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Aliases for OR4N2 Gene

Aliases for OR4N2 Gene

  • Olfactory Receptor, Family 4, Subfamily N, Member 2 2 3
  • Olfactory Receptor OR14-13 3 4
  • Olfactory Receptor OR14-8 3 4
  • Olfactory Receptor 4N2 3
  • OR14-13 3
  • OR14-8 3

External Ids for OR4N2 Gene

Previous GeneCards Identifiers for OR4N2 Gene

  • GC14U990418
  • GC14P018286
  • GC14P019341
  • GC14P020295
  • GC14P020187

Summaries for OR4N2 Gene

Entrez Gene Summary for OR4N2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a seven-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Mar 2014]

GeneCards Summary for OR4N2 Gene

OR4N2 (Olfactory Receptor, Family 4, Subfamily N, Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4D9.

UniProtKB/Swiss-Prot for OR4N2 Gene

  • Odorant receptor.

Gene Wiki entry for OR4N2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4N2 Gene

Genomics for OR4N2 Gene

Regulatory Elements for OR4N2 Gene

Genomic Location for OR4N2 Gene

Start:
19,719,015 bp from pter
End:
19,828,372 bp from pter
Size:
109,358 bases
Orientation:
Plus strand

Genomic View for OR4N2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR4N2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4N2 Gene

Proteins for OR4N2 Gene

  • Protein details for OR4N2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGD1-OR4N2_HUMAN
    Recommended name:
    Olfactory receptor 4N2
    Protein Accession:
    Q8NGD1
    Secondary Accessions:
    • Q6IEY9
    • Q6IFA2

    Protein attributes for OR4N2 Gene

    Size:
    307 amino acids
    Molecular mass:
    34721 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4N2 Gene

Proteomics data for OR4N2 Gene at MOPED

Post-translational modifications for OR4N2 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4N2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

Antibody Products

No data available for DME Specific Peptides for OR4N2 Gene

Domains for OR4N2 Gene

Gene Families for OR4N2 Gene

HGNC:
  • OR4 :GPCR / Class A : Olfactory receptors

Protein Domains for OR4N2 Gene

Suggested Antigen Peptide Sequences for OR4N2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGD1

UniProtKB/Swiss-Prot:

OR4N2_HUMAN :
  • Q8NGD1
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4N2: view

Function for OR4N2 Gene

Molecular function for OR4N2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4N2: view

Phenotypes for OR4N2 Gene

GenomeRNAi human phenotypes for OR4N2:
genes like me logo Genes that share phenotypes with OR4N2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4N2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR4N2 Gene

Localization for OR4N2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4N2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR4N2 Gene COMPARTMENTS Subcellular localization image for OR4N2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4N2: view

Pathways for OR4N2 Gene

genes like me logo Genes that share pathways with OR4N2: view

Pathways by source for OR4N2 Gene

Interacting Proteins for OR4N2 Gene

Gene Ontology (GO) - Biological Process for OR4N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4N2: view

Transcripts for OR4N2 Gene

mRNA/cDNA for OR4N2 Gene

(7) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR4N2 Gene

Olfactory receptor, family 4, subfamily N, member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR4N2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4N2 Gene

No ASD Table

Relevant External Links for OR4N2 Gene

GeneLoc Exon Structure for
OR4N2
ECgene alternative splicing isoforms for
OR4N2

Expression for OR4N2 Gene

mRNA expression in normal human tissues for OR4N2 Gene

mRNA differential expression in normal tissues according to GTEx for OR4N2 Gene

This gene is overexpressed in Testis (35.2).

Protein differential expression in normal tissues for OR4N2 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR4N2 Gene

SOURCE GeneReport for Unigene cluster for OR4N2 Gene Hs.512490

genes like me logo Genes that share expressions with OR4N2: view

Expression partners for OR4N2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OR4N2 Gene

Orthologs for OR4N2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4N2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC510931 35
  • 87.08 (n)
  • 88.6 (a)
OR4N2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR4N2 35
  • 88.06 (n)
  • 90.23 (a)
OR4N2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr733 35
  • 79.85 (n)
  • 81.05 (a)
Olfr1508 36
  • 49 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC465195 35
  • 99.78 (n)
  • 99.35 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
ManyToMany
-- 36
  • 79 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 56 (a)
OneToMany
Species with no ortholog for OR4N2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4N2 Gene

ENSEMBL:
Gene Tree for OR4N2 (if available)
TreeFam:
Gene Tree for OR4N2 (if available)

Paralogs for OR4N2 Gene

Selected SIMAP similar genes for OR4N2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for OR4N2 Gene

genes like me logo Genes that share paralogs with OR4N2: view

Variants for OR4N2 Gene

Sequence variations from dbSNP and Humsavar for OR4N2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1686558 -- 19,803,516(+) AGTTC(C/T)GCTTA upstream-variant-2KB
rs1686559 -- 19,803,820(+) gtgaa(C/T)tcctg utr-variant-5-prime
rs1686560 -- 19,803,946(+) gtttc(C/T)aataa intron-variant
rs1686561 -- 19,804,028(+) tcttt(G/T)gggtt intron-variant
rs1686562 -- 19,804,320(+) atctt(C/T)tgatg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OR4N2 Gene

Variant ID Type Subtype PubMed ID
esv23873 CNV Gain+Loss 19812545
esv33527 CNV Gain+Loss 17666407
nsv819711 CNV Loss 19587683
nsv9117 CNV Gain+Loss 18304495
dgv45e180 CNV Loss 20482838
nsv901117 CNV Gain 21882294
dgv599e1 CNV Complex 17122850
nsv428292 CNV Gain+Loss 18775914
nsv433422 CNV Gain 18776910
dgv1811n71 CNV Gain 21882294
dgv601e1 CNV Complex 17122850
dgv1814n71 CNV Gain 21882294
dgv1816n71 CNV Gain 21882294
dgv1819n71 CNV Gain 21882294
dgv6n31 CNV Duplication 19718026
nsv901168 CNV Gain+Loss 21882294
dgv1824n71 CNV Gain 21882294
nsv901192 CNV Loss 21882294
nsv901202 CNV Gain 21882294
dgv1825n71 CNV Gain 21882294
dgv1826n71 CNV Gain 21882294
dgv602e1 CNV Complex 17122850
dgv603e1 CNV Complex 17122850
dgv1827n71 CNV Gain+Loss 21882294
dgv1830n71 CNV Gain 21882294
dgv1831n71 CNV Gain+Loss 21882294
dgv1832n71 CNV Gain 21882294
dgv1833n71 CNV Loss 21882294
dgv1834n71 CNV Gain 21882294
nsv901268 CNV Loss 21882294
nsv901299 CNV Gain 21882294
nsv511546 CNV Gain 21212237
esv1002355 CNV Loss 20482838
nsv821676 CNV Gain 15273396
nsv826860 CNV Gain 20364138
dgv361n67 CNV Gain 20364138
nsv442679 CNV CNV 18776908
esv2421752 OTHER Complex 20811451
nsv514728 CNV Gain 21397061
nsv433273 CNV Loss 18776910
dgv79e55 CNV Loss 17911159
dgv80e55 CNV Gain 17911159
dgv81e55 CNV Gain 17911159
esv2751268 CNV Gain 17911159
dgv1837n71 CNV Gain 21882294
dgv1838n71 CNV Gain 21882294
dgv1839n71 CNV Gain 21882294
nsv832735 CNV Gain 17160897
dgv1840n71 CNV Loss 21882294
dgv604e1 CNV Complex 17122850
dgv82e55 CNV Gain 17911159
esv34243 CNV Loss 17911159
nsv901384 CNV Gain+Loss 21882294
dgv1841n71 CNV Loss 21882294
dgv1842n71 CNV Gain 21882294
nsv901404 CNV Loss 21882294
dgv605e1 CNV Complex 17122850
essv15197 CNV CNV 17122850
dgv1843n71 CNV Gain 21882294
dgv1844n71 CNV Gain 21882294

Relevant External Links for OR4N2 Gene

HapMap Linkage Disequilibrium report
OR4N2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4N2 Gene

Disorders for OR4N2 Gene

No disorders were found for OR4N2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for OR4N2 Gene

Publications for OR4N2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for OR4N2 Gene

Sources for OR4N2 Gene

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