR4N2 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR4N2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR4N2 gene:
    Search GeneIP for patents involving OR4N2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Block miRNA regulation of human, mouse, rat OR4N2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OR4N2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR4N2 Predesigned siRNA for gene silencing in human, mouse, rat OR4N2
     QuantiFast Probe-based Assays in human, mouse, rat OR4N2 QuantiTect SYBR Green Assays in human, mouse, rat OR4N2
     Custom PCR Arrays for OR4N2 Search Chromatin IP Primers for OR4N2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OR4N2  Search GeneGlobe Interaction Network for OR4N2
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     GenScript Custom Purified and Recombinant Proteins Services for OR4N2 GenScript cDNA clones with any tag delivered in your preferred vector for OR4N2
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     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for OR4N2
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR4N2
     Browse compounds at ApexBio
     Search Addgene for plasmids for OR4N2
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      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for OR4N2
     antibodies-online antibodies for OR4N2 (12 products)
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